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Science 315 (5811): 518-521

Copyright © 2007 by the American Association for the Advancement of Science

Asymmetric Inheritance of Mother Versus Daughter Centrosome in Stem Cell Division

Yukiko M. Yamashita,1*{dagger} Anthony P. Mahowald,2 Julie R. Perlin,1 Margaret T. Fuller1,3{dagger}

Abstract: Adult stem cells often divide asymmetrically to produce one self-renewed stem cell and one differentiating cell, thus maintaining both populations. The asymmetric outcome of stem cell divisions can be specified by an oriented spindle and local self-renewal signals from the stem cell niche. Here we show that developmentally programmed asymmetric behavior and inheritance of mother and daughter centrosomes underlies the stereotyped spindle orientation and asymmetric outcome of stem cell divisions in the Drosophila male germ line. The mother centrosome remains anchored near the niche while the daughter centrosome migrates to the opposite side of the cell before spindle formation.

1 Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305–5329, USA.
2 Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.
3 Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305–5329, USA.

* Present address: Life Sciences Institute, Room 5403, University of Michigan, Ann Arbor, 210 Washtenaw Avenue, Ann Arbor, MI 48183–2216, USA.

{dagger} To whom correspondence should be addressed. E-mail: yukikomy{at}umich.edu (Y.M.Y.); fuller{at}stanford.edu (M.T.F.)


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