Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 309 (5737): 1074-1078

Copyright © 2005 by the American Association for the Advancement of Science

TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation

Jeong-Ho Hong,1 Eun Sook Hwang,3 Michael T. McManus,1 Adam Amsterdam,1 Yu Tian,4 Ralitsa Kalmukova,1 Elisabetta Mueller,5 Thomas Benjamin,4 Bruce M. Spiegelman,5 Phillip A. Sharp,1 Nancy Hopkins,1 Michael B. Yaffe1,2*

Abstract: Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into several distinct lineages. Two key transcription factors, Runx2 and peroxisome proliferator–activated receptor {gamma} (PPAR{gamma}), drive MSCs to differentiate into either osteoblasts or adipocytes, respectively. How these two transcription factors are regulated in order to specify these alternate cell fates remains a pivotal question. Here we report that a 14-3-3–binding protein, TAZ (transcriptional coactivator with PDZ-binding motif), coactivates Runx2-dependent gene transcription while repressing PPAR{gamma}-dependent gene transcription. By modulating TAZ expression in model cell lines, mouse embryonic fibroblasts, and primary MSCs in culture and in zebrafish in vivo, we observed alterations in osteogenic versus adipogenic potential. These results indicate that TAZ functions as a molecular rheostat that modulates MSC differentiation.

1 Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E18-580, Cambridge, MA 02139, USA.
2 Division of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E18-580, Cambridge, MA 02139, USA.
3 Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA.
4 Department of Pathology, Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA.
5 Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

* To whom correspondence should be addressed. E-mail: myaffe{at}

Screening with a Novel Cell-Based Assay for TAZ Activators Identifies a Compound That Enhances Myogenesis in C2C12 Cells and Facilitates Muscle Repair in a Muscle Injury Model.
Z. Yang, K. Nakagawa, A. Sarkar, J. Maruyama, H. Iwasa, Y. Bao, M. Ishigami-Yuasa, S. Ito, H. Kagechika, S. Hata, et al. (2014)
Mol. Cell. Biol. 34, 1607-1621
   Abstract »    Full Text »    PDF »
Low Intensity Pulsed Ultrasound (LIPUS) Influences the Multilineage Differentiation of Mesenchymal Stem and Progenitor Cell Lines through ROCK-Cot/Tpl2-MEK-ERK Signaling Pathway.
J. Kusuyama, K. Bandow, M. Shamoto, K. Kakimoto, T. Ohnishi, and T. Matsuguchi (2014)
J. Biol. Chem. 289, 10330-10344
   Abstract »    Full Text »    PDF »
(-)-Epicatechin Gallate (ECG) Stimulates Osteoblast Differentiation via Runt-related Transcription Factor 2 (RUNX2) and Transcriptional Coactivator with PDZ-binding Motif (TAZ)-mediated Transcriptional Activation.
M. R. Byun, M. K. Sung, A. R. Kim, C. H. Lee, E. J. Jang, M. G. Jeong, M. Noh, E. S. Hwang, and J.-H. Hong (2014)
J. Biol. Chem. 289, 9926-9935
   Abstract »    Full Text »    PDF »
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease.
X. Varelas (2014)
Development 141, 1614-1626
   Abstract »    Full Text »    PDF »
The Role of Prolyl Hydroxylase Domain Protein (PHD) during Rosiglitazone-induced Adipocyte Differentiation.
J. Kim, H. J. Kwak, J.-Y. Cha, Y.-S. Jeong, S. D. Rhee, and H. G. Cheon (2014)
J. Biol. Chem. 289, 2755-2764
   Abstract »    Full Text »    PDF »
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation.
J. Swift, I. L. Ivanovska, A. Buxboim, T. Harada, P. C. D. P. Dingal, J. Pinter, J. D. Pajerowski, K. R. Spinler, J.-W. Shin, M. Tewari, et al. (2013)
Science 341, 1240104
   Abstract »    Full Text »    PDF »
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation.
F.-X. Yu, Y. Zhang, H. W. Park, J. L. Jewell, Q. Chen, Y. Deng, D. Pan, S. S. Taylor, Z.-C. Lai, and K.-L. Guan (2013)
Genes & Dev. 27, 1223-1232
   Abstract »    Full Text »    PDF »
Sumoylation of Kruppel-like Factor 4 Inhibits Pluripotency Induction but Promotes Adipocyte Differentiation.
S. Tahmasebi, M. Ghorbani, P. Savage, K. Yan, G. Gocevski, L. Xiao, L. You, and X.-J. Yang (2013)
J. Biol. Chem. 288, 12791-12804
   Abstract »    Full Text »    PDF »
Mesenchymal stem cell mechanobiology and emerging experimental platforms.
L. MacQueen, Y. Sun, and C. A. Simmons (2013)
J R Soc Interface 10, 20130179
   Abstract »    Full Text »    PDF »
Nuclear Receptors in Bone Physiology and Diseases.
Y. Imai, M.-Y. Youn, K. Inoue, I. Takada, A. Kouzmenko, and S. Kato (2013)
Physiol Rev 93, 481-523
   Abstract »    Full Text »    PDF »
Nuclear Receptors and Their Selective Pharmacologic Modulators.
T. P. Burris, L. A. Solt, Y. Wang, C. Crumbley, S. Banerjee, K. Griffett, T. Lundasen, T. Hughes, and D. J. Kojetin (2013)
Pharmacol. Rev. 65, 710-778
   Abstract »    Full Text »    PDF »
The Hippo pathway: regulators and regulations.
F.-X. Yu and K.-L. Guan (2013)
Genes & Dev. 27, 355-371
   Abstract »    Full Text »    PDF »
Development of the Endochondral Skeleton.
F. Long and D. M. Ornitz (2013)
Cold Spring Harb Perspect Biol 5, a008334
   Abstract »    Full Text »    PDF »
TAZ Suppresses NFAT5 Activity through Tyrosine Phosphorylation.
E. J. Jang, H. Jeong, K. H. Han, H. M. Kwon, J.-H. Hong, and E. S. Hwang (2012)
Mol. Cell. Biol. 32, 4925-4932
   Abstract »    Full Text »    PDF »
Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation.
J.-w. Yin, Y. Liang, J. Y. Park, D. Chen, X. Yao, Q. Xiao, Z. Liu, B. Jiang, Y. Fu, M. Bao, et al. (2012)
Genes & Dev. 26, 2192-2205
   Abstract »    Full Text »    PDF »
The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCF{beta}-TrCP-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition.
W. Huang, X. Lv, C. Liu, Z. Zha, H. Zhang, Y. Jiang, Y. Xiong, Q.-Y. Lei, and K.-L. Guan (2012)
J. Biol. Chem. 287, 26245-26253
   Abstract »    Full Text »    PDF »
The voyage of stem cell toward terminal differentiation: a brief overview.
S. Bhattacharyya, A. Kumar, and K. Lal Khanduja (2012)
Acta Biochim Biophys Sin 44, 463-475
   Abstract »    Full Text »    PDF »
A molecular mechanism that links Hippo signalling to the inhibition of Wnt/{beta}-catenin signalling.
M. Imajo, K. Miyatake, A. Iimura, A. Miyamoto, and E. Nishida (2012)
EMBO J. 31, 1109-1122
   Abstract »    Full Text »    PDF »
Concise Review: Adipose-Derived Stromal Vascular Fraction Cells and Platelet-Rich Plasma: Basic and Clinical Implications for Tissue Engineering Therapies in Regenerative Surgery.
P. Gentile, A. Orlandi, M. G. Scioli, C. Di Pasquali, I. Bocchini, and V. Cervelli (2012)
Stem Cells Trans Med 1, 230-236
   Abstract »    Full Text »    PDF »
Inhibition of fetal bone development through epigenetic down-regulation of HoxA10 in obese rats fed high-fat diet.
J.-R. Chen, J. Zhang, O. P. Lazarenko, P. Kang, M. L. Blackburn, M. J. J. Ronis, T. M. Badger, and K. Shankar (2012)
FASEB J 26, 1131-1141
   Abstract »    Full Text »    PDF »
A Cell-permeable Fusion Protein for the Mineralization of Human Dental Pulp Stem Cells.
J. S. Suh, K. S. Kim, J. Y. Lee, Y. J. Choi, C. P. Chung, and Y. J. Park (2012)
Journal of Dental Research 91, 90-96
   Abstract »    Full Text »    PDF »
TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis.
D. Zhao, X. Zhi, Z. Zhou, and C. Chen (2012)
Carcinogenesis 33, 59-67
   Abstract »    Full Text »    PDF »
The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma.
K. P. L. Bhat, K. L. Salazar, V. Balasubramaniyan, K. Wani, L. Heathcock, F. Hollingsworth, J. D. James, J. Gumin, K. L. Diefes, S. H. Kim, et al. (2011)
Genes & Dev. 25, 2594-2609
   Abstract »    Full Text »    PDF »
Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma.
M. R. Tanas, A. Sboner, A. M. Oliveira, M. R. Erickson-Johnson, J. Hespelt, P. J. Hanwright, J. Flanagan, Y. Luo, K. Fenwick, R. Natrajan, et al. (2011)
Science Translational Medicine 3, 98ra82
   Abstract »    Full Text »    PDF »
Tying TAZ and Nek1 into Polycystic Kidney Disease through Polycystin 2 Levels.
S. K. Dutcher and H. Lin (2011)
J. Am. Soc. Nephrol. 22, 791-793
   Full Text »    PDF »
Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF.
D. Lai, K. C. Ho, Y. Hao, and X. Yang (2011)
Cancer Res. 71, 2728-2738
   Abstract »    Full Text »    PDF »
Mammalian Hippo pathway: from development to cancer and beyond.
Y. Bao, Y. Hata, M. Ikeda, and K. Withanage (2011)
J. Biochem. 149, 361-379
   Abstract »    Full Text »    PDF »
Myocyte Enhancer Factor-2 Interacting Transcriptional Repressor (MITR) Is a Switch That Promotes Osteogenesis and Inhibits Adipogenesis of Mesenchymal Stem Cells by Inactivating Peroxisome Proliferator-activated Receptor {gamma}-2.
Y.-H. Chen, F.-L. Yeh, S.-P. Yeh, H.-T. Ma, S.-C. Hung, M.-C. Hung, and L.-Y. Li (2011)
J. Biol. Chem. 286, 10671-10680
   Abstract »    Full Text »    PDF »
Circadian Rhythm Gene Period 3 Is an Inhibitor of the Adipocyte Cell Fate.
M. J. Costa, A. Y.- L. So, K. Kaasik, K. C. Krueger, M. L. Pillsbury, Y.-H. Fu, L. J. Ptacek, K. R. Yamamoto, and B. J. Feldman (2011)
J. Biol. Chem. 286, 9063-9070
   Abstract »    Full Text »    PDF »
Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin.
S. W. Chan, C. J. Lim, Y. F. Chong, A. V. Pobbati, C. Huang, and W. Hong (2011)
J. Biol. Chem. 286, 7018-7026
   Abstract »    Full Text »    PDF »
PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ.
C.-Y. Liu, X. Lv, T. Li, Y. Xu, X. Zhou, S. Zhao, Y. Xiong, Q.-Y. Lei, and K.-L. Guan (2011)
J. Biol. Chem. 286, 5558-5566
   Abstract »    Full Text »    PDF »
Hippo signaling: growth control and beyond.
G. Halder and R. L. Johnson (2011)
Development 138, 9-22
   Abstract »    Full Text »    PDF »
The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCF{beta}-TrCP E3 Ligase.
C.-Y. Liu, Z.-Y. Zha, X. Zhou, H. Zhang, W. Huang, D. Zhao, T. Li, S. W. Chan, C. J. Lim, W. Hong, et al. (2010)
J. Biol. Chem. 285, 37159-37169
   Abstract »    Full Text »    PDF »
Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling.
M. Molzan, B. Schumacher, C. Ottmann, A. Baljuls, L. Polzien, M. Weyand, P. Thiel, R. Rose, M. Rose, P. Kuhenne, et al. (2010)
Mol. Cell. Biol. 30, 4698-4711
   Abstract »    Full Text »    PDF »
TAZ as a novel enhancer of MyoD-mediated myogenic differentiation.
H. Jeong, S. Bae, S. Y. An, M. R. Byun, J.-H. Hwang, M. B. Yaffe, J.-H. Hong, and E. S. Hwang (2010)
FASEB J 24, 3310-3320
   Abstract »    Full Text »    PDF »
Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation.
S. Urs, D. Venkatesh, Y. Tang, T. Henderson, X. Yang, R. E. Friesel, C. J. Rosen, and L. Liaw (2010)
FASEB J 24, 3264-3273
   Abstract »    Full Text »    PDF »
Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression.
K. C. Kurek, S. Del Mare, Z. Salah, S. Abdeen, H. Sadiq, S.-h. Lee, E. Gaudio, N. Zanesi, K. B. Jones, B. DeYoung, et al. (2010)
Cancer Res. 70, 5577-5586
   Abstract »    Full Text »    PDF »
Human Transcriptional Coactivator with PDZ-Binding Motif (TAZ) Is Downregulated During Decidualization.
Z. Strakova, J. Reed, and I. Ihnatovych (2010)
Biol Reprod 82, 1112-1118
   Abstract »    Full Text »    PDF »
B. Levi, S. H. Ko, and M. T. Longaker (2010)
Aesthetic Surgery Journal 30, 387-389
   Full Text »    PDF »
Ephrin B1 Regulates Bone Marrow Stromal Cell Differentiation and Bone Formation by Influencing TAZ Transactivation via Complex Formation with NHERF1.
W. Xing, J. Kim, J. Wergedal, S.-T. Chen, and S. Mohan (2010)
Mol. Cell. Biol. 30, 711-721
   Abstract »    Full Text »    PDF »
Regulation of neural crest cell fate by the retinoic acid and Pparg signalling pathways.
N. Li, R. N. Kelsh, P. Croucher, and H. H. Roehl (2010)
Development 137, 389-394
   Abstract »    Full Text »    PDF »
Novel Mediators of Amyloid Precursor Protein Signaling.
A. Swistowski, Q. Zhang, M. E. Orcholski, D. Crippen, C. Vitelli, A. Kurakin, and D. E. Bredesen (2009)
J. Neurosci. 29, 15703-15712
   Abstract »    Full Text »    PDF »
Regulation of adipogenic differentiation by LAR tyrosine phosphatase in human mesenchymal stem cells and 3T3-L1 preadipocytes.
W.-K. Kim, H. Jung, D.-H. Kim, E.-Y. Kim, J.-W. Chung, Y.-S. Cho, S.-G. Park, B.-C. Park, Y. Ko, K.-H. Bae, et al. (2009)
J. Cell Sci. 122, 4160-4167
   Abstract »    Full Text »    PDF »
The Hippo Tumor Suppressor Pathway: A Brainstorming Workshop.
G. Blandino, Y. Shaul, S. Strano, M. Sudol, and M. Yaffe (2009)
Science Signaling 2, mr6
   Abstract »    Full Text »    PDF »
Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen.
M. M. Fluck and B. S. Schaffhausen (2009)
Microbiol. Mol. Biol. Rev. 73, 542-563
   Abstract »    Full Text »    PDF »
TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation.
S. W. Chan, C. J. Lim, L. S. Loo, Y. F. Chong, C. Huang, and W. Hong (2009)
J. Biol. Chem. 284, 14347-14358
   Abstract »    Full Text »    PDF »
Glis3 Is Associated with Primary Cilia and Wwtr1/TAZ and Implicated in Polycystic Kidney Disease.
H. S. Kang, J. Y. Beak, Y.-S. Kim, R. Herbert, and A. M. Jetten (2009)
Mol. Cell. Biol. 29, 2556-2569
   Abstract »    Full Text »    PDF »
TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition.
H. Zhang, C.-Y. Liu, Z.-Y. Zha, B. Zhao, J. Yao, S. Zhao, Y. Xiong, Q.-Y. Lei, and K.-L. Guan (2009)
J. Biol. Chem. 284, 13355-13362
   Abstract »    Full Text »    PDF »
IKK{beta} and the anti-adipogenic effect of platelet-derived growth factor in human abdominal subcutaneous preadipocytes.
A. Gagnon, A. Landry, and A. Sorisky (2009)
J. Endocrinol. 201, 75-80
   Abstract »    Full Text »    PDF »
CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation.
X. Li, M. Huang, H. Zheng, Y. Wang, F. Ren, Y. Shang, Y. Zhai, D. M. Irwin, Y. Shi, D. Chen, et al. (2008)
J. Cell Biol. 181, 959-972
   Abstract »    Full Text »    PDF »
The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism.
R. I. Aqeilan, M. Q. Hassan, A. de Bruin, J. P. Hagan, S. Volinia, T. Palumbo, S. Hussain, S.-H. Lee, T. Gaur, G. S. Stein, et al. (2008)
J. Biol. Chem. 283, 21629-21639
   Abstract »    Full Text »    PDF »
A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells.
S. W. Chan, C. J. Lim, K. Guo, C. P. Ng, I. Lee, W. Hunziker, Q. Zeng, and W. Hong (2008)
Cancer Res. 68, 2592-2598
   Abstract »    Full Text »    PDF »
TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway.
Q.-Y. Lei, H. Zhang, B. Zhao, Z.-Y. Zha, F. Bai, X.-H. Pei, S. Zhao, Y. Xiong, and K.-L. Guan (2008)
Mol. Cell. Biol. 28, 2426-2436
   Abstract »    Full Text »    PDF »
Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ.
R. Makita, Y. Uchijima, K. Nishiyama, T. Amano, Q. Chen, T. Takeuchi, A. Mitani, T. Nagase, Y. Yatomi, H. Aburatani, et al. (2008)
Am J Physiol Renal Physiol 294, F542-F553
   Abstract »    Full Text »    PDF »
Regulation of Mesenchymal Stem Cell Osteogenic Differentiation by Glucocorticoid-induced Leucine Zipper (GILZ).
W. Zhang, N. Yang, and X.-M. Shi (2008)
J. Biol. Chem. 283, 4723-4729
   Abstract »    Full Text »    PDF »
Runx2 Represses Myocardin-Mediated Differentiation and Facilitates Osteogenic Conversion of Vascular Smooth Muscle Cells.
T. Tanaka, H. Sato, H. Doi, C. A. Yoshida, T. Shimizu, H. Matsui, M. Yamazaki, H. Akiyama, K. Kawai-Kowase, T. Iso, et al. (2008)
Mol. Cell. Biol. 28, 1147-1160
   Abstract »    Full Text »    PDF »
TAZ Promotes PC2 Degradation through a SCF{beta}-Trcp E3 Ligase Complex.
Y. Tian, R. Kolb, J.-H. Hong, J. Carroll, D. Li, J. You, R. Bronson, M. B. Yaffe, J. Zhou, and T. Benjamin (2007)
Mol. Cell. Biol. 27, 6383-6395
   Abstract »    Full Text »    PDF »
Adipocyte differentiation induced using nonspecific siRNA controls in cultured human mesenchymal stem cells.
Y. Xu, S.-H. Mirmalek-Sani, F. Lin, J. Zhang, and R. O.C. Oreffo (2007)
RNA 13, 1179-1183
   Abstract »    Full Text »    PDF »
Senescence-unrelated impediment of osteogenesis from Flk1+ bone marrow mesenchymal stem cells induced by total body irradiation and its contribution to long-term bone and hematopoietic injury.
J. Ma, M. Shi, J. Li, B. Chen, H. Wang, B. Li, J. Hu, Y. Cao, B. Fang, and R. C. Zhao (2007)
Haematologica 92, 889-896
   Abstract »    Full Text »    PDF »
A high-throughput siRNA library screen identifies osteogenic suppressors in human mesenchymal stem cells.
Y. Zhao and S. Ding (2007)
PNAS 104, 9673-9678
   Abstract »    Full Text »    PDF »
Wnt Signaling Stimulates Osteoblastogenesis of Mesenchymal Precursors by Suppressing CCAAT/Enhancer-binding Protein {alpha} and Peroxisome Proliferator-activated Receptor {gamma}.
S. Kang, C. N. Bennett, I. Gerin, L. A. Rapp, K. D. Hankenson, and O. A. MacDougald (2007)
J. Biol. Chem. 282, 14515-14524
   Abstract »    Full Text »    PDF »
dlk1/FA1 Regulates the Function of Human Bone Marrow Mesenchymal Stem Cells by Modulating Gene Expression of Pro-inflammatory Cytokines and Immune Response-related Factors.
B. M. Abdallah, P. Boissy, Q. Tan, J. Dahlgaard, G. A. Traustadottir, K. Kupisiewicz, J. Laborda, J.-M. Delaisse, and M. Kassem (2007)
J. Biol. Chem. 282, 7339-7351
   Abstract »    Full Text »    PDF »
Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.
Z. Hossain, S. M. Ali, H. L. Ko, J. Xu, C. P. Ng, K. Guo, Z. Qi, S. Ponniah, W. Hong, and W. Hunziker (2007)
PNAS 104, 1631-1636
   Abstract »    Full Text »    PDF »
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors.
L. Michalik, J. Auwerx, J. P. Berger, V. K. Chatterjee, C. K. Glass, F. J. Gonzalez, P. A. Grimaldi, T. Kadowaki, M. A. Lazar, S. O'Rahilly, et al. (2006)
Pharmacol. Rev. 58, 726-741
   Abstract »    Full Text »    PDF »
Primary Glioblastomas Express Mesenchymal Stem-Like Properties.
C.-L. Tso, P. Shintaku, J. Chen, Q. Liu, J. Liu, Z. Chen, K. Yoshimoto, P. S. Mischel, T. F. Cloughesy, L. M. Liau, et al. (2006)
Mol. Cancer Res. 4, 607-619
   Abstract »    Full Text »    PDF »
Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling.
D. C. Wan, Y.-Y. Shi, R. P. Nacamuli, N. Quarto, K. M. Lyons, and M. T. Longaker (2006)
PNAS 103, 12335-12340
   Abstract »    Full Text »    PDF »
Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65.
E. M. Morin-Kensicki, B. N. Boone, M. Howell, J. R. Stonebraker, J. Teed, J. G. Alb, T. R. Magnuson, W. O'Neal, and S. L. Milgram (2006)
Mol. Cell. Biol. 26, 77-87
   Abstract »    Full Text »    PDF »
A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome.
M. Murakami, M. Nakagawa, E. N. Olson, and O. Nakagawa (2005)
PNAS 102, 18034-18039
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882