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Science 308 (5721): 557-560

Copyright © 2005 by the American Association for the Advancement of Science

A Cellular MicroRNA Mediates Antiviral Defense in Human Cells

Charles-Henri Lecellier,1* Patrice Dunoyer,1 Khalil Arar,2 Jacqueline Lehmann-Che,3 Stephanie Eyquem,4 Christophe Himber,1 Ali Saïb,3 Olivier Voinnet1*

Abstract: In eukaryotes, 21- to 24-nucleotide-long RNAs engage in sequence-specific interactions that inhibit gene expression by RNA silencing. This process has regulatory roles involving microRNAs and, in plants and insects, it also forms the basis of a defense mechanism directed by small interfering RNAs that derive from replicative or integrated viral genomes. We show that a cellular microRNA effectively restricts the accumulation of the retrovirus primate foamy virus type 1 (PFV-1) in human cells. PFV-1 also encodes a protein, Tas, that suppresses microRNA-directed functions in mammalian cells and displays cross-kingdom antisilencing activities. Therefore, through fortuitous recognition of foreign nucleic acids, cellular microRNAs have direct antiviral effects in addition to their regulatory functions.

1 CNRS Unité Propre de Recherche (UPR) 2357, Institut de Biologie Moléculaire des Plantes, 12 rue du Général Zimmer, 67084 Strasbourg Cedex, France.
2 Proligo, Paris, France.
3 CNRS UPR9051, Hôpital St-Louis, Paris, France.
4 INSERM U462, Hôpital St-Louis, Paris, France.

Note added in proof: Recent findings indicate that a single 8-oligonucleotide seed (small RNA positions 1 to 8 from the 5' end) is sufficient to confer strong regulation by animals miRNAs. Thus, fortuitous targeting of foreign RNAs by cellular miRNAs could be widespread (21, 22).

* To whom correspondence should be addressed. E-mail: charles.lecellier{at}infobiogen.fr (C.-H.L.); olivier. voinnet{at}ibmp-ulp.u-strasbg.fr (O.V.)


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Lin and B. R. Cullen (2007)
J. Virol. 81, 12218-12226
   Abstract »    Full Text »    PDF »
Initial sequence and comparative analysis of the cat genome.
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   Abstract »    Full Text »    PDF »
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A. A. Matskevich and K. Moelling (2007)
J. Gen. Virol. 88, 2627-2635
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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X.-M. Chen, P. L. Splinter, S. P. O'Hara, and N. F. LaRusso (2007)
J. Biol. Chem. 282, 28929-28938
   Abstract »    Full Text »    PDF »
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B. Berkhout and K.-T. Jeang (2007)
J. Biol. Chem. 282, 26641-26645
   Full Text »    PDF »
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Circulation 116, 258-267
   Abstract »    Full Text »    PDF »
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W.-O. Lui, N. Pourmand, B. K. Patterson, and A. Fire (2007)
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   Abstract »    Full Text »    PDF »
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H. Hemmes, L. Lakatos, R. Goldbach, J. Burgyan, and M. Prins (2007)
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   Abstract »    Full Text »    PDF »
Artificial MicroRNA-Mediated Virus Resistance in Plants.
J. Qu, J. Ye, and R. Fang (2007)
J. Virol. 81, 6690-6699
   Abstract »    Full Text »    PDF »
MicroRNAs in human cancer: from research to therapy.
M. Negrini, M. Ferracin, S. Sabbioni, and C. M. Croce (2007)
J. Cell Sci. 120, 1833-1840
   Abstract »    Full Text »    PDF »
The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells.
P. Laneve, L. Di Marcotullio, U. Gioia, M. E. Fiori, E. Ferretti, A. Gulino, I. Bozzoni, and E. Caffarelli (2007)
PNAS 104, 7957-7962
   Abstract »    Full Text »    PDF »
Discovery and profiling of bovine microRNAs from immune-related and embryonic tissues.
L. L. Coutinho, L. K. Matukumalli, T. S. Sonstegard, C. P. Van Tassell, L. C. Gasbarre, A. V. Capuco, and T. P. L. Smith (2007)
Physiol Genomics 29, 35-43
   Abstract »    Full Text »    PDF »
Antiviral Protein APOBEC3G Localizes to Ribonucleoprotein Complexes Found in P Bodies and Stress Granules.
S. Gallois-Montbrun, B. Kramer, C. M. Swanson, H. Byers, S. Lynham, M. Ward, and M. H. Malim (2007)
J. Virol. 81, 2165-2178
   Abstract »    Full Text »    PDF »
MicroRNA-155 is induced during the macrophage inflammatory response.
R. M. O'Connell, K. D. Taganov, M. P. Boldin, G. Cheng, and D. Baltimore (2007)
PNAS 104, 1604-1609
   Abstract »    Full Text »    PDF »
ViTa: prediction of host microRNAs targets on viruses.
P. W.-C. Hsu, L.-Z. Lin, S.-D. Hsu, J. B.-K. Hsu, and H.-D. Huang (2007)
Nucleic Acids Res. 35, D381-D385
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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X. Zhang, Y.-R. Yuan, Y. Pei, S.-S. Lin, T. Tuschl, D. J. Patel, and N.-H. Chua (2006)
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   Abstract »    Full Text »    PDF »
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S. Katiyar-Agarwal, R. Morgan, D. Dahlbeck, O. Borsani, A. Villegas Jr., J.-K. Zhu, B. J. Staskawicz, and H. Jin (2006)
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