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Juvenile Hormone Is Required to Couple Imaginal Disc Formation with Nutrition in Insects
J. W. Truman,1*
K. Hiruma,2
J. P. Allee,3
S. G. B. MacWhinnie,3
D. T. Champlin,3
L. M. Riddiford1
Abstract:
In starved larvae of the tobacco hornworm moth Manduca sexta,larval and imaginal tissues stop growing, the former becausethey lack nutrient-dependent signals but the latter becauseof suppression by juvenile hormone. Without juvenile hormone,imaginal discs form and grow despite severe starvation. Thishormone inhibits the intrinsic signaling needed for disc morphogenesisand does so independently of ecdysteroid action. Starvationand juvenile hormone treatments allowed the separation of intrinsicand nutrient-dependent aspects of disc growth and showed thatboth aspects must occur during the early phases of disc morphogenesisto ensure normal growth leading to typical-sized adults.
1 Department of Biology, University of Washington, Seattle, WA 98195–1800, USA. 2 Faculty of Agriculture and Life Sciences, Hirosaki University, Hirosaki 036–8561, Japan. 3 Department of Biological Sciences, University of Southern Maine, Portland, ME 04103, USA.
* To whom correspondence should be addressed. E-mail: jwt{at}u.washington.edu
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Pierre Léopold and Sophie Layalle (2 June 2006) Science312 (5778), 1317.
[DOI: 10.1126/science.1128343] |Summary »|Full Text »|PDF »
