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Science 308 (5728): 1592-1594

Copyright © 2005 by the American Association for the Advancement of Science

Latest Advances in Understanding Preeclampsia

Christopher W. Redman*, and Ian L. Sargent

Abstract: Preeclampsia is a relatively common pregnancy disorder that originates in the placenta and causes variable maternal and fetal problems. In the worst cases, it may threaten the survival of both mother and baby. We summarize recent work on the causes of preeclampsia, which reveals a new mode of maternal immune recognition of the fetus, relevant to the condition. The circulating factors derived from the placenta, which contributes to the clinical syndrome, are now better understood. This brief review on preeclampsia does not cover all aspects of this intriguing condition but focuses on some new and interesting findings.

Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

* To whom correspondence should be addressed. E-mail: christopher.redman{at}obs-gyn.ox.ac.uk


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Embryonic stem cells as models of trophoblast differentiation: progress, opportunities, and limitations.
T. G. Golos, M. Giakoumopoulos, and M. A. Garthwaite (2010)
Reproduction 140, 3-9
   Abstract »    Full Text »    PDF »
Upregulation of Urotensin II Receptor in Preeclampsia Causes In Vitro Placental Release of Soluble Vascular Endothelial Growth Factor Receptor 1 in Hypoxia.
P. S. Gould, M. Gu, J. Liao, S. Ahmad, M. J. Cudmore, A. Ahmed, and M. Vatish (2010)
Hypertension 56, 172-178
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Activation of AP-1 Transcription Factors Differentiates FGF2 and Vascular Endothelial Growth Factor Regulation of Endothelial Nitric-oxide Synthase Expression in Placental Artery Endothelial Cells.
E. Mata-Greenwood, W. x. Liao, W. Wang, J. Zheng, and D. b. Chen (2010)
J. Biol. Chem. 285, 17348-17358
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Nicotine Suppresses Interleukin-6 Production From Vascular Endothelial Cells: A Possible Therapeutic Role of Nicotine for Preeclampsia.
N. Sharentuya, T. Tomimatsu, K. Mimura, E. Tskitishvili, Y. Kinugasa-Taniguchi, T. Kanagawa, and T. Kimura (2010)
Reproductive Sciences 17, 556-563
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