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Science 316 (5823): 409-410

Copyright © 2007 by the American Association for the Advancement of Science

Gametes from Embryonic Stem Cells: A Cup Half Empty or Half Full?

George Q. Daley

Abstract: When first reported 4 years ago, gametogenesis from embryonic stem (ES) cells promised an accessible in vitro model to facilitate molecular analysis of the germ lineage. Formation of primordial germ cells is robust, but terminal gametogenesis remains inefficient and doubts about gamete function persist. Although useful for research, clinical use of ES cell–derived gametes appears a distant prospect.

Division of Pediatric Hematology/Oncology, Children's Hospital Boston; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham and Women's Hospital, Boston, MA; Harvard Stem Cell Institute, Cambridge, MA, USA.

E-mail: george.daley{at}

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