Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 315 (5809): 201-205

Copyright © 2007 by the American Association for the Advancement of Science

Proteasome-Independent Functions of Ubiquitin in Endocytosis and Signaling

Debdyuti Mukhopadhyay, and Howard Riezman*

Abstract: Ubiquitination is a reversible posttranslational modification of cellular proteins, in which a 76–amino acid polypeptide, ubiquitin, is primarily attached to the {epsilon}-amino group of lysines in target proteins. Ubiquitination is a major player in regulating a broad host of cellular processes, including cell division, differentiation, signal transduction, protein trafficking, and quality control. Aberrations in the ubiquitination system are implicated in pathogenesis of some diseases, certain malignancies, neurodegenerative disorders, and pathologies of the inflammatory immune response. Here, we discuss the proteasome-independent roles of ubiquitination in signaling and endocytosis.

Department of Biochemistry, University of Geneva, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.

* To whom correspondence should be addressed. E-mail: Howard.Riezman{at}

Proteomic snapshot of the EGF-induced ubiquitin network.
E. Argenzio, T. Bange, B. Oldrini, F. Bianchi, R. Peesari, S. Mari, P. P. Di Fiore, M. Mann, and S. Polo (2014)
Mol Syst Biol 7, 462
   Abstract »    Full Text »    PDF »
Evolution and functional cross-talk of protein post-translational modifications.
P. Beltrao, P. Bork, N. J. Krogan, and V. van Noort (2014)
Mol Syst Biol 9, 714
   Abstract »    Full Text »    PDF »
Fertilization-induced K63-linked ubiquitylation mediates clearance of maternal membrane proteins.
M. Sato, R. Konuma, K. Sato, K. Tomura, and K. Sato (2014)
Development 141, 1324-1331
   Abstract »    Full Text »    PDF »
Regulation of TGF-{beta} family signalling by ubiquitination and deubiquitination.
T. Imamura, Y. Oshima, and A. Hikita (2013)
J. Biochem. 154, 481-489
   Abstract »    Full Text »    PDF »
The TREX1 C-terminal Region Controls Cellular Localization through Ubiquitination.
C. D. Orebaugh, J. M. Fye, S. Harvey, T. Hollis, J. C. Wilkinson, and F. W. Perrino (2013)
J. Biol. Chem. 288, 28881-28892
   Abstract »    Full Text »    PDF »
SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria.
H. Murata, M. Sakaguchi, K. Kataoka, and N.-h. Huh (2013)
Mol. Biol. Cell 24, 2772-2784
   Abstract »    Full Text »    PDF »
NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation.
V. Pietiainen, B. Vassilev, T. Blom, W. Wang, J. Nelson, R. Bittman, N. Back, N. Zelcer, and E. Ikonen (2013)
J. Cell Sci. 126, 3961-3971
   Abstract »    Full Text »    PDF »
Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor.
H. Fujita, Y. Iwabu, K. Tokunaga, and Y. Tanaka (2013)
J. Cell Sci. 126, 2798-2809
   Abstract »    Full Text »    PDF »
A Genomic Survey of HECT Ubiquitin Ligases in Eukaryotes Reveals Independent Expansions of the HECT System in Several Lineages.
X. Grau-Bove, A. Sebe-Pedros, and I. Ruiz-Trillo (2013)
Genome Biol Evol 5, 833-847
   Abstract »    Full Text »    PDF »
Agonist-induced Down-regulation of Endogenous Protein Kinase C {alpha} through an Endolysosomal Mechanism.
M. A. Lum, K. E. Pundt, B. E. Paluch, A. R. Black, and J. D. Black (2013)
J. Biol. Chem. 288, 13093-13109
   Abstract »    Full Text »    PDF »
Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor.
L. Zhang, M. Xu, E. Scotti, Z. J. Chen, and P. Tontonoz (2013)
J. Lipid Res. 54, 1410-1420
   Abstract »    Full Text »    PDF »
Advanced Proteomic Analyses Yield a Deep Catalog of Ubiquitylation Targets in Arabidopsis.
D.-Y. Kim, M. Scalf, L. M. Smith, and R. D. Vierstra (2013)
PLANT CELL 25, 1523-1540
   Abstract »    Full Text »    PDF »
Oxidative stress regulates the ubiquitin-proteasome system and immunoproteasome functioning in a mouse model of X-adrenoleukodystrophy.
N. Launay, M. Ruiz, S. Fourcade, A. Schluter, C. Guilera, I. Ferrer, E. Knecht, and A. Pujol (2013)
Brain 136, 891-904
   Abstract »    Full Text »    PDF »
Lysine 63-linked Ubiquitination Modulates Mixed Lineage Kinase-3 Interaction with JIP1 Scaffold Protein in Cytokine-induced Pancreatic {beta} Cell Death.
R. K. Humphrey, S. M. A. Yu, A. Bellary, S. Gonuguntla, M. Yebra, and U. S. Jhala (2013)
J. Biol. Chem. 288, 2428-2440
   Abstract »    Full Text »    PDF »
Lysine 48-Linked Polyubiquitination of Organic Anion Transporter-1 Is Essential for Its Protein Kinase C-Regulated Endocytosis.
Q. Zhang, S. Li, C. Patterson, and G. You (2013)
Mol. Pharmacol. 83, 217-224
   Abstract »    Full Text »    PDF »
BACE1 Protein Endocytosis and Trafficking Are Differentially Regulated by Ubiquitination at Lysine 501 and the Di-leucine Motif in the Carboxyl Terminus.
E. L. Kang, B. Biscaro, F. Piazza, and G. Tesco (2012)
J. Biol. Chem. 287, 42867-42880
   Abstract »    Full Text »    PDF »
A Targeted In Vivo RNAi Screen Reveals Deubiquitinases as New Regulators of Notch Signaling.
J. Zhang, M. Liu, Y. Su, J. Du, and A. J. Zhu (2012)
g3 2, 1563-1575
   Abstract »    Full Text »    PDF »
Spatiotemporal Regulation of the Ubiquitinated Cargo-binding Activity of Rabex-5 in the Endocytic Pathway.
Y. Aikawa, H. Hirakawa, and S. Lee (2012)
J. Biol. Chem. 287, 40586-40597
   Abstract »    Full Text »    PDF »
XBAT35, a Novel Arabidopsis RING E3 Ligase Exhibiting Dual Targeting of Its Splice Isoforms, Is Involved in Ethylene-Mediated Regulation of Apical Hook Curvature.
S. D. Carvalho, R. Saraiva, T. M. Maia, I. A. Abreu, and P. Duque (2012)
Mol Plant 5, 1295-1309
   Abstract »    Full Text »    PDF »
A Genome-Wide RNAi Screen for Enhancers of par Mutants Reveals New Contributors to Early Embryonic Polarity in Caenorhabditis elegans.
D. G. Morton, W. A. Hoose, and K. J. Kemphues (2012)
Genetics 192, 929-942
   Abstract »    Full Text »    PDF »
The KEEP ON GOING Protein of Arabidopsis Regulates Intracellular Protein Trafficking and Is Degraded during Fungal Infection.
Y. Gu and R. W. Innes (2012)
PLANT CELL 24, 4717-4730
   Abstract »    Full Text »    PDF »
Drosophila as a Model to Study Mitochondrial Dysfunction in Parkinson's Disease.
M. Guo (2012)
Cold Spring Harb Perspect Med 2, a009944
   Abstract »    Full Text »    PDF »
Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration.
K. Schaeuble, M. A. Hauser, A. V. Rippl, R. Bruderer, C. Otero, M. Groettrup, and D. F. Legler (2012)
J. Cell Sci. 125, 4463-4474
   Abstract »    Full Text »    PDF »
Rabex-5 Protein Regulates the Endocytic Trafficking Pathway of Ubiquitinated Neural Cell Adhesion Molecule L1.
Y. Aikawa (2012)
J. Biol. Chem. 287, 32312-32323
   Abstract »    Full Text »    PDF »
Subversion of Cell Signaling by Pathogens.
N. M. Alto and K. Orth (2012)
Cold Spring Harb Perspect Biol 4, a006114
   Abstract »    Full Text »    PDF »
The Expanding Universe of Ubiquitin and Ubiquitin-Like Modifiers.
R. D. Vierstra (2012)
Plant Physiology 160, 2-14
   Full Text »    PDF »
The U-Box E3 Ligase SPL11/PUB13 Is a Convergence Point of Defense and Flowering Signaling in Plants.
J. Liu, W. Li, Y. Ning, G. Shirsekar, Y. Cai, X. Wang, L. Dai, Z. Wang, W. Liu, and G.-L. Wang (2012)
Plant Physiology 160, 28-37
   Full Text »    PDF »
Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-{kappa}B activation.
T. Tao, C. Cheng, Y. Ji, G. Xu, J. Zhang, L. Zhang, and A. Shen (2012)
Mol. Biol. Cell 23, 2635-2644
   Abstract »    Full Text »    PDF »
Physiological and pathological role of the ubiquitin-proteasome system in the vascular smooth muscle cell.
M. Demasi and F. R. M. Laurindo (2012)
Cardiovasc Res 95, 183-193
   Abstract »    Full Text »    PDF »
Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications.
S. Fulda, K. Rajalingam, and I. Dikic (2012)
EMBO Mol Med. 4, 545-556
   Abstract »    Full Text »    PDF »
MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length.
J. K. Ma, M. Y. Platt, J. Eastham-Anderson, J.-S. Shin, and I. Mellman (2012)
PNAS 109, 8820-8827
   Abstract »    Full Text »    PDF »
Arsenic Promotes Ubiquitinylation and Lysosomal Degradation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channels in Human Airway Epithelial Cells.
J. M. Bomberger, B. A. Coutermarsh, R. L. Barnaby, and B. A. Stanton (2012)
J. Biol. Chem. 287, 17130-17139
   Abstract »    Full Text »    PDF »
PHO2-Dependent Degradation of PHO1 Modulates Phosphate Homeostasis in Arabidopsis.
T.-Y. Liu, T.-K. Huang, C.-Y. Tseng, Y.-S. Lai, S.-I. Lin, W.-Y. Lin, J.-W. Chen, and T.-J. Chiou (2012)
PLANT CELL 24, 2168-2183
   Abstract »    Full Text »    PDF »
The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane.
H. Tanno, T. Yamaguchi, E. Goto, S. Ishido, and M. Komada (2012)
Mol. Biol. Cell 23, 1343-1353
   Abstract »    Full Text »    PDF »
EGFR-dependent phosphorylation of leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR.
K. Ishikawa, A. Nara, K. Matsumoto, and H. Hanafusa (2012)
Mol. Biol. Cell 23, 1294-1306
   Abstract »    Full Text »    PDF »
Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme.
A. A. Sarkar and I. E. Zohn (2012)
J. Cell Biol. 196, 789-800
   Abstract »    Full Text »    PDF »
Notch Signaling Is Antagonized by SAO-1, a Novel GYF-Domain Protein That Interacts with the E3 Ubiquitin Ligase SEL-10 in Caenorhabditis elegans.
V. A. Hale, E. L. Guiney, L. Y. Goldberg, J. H. Haduong, C. S. Kwartler, K. W. Scangos, and C. Goutte (2012)
Genetics 190, 1043-1057
   Abstract »    Full Text »    PDF »
Posttranslational Modifications of Proteins in the Pathobiology of Medically Relevant Fungi.
M. D. Leach and A. J. P. Brown (2012)
Eukaryot. Cell 11, 98-108
   Abstract »    Full Text »    PDF »
Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control.
A. Mocciaro and M. Rape (2012)
J. Cell Sci. 125, 255-263
   Abstract »    Full Text »    PDF »
Abiotic stress tolerance mediated by protein ubiquitination.
W. J. Lyzenga and S. L. Stone (2012)
J. Exp. Bot. 63, 599-616
   Abstract »    Full Text »    PDF »
The Arabidopsis RING E3 Ubiquitin Ligase AtAIRP2 Plays Combinatory Roles with AtAIRP1 in Abscisic Acid-Mediated Drought Stress Responses.
S. K. Cho, M. Y. Ryu, D. H. Seo, B. G. Kang, and W. T. Kim (2011)
Plant Physiology 157, 2240-2257
   Abstract »    Full Text »    PDF »
The Deubiquitinase CYLD Targets Smad7 Protein to Regulate Transforming Growth Factor {beta} (TGF-{beta}) Signaling and the Development of Regulatory T Cells.
Y. Zhao, A. M. Thornton, M. C. Kinney, C. A. Ma, J. J. Spinner, I. J. Fuss, E. M. Shevach, and A. Jain (2011)
J. Biol. Chem. 286, 40520-40530
   Abstract »    Full Text »    PDF »
Expression Strategy of Densonucleosis Virus from the German Cockroach, Blattella germanica.
T. V. Kapelinskaya, E. U. Martynova, C. Schal, and D. V. Mukha (2011)
J. Virol. 85, 11855-11870
   Abstract »    Full Text »    PDF »
Multicopy Suppression Screening of Saccharomyces cerevisiae Identifies the Ubiquitination Machinery as a Main Target for Improving Growth at Low Temperatures.
M. J. Hernandez-Lopez, S. Garcia-Marques, F. Randez-Gil, and J. A. Prieto (2011)
Appl. Envir. Microbiol. 77, 7517-7525
   Abstract »    Full Text »    PDF »
Tissue-specific expression and post-translational modifications of plant- and bacterial-type phosphoenolpyruvate carboxylase isozymes of the castor oil plant, Ricinus communis L..
B. O'Leary, E. T. Fedosejevs, A. T. Hill, J. Bettridge, J. Park, S. K. Rao, C. A. Leach, and W. C. Plaxton (2011)
J. Exp. Bot. 62, 5485-5495
   Abstract »    Full Text »    PDF »
X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction.
P. Stromme, K. Dobrenis, R. V. Sillitoe, M. Gulinello, N. F. Ali, C. Davidson, M. C. Micsenyi, G. Stephney, L. Ellevog, A. Klungland, et al. (2011)
Brain 134, 3369-3383
   Abstract »    Full Text »    PDF »
Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8{alpha} and promote its ubiquitylation and endocytosis.
M. D'Agostino, G. Tornillo, M. G. Caporaso, M. V. Barone, E. Ghigo, S. Bonatti, and G. Mottola (2011)
J. Cell Sci. 124, 3545-3556
   Abstract »    Full Text »    PDF »
Increased Gene Dosage of Ube3a Results in Autism Traits and Decreased Glutamate Synaptic Transmission in Mice.
S. E. P. Smith, Y.-D. Zhou, G. Zhang, Z. Jin, D. C. Stoppel, and M. P. Anderson (2011)
Science Translational Medicine 3, 103ra97
   Abstract »    Full Text »    PDF »
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles.
S. A. Wagner, P. Beli, B. T. Weinert, M. L. Nielsen, J. Cox, M. Mann, and C. Choudhary (2011)
Mol. Cell. Proteomics 10, M111.013284
   Abstract »    Full Text »    PDF »
A BEN-domain-containing protein associates with heterochromatin and represses transcription.
K. M. Sathyan, Z. Shen, V. Tripathi, K. V. Prasanth, and S. G. Prasanth (2011)
J. Cell Sci. 124, 3149-3163
   Abstract »    Full Text »    PDF »
The SINA E3 Ligase OsDIS1 Negatively Regulates Drought Response in Rice.
Y. Ning, C. Jantasuriyarat, Q. Zhao, H. Zhang, S. Chen, J. Liu, L. Liu, S. Tang, C. H. Park, X. Wang, et al. (2011)
Plant Physiology 157, 242-255
   Abstract »    Full Text »    PDF »
Distinct Functional Domains Contribute to Degradation of the Low Density Lipoprotein Receptor (LDLR) by the E3 Ubiquitin Ligase Inducible Degrader of the LDLR (IDOL).
V. Sorrentino, L. Scheer, A. Santos, E. Reits, B. Bleijlevens, and N. Zelcer (2011)
J. Biol. Chem. 286, 30190-30199
   Abstract »    Full Text »    PDF »
Cyclin-Dependent Kinase 5 Regulates PSD-95 Ubiquitination in Neurons.
M. J. Bianchetta, T. T. Lam, S. N. Jones, and M. A. Morabito (2011)
J. Neurosci. 31, 12029-12035
   Abstract »    Full Text »    PDF »
Noncanonical K27-Linked Polyubiquitination of TIEG1 Regulates Foxp3 Expression and Tumor Growth.
D.-J. Peng, M. Zeng, R. Muromoto, T. Matsuda, K. Shimoda, M. Subramaniam, T. C. Spelsberg, W.-Z. Wei, and K. Venuprasad (2011)
J. Immunol. 186, 5638-5647
   Abstract »    Full Text »    PDF »
PP2A Phosphatases: The "On-Off" Regulatory Switches of Brassinosteroid Signaling.
S. Di Rubbo, N. G. Irani,, and E. Russinova (2011)
Science Signaling 4, pe25
   Abstract »    Full Text »    PDF »
New Roles for Lysosomal Trafficking in Morphogen Gradient Sensing.
E. Rainero and J. C. Norman (2011)
Science Signaling 4, pe24
   Abstract »    Full Text »    PDF »
A Novel Strategy to Isolate Ubiquitin Conjugates Reveals Wide Role for Ubiquitination during Neural Development.
M. Franco, N. T. Seyfried, A. H. Brand, J. Peng, and U. Mayor (2011)
Mol. Cell. Proteomics 10, M110.002188
   Abstract »    Full Text »    PDF »
A Perturbed Ubiquitin Landscape Distinguishes Between Ubiquitin in Trafficking and in Proteolysis.
I. Ziv, Y. Matiuhin, D. S. Kirkpatrick, Z. Erpapazoglou, S. Leon, M. Pantazopoulou, W. Kim, S. P. Gygi, R. Haguenauer-Tsapis, N. Reis, et al. (2011)
Mol. Cell. Proteomics 10, M111.009753
   Abstract »    Full Text »    PDF »
SCCRO (DCUN1D1) Promotes Nuclear Translocation and Assembly of the Neddylation E3 Complex.
G. Huang, A. J. Kaufman, Y. Ramanathan, and B. Singh (2011)
J. Biol. Chem. 286, 10297-10304
   Abstract »    Full Text »    PDF »
Lys-63-specific Deubiquitination of SDS3 by USP17 Regulates HDAC Activity.
S. Ramakrishna, B. Suresh, E.-J. Lee, H.-J. Lee, W.-S. Ahn, and K.-H. Baek (2011)
J. Biol. Chem. 286, 10505-10514
   Abstract »    Full Text »    PDF »
Ubiquitylation of an Internalized Killer Cell Ig-Like Receptor by Triad3A Disrupts Sustained NF-{kappa}B Signaling.
S. M. S. Miah, A. K. Purdy, N. B. Rodin, A. W. MacFarlane IV, J. Oshinsky, D. A. Alvarez-Arias, and K. S. Campbell (2011)
J. Immunol. 186, 2959-2969
   Abstract »    Full Text »    PDF »
High Boron-induced Ubiquitination Regulates Vacuolar Sorting of the BOR1 Borate Transporter in Arabidopsis thaliana.
K. Kasai, J. Takano, K. Miwa, A. Toyoda, and T. Fujiwara (2011)
J. Biol. Chem. 286, 6175-6183
   Abstract »    Full Text »    PDF »
S. D. Weeks, K. C. Grasty, L. Hernandez-Cuebas, and P. J. Loll (2011)
J. Biol. Chem. 286, 4555-4565
   Abstract »    Full Text »    PDF »
Processing of Optineurin in Neuronal Cells.
X. Shen, H. Ying, Y. Qiu, J.-S. Park, R. Shyam, Z.-L. Chi, T. Iwata, and B. Y. J. T. Yue (2011)
J. Biol. Chem. 286, 3618-3629
   Abstract »    Full Text »    PDF »
The Deubiquitinating Enzyme USP-46 Negatively Regulates the Degradation of Glutamate Receptors to Control Their Abundance in the Ventral Nerve Cord of Caenorhabditis elegans.
J. R. Kowalski, C. L. Dahlberg, and P. Juo (2011)
J. Neurosci. 31, 1341-1354
   Abstract »    Full Text »    PDF »
The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.
T. M. Durcan, M. Kontogiannea, T. Thorarinsdottir, L. Fallon, A. J. Williams, A. Djarmati, T. Fantaneanu, H. L. Paulson, and E. A. Fon (2011)
Hum. Mol. Genet. 20, 141-154
   Abstract »    Full Text »    PDF »
Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice.
P. K. Paul, S. K. Gupta, S. Bhatnagar, S. K. Panguluri, B. G. Darnay, Y. Choi, and A. Kumar (2010)
J. Cell Biol. 191, 1395-1411
   Abstract »    Full Text »    PDF »
Comparative analyses of differentially induced T-cell receptor-mediated phosphorylation pathways in T lymphoma cells.
S. Ortiz, W. Lee, D. Smith, S. J. Forman, T. D. Lee, and C.-P. Liu (2010)
Experimental Biology and Medicine 235, 1450-1463
   Abstract »    Full Text »    PDF »
The Arabidopsis C3H2C3-Type RING E3 Ubiquitin Ligase AtAIRP1 Is a Positive Regulator of an Abscisic Acid-Dependent Response to Drought Stress.
M. Y. Ryu, S. K. Cho, and W. T. Kim (2010)
Plant Physiology 154, 1983-1997
   Abstract »    Full Text »    PDF »
An Atypical E3 Ligase Zinc Finger Protein 91 Stabilizes and Activates NF-{kappa}B-inducing Kinase via Lys63-linked Ubiquitination.
X. Jin, H. R. Jin, H. S. Jung, S. J. Lee, J.-H. Lee, and J. J. Lee (2010)
J. Biol. Chem. 285, 30539-30547
   Abstract »    Full Text »    PDF »
Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure.
C. Michele Nawata, S. Hirose, T. Nakada, C. M. Wood, and A. Kato (2010)
J. Exp. Biol. 213, 3150-3160
   Abstract »    Full Text »    PDF »
Transcriptional responses to thermal acclimation in the eurythermal fish Gillichthys mirabilis (Cooper 1864).
C. A. Logan and G. N. Somero (2010)
Am J Physiol Regulatory Integrative Comp Physiol 299, R843-R852
   Abstract »    Full Text »    PDF »
Multiple Pathways Involved in Porcine Parvovirus Cellular Entry and Trafficking toward the Nucleus.
M. Boisvert, S. Fernandes, and P. Tijssen (2010)
J. Virol. 84, 7782-7792
   Abstract »    Full Text »    PDF »
The Activity of Hyaluronan Synthase 2 Is Regulated by Dimerization and Ubiquitination.
E. Karousou, M. Kamiryo, S. S. Skandalis, A. Ruusala, T. Asteriou, A. Passi, H. Yamashita, U. Hellman, C.-H. Heldin, and P. Heldin (2010)
J. Biol. Chem. 285, 23647-23654
   Abstract »    Full Text »    PDF »
Ubiquitin Regulates GGA3-mediated Degradation of BACE1.
E. L. Kang, A. N. Cameron, F. Piazza, K. R. Walker, and G. Tesco (2010)
J. Biol. Chem. 285, 24108-24119
   Abstract »    Full Text »    PDF »
The Yeast E4 Ubiquitin Ligase Ufd2 Interacts with the Ubiquitin-like Domains of Rad23 and Dsk2 via a Novel and Distinct Ubiquitin-like Binding Domain.
P. Hanzelmann, J. Stingele, K. Hofmann, H. Schindelin, and S. Raasi (2010)
J. Biol. Chem. 285, 20390-20398
   Abstract »    Full Text »    PDF »
Cbl and Human Myeloid Neoplasms: The Cbl Oncogene Comes of Age.
S. C. Kales, P. E. Ryan, M. M. Nau, and S. Lipkowitz (2010)
Cancer Res. 70, 4789-4794
   Abstract »    Full Text »    PDF »
Regulatory mechanisms involved in the control of ubiquitin homeostasis.
Y. Kimura and K. Tanaka (2010)
J. Biochem. 147, 793-798
   Abstract »    Full Text »    PDF »
The Deubiquitinating Enzyme AMSH3 Is Required for Intracellular Trafficking and Vacuole Biogenesis in Arabidopsis thaliana.
E. Isono, A. Katsiarimpa, I. K. Muller, F. Anzenberger, Y.-D. Stierhof, N. Geldner, J. Chory, and C. Schwechheimer (2010)
PLANT CELL 22, 1826-1837
   Abstract »    Full Text »    PDF »
AMSH Interacts with ESCRT-0 to Regulate the Stability and Trafficking of CXCR4.
M. I. Sierra, M. H. Wright, and P. D. Nash (2010)
J. Biol. Chem. 285, 13990-14004
   Abstract »    Full Text »    PDF »
Dependence of Phospholipase D1 Multi-monoubiquitination on Its Enzymatic Activity and Palmitoylation.
H. Yin, Y. Gui, G. Du, M. A. Frohman, and X. L. Zheng (2010)
J. Biol. Chem. 285, 13580-13588
   Abstract »    Full Text »    PDF »
Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development.
H. Wang, J. Holst, S.-R. Woo, C. Guy, M. Bettini, Y. Wang, A. Shafer, M. Naramura, M. Mingueneau, L. L. Dragone, et al. (2010)
EMBO J. 29, 1285-1298
   Abstract »    Full Text »    PDF »
Regulation of Drosophila Vasa In Vivo through Paralogous Cullin-RING E3 Ligase Specificity Receptors.
J.-M. Kugler, J.-S. Woo, B.-H. Oh, and P. Lasko (2010)
Mol. Cell. Biol. 30, 1769-1782
   Abstract »    Full Text »    PDF »
'A life or death decision' for pollen tubes in S-RNase-based self-incompatibility.
G. Chen, B. Zhang, Z. Zhao, Z. Sui, H. Zhang, and Y. Xue (2010)
J. Exp. Bot. 61, 2027-2037
   Abstract »    Full Text »    PDF »
Ubiquitin, a novel paracrine messenger of cardiac cell survival.
D. Li and C. Depre (2010)
Cardiovasc Res 86, 1-3
   Full Text »    PDF »
Lysine 63-linked Polyubiquitination of the Dopamine Transporter Requires WW3 and WW4 Domains of Nedd4-2 and UBE2D Ubiquitin-conjugating Enzymes.
A. Vina-Vilaseca and A. Sorkin (2010)
J. Biol. Chem. 285, 7645-7656
   Abstract »    Full Text »    PDF »
Ubiquitination Acutely Regulates Presynaptic Neurotransmitter Release in Mammalian Neurons.
G. V. Rinetti and F. E. Schweizer (2010)
J. Neurosci. 30, 3157-3166
   Abstract »    Full Text »    PDF »
A Novel Type of E3 Ligase for the Ufm1 Conjugation System.
K. Tatsumi, Y.-s. Sou, N. Tada, E. Nakamura, S.-i. Iemura, T. Natsume, S. H. Kang, C. H. Chung, M. Kasahara, E. Kominami, et al. (2010)
J. Biol. Chem. 285, 5417-5427
   Abstract »    Full Text »    PDF »
Phosphoenolpyruvate Carboxylase from C4 Leaves Is Selectively Targeted for Inhibition by Anionic Phospholipids.
J. A. Monreal, F. McLoughlin, C. Echevarria, S. Garcia-Maurino, and C. Testerink (2010)
Plant Physiology 152, 634-638
   Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882