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Gametes from Embryonic Stem Cells: A Cup Half Empty or Half Full?
George Q. Daley
When first reported 4 years ago, gametogenesis from embryonicstem (ES) cells promised an accessible in vitro model to facilitatemolecular analysis of the germ lineage. Formation of primordialgerm cells is robust, but terminal gametogenesis remains inefficientand doubts about gamete function persist. Although useful forresearch, clinical use of ES cellderived gametes appearsa distant prospect.
Division of Pediatric Hematology/Oncology, Children's Hospital Boston; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham and Women's Hospital, Boston, MA; Harvard Stem Cell Institute, Cambridge, MA, USA.
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In Science Magazine
INTRODUCTION TO SPECIAL ISSUE
Beverly A. Purnell and John Travis (20 April 2007) Science316 (5823), 387.
[DOI: 10.1126/science.316.5823.387] |Summary »|PDF »
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