Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 311 (5760): 518-522

Copyright © 2006 by the American Association for the Advancement of Science

The Cellular Basis of a Corollary Discharge

James F. A. Poulet1,2*, and Berthold Hedwig2

Abstract: How do animals discriminate self-generated from external stimuli during behavior and prevent desensitization of their sensory pathways? A fundamental concept in neuroscience states that neural signals, termed corollary discharges or efference copies, are forwarded from motor to sensory areas. Neurons mediating these signals have proved difficult to identify. We show that a single, multisegmental interneuron is responsible for the pre- and postsynaptic inhibition of auditory neurons in singing crickets (Gryllus bimaculatus). Therefore, this neuron represents a corollary discharge interneuron that provides a neuronal basis for the central control of sensory responses.

1 Laboratory of Sensory Processing, Brain Mind Institute, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
2 Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.

* To whom correspondence should be addressed. E-mail: james.poulet{at}

Vocal Corollary Discharge Communicates Call Duration to Vertebrate Auditory System.
B. P. Chagnaud and A. H. Bass (2013)
J. Neurosci. 33, 18775-18780
   Abstract »    Full Text »    PDF »
Neurophysiological Evidence of Corollary Discharge Function During Vocalization in Psychotic Patients and Their Nonpsychotic First-Degree Relatives.
J. M. Ford, D. H. Mathalon, B. J. Roach, S. K. Keedy, J. L. Reilly, E. S. Gershon, and J. A. Sweeney (2013)
Schizophr Bull 39, 1272-1280
   Abstract »    Full Text »    PDF »
What Does Motor Efference Copy Represent? Evidence from Speech Production.
C. A. Niziolek, S. S. Nagarajan, and J. F. Houde (2013)
J. Neurosci. 33, 16110-16116
   Abstract »    Full Text »    PDF »
A Circuit for Motor Cortical Modulation of Auditory Cortical Activity.
A. Nelson, D. M. Schneider, J. Takatoh, K. Sakurai, F. Wang, and R. Mooney (2013)
J. Neurosci. 33, 14342-14353
   Abstract »    Full Text »    PDF »
Did I Do That? Abnormal Predictive Processes in Schizophrenia When Button Pressing to Deliver a Tone.
J. M. Ford, V. A. Palzes, B. J. Roach, and D. H. Mathalon (2013)
Schizophr Bull
   Abstract »    Full Text »    PDF »
Primary Afferent Depolarization and Frequency Processing in Auditory Afferents.
T. Baden and B. Hedwig (2010)
J. Neurosci. 30, 14862-14869
   Abstract »    Full Text »    PDF »
Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring.
K. E. Stephan, K. J. Friston, and C. D. Frith (2009)
Schizophr Bull 35, 509-527
   Abstract »    Full Text »    PDF »
Frontal Eye Field Neurons with Spatial Representations Predicted by Their Subcortical Input.
T. B. Crapse and M. A. Sommer (2009)
J. Neurosci. 29, 5308-5318
   Abstract »    Full Text »    PDF »
Corollary Discharge Dysfunction in Schizophrenia: Evidence for an Elemental Deficit.
D. H. Mathalon and J. M. Ford (2008)
Clinical EEG and Neuroscience 39, 82-86
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882