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Science 309 (5736): 929-932

Copyright © 2005 by the American Association for the Advancement of Science

Antagonistic Control of Disease Resistance Protein Stability in the Plant Immune System

Ben F. Holt, III,1* Youssef Belkhadir,1* Jeffery L. Dangl1,2,3,4{dagger}

Abstract: Pathogen recognition by the plant immune system is governed by structurally related, polymorphic products of disease resistance (R) genes. RAR1 and/or SGT1b mediate the function of many R proteins. RAR1 controls preactivation R protein accumulation by an unknown mechanism. We demonstrate that Arabidopsis SGT1b has two distinct, genetically separable functions in the plant immune system: SGT1b antagonizes RAR1 to negatively regulate R protein accumulation before infection, and SGT1b has a RAR1-independent function that regulates programmed cell death during infection. The balanced activities of RAR1 and SGT1, in concert with cytosolic HSP90, modulate preactivation R protein accumulation and signaling competence.

1 Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
2 Curriculum in Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
3 Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.
4 Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. Department of Biology, 108 Coker Hall, University of North Carolina, CB# 3280, Chapel Hill, NC 27599–3280, USA. E-mail: dangl{at}email.unc.edu

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