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Science 313 (5790): 1093-1097

Copyright © 2006 by the American Association for the Advancement of Science

Learning Induces Long-Term Potentiation in the Hippocampus

Jonathan R. Whitlock,1,2* Arnold J. Heynen,1* Marshall G. Shuler,1 Mark F. Bear1{dagger}

Abstract: Years of intensive investigation have yielded a sophisticated understanding of long-term potentiation (LTP) induced in hippocampal area CA1 by high-frequency stimulation (HFS). These efforts have been motivated by the belief that similar synaptic modifications occur during memory formation, but it has never been shown that learning actually induces LTP in CA1. We found that one-trial inhibitory avoidance learning in rats produced the same changes in hippocampal glutamate receptors as induction of LTP with HFS and caused a spatially restricted increase in the amplitude of evoked synaptic transmission in CA1 in vivo. Because the learning-induced synaptic potentiation occluded HFS-induced LTP, we conclude that inhibitory avoidance training induces LTP in CA1.

1 Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2 Department of Neuroscience, Brown University, Providence, RI 02912, USA.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed: mbear{at}mit.edu

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{beta}-Adrenergic receptor activation during distinct patterns of stimulation critically modulates the PKA-dependence of LTP in the mouse hippocampus.
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AKAP79 Selectively Enhances Protein Kinase C Regulation of GluR1 at a Ca2+-Calmodulin-dependent Protein Kinase II/Protein Kinase C Site.
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Physiology of the Prion Protein.
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