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Science 310 (5749): 805-810

Copyright © 2005 by the American Association for the Advancement of Science

Patterning and Plasticity of the Cerebral Cortex

Mriganka Sur1*, and John L. R. Rubenstein2*

Abstract: The cerebral cortex of the human brain is a sheet of about 10 billion neurons divided into discrete subdivisions or areas that process particular aspects of sensation, movement, and cognition. Recent evidence has begun to transform our understanding of how cortical areas form, make specific connections with other brain regions, develop unique processing networks, and adapt to changes in inputs.

1 Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Ave., 46-6237, Cambridge, MA 02139, USA.
2 Nina Ireland Laboratory of Developmental Neurobiology, 1550 4th Street, 2nd Floor South, Room GD 284C, University of California at San Francisco, San Francisco, CA 94143–2611, USA.

* To whom correspondence should be addressed: E-mail: msur{at} (M.S.); john.rubenstein{at} (J.L.R.R.)

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V. Paul, A. B. Tonchev, K. A. Henningfeld, E. Pavlakis, B. Rust, T. Pieler, and A. Stoykova (2014)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Cell Sci. 126, 3533-3540
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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H. Chen, T. Zhang, L. Guo, K. Li, X. Yu, L. Li, X. Hu, J. Han, X. Hu, and T. Liu (2013)
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   Abstract »    Full Text »    PDF »
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G. Y. Cederquist, E. Azim, S. J. Shnider, H. Padmanabhan, and J. D. Macklis (2013)
J. Neurosci. 33, 6321-6332
   Abstract »    Full Text »    PDF »
Sox2 is required for embryonic development of the ventral telencephalon through the activation of the ventral determinants Nkx2.1 and Shh.
A. Ferri, R. Favaro, L. Beccari, J. Bertolini, S. Mercurio, F. Nieto-Lopez, C. Verzeroli, F. La Regina, D. De Pietri Tonelli, S. Ottolenghi, et al. (2013)
Development 140, 1250-1261
   Abstract »    Full Text »    PDF »
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Phil Trans R Soc B 367, 3229-3241
   Abstract »    Full Text »    PDF »
Axonal Fiber Terminations Concentrate on Gyri.
J. Nie, L. Guo, K. Li, Y. Wang, G. Chen, L. Li, H. Chen, F. Deng, X. Jiang, T. Zhang, et al. (2012)
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   Abstract »    Full Text »    PDF »
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J. Diaz-Alonso, T. Aguado, C.-S. Wu, J. Palazuelos, C. Hofmann, P. Garcez, F. Guillemot, H.-C. Lu, B. Lutz, M. Guzman, et al. (2012)
J. Neurosci. 32, 16651-16665
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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PNAS 109, 11049-11052
   Abstract »    Full Text »    PDF »
Transcriptional Mechanisms of EphA7 Gene Expression in the Developing Cerebral Cortex.
S. Pietri, J. Dimidschstein, L. Tiberi, P. A. Sotiropoulou, A. Bilheu, A. Goffinet, Y. Achouri, F. Tissir, C. Blanpain, P. Jacquemin, et al. (2012)
Cereb Cortex 22, 1678-1689
   Abstract »    Full Text »    PDF »
A hierarchical model of the evolution of human brain specializations.
H. C. Barrett (2012)
PNAS 109, 10733-10740
   Abstract »    Full Text »    PDF »
Parental Age Effects on Cortical Morphology in Offspring.
P. Shaw, M. Gilliam, M. Malek, N. Rodriguez, D. Greenstein, L. Clasen, A. Evans, J. Rapoport, and J. Giedd (2012)
Cereb Cortex 22, 1256-1262
   Abstract »    Full Text »    PDF »
Astrocytes and disease: a neurodevelopmental perspective.
A. V. Molofsky, R. Krenick, E. Ullian, H.-h. Tsai, B. Deneen, W. D. Richardson, B. A. Barres, and D. H. Rowitch (2012)
Genes & Dev. 26, 891-907
   Abstract »    Full Text »    PDF »
COUP-TFII controls amygdala patterning by regulating neuropilin expression.
K. Tang, J. L. R. Rubenstein, S. Y. Tsai, and M.-J. Tsai (2012)
Development 139, 1630-1639
   Abstract »    Full Text »    PDF »
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K. A. Barnes, S. M. Nelson, A. L. Cohen, J. D. Power, R. S. Coalson, F. M. Miezin, A. C. Vogel, J. W. Dubis, J. A. Church, S. E. Petersen, et al. (2012)
Cereb Cortex 22, 1148-1158
   Abstract »    Full Text »    PDF »
Abnormal Structure-Function Relationship in Spasmodic Dysphonia.
K. Simonyan and C. L. Ludlow (2012)
Cereb Cortex 22, 417-425
   Abstract »    Full Text »    PDF »
Satb1 Ablation Alters Temporal Expression of Immediate Early Genes and Reduces Dendritic Spine Density during Postnatal Brain Development.
M. A. Balamotis, N. Tamberg, Y. J. Woo, J. Li, B. Davy, T. Kohwi-Shigematsu, and Y. Kohwi (2012)
Mol. Cell. Biol. 32, 333-347
   Abstract »    Full Text »    PDF »
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J. Panksepp and D. Watt (2011)
Emotion Review 3, 387-396
   Abstract »    PDF »
A Lifespan Analysis of Intraneocortical Connections and Gene Expression in the Mouse II.
C. A. Dye, H. El Shawa, and K. J. Huffman (2011)
Cereb Cortex 21, 1331-1350
   Abstract »    Full Text »    PDF »
A Lifespan Analysis of Intraneocortical Connections and Gene Expression in the Mouse I.
C. A. Dye, H. El Shawa, and K. J. Huffman (2011)
Cereb Cortex 21, 1311-1330
   Abstract »    Full Text »    PDF »
Neocortical layer 4 as a pluripotent function linearizer.
O. V. Favorov and O. Kursun (2011)
J Neurophysiol 105, 1342-1360
   Abstract »    Full Text »    PDF »
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R. Toyoda, S. Assimacopoulos, J. Wilcoxon, A. Taylor, P. Feldman, A. Suzuki-Hirano, T. Shimogori, and E. A. Grove (2010)
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   Abstract »    Full Text »    PDF »
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C. R. Gajera, H. Emich, O. Lioubinski, A. Christ, R. Beckervordersandforth-Bonk, K. Yoshikawa, S. Bachmann, E. I. Christensen, M. Gotz, G. Kempermann, et al. (2010)
J. Cell Sci. 123, 1922-1930
   Abstract »    Full Text »    PDF »
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A. Chedotal and L. J. Richards (2010)
Cold Spring Harb Perspect Biol 2, a001917
   Abstract »    Full Text »    PDF »
Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells.
C. Zimmer, J. Lee, A. Griveau, S. Arber, A. Pierani, S. Garel, and F. Guillemot (2010)
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   Abstract »    Full Text »    PDF »
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S. Horng, G. Kreiman, C. Ellsworth, D. Page, M. Blank, K. Millen, and M. Sur (2009)
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   Abstract »    Full Text »    PDF »
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L. Muckli, M. J. Naumer, and W. Singer (2009)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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D. Tropea, A. Van Wart, and M. Sur (2009)
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   Abstract »    Full Text »    PDF »
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T. Andersson, E. Sodersten, J. K. Duckworth, A. Cascante, N. Fritz, P. Sacchetti, I. Cervenka, V. Bryja, and O. Hermanson (2009)
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   Abstract »    Full Text »    PDF »
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T. Grigoryan, P. Wend, A. Klaus, and W. Birchmeier (2008)
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   Abstract »    Full Text »    PDF »
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A. Faedo, G. S. Tomassy, Y. Ruan, H. Teichmann, S. Krauss, S. J. Pleasure, S. Y. Tsai, M.-J. Tsai, M. Studer, and J. L. R. Rubenstein (2008)
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   Abstract »    Full Text »    PDF »
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M. C. Pinon, T. C. Tuoc, R. Ashery-Padan, Z. Molnar, and A. Stoykova (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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E. M. Morrow, S.-Y. Yoo, S. W. Flavell, T.-K. Kim, Y. Lin, R. S. Hill, N. M. Mukaddes, S. Balkhy, G. Gascon, A. Hashmi, et al. (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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N. Bayatti, J. A. Moss, L. Sun, P. Ambrose, J. F. H. Ward, S. Lindsay, and G. J. Clowry (2008)
Cereb Cortex 18, 1536-1548
   Abstract »    Full Text »    PDF »
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T. Iwasato, M. Inan, H. Kanki, R. S. Erzurumlu, S. Itohara, and M. C. Crair (2008)
J. Neurosci. 28, 5931-5943
   Abstract »    Full Text »    PDF »
Plasticity of Representational Maps in Somatosensory Cortex Observed by In Vivo Voltage-Sensitive Dye Imaging.
D. J. Wallace and B. Sakmann (2008)
Cereb Cortex 18, 1361-1373
   Abstract »    Full Text »    PDF »
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P. Shaw, N. J. Kabani, J. P. Lerch, K. Eckstrand, R. Lenroot, N. Gogtay, D. Greenstein, L. Clasen, A. Evans, J. L. Rapoport, et al. (2008)
J. Neurosci. 28, 3586-3594
   Abstract »    Full Text »    PDF »
Embryonic and Postnatal Development of the Layer I-Directed ("Matrix") Thalamocortical System in the Rat.
M. J. Galazo, V. Martinez-Cerdeno, C. Porrero, and F. Clasca (2008)
Cereb Cortex 18, 344-363
   Abstract »    Full Text »    PDF »
Differential Gene Expression between Sensory Neocortical Areas: Potential Roles for Ten_m3 and Bcl6 in Patterning Visual and Somatosensory Pathways.
C. A. Leamey, K. A. Glendining, G. Kreiman, N.-D. Kang, K. H. Wang, R. Fassler, A. Sawatari, S. Tonegawa, and M. Sur (2008)
Cereb Cortex 18, 53-66
   Abstract »    Full Text »    PDF »
Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation.
P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J. P. Lerch, D. Greenstein, L. Clasen, A. Evans, J. Giedd, and J. L. Rapoport (2007)
PNAS 104, 19649-19654
   Abstract »    Full Text »    PDF »
Alteration of Visual Input Results in a Coordinated Reorganization of Multiple Visual Cortex Maps.
B. J. Farley, H. Yu, D. Z. Jin, and M. Sur (2007)
J. Neurosci. 27, 10299-10310
   Abstract »    Full Text »    PDF »
Temporal Dynamics of Plastic Changes in Human Primary Somatosensory Cortex after Finger Webbing.
M. L. Stavrinou, S. Della Penna, V. Pizzella, K. Torquati, F. Cianflone, R. Franciotti, A. Bezerianos, G. L. Romani, and P. M. Rossini (2007)
Cereb Cortex 17, 2134-2142
   Abstract »    Full Text »    PDF »
Evidence for Activity-Dependent Cortical Wiring: Formation of Interhemispheric Connections in Neonatal Mouse Visual Cortex Requires Projection Neuron Activity.
H. Mizuno, T. Hirano, and Y. Tagawa (2007)
J. Neurosci. 27, 6760-6770
   Abstract »    Full Text »    PDF »
Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly.
X. Huang, Y. Litingtung, and C. Chiang (2007)
Hum. Mol. Genet. 16, 1454-1468
   Abstract »    Full Text »    PDF »
Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord.
X. Huang, Y. Litingtung, and C. Chiang (2007)
Development 134, 2095-2105
   Abstract »    Full Text »    PDF »
Patterning of frontal cortex subdivisions by Fgf17.
J. A. Cholfin and J. L. R. Rubenstein (2007)
PNAS 104, 7652-7657
   Abstract »    Full Text »    PDF »
Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice.
J. V. Nielsen, F. H. Nielsen, R. Ismail, J. Noraberg, and N. A. Jensen (2007)
Development 134, 1133-1140
   Abstract »    Full Text »    PDF »
Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons.
J. Ster, F. De Bock, N. C. Guerineau, A. Janossy, S. Barrere-Lemaire, J. L. Bos, J. Bockaert, and L. Fagni (2007)
PNAS 104, 2519-2524
   Abstract »    Full Text »    PDF »
Transcriptional regulation of neuronal phenotype in mammals.
Q. Ma (2006)
J. Physiol. 575, 379-387
   Abstract »    Full Text »    PDF »
Can autism speak to neuroscience?.
S. O. Moldin, J. L. R. Rubenstein, and S. E. Hyman (2006)
J. Neurosci. 26, 6893-6896
   Full Text »    PDF »

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