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Science 312 (5777): 1162-1165

Copyright © 2006 by the American Association for the Advancement of Science

The New Era in Cancer Research

Harold Varmus

Abstract: For many years, discoveries about the genetic determinants of cancer appeared to be having only minor effects on efforts to control the disease in the clinic. Following advances made over the past decade, however, a description of cancer in molecular terms seems increasingly likely to improve the ways in which human cancers are detected, classified, monitored, and (especially) treated. Achieving the medical promise of this new era in cancer research will require a deeper understanding of the biology of cancer and imaginative application of new knowledge in the clinic, as well as political, social, and cultural changes.

Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

E-mail: varmus{at}

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EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts.
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Durable Long-Term Remission With Chemotherapy Alone for Stage II to IV Laryngeal Cancer.
F. C. Holsinger, M. S. Kies, E. M. Diaz Jr, A. M. Gillenwater, J. S. Lewin, L. E. Ginsberg, B. S. Glisson, A. S. Garden, N. Ark, H. Y. Lin, et al. (2009)
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C. SHEN, W. LIU, A. K. BUCK, and S. N. RESKE (2009)
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Genome-Wide Promoter Analysis Uncovers Portions of the Cancer Methylome.
M. O. Hoque, M. S. Kim, K. L. Ostrow, J. Liu, G. B. A. Wisman, H. L. Park, M. L. Poeta, C. Jeronimo, R. Henrique, A. Lendvai, et al. (2008)
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An In vivo Model of Met-Driven Lymphoma as a Tool to Explore the Therapeutic Potential of Met Inhibitors.
P. Accornero, G. Lattanzio, T. Mangano, R. Chiarle, R. Taulli, F. Bersani, P. E. Forni, S. Miretti, C. Scuoppo, W. Dastru, et al. (2008)
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Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies.
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Histological and proteomic analysis of reversible H-RasV12G expression in transgenic mouse skin.
W.-J. Oh, V. Rishi, S. Pelech, and C. Vinson (2007)
Carcinogenesis 28, 2244-2252
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Y. Su, R. R. Eason, Y. Geng, S. Till, T. M. Badger, and R. C.M. Simmen (2007)
Carcinogenesis 28, 1046-1051
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Human Bone Marrow Activates the Akt Pathway in Metastatic Prostate Cells through Transactivation of the {alpha}-Platelet-Derived Growth Factor Receptor.
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PTEN-Mediated Resistance to Epidermal Growth Factor Receptor Kinase Inhibitors.
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The Consensus Coding Sequences of Human Breast and Colorectal Cancers.
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