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Science 8 April 2005: Vol. 308. no. 5719, pp. 252 - 255 DOI: 10.1126/science.1106480
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Reports
Antigen Recognition Determinants of  T Cell Receptors
Sunny Shin,1
Ramy El-Diwany,1,2
Steven Schaffert,1
Erin J. Adams,1,2
K. Christopher Garcia,1,2
Pablo Pereira,3
Yueh-hsiu Chien1,2*
The molecular basis of  T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences of a natural  T cell population specific for the major histocompatibility complex class Ib molecule T22. We find that T22 recognition correlates strongly with a somatically recombined TCR complementarity-determining region 3 (CDR3) motif derived from germ lineencoded residues. Sequence diversity around these residues modulates TCR ligand-binding affinities, whereas V gene usage correlates mainly with tissue origin. These results show how an antigen-specific  TCR repertoire can be generated at a high frequency and suggest that  T cells recognize a limited number of antigens.
1 Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
2 Department of Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
3 Unité du Développement des Lymphocytes, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1961, Institut Pasteur, 75724 Paris, France.
* To whom correspondence should be addressed. E-mail: chien{at}stanford.edu
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