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Henrietta C. E. Rooney,1*
John W. van't Klooster,2*
Renier A. L. van der Hoorn,2
Matthieu H. A. J. Joosten,2
Jonathan D. G. Jones,1
Pierre J. G. M. de Wit2
Abstract:
How plants recognize pathogens and activate defense is stillmysterious. Direct interaction between pathogen avirulence (Avr)proteins and plant disease resistance proteins is the exceptionrather than the rule. During infection, Cladosporium fulvumsecretes Avr2 protein into the apoplast of tomato leaves and,in the presence of the extracellular leucine-rich repeat receptor-likeCf-2 protein, triggers a hypersensitive response (HR) that alsorequires the extracellular tomato cysteine protease Rcr3. Weshow here that Avr2 binds and inhibits Rcr3 and propose thatthe Rcr3-Avr2 complex enables the Cf-2 protein to activate anHR.
1 Sainsbury Laboratory, John Innes Centre, Norwich NR4 7UH, UK. 2 Laboratory of Phytopathology, Wageningen University, Binnenhaven 5, 6709 PD Wageningen, Netherlands.
* These authors contributed equally to this work.
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: pierre.dewit{at}wur.nl
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Pierre J. G. M. de Wit2
These authors contributed equally to this work. 
To whom correspondence should be addressed. E-mail: 
