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Science 314 (5802): 1157-1160

Copyright © 2006 by the American Association for the Advancement of Science

Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells

J. Rodrigo Mora,1*{dagger} Makoto Iwata,2* Bertus Eksteen,3* Si-Young Song,2 Tobias Junt,1 Balimkiz Senman,1 Kevin L. Otipoby,1 Aya Yokota,2 Hajime Takeuchi,2 Paola Ricciardi-Castagnoli,4 Klaus Rajewsky,1 David H. Adams,3 Ulrich H. von Andrian1{dagger}

Abstract: Normal intestinal mucosa contains abundant immunoglobulin A (IgA)–secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell–independent expression of IgA and gut-homing receptors on B cells. GALT-DC–derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC–derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion. Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine. Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators.

1 CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
2 Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki-shi, Kagawa 769-2193, Japan.
3 MRC Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, UK.
4 Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, Milan, Italy.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: uva{at}cbr.med.harvard.edu (U.H.V.A.); mora{at}cbr.med.harvard.edu (J.R.M.)


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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R. Molenaar, M. Greuter, A. P. J. van der Marel, R. Roozendaal, S. F. Martin, F. Edele, J. Huehn, R. Forster, T. O'Toole, W. Jansen, et al. (2009)
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   Abstract »    Full Text »    PDF »
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I D Iliev, I Spadoni, E Mileti, G Matteoli, A Sonzogni, G M Sampietro, D Foschi, F Caprioli, G Viale, and M Rescigno (2009)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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T. Bianchi, L. B. Pincus, M.-A. Wurbel, B. E. Rich, T. S. Kupper, R. C. Fuhlbrigge, and M. Boes (2009)
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   Abstract »    Full Text »    PDF »
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A. Yokota, H. Takeuchi, N. Maeda, Y. Ohoka, C. Kato, S.-Y. Song, and M. Iwata (2009)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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S. Yamazaki, D. Dudziak, G. F. Heidkamp, C. Fiorese, A. J. Bonito, K. Inaba, M. C. Nussenzweig, and R. M. Steinman (2008)
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   Abstract »    Full Text »    PDF »
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S. C. Bischoff (2008)
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
Selected natural and synthetic retinoids impair CCR7- and CXCR4-dependent cell migration in vitro and in vivo.
E. J. Villablanca, D. Zhou, B. Valentinis, A. Negro, L. Raccosta, L. Mauri, A. Prinetti, S. Sonnino, C. Bordignon, C. Traversari, et al. (2008)
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   Abstract »    Full Text »    PDF »
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E. Jaensson, H. Uronen-Hansson, O. Pabst, B. Eksteen, J. Tian, J. L. Coombes, P.-L. Berg, T. Davidsson, F. Powrie, B. Johansson-Lindbom, et al. (2008)
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   Abstract »    Full Text »    PDF »
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G. R.A. Ehrhardt, A. Hijikata, H. Kitamura, O. Ohara, J.-Y. Wang, and M. D. Cooper (2008)
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   Abstract »    Full Text »    PDF »
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M. Ahrendt, S. I. Hammerschmidt, O. Pabst, R. Pabst, and U. Bode (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. M. Thompson, M. G. Nicholson, A. C. Whitmore, M. Zamora, A. West, A. Iwasaki, H. F. Staats, and R. E. Johnston (2008)
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   Abstract »    Full Text »    PDF »
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A. Miles, E. Liaskou, B. Eksteen, P. F. Lalor, and D. H. Adams (2008)
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   Abstract »    Full Text »    PDF »
Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NF{kappa}B-inducing kinase in stromal cells.
J. Kunisawa, M. Gohda, Y. Kurashima, I. Ishikawa, M. Higuchi, and H. Kiyono (2008)
Blood 111, 4646-4652
   Abstract »    Full Text »    PDF »
Sphingosine 1-Phosphate Regulates the Egress of IgA Plasmablasts from Peyer's Patches for Intestinal IgA Responses.
M. Gohda, J. Kunisawa, F. Miura, Y. Kagiyama, Y. Kurashima, M. Higuchi, I. Ishikawa, I. Ogahara, and H. Kiyono (2008)
J. Immunol. 180, 5335-5343
   Abstract »    Full Text »    PDF »
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S.-Y. Chang, H.-R. Cha, O. Igarashi, P. D. Rennert, A. Kissenpfennig, B. Malissen, M. Nanno, H. Kiyono, and M.-N. Kweon (2008)
J. Immunol. 180, 4361-4365
   Abstract »    Full Text »    PDF »
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E. Beli, M. Li, C. Cuff, and J. J. Pestka (2008)
J. Nutr. 138, 813-819
   Abstract »    Full Text »    PDF »
Effects of adding fibrous feedstuffs to the diet of young pigs on growth performance, intestinal cytokines, and circulating acute-phase proteins.
T. E. Weber, C. J. Ziemer, and B. J. Kerr (2008)
J Anim Sci 86, 871-881
   Abstract »    Full Text »    PDF »
Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia.
H. M. Joo, Y. He, and M. Y. Sangster (2008)
PNAS 105, 3485-3490
   Abstract »    Full Text »    PDF »
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A.-K. Shirakawa, D. Nagakubo, K. Hieshima, T. Nakayama, Z. Jin, and O. Yoshie (2008)
J. Immunol. 180, 2786-2795
   Abstract »    Full Text »    PDF »
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T. D. Kim, T. H. Terwey, J. L. Zakrzewski, D. Suh, A. A. Kochman, M. E. Chen, C. G. King, C. Borsotti, J. Grubin, O. M. Smith, et al. (2008)
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   Abstract »    Full Text »    PDF »
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S.-Y. Chang, H.-R. Cha, S. Uematsu, S. Akira, O. Igarashi, H. Kiyono, and M.-N. Kweon (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
Retinoids Accelerate B Lineage Lymphoid Differentiation.
X. Chen, B. L. Esplin, K. P. Garrett, R. S. Welner, C. F. Webb, and P. W. Kincade (2008)
J. Immunol. 180, 138-145
   Abstract »    Full Text »    PDF »
Retinol Combined with Retinoic Acid Increases Retinol Uptake and Esterification in the Lungs of Young Adult Rats when Delivered by the Intramuscular as well as Oral Routes.
A. C. Ross and N.-q. Li (2007)
J. Nutr. 137, 2371-2376
   Abstract »    Full Text »    PDF »
Lymphoma dissemination: the other face of lymphocyte homing.
S. T. Pals, D. J. J. de Gorter, and M. Spaargaren (2007)
Blood 110, 3102-3111
   Abstract »    Full Text »    PDF »
The yin and yang of intestinal epithelial cells in controlling dendritic cell function.
I. D. Iliev, G. Matteoli, and M. Rescigno (2007)
J. Exp. Med. 204, 2253-2257
   Abstract »    Full Text »    PDF »
In Vitro Induction of Mucosa-Type Dendritic Cells by All-Trans Retinoic Acid.
L. Saurer, K. C. McCullough, and A. Summerfield (2007)
J. Immunol. 179, 3504-3514
   Abstract »    Full Text »    PDF »
Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells.
S. G. Kang, H. W. Lim, O. M. Andrisani, H. E. Broxmeyer, and C. H. Kim (2007)
J. Immunol. 179, 3724-3733
   Abstract »    Full Text »    PDF »
Th2 Differentiation in Distinct Lymph Nodes Influences the Site of Mucosal Th2 Immune-Inflammatory Responses.
D. Alvarez, J. L. Arkinson, J. Sun, R. Fattouh, T. Walker, and M. Jordana (2007)
J. Immunol. 179, 3287-3296
   Abstract »    Full Text »    PDF »
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.
C.-M. Sun, J. A. Hall, R. B. Blank, N. Bouladoux, M. Oukka, J. R. Mora, and Y. Belkaid (2007)
J. Exp. Med. 204, 1775-1785
   Abstract »    Full Text »    PDF »

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