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Science 310 (5756): 1919-1923

Copyright © 2005 by the American Association for the Advancement of Science

Appendage Regeneration in Adult Vertebrates and Implications for Regenerative Medicine

Jeremy P. Brockes*, and Anoop Kumar

Abstract: The regeneration of complex structures in adult salamanders depends on mechanisms that offer pointers for regenerative medicine. These include the plasticity of differentiated cells and the retention in regenerative cells of local cues such as positional identity. Limb regeneration proceeds by the local formation of a blastema, a growth zone of mesenchymal stem cells on the stump. The blastema can regenerate autonomously as a self-organizing system over variable linear dimensions. Here we consider the prospects for limb regeneration in mammals from this viewpoint.

Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.

* To whom correspondence should be addressed. E-mail: j.brockes{at}ucl.ac.uk

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