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Science 314 (5804): 1412-1413

Copyright © 2006 by the American Association for the Advancement of Science

G Protein Signaling in Yeast: New Components, New Connections, New Compartments

Janna E. Slessareva, and Henrik G. Dohlman*

Abstract: Signaling by cell surface receptors and heterotrimeric guanine nucleotide–binding proteins (G proteins) is one of the most exhaustively studied processes in the cell but remains a major focus of molecular pharmacology research. The pheromone-response system in yeast (see the Connections Map at Science's Signal Transduction Knowledge Environment) has provided numerous major advances in our understanding of G protein signaling and regulation. However, the basic features of this prototypical pathway have remained largely unchanged since the mid-1990s. New tools available in yeast are beginning to uncover new pathway components and interactions and have revealed signaling in unexpected locations within the cell.

Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599–7260, USA.

* To whom correspondence should be addressed. E-mail: hdohlman{at}

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