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Science 309 (5732): 264-268

Copyright © 2005 by the American Association for the Advancement of Science

Professional Antigen-Presentation Function by Human {gamma}{delta} T Cells

Marlène Brandes, Katharina Willimann, Bernhard Moser*

Abstract: Human {gamma}{delta} T cells are considered to play a vital role in protective immunity through cytokine secretion and cytotoxic activity. We report that cells expressing the V{gamma}2V{delta}2+–T cell receptor (V{delta}2+ T cells) also display principal characteristics of professional antigen-presenting cells such as dendritic cells. Thus, when activated, these cells efficiently processed and displayed antigens and provided co-stimulatory signals sufficient for strong induction of naïve {alpha}ß T cell proliferation and differentiation. We suggest that, upon microbial activation, V{delta}2+ T cells participate in the induction of adaptive immune responses and that these cells may be a useful tool in vaccine development and immunotherapy.

Institute of Cell Biology, University of Bern, CH-3012, Switzerland.

* To whom correspondence should be addressed. E-mail: bernhard.moser{at}izb.unibe.ch


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