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Science 309 (5732): 310-311

Copyright © 2005 by the American Association for the Advancement of Science

MicroRNA Expression in Zebrafish Embryonic Development

Erno Wienholds,1 Wigard P. Kloosterman,1 Eric Miska,2,3 Ezequiel Alvarez-Saavedra,2 Eugene Berezikov,1 Ewart de Bruijn,1 H. Robert Horvitz,2 Sakari Kauppinen,4 Ronald H. A. Plasterk1*

Abstract: MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by miRNAs can play essential roles in embryonic development. We determined the temporal and spatial expression patterns of 115 conserved vertebrate miRNAs in zebrafish embryos by microarrays and by in situ hybridizations, using locked-nucleic acid–modified oligonucleotide probes. Most miRNAs were expressed in a highly tissue-specific manner during segmentation and later stages, but not early in development, which suggests that their role is not in tissue fate establishment but in differentiation or maintenance of tissue identity.

1 Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, the Netherlands.
2 Howard Hughes Medical Institute, Department of Biology and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3 Wellcome Trust, Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK.
4 Wilhelm Johannsen Centre for Functional Genome Research, Institute of Medical Biochemistry and Genetics, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

* To whom correspondence should be addressed. E-mail: plasterk{at}niob.knaw.nl

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