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Science 313 (5794): 1775-1781

Copyright © 2006 by the American Association for the Advancement of Science

Waking Experience Affects Sleep Need in Drosophila

Indrani Ganguly-Fitzgerald,1* Jeff Donlea,2 Paul J. Shaw2

Abstract: Sleep is a vital, evolutionarily conserved phenomenon, whose function is unclear. Although mounting evidence supports a role for sleep in the consolidation of memories, until now, a molecular connection between sleep, plasticity, and memory formation has been difficult to demonstrate. We establish Drosophila as a model to investigate this relation and demonstrate that the intensity and/or complexity of prior social experience stably modifies sleep need and architecture. Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3',5'-monophosphate signaling pathways and a particular subset of 17 long-term memory genes.

1 The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92101, USA.
2 Washington University in St. Louis, School of Medicine, 660 South Euclid Avenue, Campus Box 8108, St. Louis, MO 63110, USA.

* To whom correspondence should be addressed. E-mail: transposase{at}gmail.com

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