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Science 312 (5779): 1533-1537

Copyright © 2006 by the American Association for the Advancement of Science

Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca2+-Permeable AMPA Receptors

Woo-Ping Ge,1,2* Xiu-Juan Yang,1,2* Zhijun Zhang,1,2 Hui-Kun Wang,1,2 Wanhua Shen,1,2 Qiu-Dong Deng,1,2 Shumin Duan1{dagger}

Abstract: Interactions between neurons and glial cells in the brain may serve important functions in the development, maintenance, and plasticity of neural circuits. Fast neuron-glia synaptic transmission has been found between hippocampal neurons and NG2 cells, a distinct population of macroglia-like cells widely distributed in the brain. We report that these neuron-glia synapses undergo activity-dependent modifications analogous to long-term potentiation (LTP) at excitatory synapses, a hallmark of neuronal plasticity. However, unlike the induction of LTP at many neuron-neuron synapses, both induction and expression of LTP at neuron-NG2 synapses involve Ca2+-permeable AMPA receptors on NG2 cells.

1 Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
2 Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: shumin{at}ion.ac.cn


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