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Science 315 (5808): 107-111

Copyright © 2007 by the American Association for the Advancement of Science

Differential Antigen Processing by Dendritic Cell Subsets in Vivo

Diana Dudziak,1 Alice O. Kamphorst,1 Gordon F. Heidkamp,1 Veit R. Buchholz,1 Christine Trumpfheller,2 Sayuri Yamazaki,2 Cheolho Cheong,2 Kang Liu,1 Han-Woong Lee,3 Chae Gyu Park,2 Ralph M. Steinman,2 Michel C. Nussenzweig1,4*

Abstract: Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo, we specifically targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies. Unlike CD8+ DCs that express the cell surface protein CD205, CD8 DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II. This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.

1 Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA.
2 Laboratory of Cellular Immunology and Physiology, The Rockefeller University, New York, NY 10021, USA.
3 Department of Biochemistry, College of Sciences, Yonsei University, Seoul 120-749, Korea.
4 Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021 USA.

* To whom correspondence should be addressed. E-mail: nussen{at}rockefeller.edu


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Existence of CD8{alpha}-Like Dendritic Cells with a Conserved Functional Specialization and a Common Molecular Signature in Distant Mammalian Species.
V. Contreras, C. Urien, R. Guiton, Y. Alexandre, T.-P. Vu Manh, T. Andrieu, K. Crozat, L. Jouneau, N. Bertho, M. Epardaud, et al. (2010)
J. Immunol. 185, 3313-3325
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Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR.
E. Klechevsky, A.-L. Flamar, Y. Cao, J.-P. Blanck, M. Liu, A. O'Bar, O. Agouna-Deciat, P. Klucar, L. Thompson-Snipes, S. Zurawski, et al. (2010)
Blood 116, 1685-1697
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Robust Stimulation of Humoral and Cellular Immune Responses following Vaccination with Antigen-Loaded {beta}-Glucan Particles.
H. Huang, G. R. Ostroff, C. K. Lee, C. A. Specht, and S. M. Levitz (2010)
mBio 1, e00164-10
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CX3CR1+ CD8{alpha}+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells.
L. Bar-On, T. Birnberg, K. L. Lewis, B. T. Edelson, D. Bruder, K. Hildner, J. Buer, K. M. Murphy, B. Reizis, and S. Jung (2010)
PNAS 107, 14745-14750
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Comparison of OX40 Ligand and CD70 in the Promotion of CD4+ T Cell Responses.
J. S. Kurche, M. A. Burchill, P. J. Sanchez, C. Haluszczak, and R. M. Kedl (2010)
J. Immunol. 185, 2106-2115
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Direct CD4 Help Provision following Interaction of Memory CD4 and CD8 T Cells with Distinct Antigen-Presenting Dendritic Cells.
M.-G. de Goer de Herve, B. Dembele, M. Vallee, F. Herr, A. Cariou, and Y. Taoufik (2010)
J. Immunol. 185, 1028-1036
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Dicer-Dependent MicroRNAs Control Maturation, Function, and Maintenance of Langerhans Cells In Vivo.
H. Kuipers, F. M. Schnorfeil, H.-J. Fehling, H. Bartels, and T. Brocker (2010)
J. Immunol. 185, 400-409
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The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8{alpha}+ dendritic cells.
K. Crozat, R. Guiton, V. Contreras, V. Feuillet, C.-A. Dutertre, E. Ventre, T.-P. Vu Manh, T. Baranek, A. K. Storset, J. Marvel, et al. (2010)
J. Exp. Med. 207, 1283-1292
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Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8{alpha}+ dendritic cells.
L. F. Poulin, M. Salio, E. Griessinger, F. Anjos-Afonso, L. Craciun, J.-L. Chen, A. M. Keller, O. Joffre, S. Zelenay, E. Nye, et al. (2010)
J. Exp. Med. 207, 1261-1271
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Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens.
S. L. Jongbloed, A. J. Kassianos, K. J. McDonald, G. J. Clark, X. Ju, C. E. Angel, C.-J. J. Chen, P. R. Dunbar, R. B. Wadley, V. Jeet, et al. (2010)
J. Exp. Med. 207, 1247-1260
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