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Science 313 (5788): 839-842

Copyright © 2006 by the American Association for the Advancement of Science

Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis

Niko Föger,1 Linda Rangell,2 Dimitry M. Danilenko,2 Andrew C. Chan1*

Abstract: The evolutionarily conserved actin-related protein (Arp2/3) complex is a key component of actin filament networks that is dynamically regulated by nucleation-promoting and inhibitory factors. Although much is known about actin assembly, the physiologic functions of inhibitory proteins are unclear. We generated coronin 1–/– mice and found that coronin 1 exerted an inhibitory effect on cellular steady-state F-actin formation via an Arp2/3-dependent mechanism. Whereas coronin 1 was required for chemokine-mediated migration, it was dispensable for T cell antigen receptor functions in T cells. Moreover, actin dynamics, through a mitochondrial pathway, was linked to lymphocyte homeostasis.

1 Department of Immunology, Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA.
2 Department of Pathology, Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA.

* To whom correspondence should be addressed. E-mail: acc{at}gene.com

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