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Science 313 (5790): 1141-1144

Copyright © 2006 by the American Association for the Advancement of Science

Storage of Spatial Information by the Maintenance Mechanism of LTP

Eva Pastalkova,* Peter Serrano,* Deana Pinkhasova, Emma Wallace, André Antonio Fenton,{dagger} Todd Charlton Sacktor{dagger}

Abstract: Analogous to learning and memory storage, long-term potentiation (LTP) is divided into induction and maintenance phases. Testing the hypothesis that the mechanism of LTP maintenance stores information requires reversing this mechanism in vivo and finding out whether long-term stored information is lost. This was not previously possible. Recently however, persistent phosphorylation by the atypical protein kinase C isoform, protein kinase Mzeta (PKMz), has been found to maintain late LTP in hippocampal slices. Here we show that a cell-permeable PKMz inhibitor, injected in the rat hippocampus, both reverses LTP maintenance in vivo and produces persistent loss of 1-day-old spatial information. Thus, the mechanism maintaining LTP sustains spatial memory.

Departments of Physiology, Pharmacology, and Neurology, The Robert F. Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: afenton{at}downstate.edu (A.A.F.); tsacktor{at}downstate.edu (T.C.S.)


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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T. Abrahamsson, B. Gustafsson, and E. Hanse (2008)
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   Abstract »    Full Text »    PDF »
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Y. Yao, M. T. Kelly, S. Sajikumar, P. Serrano, D. Tian, P. J. Bergold, J. U. Frey, and T. C. Sacktor (2008)
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   Abstract »    Full Text »    PDF »
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P. McCoy, T. T. Norton, and L. L. McMahon (2008)
J Neurophysiol 100, 336-345
   Abstract »    Full Text »    PDF »
Involvement of the mGluR1 Receptor in Hippocampal Synaptic Plasticity and Associative Learning in Behaving Mice.
C. Gil-Sanz, J. M. Delgado-Garcia, A. Fairen, and A. Gruart (2008)
Cereb Cortex 18, 1653-1663
   Abstract »    Full Text »    PDF »
Prenatal Morphine Exposure Attenuates the Maintenance of Late LTP in Lateral Perforant Path Projections to the Dentate Gyrus and the CA3 Region In Vivo.
D. M. Villarreal, B. Derrick, and I. Vathy (2008)
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   Abstract »    Full Text »    PDF »
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P. Bekinschtein, M. Cammarota, C. Katche, L. Slipczuk, J. I. Rossato, A. Goldin, I. Izquierdo, and J. H. Medina (2008)
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   Abstract »    Full Text »    PDF »
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P. Smolen, D. A. Baxter, and J. H. Byrne (2008)
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   Abstract »    Full Text »    PDF »
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N. Granado, O. Ortiz, L. M. Suarez, E. D. Martin, V. Cena, J. M. Solis, and R. Moratalla (2008)
Cereb Cortex 18, 1-12
   Abstract »    Full Text »    PDF »
Functional Compartmentalization of Endosomal Trafficking for the Synaptic Delivery of AMPA Receptors during Long-Term Potentiation.
T. C. Brown, S. S. Correia, C. N. Petrok, and J. A. Esteban (2007)
J. Neurosci. 27, 13311-13315
   Abstract »    Full Text »    PDF »
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E. Bruel-Jungerman, S. Davis, and S. Laroche (2007)
Neuroscientist 13, 492-505
   Abstract »    PDF »
Sustained Arc/Arg3.1 Synthesis Controls Long-Term Potentiation Consolidation through Regulation of Local Actin Polymerization in the Dentate Gyrus In Vivo.
E. Messaoudi, T. Kanhema, J. Soule, A. Tiron, G. Dagyte, B. da Silva, and C. R. Bramham (2007)
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   Abstract »    Full Text »    PDF »
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V. Nagy, O. Bozdagi, and G. W. Huntley (2007)
Learn. Mem. 14, 655-664
   Abstract »    Full Text »    PDF »
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R. Shema, T. C. Sacktor, and Y. Dudai (2007)
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   Abstract »    Full Text »    PDF »
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T. P. Wong, J. G. Howland, J. M. Robillard, Y. Ge, W. Yu, A. K. Titterness, K. Brebner, L. Liu, J. Weinberg, B. R. Christie, et al. (2007)
PNAS 104, 11471-11476
   Abstract »    Full Text »    PDF »
In Vivo Roles for Matrix Metalloproteinase-9 in Mature Hippocampal Synaptic Physiology and Plasticity.
O. Bozdagi, V. Nagy, K. T. Kwei, and G. W. Huntley (2007)
J Neurophysiol 98, 334-344
   Abstract »    Full Text »    PDF »
{beta}-Estradiol Increases Dentate Gyrus Inhibition in Female Rats via Augmentation of Hilar Neuropeptide Y.
J. Veliskova and L. Velisek (2007)
J. Neurosci. 27, 6054-6063
   Abstract »    Full Text »    PDF »
Reversal of Synaptic Memory by Ca2+/Calmodulin-Dependent Protein Kinase II Inhibitor.
M. Sanhueza, C. C. McIntyre, and J. E. Lisman (2007)
J. Neurosci. 27, 5190-5199
   Abstract »    Full Text »    PDF »
Isoform specificity of protein kinase Cs in synaptic plasticity.
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Learn. Mem. 14, 236-246
   Abstract »    Full Text »    PDF »
Regulation of Protein Kinase M{zeta} Synthesis by Multiple Kinases in Long-Term Potentiation.
M. T. Kelly, J. F. Crary, and T. C. Sacktor (2007)
J. Neurosci. 27, 3439-3444
   Abstract »    Full Text »    PDF »
Dopamine D1/5 Receptor-Mediated Long-Term Potentiation of Intrinsic Excitability in Rat Prefrontal Cortical Neurons: Ca2+-Dependent Intracellular Signaling.
L. Chen, J. D. Bohanick, M. Nishihara, J. K. Seamans, and C. R. Yang (2007)
J Neurophysiol 97, 2448-2464
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »

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