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Science 315 (5808): 107-111

Copyright © 2007 by the American Association for the Advancement of Science

Differential Antigen Processing by Dendritic Cell Subsets in Vivo

Diana Dudziak,1 Alice O. Kamphorst,1 Gordon F. Heidkamp,1 Veit R. Buchholz,1 Christine Trumpfheller,2 Sayuri Yamazaki,2 Cheolho Cheong,2 Kang Liu,1 Han-Woong Lee,3 Chae Gyu Park,2 Ralph M. Steinman,2 Michel C. Nussenzweig1,4*

Abstract: Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo, we specifically targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies. Unlike CD8+ DCs that express the cell surface protein CD205, CD8– DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II. This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.

1 Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA.
2 Laboratory of Cellular Immunology and Physiology, The Rockefeller University, New York, NY 10021, USA.
3 Department of Biochemistry, College of Sciences, Yonsei University, Seoul 120-749, Korea.
4 Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021 USA.

* To whom correspondence should be addressed. E-mail: nussen{at}rockefeller.edu

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Targeting MHC Class I Monomers to Dendritic Cells Inhibits the Indirect Pathway of Allorecognition and the Production of IgG Alloantibodies Leading to Long-Term Allograft Survival.
Y. Tanriver, K. Ratnasothy, R. P. Bucy, G. Lombardi, and R. Lechler (2010)
J. Immunol. 184, 1757-1764
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Vascular Dendritic Cells as Gatekeepers of Lipid Accumulation Within Nascent Atherosclerotic Plaques.
G. J. Randolph and S. Potteaux (2010)
Circ. Res. 106, 227-229
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Nucleotide Oligomerization Binding Domain-Like Receptor Signaling Enhances Dendritic Cell-Mediated Cross-Priming In Vivo.
J. Asano, H. Tada, N. Onai, T. Sato, Y. Horie, Y. Fujimoto, K. Fukase, A. Suzuki, T. W. Mak, and T. Ohteki (2010)
J. Immunol. 184, 736-745
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Effective collaboration between marginal metallophilic macrophages and CD8+ dendritic cells in the generation of cytotoxic T cells.
R. Backer, T. Schwandt, M. Greuter, M. Oosting, F. Jungerkes, T. Tuting, L. Boon, T. O'Toole, G. Kraal, A. Limmer, et al. (2010)
PNAS 107, 216-221
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Dendritic cells in chronic viral hepatitis B and C: victims or guardian angels?.
A M Woltman, A Boonstra, and H L A Janssen (2010)
Gut 59, 115-125
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Cutting Edge: Limited Specialization of Dendritic Cell Subsets for MHC Class II-Associated Presentation of Viral Particles.
S. A. Keller, M. Bauer, V. Manolova, S. Muntwiler, P. Saudan, and M. F. Bachmann (2010)
J. Immunol. 184, 26-29
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The origin and development of nonlymphoid tissue CD103+ DCs.
F. Ginhoux, K. Liu, J. Helft, M. Bogunovic, M. Greter, D. Hashimoto, J. Price, N. Yin, J. Bromberg, S. A. Lira, et al. (2009)
J. Exp. Med. 206, 3115-3130
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Langerin+CD8{alpha}+ Dendritic Cells Are Critical for Cross-Priming and IL-12 Production in Response to Systemic Antigens.
K. J. Farrand, N. Dickgreber, P. Stoitzner, F. Ronchese, T. R. Petersen, and I. F. Hermans (2009)
J. Immunol. 183, 7732-7742
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