Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 315 (5818): 1576-1579

Copyright © 2007 by the American Association for the Advancement of Science

Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation

Christine Mayr,1 Michael T. Hemann,2 David P. Bartel1*

Abstract: MicroRNAs (miRNAs) are ~22-nucleotide RNAs that can pair to sites within messenger RNAs to specify posttranscriptional repression of these messages. Aberrant miRNA expression can contribute to tumorigenesis, but which of the many miRNA-target relationships are relevant to this process has been unclear. Here, we report that chromosomal translocations previously associated with human tumors disrupt repression of High Mobility Group A2 (Hmga2) by let-7 miRNA. This disrupted repression promotes anchorage-independent growth, a characteristic of oncogenic transformation. Thus, losing miRNA-directed repression of an oncogene provides a mechanism for tumorigenesis, and disrupting a single miRNA-target interaction can produce an observable phenotype in mammalian cells.

1 Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
2 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

* To whom correspondence should be addressed. E-mail: dbartel{at}

Let-7d microRNA affects mesenchymal phenotypic properties of lung fibroblasts.
L. Huleihel, A. Ben-Yehudah, J. Milosevic, G. Yu, K. Pandit, K. Sakamoto, H. Yousef, M. LeJeune, T. A. Coon, C. J. Redinger, et al. (2014)
Am J Physiol Lung Cell Mol Physiol 306, L534-L542
   Abstract »    Full Text »    PDF »
MicroRNAs and anticancer drugs.
Z. Xing, D. Li, L. Yang, Y. Xi, and X. Su (2014)
Acta Biochim Biophys Sin 46, 233-239
   Abstract »    Full Text »    PDF »
Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing.
A. Kamenska, W.-T. Lu, D. Kubacka, H. Broomhead, N. Minshall, M. Bushell, and N. Standart (2014)
Nucleic Acids Res. 42, 3298-3313
   Abstract »    Full Text »    PDF »
Frequent Overexpression of HMGA2 in Human Atypical Teratoid/Rhabdoid Tumor and Its Correlation with let-7a3/let-7b miRNA.
K. Zhang, H. Gao, X. Wu, J. Wang, W. Zhou, G. Sun, J. Wang, Y. Wang, B. Mu, C. Kim, et al. (2014)
Clin. Cancer Res. 20, 1179-1189
   Abstract »    Full Text »    PDF »
Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression.
S. Lianoglou, V. Garg, J. L. Yang, C. S. Leslie, and C. Mayr (2013)
Genes & Dev. 27, 2380-2396
   Abstract »    Full Text »    PDF »
let-7 and miR-140 microRNAs coordinately regulate skeletal development.
G. Papaioannou, J. B. Inloes, Y. Nakamura, E. Paltrinieri, and T. Kobayashi (2013)
PNAS 110, E3291-E3300
   Abstract »    Full Text »    PDF »
HMGA2 Expression in the PC-3 Prostate Cancer Cell Line Is Autonomous of Growth Factor Stimulation.
Anticancer Res 33, 3069-3078
   Abstract »    Full Text »    PDF »
MicroRNA-33a Mediates the Regulation of High Mobility Group AT-Hook 2 Gene (HMGA2) by Thyroid Transcription Factor 1 (TTF-1/NKX2-1).
S. J. Rice, S.-C. Lai, L. W. Wood, K. R. Helsley, E. A. Runkle, M. M. Winslow, and D. Mu (2013)
J. Biol. Chem. 288, 16348-16360
   Abstract »    Full Text »    PDF »
Oncogenic NRAS, Required for Pathogenesis of Embryonic Rhabdomyosarcoma, Relies upon the HMGA2-IGF2BP2 Pathway.
Z. Li, Y. Zhang, K. Ramanujan, Y. Ma, D. G. Kirsch, and D. J. Glass (2013)
Cancer Res. 73, 3041-3050
   Abstract »    Full Text »    PDF »
Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.
A. M. Gurtan, A. Ravi, P. B. Rahl, A. D. Bosson, C. K. JnBaptiste, A. Bhutkar, C. A. Whittaker, R. A. Young, and P. A. Sharp (2013)
Genes & Dev. 27, 941-954
   Abstract »    Full Text »    PDF »
Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation.
H. A. Meijer, Y. W. Kong, W. T. Lu, A. Wilczynska, R. V. Spriggs, S. W. Robinson, J. D. Godfrey, A. E. Willis, and M. Bushell (2013)
Science 340, 82-85
   Abstract »    Full Text »    PDF »
Reprogramming of the MicroRNA Transcriptome Mediates Resistance to Rapamycin.
H. Totary-Jain, D. Sanoudou, I. Z. Ben-Dov, C. N. Dautriche, P. Guarnieri, S. O. Marx, T. Tuschl, and A. R. Marks (2013)
J. Biol. Chem. 288, 6034-6044
   Abstract »    Full Text »    PDF »
The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer.
X. Hu, J. Guo, L. Zheng, C. Li, T. M. Zheng, J. L. Tanyi, S. Liang, C. Benedetto, M. Mitidieri, D. Katsaros, et al. (2013)
Mol. Cancer Res. 11, 240-250
   Abstract »    Full Text »    PDF »
MicroRNA-10A* and MicroRNA-21 Modulate Endothelial Progenitor Cell Senescence Via Suppressing High-Mobility Group A2.
S. Zhu, S. Deng, Q. Ma, T. Zhang, C. Jia, D. Zhuo, F. Yang, J. Wei, L. Wang, D. M. Dykxhoorn, et al. (2013)
Circ. Res. 112, 152-164
   Abstract »    Full Text »    PDF »
The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.
E. Huntzinger, D. Kuzuoglu-Ozturk, J. E. Braun, A. Eulalio, L. Wohlbold, and E. Izaurralde (2013)
Nucleic Acids Res. 41, 978-994
   Abstract »    Full Text »    PDF »
Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies.
Y. Sun, Y. Fu, Y. Li, and A. Xu (2012)
J Mol Cell Biol 4, 352-361
   Abstract »    Full Text »    PDF »
Regulation of human Dicer by the resident ER membrane protein CLIMP-63.
G. Pepin, M. P. Perron, and P. Provost (2012)
Nucleic Acids Res. 40, 11603-11617
   Abstract »    Full Text »    PDF »
Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis.
A. R. Colas, W. L. McKeithan, T. J. Cunningham, P. J. Bushway, L. X. Garmire, G. Duester, S. Subramaniam, and M. Mercola (2012)
Genes & Dev. 26, 2567-2579
   Abstract »    Full Text »    PDF »
Dicer-dependent and -independent Argonaute2 Protein Interaction Networks in Mammalian Cells.
A. Frohn, H. C. Eberl, J. Stohr, E. Glasmacher, S. Rudel, V. Heissmeyer, M. Mann, and G. Meister (2012)
Mol. Cell. Proteomics 11, 1442-1456
   Abstract »    Full Text »    PDF »
Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer.
L. Lu, D. Katsaros, S. T. Mayne, H. A. Risch, C. Benedetto, E. M. Canuto, and H. Yu (2012)
Carcinogenesis 33, 2119-2125
   Abstract »    Full Text »    PDF »
Disease-linked microRNA-21 exhibits drastically reduced mRNA binding and silencing activity in healthy mouse liver.
J. R. Androsavich, B. N. Chau, B. Bhat, P. S. Linsley, and N. G. Walter (2012)
RNA 18, 1510-1526
   Abstract »    Full Text »    PDF »
Intracellular single molecule microscopy reveals two kinetically distinct pathways for microRNA assembly.
S. Pitchiaya, J. R. Androsavich, and N. G. Walter (2012)
EMBO Rep. 13, 709-715
   Abstract »    Full Text »    PDF »
Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells.
J. Bethune, C. G. Artus-Revel, and W. Filipowicz (2012)
EMBO Rep. 13, 716-723
   Abstract »    Full Text »    PDF »
The Lin28 cold-shock domain remodels pre-let-7 microRNA.
F. Mayr, A. Schutz, N. Doge, and U. Heinemann (2012)
Nucleic Acids Res. 40, 7492-7506
   Abstract »    Full Text »    PDF »
Microphthalmia-associated Transcription Factor (MITF) Promotes Differentiation of Human Retinal Pigment Epithelium (RPE) by Regulating microRNAs-204/211 Expression.
J. Adijanto, J. J. Castorino, Z.-X. Wang, A. Maminishkis, G. B. Grunwald, and N. J. Philp (2012)
J. Biol. Chem. 287, 20491-20503
   Abstract »    Full Text »    PDF »
Ectopic over-expression of tristetraprolin in human cancer cells promotes biogenesis of let-7 by down-regulation of Lin28.
C. W. Kim, M.-T. Vo, H. K. Kim, H. H. Lee, N. A. Yoon, B. J. Lee, Y. J. Min, W. D. Joo, H. J. Cha, J. W. Park, et al. (2012)
Nucleic Acids Res. 40, 3856-3869
   Abstract »    Full Text »    PDF »
Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer.
Y. W. Asmann, B. M. Necela, K. R. Kalari, A. Hossain, T. R. Baker, J. M. Carr, C. Davis, J. E. Getz, G. Hostetter, X. Li, et al. (2012)
Cancer Res. 72, 1921-1928
   Abstract »    Full Text »    PDF »
Targeted therapies through microRNAs: pulp or fiction?.
C. Langer, F. G. Rucker, C. Buske, H. Dohner, and F. Kuchenbauer (2012)
Therapeutic Advances in Hematology 3, 97-104
   Abstract »    PDF »
MicroRNA-29a Inhibited Epididymal Epithelial Cell Proliferation by Targeting Nuclear Autoantigenic Sperm Protein (NASP).
W. Ma, S. Xie, M. Ni, X. Huang, S. Hu, Q. Liu, A. Liu, J. Zhang, and Y. Zhang (2012)
J. Biol. Chem. 287, 10189-10199
   Abstract »    Full Text »    PDF »
Downregulation of BCL2 by miRNAs augments drug-induced apoptosis - a combined computational and experimental approach.
R. Singh and N. Saini (2012)
J. Cell Sci. 125, 1568-1578
   Abstract »    Full Text »    PDF »
Lin28b Reprograms Adult Bone Marrow Hematopoietic Progenitors to Mediate Fetal-Like Lymphopoiesis.
J. Yuan, C. K. Nguyen, X. Liu, C. Kanellopoulou, and S. A. Muljo (2012)
Science 335, 1195-1200
   Abstract »    Full Text »    PDF »
Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs.
R. J. A. Frost and E. N. Olson (2011)
PNAS 108, 21075-21080
   Abstract »    Full Text »    PDF »
Genomic Investigation of Dedifferentiated Liposarcoma Suggests a Role for Therapeutic Targeting of the Tumor Epigenome.
P. S. Meltzer and L. J. Helman (2011)
Cancer Discovery 1, 555-556
   Abstract »    Full Text »    PDF »
Post-Transcriptional Regulation by MicroRNA-21 and let-7a MicroRNA in Paediatric Cholesteatoma.
X. Chen and Z. Qin (2011)
Journal of International Medical Research 39, 2110-2118
   Abstract »    PDF »
Frequent Alterations and Epigenetic Silencing of Differentiation Pathway Genes in Structurally Rearranged Liposarcomas.
B. S. Taylor, P. L. DeCarolis, C. V. Angeles, F. Brenet, N. Schultz, C. R. Antonescu, J. M. Scandura, C. Sander, A. J. Viale, N. D. Socci, et al. (2011)
Cancer Discovery 1, 587-597
   Abstract »    Full Text »    PDF »
Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer.
J. Yun, C. A. Frankenberger, W.-L. Kuo, M. C. Boelens, E. M. Eves, N. Cheng, H. Liang, W.-H. Li, H. Ishwaran, A. J. Minn, et al. (2011)
EMBO J. 30, 4500-4514
   Abstract »    Full Text »    PDF »
Chondrocyte-Specific MicroRNA-140 Regulates Endochondral Bone Development and Targets Dnpep To Modulate Bone Morphogenetic Protein Signaling.
Y. Nakamura, J. B. Inloes, T. Katagiri, and T. Kobayashi (2011)
Mol. Cell. Biol. 31, 3019-3028
   Abstract »    Full Text »    PDF »
High-Mobility Group A2 Protein Modulates hTERT Transcription To Promote Tumorigenesis.
A. Y.-J. Li, H. H. Lin, C.-Y. Kuo, H.-M. Shih, C. C. C. Wang, Y. Yen, and D. K. Ann (2011)
Mol. Cell. Biol. 31, 2605-2617
   Abstract »    Full Text »    PDF »
Expression of Mirlet7 Family MicroRNAs in Response to Retinoic Acid-Induced Spermatogonial Differentiation in Mice.
M.-H. Tong, D. Mitchell, R. Evanoff, and M. D. Griswold (2011)
Biol Reprod 85, 189-197
   Abstract »    Full Text »    PDF »
LIN28B Promotes Colon Cancer Progression and Metastasis.
C. E. King, M. Cuatrecasas, A. Castells, A. R. Sepulveda, J.-S. Lee, and A. K. Rustgi (2011)
Cancer Res. 71, 4260-4268
   Abstract »    Full Text »    PDF »
3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice.
K. Ikeda, P. J. Mason, and M. Bessler (2011)
Blood 117, 5860-5869
   Abstract »    Full Text »    PDF »
MicroRNAs and their roles in mammalian stem cells.
R. Yi and E. Fuchs (2011)
J. Cell Sci. 124, 1775-1783
   Abstract »    Full Text »    PDF »
MicroRNAs in skin and wound healing.
J. Banerjee, Y. C. Chan, and C. K. Sen (2011)
Physiol Genomics 43, 543-556
   Abstract »    Full Text »    PDF »
Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C.
Q. Yang, Z. Jie, H. Cao, A. R. Greenlee, C. Yang, F. Zou, and Y. Jiang (2011)
Carcinogenesis 32, 713-722
   Abstract »    Full Text »    PDF »
Overexpression of HMGA2 Promotes Metastasis and Impacts Survival of Colorectal Cancers.
X. Wang, X. Liu, A. Y.-J. Li, L. Chen, L. Lai, H. H. Lin, S. Hu, L. Yao, J. Peng, S. Loera, et al. (2011)
Clin. Cancer Res. 17, 2570-2580
   Abstract »    Full Text »    PDF »
Cell stress is related to re-localization of Argonaute 2 and to decreased RNA interference in human cells.
A. Detzer, C. Engel, W. Wunsche, and G. Sczakiel (2011)
Nucleic Acids Res. 39, 2727-2741
   Abstract »    Full Text »    PDF »
IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2.
P. S. Mongroo, F. K. Noubissi, M. Cuatrecasas, J. Kalabis, C. E. King, C. N. Johnstone, M. J. Bowser, A. Castells, V. S. Spiegelman, and A. K. Rustgi (2011)
Cancer Res. 71, 2172-2182
   Abstract »    Full Text »    PDF »
Regulation of HMGA1 Expression by MicroRNA-296 Affects Prostate Cancer Growth and Invasion.
J.-J. Wei, X. Wu, Y. Peng, G. Shi, B. Olca, X. Yang, G. Daniels, I. Osman, J. Ouyang, E. Hernando, et al. (2011)
Clin. Cancer Res. 17, 1297-1305
   Abstract »    Full Text »    PDF »
Promise and Challenge of RNA Interference-Based Therapy for Cancer.
F. Petrocca and J. Lieberman (2011)
J. Clin. Oncol. 29, 747-754
   Abstract »    Full Text »    PDF »
Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
Y. Yang, T. Ago, P. Zhai, M. Abdellatif, and J. Sadoshima (2011)
Circ. Res. 108, 305-313
   Abstract »    Full Text »    PDF »
Impaired MicroRNA Processing Facilitates Breast Cancer Cell Invasion by Upregulating Urokinase-Type Plasminogen Activator Expression.
H. Noh, S. Hong, Z. Dong, Z. K. Pan, Q. Jing, and S. Huang (2011)
Genes & Cancer 2, 140-150
   Abstract »    Full Text »    PDF »
Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP-Mediated Expression of HMGA2.
S. Dangi-Garimella, S. B. Krantz, M. R. Barron, M. A. Shields, M. J. Heiferman, P. J. Grippo, D. J. Bentrem, and H. G. Munshi (2011)
Cancer Res. 71, 1019-1028
   Abstract »    Full Text »    PDF »
HMGA2 Overexpression-Induced Ovarian Surface Epithelial Transformation Is Mediated Through Regulation of EMT Genes.
J. Wu, Z. Liu, C. Shao, Y. Gong, E. Hernando, P. Lee, M. Narita, W. Muller, J. Liu, and J.-J. Wei (2011)
Cancer Res. 71, 349-359
   Abstract »    Full Text »    PDF »
miR-206 and -486 Induce Myoblast Differentiation by Downregulating Pax7.
B. K. Dey, J. Gagan, and A. Dutta (2011)
Mol. Cell. Biol. 31, 203-214
   Abstract »    Full Text »    PDF »
Role of Ribosomal Protein RPS2 in Controlling let-7a Expression in Human Prostate Cancer.
M. Wang, Y. Hu, M. D. Amatangelo, and M. E. Stearns (2011)
Mol. Cancer Res. 9, 36-50
   Abstract »    Full Text »    PDF »
Antisense tools for functional studies of human Argonaute proteins.
A. Mescalchin, A. Detzer, U. Weirauch, M. J. Hahnel, C. Engel, and G. Sczakiel (2010)
RNA 16, 2529-2536
   Abstract »    Full Text »    PDF »
Ratio of miR-196s to HOXC8 Messenger RNA Correlates with Breast Cancer Cell Migration and Metastasis.
Y. Li, M. Zhang, H. Chen, Z. Dong, V. Ganapathy, M. Thangaraju, and S. Huang (2010)
Cancer Res. 70, 7894-7904
   Abstract »    Full Text »    PDF »
A comprehensive survey of 3' animal miRNA modification events and a possible role for 3' adenylation in modulating miRNA targeting effectiveness.
A. M. Burroughs, Y. Ando, M. J. L. de Hoon, Y. Tomaru, T. Nishibu, R. Ukekawa, T. Funakoshi, T. Kurokawa, H. Suzuki, Y. Hayashizaki, et al. (2010)
Genome Res. 20, 1398-1410
   Abstract »    Full Text »    PDF »
MicroRNA-340-mediated Degradation of Microphthalmia-associated Transcription Factor mRNA Is Inhibited by the Coding Region Determinant-binding Protein.
S. Goswami, R. S. Tarapore, J. J. TeSlaa, Y. Grinblat, V. Setaluri, and V. S. Spiegelman (2010)
J. Biol. Chem. 285, 20532-20540
   Abstract »    Full Text »    PDF »
Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial.
G. P. Wang, C. C. Berry, N. Malani, P. Leboulch, A. Fischer, S. Hacein-Bey-Abina, M. Cavazzana-Calvo, and F. D. Bushman (2010)
Blood 115, 4356-4366
   Abstract »    Full Text »    PDF »
Role of the high mobility group A proteins in the regulation of pituitary cell cycle.
M. Fedele and A. Fusco (2010)
J. Mol. Endocrinol. 44, 309-318
   Abstract »    Full Text »    PDF »
Targeting MYC-Regulated miRNAs to Combat Cancer.
A. Frenzel, J. Loven, and M. A. Henriksson (2010)
Genes & Cancer 1, 660-667
   Abstract »    Full Text »    PDF »
Survival prediction of gastric cancer by a seven-microRNA signature.
X. Li, Y. Zhang, Y. Zhang, J. Ding, K. Wu, and D. Fan (2010)
Gut 59, 579-585
   Abstract »    Full Text »    PDF »
MicroRNAs and prostate cancer.
V. Coppola, R. De Maria, and D. Bonci (2010)
Endocr. Relat. Cancer 17, F1-F17
   Abstract »    Full Text »    PDF »
The role of let-7 in cell differentiation and cancer.
B. Boyerinas, S.-M. Park, A. Hau, A. E Murmann, and M. E Peter (2010)
Endocr. Relat. Cancer 17, F19-F36
   Abstract »    Full Text »    PDF »
MicroRNAs: a complex regulatory network drives the acquisition of malignant cell phenotype.
L. Santarpia, M. Nicoloso, and G. A Calin (2010)
Endocr. Relat. Cancer 17, F51-F75
   Abstract »    Full Text »    PDF »
Derepression of HMGA2 via Removal of ZBRK1/BRCA1/CtIP Complex Enhances Mammary Tumorigenesis.
K. M. Ahmed, C. Y. Tsai, and W.-H. Lee (2010)
J. Biol. Chem. 285, 4464-4471
   Abstract »    Full Text »    PDF »
Fusion genes in epithelial neoplasia.
H Zhang and A M Oliveira (2010)
J. Clin. Pathol. 63, 4-11
   Abstract »    Full Text »    PDF »
MicroRNAs in Cancer: Small Molecules With a Huge Impact.
M. V. Iorio and C. M. Croce (2009)
J. Clin. Oncol. 27, 5848-5856
   Abstract »    Full Text »    PDF »
Dicer1 functions as a haploinsufficient tumor suppressor.
M. S. Kumar, R. E. Pester, C. Y. Chen, K. Lane, C. Chin, J. Lu, D. G. Kirsch, T. R. Golub, and T. Jacks (2009)
Genes & Dev. 23, 2700-2704
   Abstract »    Full Text »    PDF »
Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck.
M. Persson, Y. Andren, J. Mark, H. M. Horlings, F. Persson, and G. Stenman (2009)
PNAS 106, 18740-18744
   Abstract »    Full Text »    PDF »
Human UPF1 Participates in Small RNA-Induced mRNA Downregulation.
H. Jin, M. R. Suh, J. Han, K.-H. Yeom, Y. Lee, I. Heo, M. Ha, S. Hyun, and V. N. Kim (2009)
Mol. Cell. Biol. 29, 5789-5799
   Abstract »    Full Text »    PDF »
miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia.
C. P. Pallasch, M. Patz, Y. J. Park, S. Hagist, D. Eggle, R. Claus, S. Debey-Pascher, A. Schulz, L. P. Frenzel, J. Claasen, et al. (2009)
Blood 114, 3255-3264
   Abstract »    Full Text »    PDF »
Estradiol-regulated microRNAs control estradiol response in breast cancer cells.
P. Bhat-Nakshatri, G. Wang, N. R. Collins, M. J. Thomson, T. R. Geistlinger, J. S. Carroll, M. Brown, S. Hammond, E. F. Srour, Y. Liu, et al. (2009)
Nucleic Acids Res. 37, 4850-4861
   Abstract »    Full Text »    PDF »
Suppression of Nonhomologous End Joining Repair by Overexpression of HMGA2.
A. Y.J. Li, L. M. Boo, S.-Y. Wang, H. H. Lin, C. C.C. Wang, Y. Yen, B. P.C. Chen, D. J. Chen, and D. K. Ann (2009)
Cancer Res. 69, 5699-5706
   Abstract »    Full Text »    PDF »
MicroRNA Classifiers for Predicting Prognosis of Squamous Cell Lung Cancer.
M. Raponi, L. Dossey, T. Jatkoe, X. Wu, G. Chen, H. Fan, and D. G. Beer (2009)
Cancer Res. 69, 5776-5783
   Abstract »    Full Text »    PDF »
The NF90-NF45 Complex Functions as a Negative Regulator in the MicroRNA Processing Pathway.
S. Sakamoto, K. Aoki, T. Higuchi, H. Todaka, K. Morisawa, N. Tamaki, E. Hatano, A. Fukushima, T. Taniguchi, and Y. Agata (2009)
Mol. Cell. Biol. 29, 3754-3769
   Abstract »    Full Text »    PDF »
HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy.
H. Summer, O. Li, Q. Bao, L. Zhan, S. Peter, P. Sathiyanathan, D. Henderson, T. Klonisch, S. D. Goodman, and P. Droge (2009)
Nucleic Acids Res. 37, 4371-4384
   Abstract »    Full Text »    PDF »
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
C. Li, S.-W. Kim, D. Rai, A. R. Bolla, S. Adhvaryu, M. C. Kinney, R. S. Robetorye, and R. C. T. Aguiar (2009)
Blood 113, 6681-6690
   Abstract »    Full Text »    PDF »
Thrombin Induces Tumor Cell Cycle Activation and Spontaneous Growth by Down-regulation of p27Kip1, in Association with the Up-regulation of Skp2 and MiR-222.
L. Hu, S. Ibrahim, C. Liu, J. Skaar, M. Pagano, and S. Karpatkin (2009)
Cancer Res. 69, 3374-3381
   Abstract »    Full Text »    PDF »
let-7 Overexpression Leads to an Increased Fraction of Cells in G2/M, Direct Down-regulation of Cdc34, and Stabilization of Wee1 Kinase in Primary Fibroblasts.
A. Legesse-Miller, O. Elemento, S. J. Pfau, J. J. Forman, S. Tavazoie, and H. A. Coller (2009)
J. Biol. Chem. 284, 6605-6609
   Abstract »    Full Text »    PDF »
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation.
T.-C. Chang, L. R. Zeitels, H.-W. Hwang, R. R. Chivukula, E. A. Wentzel, M. Dews, J. Jung, P. Gao, C. V. Dang, M. A. Beer, et al. (2009)
PNAS 106, 3384-3389
   Abstract »    Full Text »    PDF »
Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7.
S. Dangi-Garimella, J. Yun, E. M. Eves, M. Newman, S. J. Erkeland, S. M. Hammond, A. J. Minn, and M. R. Rosner (2009)
EMBO J. 28, 347-358
   Abstract »    Full Text »    PDF »
Stem Cells Use Distinct Self-renewal Programs at Different Ages.
B.P. Levi and S.J. Morrison (2009)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
miR2Disease: a manually curated database for microRNA deregulation in human disease.
Q. Jiang, Y. Wang, Y. Hao, L. Juan, M. Teng, X. Zhang, M. Li, G. Wang, and Y. Liu (2009)
Nucleic Acids Res. 37, D98-D104
   Abstract »    Full Text »    PDF »
Coordinated Regulation of Cell Cycle Transcripts by p53-Inducible microRNAs, miR-192 and miR-215.
S. A. Georges, M. C. Biery, S.-y. Kim, J. M. Schelter, J. Guo, A. N. Chang, A. L. Jackson, M. O. Carleton, P. S. Linsley, M. A. Cleary, et al. (2008)
Cancer Res. 68, 10105-10112
   Abstract »    Full Text »    PDF »
MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer.
N. Yang, S. Kaur, S. Volinia, J. Greshock, H. Lassus, K. Hasegawa, S. Liang, A. Leminen, S. Deng, L. Smith, et al. (2008)
Cancer Res. 68, 10307-10314
   Abstract »    Full Text »    PDF »
In-depth characterization of the microRNA transcriptome in a leukemia progression model.
F. Kuchenbauer, R. D. Morin, B. Argiropoulos, O. I. Petriv, M. Griffith, M. Heuser, E. Yung, J. Piper, A. Delaney, A.-L. Prabhu, et al. (2008)
Genome Res. 18, 1787-1797
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882