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Science 313 (5790): 1141-1144

Copyright © 2006 by the American Association for the Advancement of Science

Storage of Spatial Information by the Maintenance Mechanism of LTP

Eva Pastalkova,* Peter Serrano,* Deana Pinkhasova, Emma Wallace, André Antonio Fenton,{dagger} Todd Charlton Sacktor{dagger}

Abstract: Analogous to learning and memory storage, long-term potentiation (LTP) is divided into induction and maintenance phases. Testing the hypothesis that the mechanism of LTP maintenance stores information requires reversing this mechanism in vivo and finding out whether long-term stored information is lost. This was not previously possible. Recently however, persistent phosphorylation by the atypical protein kinase C isoform, protein kinase Mzeta (PKMz), has been found to maintain late LTP in hippocampal slices. Here we show that a cell-permeable PKMz inhibitor, injected in the rat hippocampus, both reverses LTP maintenance in vivo and produces persistent loss of 1-day-old spatial information. Thus, the mechanism maintaining LTP sustains spatial memory.

Departments of Physiology, Pharmacology, and Neurology, The Robert F. Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: afenton{at} (A.A.F.); tsacktor{at} (T.C.S.)

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