Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Abstract:
Large numbers of noncoding RNA transcripts (ncRNAs) are beingrevealed by complementary DNA cloning and genome tiling arraystudies in animals. The big and as yet largely unanswered questionis whether these transcripts are relevant. A paper by Willinghamet al. shows the way forward by developing a strategy for large-scalefunctional screening of ncRNAs, involving small interferingRNA knockdowns in cell-based screens, which identified a previouslyunidentified ncRNA repressor of the transcription factor NFAT.It appears likely that ncRNAs constitute a critical hidden layerof gene regulation in complex organisms, the understanding ofwhich requires new approaches in functional genomics.
Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia. E-mail: j.mattick{at}imb.uq.edu.au
The editors suggest the following Related Resources on Science sites:
In Science Magazine
INTRODUCTION TO SPECIAL ISSUE
Guy Riddihough (2 September 2005) Science309 (5740), 1507.
[DOI: 10.1126/science.309.5740.1507] |Summary »|PDF »
REPORTS
A. T. Willingham, A. P. Orth, S. Batalov, E. C. Peters, B. G. Wen, P. Aza-Blanc, J. B. Hogenesch, and P. G. Schultz (2 September 2005) Science309 (5740), 1570.
[DOI: 10.1126/science.1115901] |Abstract »|Full Text »|PDF »|Supporting Online Material »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5).
M. Mourtada-Maarabouni, V. L. Hedge, L. Kirkham, F. Farzaneh, and G. T. Williams (2008)
J. Cell Sci.
121, 939-946
|Abstract »|Full Text »|PDF »
Reassortment and Concerted Evolution in Banana Bunchy Top Virus Genomes.
J.-M. Hu, H.-C. Fu, C.-H. Lin, H.-J. Su, and H.-H. Yeh (2007)
J. Virol.
81, 1746-1761
|Abstract »|Full Text »|PDF »
RNAdb 2.0--an expanded database of mammalian non-coding RNAs.
K. C. Pang, S. Stephen, M. E. Dinger, P. G. Engstrom, B. Lenhard, and J. S. Mattick (2007)
Nucleic Acids Res.
35, D178-D182
|Abstract »|Full Text »|PDF »
Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum.
A Novel Class of Developmentally Regulated Noncoding RNAs in Leishmania.
C. Dumas, C. Chow, M. Muller, and B. Papadopoulou (2006)
Eukaryot. Cell
5, 2033-2046
|Abstract »|Full Text »|PDF »
Exportin-5 orthologues are functionally divergent among species.
S. Shibata, M. Sasaki, T. Miki, A. Shimamoto, Y. Furuichi, J. Katahira, and Y. Yoneda (2006)
Nucleic Acids Res.
34, 4711-4721
|Abstract »|Full Text »|PDF »
The complexity of the mammalian transcriptome.
S. Gustincich, A. Sandelin, C. Plessy, S. Katayama, R. Simone, D. Lazarevic, Y. Hayashizaki, and P. Carninci (2006)
J. Physiol.
575, 321-332
|Abstract »|Full Text »|PDF »
A noncoding RNA is a potential marker of cell fate during mammary gland development.
M. R. Ginger, A. N. Shore, A. Contreras, M. Rijnkels, J. Miller, M. F. Gonzalez-Rimbau, and J. M. Rosen (2006)
PNAS
103, 5781-5786
|Abstract »|Full Text »|PDF »
The positive aspects of stress: strain initiates domain decondensation (SIDD).
S. Winkelmann, M. Klar, C. Benham, A. Prashanth, S. Goetze, A. Gluch, and J. Bode (2006)
Brief Funct Genomic Proteomic
5, 24-31
|Abstract »|Full Text »|PDF »
Experimental approaches to identify non-coding RNAs.
