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Science 312 (5778): 1385-1388

Copyright © 2006 by the American Association for the Advancement of Science

Juvenile Hormone Is Required to Couple Imaginal Disc Formation with Nutrition in Insects

J. W. Truman,1* K. Hiruma,2 J. P. Allee,3 S. G. B. MacWhinnie,3 D. T. Champlin,3 L. M. Riddiford1

Abstract: In starved larvae of the tobacco hornworm moth Manduca sexta, larval and imaginal tissues stop growing, the former because they lack nutrient-dependent signals but the latter because of suppression by juvenile hormone. Without juvenile hormone, imaginal discs form and grow despite severe starvation. This hormone inhibits the intrinsic signaling needed for disc morphogenesis and does so independently of ecdysteroid action. Starvation and juvenile hormone treatments allowed the separation of intrinsic and nutrient-dependent aspects of disc growth and showed that both aspects must occur during the early phases of disc morphogenesis to ensure normal growth leading to typical-sized adults.

1 Department of Biology, University of Washington, Seattle, WA 98195–1800, USA.
2 Faculty of Agriculture and Life Sciences, Hirosaki University, Hirosaki 036–8561, Japan.
3 Department of Biological Sciences, University of Southern Maine, Portland, ME 04103, USA.

* To whom correspondence should be addressed. E-mail: jwt{at}u.washington.edu


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