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Science 313 (5793): 1628-1632

Copyright © 2006 by the American Association for the Advancement of Science

Caveolin-1 Is Essential for Liver Regeneration

Manuel A. Fernández,1,2* Cecilia Albor,1* Mercedes Ingelmo-Torres,1 Susan J. Nixon,2 Charles Ferguson,2 Teymuras Kurzchalia,3 Francesc Tebar,1 Carlos Enrich,1 Robert G. Parton,2{dagger} Albert Pol1{dagger}

Abstract: Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division. We found that caveolin-1 gene–disrupted mice (cav1–/– mice) exhibited impaired liver regeneration and low survival after a partial hepatectomy. Hepatocytes showed dramatically reduced lipid droplet accumulation and did not advance through the cell division cycle. Treatment of cav1–/– mice with glucose (which is a predominant energy substrate when compared to lipids) drastically increased survival and reestablished progression of the cell cycle. Thus, caveolin-1 plays a crucial role in the mechanisms that coordinate lipid metabolism with the proliferative response occurring in the liver after cellular injury.

1 Departament de Biologia Cellular, Facultat de Medicina, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain.
2 Institute for Molecular Bioscience, Centre for Microscopy and Microanalysis and School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.
3 Max-Plank-Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: R.Parton{at}imb.uq.edu.au (R.G.P.); apols{at}ub.edu (A.P.).

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