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Science 312 (5775): 883-

Copyright © 2006 by the American Association for the Advancement of Science

Polar PIN Localization Directs Auxin Flow in Plants

Justyna Wisniewska,1,3 Jian Xu,2 Daniela Seifertová,1 Philip B. Brewer,1 Kamil Ruzicka,1 Ikram Blilou,2 David Rouquié,1* Eva Benková,1 Ben Scheres,2 Jirí Friml1{dagger}

Abstract: Polar flow of the phytohormone auxin requires plasma membrane-associated PIN proteins and underlies multiple developmental processes in plants. Here we address the importance of the polarity of subcellular PIN localization for the directionality of auxin transport in Arabidopsis thaliana. Expression of different PINs in the root epidermis revealed the importance of PIN polar positions for directional auxin flow and root gravitropic growth. Interfering with sequence-embedded polarity signals directly demonstrates that PIN polarity is a primary factor in determining the direction of auxin flow in meristematic tissues. This finding provides a crucial piece in the puzzle of how auxin flow can be redirected via rapid changes in PIN polarity.

1 Center for Plant Molecular Biology (ZMBP), Tübingen University, D-72076 Tübingen, Germany.
2 Department of Molecular Genetics, Utrecht University, 3584CH Utrecht, Netherlands.
3 Department of Biotechnology, Institute of General and Molecular Biology, 87-100 Torun, Poland.

* Present address: Bayer CropScience, F-06560 Sophia Antipolis Cedex, France.

{dagger} To whom correspondence should be addressed. E-mail: jiri.friml{at}

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Cellular and Molecular Requirements for Polar PIN Targeting and Transcytosis in Plants.
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Mol Plant 1, 1056-1066
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Interaction of PIN and PGP transport mechanisms in auxin distribution-dependent development.
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Development 135, 3345-3354
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sparse inflorescence1 encodes a monocot-specific YUCCA-like gene required for vegetative and reproductive development in maize.
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PNAS 105, 15196-15201
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PIN Polar Targeting.
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Plasma Membrane Receptor Complexes.
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The Relationship between Auxin Transport and Maize Branching.
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Plant Physiology 147, 1913-1923
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Endosidin1 defines a compartment involved in endocytosis of the brassinosteroid receptor BRI1 and the auxin transporters PIN2 and AUX1.
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PNAS 105, 8464-8469
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Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes.
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PNAS 105, 4489-4494
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The Root Cap Determines Ethylene-Dependent Growth and Development in Maize Roots.
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Mol Plant 1, 359-367
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Regeneration of zygotic-like microspore-derived embryos suggests an important role for the suspensor in early embryo patterning.
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