Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 313 (5789): 971-975

Copyright © 2006 by the American Association for the Advancement of Science

Mutations That Increase the Life Span of C. elegans Inhibit Tumor Growth

Julie M. Pinkston, Delia Garigan, Malene Hansen, Cynthia Kenyon*

Abstract: Mutations in gld-1 cause lethal germline tumors in the nematode Caenorhabditis elegans. We find that a wide variety of mutations that extend C. elegans' life span confer resistance to these tumors. The long life spans of daf-2/insulin-receptor mutants were not shortened at all by gld-1 mutations; we attribute this finding to decreased cell division and increased DAF-16/p53–dependent apoptosis within the tumors. Mutations that increase life span by restricting food intake or inhibiting respiration did not affect apoptosis but reduced tumor cell division. Unexpectedly, none of these longevity mutations affected mitosis in normal germlines; this finding suggests that cellular changes that lead to longevity preferentially antagonize tumor cell growth.

Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.

* To whom correspondence should be addressed. E-mail: ckenyon{at}biochem.ucsf.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Longevity Manipulations Differentially Affect Serotonin/Dopamine Level and Behavioral Deterioration in Aging Caenorhabditis elegans.
J.-A. Yin, X.-J. Liu, J. Yuan, J. Jiang, and S.-Q. Cai (2014)
J. Neurosci. 34, 3947-3958
   Abstract »    Full Text »    PDF »
Key events during the transition from rapid growth to quiescence in budding yeast require posttranscriptional regulators.
L. Li, S. Miles, Z. Melville, A. Prasad, G. Bradley, and L. L. Breeden (2013)
Mol. Biol. Cell 24, 3697-3709
   Abstract »    Full Text »    PDF »
The TP53 signaling network in mammals and worms.
A. K. Jolliffe and W. B. Derry (2013)
Briefings in Functional Genomics 12, 129-141
   Abstract »    Full Text »    PDF »
Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle.
N. Didier, C. Hourde, H. Amthor, G. Marazzi, and D. Sassoon (2012)
EMBO Mol Med. 4, 910-923
   Abstract »    Full Text »    PDF »
Spontaneous Age-Related Neurite Branching in Caenorhabditis elegans.
E. M. H. Tank, K. E. Rodgers, and C. Kenyon (2011)
J. Neurosci. 31, 9279-9288
   Abstract »    Full Text »    PDF »
Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans.
J. Guevara-Aguirre, P. Balasubramanian, M. Guevara-Aguirre, M. Wei, F. Madia, C.-W. Cheng, D. Hwang, A. Martin-Montalvo, J. Saavedra, S. Ingles, et al. (2011)
Science Translational Medicine 3, 70ra13
   Abstract »    Full Text »    PDF »
Paradoxical suppression of cellular senescence by p53.
Z. N. Demidenko, L. G. Korotchkina, A. V. Gudkov, and M. V. Blagosklonny (2010)
PNAS 107, 9660-9664
   Abstract »    Full Text »    PDF »
Insulin signaling promotes germline proliferation in C. elegans.
D. Michaelson, D. Z. Korta, Y. Capua, and E. J. A. Hubbard (2010)
Development 137, 671-680
   Abstract »    Full Text »    PDF »
The new biology of ageing.
L. Partridge (2010)
Phil Trans R Soc B 365, 147-154
   Abstract »    Full Text »    PDF »
Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.
A. P. Siebold, R. Banerjee, F. Tie, D. L. Kiss, J. Moskowitz, and P. J. Harte (2010)
PNAS 107, 169-174
   Abstract »    Full Text »    PDF »
Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Pol{zeta}-dependent mechanism.
F. Madia, M. Wei, V. Yuan, J. Hu, C. Gattazzo, P. Pham, M. F. Goodman, and V. D. Longo (2009)
J. Cell Biol. 186, 509-523
   Abstract »    Full Text »    PDF »
A "latent niche" mechanism for tumor initiation.
M. McGovern, R. Voutev, J. Maciejowski, A. K. Corsi, and E. J. A. Hubbard (2009)
PNAS 106, 11617-11622
   Abstract »    Full Text »    PDF »
C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis.
S. Greiss, J. Hall, S. Ahmed, and A. Gartner (2008)
Genes & Dev. 22, 2831-2842
   Abstract »    Full Text »    PDF »
The Arf/p53 Pathway in Cancer and Aging.
A. Matheu, A. Maraver, and M. Serrano (2008)
Cancer Res. 68, 6031-6034
   Abstract »    Full Text »    PDF »
Science of Cancer and Aging.
I. Irminger-Finger (2007)
J. Clin. Oncol. 25, 1844-1851
   Abstract »    Full Text »    PDF »
Is eternal youth scientifically plausible?: Research on the role of free radicals in ageing gives cause for optimism.
P. Hunter (2007)
EMBO Rep. 8, 18-20
   Full Text »    PDF »
Certain Gene Mutations Extend Lifespan and Inhibit Tumor Growth.
(2006)
Journal Watch (General) 2006, 5
   Full Text »
Live long and cancer-free.
R. Williams (2006)
J. Cell Biol. 174, 739b
   Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882