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Science 312 (5778): 1381-1385

Copyright © 2006 by the American Association for the Advancement of Science

Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans

Anders Olsen, Maithili C. Vantipalli, Gordon J. Lithgow*

Abstract: Checkpoints are evolutionarily conserved signaling mechanisms that arrest cell division and alter cellular stress resistance in response to DNA damage or stalled replication forks. To study the consequences of loss of checkpoint functions in whole animals, checkpoint genes were inactivated in the nematode C. elegans. We show that checkpoint proteins are not only essential for normal development but also determine adult somatic maintenance. Checkpoint proteins play a role in the survival of postmitotic adult cells.

The Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA.

* To whom correspondence should be addressed. E-mail: glithgow{at}

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