Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Logo for

Science 315 (5809): 230-233

Copyright © 2007 by the American Association for the Advancement of Science

Regulation of {gamma}{delta} Versus {alpha}ß T Lymphocyte Differentiation by the Transcription Factor SOX13

Heather J. Melichar,1 Kavitha Narayan,1 Sandy D. Der,2 Yoshiki Hiraoka,3 Noemie Gardiol,4 Gregoire Jeannet,4 Werner Held,4 Cynthia A. Chambers,1 Joonsoo Kang1*

Abstract: {alpha}ß and {gamma}{delta} T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a {gamma}{delta}-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes {gamma}{delta} T cell development while opposing {alpha}ß T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of {gamma}{delta} T cells but not {alpha}ß T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.

1 Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
2 Department of Laboratory Medicine and Pathobiology, Program in Proteomics and Bioinformatics, University of Toronto, Toronto, Canada.
3 Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
4 Ludwig Institute for Cancer Research, Lausanne Branch and University of Lausanne, Chemin Des Boveresses 155, 1066 Epalinges, Switzerland.

* To whom correspondence should be addressed. E-mail: Joonsoo.Kang{at}umassmed.edu

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lineage Divergence at the First TCR-Dependent Checkpoint: Preferential {gamma}{delta} and Impaired {alpha}{beta} T Cell Development in Nonobese Diabetic Mice.
N. Feng, P. Vegh, E. V. Rothenberg, and M. A. Yui (2011)
J. Immunol. 186, 826-837
   Abstract »    Full Text »    PDF »
Unexpected Role for the B Cell-Specific Src Family Kinase B Lymphoid Kinase in the Development of IL-17-Producing {gamma}{delta} T Cells.
R. M. Laird, K. Laky, and S. M. Hayes (2010)
J. Immunol. 185, 6518-6527
   Abstract »    Full Text »    PDF »
Analysis of {gamma}{delta} T Cell Functions in the Mouse.
W. K. Born, Z. Yin, Y. S. Hahn, D. Sun, and R. L. O'Brien (2010)
J. Immunol. 184, 4055-4061
   Abstract »    Full Text »    PDF »
Systematic discovery of nonobvious human disease models through orthologous phenotypes.
K. L. McGary, T. J. Park, J. O. Woods, H. J. Cha, J. B. Wallingford, and E. M. Marcotte (2010)
PNAS 107, 6544-6549
   Abstract »    Full Text »    PDF »
Interaction between Hhex and SOX13 Modulates Wnt/TCF Activity.
V. Marfil, M. Moya, C. E. Pierreux, J. V. Castell, F. P. Lemaigre, F. X. Real, and R. Bort (2010)
J. Biol. Chem. 285, 5726-5737
   Abstract »    Full Text »    PDF »
To Be {gamma}{delta} or Not to Be {gamma}{delta}? Signaling Pathways in {alpha}{beta} Versus {gamma}{delta} T Cell Maturation.
J. K. Archbold (2009)
Science Signaling 2, jc2
   Abstract »    Full Text »    PDF »
The transcription factor Sox5 modulates Sox10 function during melanocyte development.
C. C. Stolt, P. Lommes, S. Hillgartner, and M. Wegner (2008)
Nucleic Acids Res. 36, 5427-5440
   Abstract »    Full Text »    PDF »
Epigenetic Inactivation of the Canonical Wnt Antagonist SRY-Box Containing Gene 17 in Colorectal Cancer.
W. Zhang, S. C. Glockner, M. Guo, E. O. Machida, D. H. Wang, H. Easwaran, L. Van Neste, J. G. Herman, K. E. Schuebel, D. N. Watkins, et al. (2008)
Cancer Res. 68, 2764-2772
   Abstract »    Full Text »    PDF »
Partners in Crime: How Two Sox Proteins Cooperate to Specify Arterial Fate.
S.-W. Jin and C. Patterson (2008)
Circ. Res. 102, 1-2
   Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882