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Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake
Jian V. Zhang,
Pei-Gen Ren,
Orna Avsian-Kretchmer,
Ching-Wei Luo,
Rami Rauch,
Cynthia Klein,
Aaron J. W. Hsueh*
Abstract:
Ghrelin, a circulating appetite-inducing hormone, is derivedfrom a prohormone by posttranslational processing. On the basisof the bioinformatic prediction that another peptide also derivedfrom proghrelin exists, we isolated a hormone from rat stomachand named it obestatin—a contraction of obese, from theLatin "obedere," meaning to devour, and "statin," denoting suppression.Contrary to the appetite-stimulating effects of ghrelin, treatmentof rats with obestatin suppressed food intake, inhibited jejunalcontraction, and decreased body-weight gain. Obestatin boundto the orphan G protein–coupled receptor GPR39. Thus,two peptide hormones with opposing action in weight regulationare derived from the same ghrelin gene. After differential modification,these hormones activate distinct receptors.
Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305–5317, USA.
* To whom correspondence should be addressed: E-mail: aaron.hsueh{at}stanford.edu
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R. Nogueiras, P. Pfluger, S. Tovar, M. Arnold, S. Mitchell, A. Morris, D. Perez-Tilve, M. J. Vazquez, P. Wiedmer, T. R. Castaneda, et al. (2007)
Endocrinology
148, 21-26
|Abstract »|Full Text »|PDF »
Ghrelin improves burn-induced delayed gastrointestinal transit in rats.
H. S. Sallam, H. M. Oliveira, H. T. Gan, D. N. Herndon, and J. D. Z. Chen (2007)
Am J Physiol Regulatory Integrative Comp Physiol
292, R253-R257
|Abstract »|Full Text »|PDF »
Obestatin acts in brain to inhibit thirst.
W. K. Samson, M. M. White, C. Price, and A. V. Ferguson (2007)
Am J Physiol Regulatory Integrative Comp Physiol
292, R637-R643
|Abstract »|Full Text »|PDF »
On the Processing of Proghrelin to Ghrelin.
X. Zhu, Y. Cao, K. Voodg, and D. F. Steiner (2006)
J. Biol. Chem.
281, 38867-38870
|Abstract »|Full Text »|PDF »
Gut Peptides in the Regulation of Food Intake and Energy Homeostasis.
K. G. Murphy, W. S. Dhillo, and S. R. Bloom (2006)
Endocr. Rev.
27, 719-727
|Abstract »|Full Text »|PDF »
Impact of Gastric Bypass Surgery on Gut Hormones and Glucose Homeostasis in Type 2 Diabetes.
Distribution and biological activity of obestatin in the rat.
S. L Dun, G C. Brailoiu, E. Brailoiu, J. Yang, J. K. Chang, and N. J Dun (2006)
J. Endocrinol.
191, 481-489
|Abstract »|Full Text »|PDF »
Genetics of obesity and the prediction of risk for health.
A. J. Walley, A. I.F. Blakemore, and P. Froguel (2006)
Hum. Mol. Genet.
15, R124-R130
|Abstract »|Full Text »|PDF »
A simple twist of science: the convoluted tale of ghrelin continues..
J. O. L. Jorgensen (2006)
J. Clin. Endocrinol. Metab.
91, 3279-3280
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Vaccination against weight gain.
E. P. Zorrilla, S. Iwasaki, J. A. Moss, J. Chang, J. Otsuji, K. Inoue, M. M. Meijler, and K. D. Janda (2006)
PNAS
103, 13226-13231
|Abstract »|Full Text »|PDF »
Seabream ghrelin: cDNA cloning, genomic organization and promoter studies..
C.-M. Yeung, C.-B. Chan, N. Y S Woo, and C. H K Cheng (2006)
J. Endocrinol.
189, 365-379
|Abstract »|Full Text »|PDF »
Intranasal Leptin: Blood-Brain Barrier Bypass (BBBB) for Obesity?.
A. J. Kastin and W. Pan (2006)
Endocrinology
147, 2086-2087
|Full Text »|PDF »
Suppression of Acylated Ghrelin during Oral Glucose Tolerance Test Is Correlated with Whole-Body Insulin Sensitivity in Children with Prader-Willi Syndrome.
K. H. Paik, Y. H. Choe, W. H. Park, Y. J. Oh, A. H. Kim, S. H. Chu, S. W. Kim, E. K. Kwon, S. J. Han, W. Y. Shon, et al. (2006)
J. Clin. Endocrinol. Metab.
91, 1876-1881
|Abstract »|Full Text »|PDF »
IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.
A. Doi, T. Shono, M. Nishi, H. Furuta, H. Sasaki, and K. Nanjo (2006)
PNAS
103, 885-890
|Abstract »|Full Text »|PDF »
Bioinformatics Identifies a New Antiobesity Hormone.
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Journal Watch Psychiatry
2006, 3
|Full Text »
BIOMEDICINE: Separation of Conjoined Hormones Yields Appetite Rivals.
