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Science 310 (5753): 1487-1489

Copyright © 2005 by the American Association for the Advancement of Science

Stem Cell Self-Renewal Controlled by Chromatin Remodeling Factors

Rongwen Xi1, and Ting Xie1,2*

Abstract: The self-renewing ability of a stem cell is controlled by its specialized micro-environment or niche, whereas epigenetic regulation of gene expression by chromatin remodeling factors underlies cell fate determination. Here we report that the adenosine triphosphate–dependent chromatin remodeling factors ISWI and DOM control germline stem cell and somatic stem cell self-renewal in the Drosophila ovary, respectively. The iswi mutant germline stem cells are lost rapidly because of defects in responding to bone morphogenetic protein niche signals and in repressing differentiation, whereas the dom mutant somatic stem cells are lost because of defective self-renewal. This work demonstrates that different stem cell types can use different chromatin remodeling factors to control cell self-renewal.

1 Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
2 Department of Anatomy and Cell Biology, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

* To whom correspondence should be addressed. E-mail: tgx{at}stowers-institute.org

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