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Science 308 (5719): 227-231

Copyright © 2005 by the American Association for the Advancement of Science

Structure of a {gamma}{delta} T Cell Receptor in Complex with the Nonclassical MHC T22

Erin J. Adams,1,2,3 Yueh-Hsiu Chien,1,3 K. Christopher Garcia1,2,3*

Abstract: {gamma}{delta} T cell receptors (TCRs), {alpha}ß TCRs, and antibodies are the three lineages of somatically recombined antigen receptors. The structural basis for ligand recognition is well defined for {alpha}ß TCR and antibodies but is lacking for {gamma}{delta} TCRs. We present the 3.4 Å structure of the murine {gamma}{delta} TCR G8 bound to its major histocompatibility complex (MHC) class Ib ligand, T22. G8 predominantly uses germline-encoded residues of its {delta} chain complementarity-determining region 3 (CDR3) loop to bind T22 in an orientation substantially different from that seen in {alpha}ß TCR/peptide-MHC. That junctionally encoded G8 residues play an ancillary role in binding suggests a fusion of innate and adaptive recognition strategies.

1 Department of Microbiology and Immunology
2 Department of Structural Biology
3 Program in Immunology, Stanford University School of Medicine, Fairchild D319, 299 Campus Drive, Stanford, CA 94035–5124, USA.

* To whom correspondence should be addressed. E-mail: kcgarcia{at}stanford.edu

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