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Science 308 (5725): 1181-1184

Copyright © 2005 by the American Association for the Advancement of Science

Functional Interaction Between ß-Catenin and FOXO in Oxidative Stress Signaling

Marieke A. G. Essers,1 Lydia M. M. de Vries-Smits,1 Nick Barker,2 Paulien E. Polderman,1 Boudewijn M. T. Burgering,1* Hendrik C. Korswagen2*

Abstract: ß-Catenin is a multifunctional protein that mediates Wnt signaling by binding to members of the T cell factor (TCF) family of transcription factors. Here, we report an evolutionarily conserved interaction of ß-catenin with FOXO transcription factors, which are regulated by insulin and oxidative stress signaling. ß-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells. In Caenorhabditis elegans, loss of the ß-catenin BAR-1 reduces the activity of the FOXO ortholog DAF-16 in dauer formation and life span. Association of ß-catenin with FOXO was enhanced in cells exposed to oxidative stress. Furthermore, BAR-1 was required for the oxidative stress–induced expression of the DAF-16 target gene sod-3 and for resistance to oxidative damage. These results demonstrate a role for ß-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress.

1 Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands.
2 Hubrecht Laboratory and Center for Biomedical Genetics, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.

* To whom correspondence should be addressed. E-mail: b.m.t.burgering{at}med.uu.nl and rkors{at}niob.knaw.nl


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
Role for {beta}-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.
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   Abstract »    Full Text »    PDF »
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R. C.-Y. Hui, A. R. Gomes, D. Constantinidou, J. R. Costa, C. T. Karadedou, S. Fernandez de Mattos, M. P. Wymann, J. J. Brosens, A. Schulze, and E. W.-F. Lam (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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K. S Lau and J. W Dennis (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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M. Horikawa, T. Nomura, T. Hashimoto, and K. Sakamoto (2008)
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   Abstract »    Full Text »    PDF »
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M. Dehner, M. Hadjihannas, J. Weiske, O. Huber, and J. Behrens (2008)
J. Biol. Chem. 283, 19201-19210
   Abstract »    Full Text »    PDF »
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D. Hoogeboom, M. A. G. Essers, P. E. Polderman, E. Voets, L. M. M. Smits, and B. M. Th. Burgering (2008)
J. Biol. Chem. 283, 9224-9230
   Abstract »    Full Text »    PDF »
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K. N. Papanicolaou, Y. Izumiya, and K. Walsh (2008)
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   Abstract »    Full Text »    PDF »
Shear stress-induced activation of the AMP-activated protein kinase regulates FoxO1a and angiopoietin-2 in endothelial cells.
M. Dixit, E. Bess, B. Fisslthaler, F. V. Hartel, T. Noll, R. Busse, and I. Fleming (2008)
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   Abstract »    Full Text »    PDF »
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S. Wohrle, B. Wallmen, and A. Hecht (2007)
Mol. Cell. Biol. 27, 8164-8177
   Abstract »    Full Text »    PDF »
A food's-eye view of the transition from basal metazoans to bilaterians.
N. W. Blackstone (2007)
Integr. Comp. Biol. 47, 724-733
   Abstract »    Full Text »    PDF »
Complex N-Glycan and Metabolic Control in Tumor Cells.
R. Mendelsohn, P. Cheung, L. Berger, E. Partridge, K. Lau, A. Datti, J. Pawling, and J. W. Dennis (2007)
Cancer Res. 67, 9771-9780
   Abstract »    Full Text »    PDF »
Oxidative Stress Antagonizes Wnt Signaling in Osteoblast Precursors by Diverting beta-Catenin from T Cell Factor- to Forkhead Box O-mediated Transcription.
M. Almeida, L. Han, M. Martin-Millan, C. A. O'Brien, and S. C. Manolagas (2007)
J. Biol. Chem. 282, 27298-27305
   Abstract »    Full Text »    PDF »
Dynamic FoxO transcription factors.
H. Huang and D. J. Tindall (2007)
J. Cell Sci. 120, 2479-2487
   Abstract »    Full Text »    PDF »
Constitutively active FOXO1a and a DNA-binding domain mutant exhibit distinct co-regulatory functions to enhance progesterone receptor A activity.
M. D Rudd, I. Gonzalez-Robayna, I. Hernandez-Gonzalez, N. L Weigel, W. E Bingman III, and J. S Richards (2007)
J. Mol. Endocrinol. 38, 673-690
   Abstract »    Full Text »    PDF »
FOXO Transcription Factors in the Regulatory Networks of Longevity.
H. Daitoku and A. Fukamizu (2007)
J. Biochem. 141, 769-774
   Abstract »    Full Text »    PDF »
Differential Regulation of Foxo3a Target Genes in Erythropoiesis.
W. J. Bakker, T. B. van Dijk, M. Parren-van Amelsvoort, A. Kolbus, K. Yamamoto, P. Steinlein, R. G. W. Verhaak, T. W. Mak, H. Beug, B. Lowenberg, et al. (2007)
Mol. Cell. Biol. 27, 3839-3854
   Abstract »    Full Text »    PDF »
The emerging role of FOXO transcription factors in pancreatic {beta} cells.
D. A Glauser and W. Schlegel (2007)
J. Endocrinol. 193, 195-207
   Abstract »    Full Text »    PDF »
Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells.
G. S. Yochum, S. McWeeney, V. Rajaraman, R. Cleland, S. Peters, and R. H. Goodman (2007)
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   Abstract »    Full Text »    PDF »
The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling.
A. Bosque, J. I. Aguilo, M. A. Alava, E. Paz-Artal, J. Naval, L. M. Allende, and A. Anel (2007)
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   Abstract »    Full Text »    PDF »
Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation.
X. Luo, O. Puig, J. Hyun, D. Bohmann, and H. Jasper (2007)
EMBO J. 26, 380-390
   Abstract »    Full Text »    PDF »
Down-regulation of Manganese-Superoxide Dismutase through Phosphorylation of FOXO3a by Akt in Explanted Vascular Smooth Muscle Cells from Old Rats.
M. Li, J.-F. Chiu, B. T. Mossman, and N. K. Fukagawa (2006)
J. Biol. Chem. 281, 40429-40439
   Abstract »    Full Text »    PDF »
Chronic Protein Kinase B (PKB/c-akt) Activation Leads to Apoptosis Induced by Oxidative Stress-Mediated Foxo3a Transcriptional Up-regulation..
A. G.M. van Gorp, K. M. Pomeranz, K. U. Birkenkamp, R. C-Y. Hui, E. W-F. Lam, and P. J. Coffer (2006)
Cancer Res. 66, 10760-10769
   Abstract »    Full Text »    PDF »
Endocrine signaling in Caenorhabditis elegans controls stress response and longevity.
R. Baumeister, E. Schaffitzel, and M. Hertweck (2006)
J. Endocrinol. 190, 191-202
   Abstract »    Full Text »    PDF »
G1/S Arrest Induced by Histone Deacetylase Inhibitor Sodium Butyrate in E1A + Ras-transformed Cells Is Mediated through Down-regulation of E2F Activity and Stabilization of beta-Catenin.
M. V. Abramova, T. V. Pospelova, F. P. Nikulenkov, C. M. Hollander, A. J. Fornace Jr., and V. A. Pospelov (2006)
J. Biol. Chem. 281, 21040-21051
   Abstract »    Full Text »    PDF »
Regulation of Human Nitric Oxide Synthase 2 Expression by Wnt {beta}-Catenin Signaling..
Q. Du, K. S. Park, Z. Guo, P. He, M. Nagashima, L. Shao, R. Sahai, D. A. Geller, and S. P. Hussain (2006)
Cancer Res. 66, 7024-7031
   Abstract »    Full Text »    PDF »
The Heat-Shock Protein Apg-2 Binds to the Tight Junction Protein ZO-1 and Regulates Transcriptional Activity of ZONAB.
A. Tsapara, K. Matter, and M. S. Balda (2006)
Mol. Biol. Cell 17, 1322-1330
   Abstract »    Full Text »    PDF »
RUNX3 Cooperates with FoxO3a to Induce Apoptosis in Gastric Cancer Cells.
Y. Yamamura, W. L. Lee, K.-i. Inoue, H. Ida, and Y. Ito (2006)
J. Biol. Chem. 281, 5267-5276
   Abstract »    Full Text »    PDF »
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J. Harper, J. L. Burns, E. J. Foulstone, M. Pignatelli, S. Zaina, and A. B. Hassan (2006)
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   Abstract »    Full Text »    PDF »
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M. Yamamoto, J. D. Clark, J. V. Pastor, P. Gurnani, A. Nandi, H. Kurosu, M. Miyoshi, Y. Ogawa, D. H. Castrillon, K. P. Rosenblatt, et al. (2005)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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