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Science 309 (5740): 1514-1518

Copyright © 2005 by the American Association for the Advancement of Science

From Birth to Death: The Complex Lives of Eukaryotic mRNAs

Melissa J. Moore

Abstract: Recent work indicates that the posttranscriptional control of eukaryotic gene expression is much more elaborate and extensive than previously thought, with essentially every step of messenger RNA (mRNA) metabolism being subject to regulation in an mRNA-specific manner. Thus, a comprehensive understanding of eukaryotic gene expression requires an appreciation for how the lives of mRNAs are influenced by a wide array of diverse regulatory mechanisms.

Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, 415 South Street, Waltham, MA 02454. E-mail: mmoore{at}brandeis.edu


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