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Science 308 (5728): 1592-1594

Copyright © 2005 by the American Association for the Advancement of Science

Latest Advances in Understanding Preeclampsia

Christopher W. Redman*, and Ian L. Sargent

Abstract: Preeclampsia is a relatively common pregnancy disorder that originates in the placenta and causes variable maternal and fetal problems. In the worst cases, it may threaten the survival of both mother and baby. We summarize recent work on the causes of preeclampsia, which reveals a new mode of maternal immune recognition of the fetus, relevant to the condition. The circulating factors derived from the placenta, which contributes to the clinical syndrome, are now better understood. This brief review on preeclampsia does not cover all aspects of this intriguing condition but focuses on some new and interesting findings.

Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

* To whom correspondence should be addressed. E-mail: christopher.redman{at}obs-gyn.ox.ac.uk


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Spiral Arterial Remodeling Is Not Essential for Normal Blood Pressure Regulation in Pregnant Mice.
S. D. Burke, V. F. Barrette, J. Bianco, J. G. Thorne, A. T. Yamada, S. C. Pang, M. A. Adams, and B. A. Croy (2010)
Hypertension 55, 729-737
   Abstract »    Full Text »    PDF »
National cohort study of reproductive risk factors for rheumatoid arthritis in Denmark: a role for hyperemesis, gestational hypertension and pre-eclampsia?.
K T Jorgensen, B V Pedersen, S Jacobsen, R J Biggar, and M Frisch (2010)
Ann Rheum Dis 69, 358-363
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Angiotensin Receptor Agonistic Autoantibody Is Highly Prevalent in Preeclampsia: Correlation With Disease Severity.
A. H. Siddiqui, R. A. Irani, S. C. Blackwell, S. M. Ramin, R. E. Kellems, and Y. Xia (2010)
Hypertension 55, 386-393
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Angiotensin Receptor Agonistic Autoantibody-Mediated Tumor Necrosis Factor-{alpha} Induction Contributes to Increased Soluble Endoglin Production in Preeclampsia.
C. C. Zhou, R. A. Irani, Y. Zhang, S. C. Blackwell, T. Mi, J. Wen, H. Shelat, Y.-J. Geng, S. M. Ramin, R. E. Kellems, et al. (2010)
Circulation 121, 436-444
   Abstract »    Full Text »    PDF »
Subclinical hypothyroidism after pre-eclampsia.
R. A North and R. N Taylor (2009)
BMJ 339, b5183
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