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Science 309 (5737): 1071-1073

Copyright © 2005 by the American Association for the Advancement of Science

Direct Control of Germline Stem Cell Division and Cyst Growth by Neural Insulin in Drosophila

Leesa LaFever, and Daniela Drummond-Barbosa*

Abstract: Stem cells reside in specialized niches that provide signals required for their maintenance and division. Tissue-extrinsic signals can also modify stem cell activity, although this is poorly understood. Here, we report that neural-derived Drosophila insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating the ovarian response to nutritional input can modify stem cell activity in a niche-independent manner. We also reveal a crucial direct role of DILPs in controlling germline cyst growth and vitellogenesis.

Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4120B Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232–8240, USA.

* To whom correspondence should be addressed. E-mail: daniela.drummond-barbosa{at}vanderbilt.edu

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