Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Regulation of the Germinal Center Response by MicroRNA-155
To-Ha Thai,1
Dinis Pedro Calado,1
Stefano Casola,2
K. Mark Ansel,1
Changchun Xiao,1
Yingzi Xue,3
Andrew Murphy,3
David Frendewey,3
David Valenzuela,3
Jeffery L. Kutok,4
Marc Schmidt-Supprian,1
Nikolaus Rajewsky,5
George Yancopoulos,3
Anjana Rao,1
Klaus Rajewsky1*
Abstract:
MicroRNAs are small RNA species involved in biological controlat multiple levels. Using genetic deletion and transgenic approaches,we show that the evolutionarily conserved microRNA-155 (miR-155)has an important role in the mammalian immune system, specificallyin regulating T helper cell differentiation and the germinalcenter reaction to produce an optimal T cell–dependentantibody response. miR-155 exerts this control, at least inpart, by regulating cytokine production. These results alsosuggest that individual microRNAs can exert critical controlover mammalian differentiation processes in vivo.
1 CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA. 2 IFOM–The FIRC Institute for Molecular Oncology, Milano, Via Adamello 16 Milan 20139, Italy. 3 Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA. 4 Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. 5 Max Delbrück Center for Molecular Medicine, Robert-Rössle-Strasse 10, D-13125 Berlin, Germany.
* To whom correspondence should be addressed. E-mail: rajewsky{at}cbr.med.harvard.edu
The editors suggest the following Related Resources on Science sites:
In Science Magazine
RESEARCH ARTICLES
Eva van Rooij, Lillian B. Sutherland, Xiaoxia Qi, James A. Richardson, Joseph Hill, and Eric N. Olson (27 April 2007) Science316 (5824), 575.
[DOI: 10.1126/science.1139089] |Abstract »|Full Text »|PDF »|Supporting Online Material »
In Science Signaling
PERSPECTIVES
James E. Dahlberg and Elsebet Lund (22 May 2007) Sci. STKE2007 (387), pe25.
[DOI: 10.1126/stke.3872007pe25] |Abstract »|Full Text »|PDF »
EDITORS' CHOICE
Stephen Simpson (1 May 2007) Sci. STKE2007 (384), tw152.
[DOI: 10.1126/stke.3842007tw152] |Abstract »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Autoantibody Induction by DNA-Containing Immune Complexes Requires HMGB1 with the TLR2/MicroRNA-155 Pathway.
Z. Wen, L. Xu, X. Chen, W. Xu, Z. Yin, X. Gao, and S. Xiong (2013)
J. Immunol.
190, 5411-5422
|Abstract »|Full Text »|PDF »
MicroRNAs in flow-dependent vascular remodelling.
P. Neth, M. Nazari-Jahantigh, A. Schober, and C. Weber (2013)
Cardiovasc Res
|Abstract »|Full Text »|PDF »
Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155.
C. L. Zawislak, A. M. Beaulieu, G. B. Loeb, J. Karo, D. Canner, N. A. Bezman, L. L. Lanier, A. Y. Rudensky, and J. C. Sun (2013)
PNAS
110, 6967-6972
|Abstract »|Full Text »|PDF »
Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells.
R. Trotta, L. Chen, S. Costinean, S. Josyula, B. L. Mundy-Bosse, D. Ciarlariello, C. Mao, E. L. Briercheck, K. K. McConnell, A. Mishra, et al. (2013)
Blood
121, 3126-3134
|Abstract »|Full Text »|PDF »
Immunosenescence-associated microRNAs in age and heart failure.
T. Seeger, F. Haffez, A. Fischer, U. Koehl, D. M. Leistner, F. H. Seeger, R. A. Boon, A. M. Zeiher, and S. Dimmeler (2013)
Eur J Heart Fail
15, 385-393
|Abstract »|Full Text »|PDF »
Combined Serum CA19-9 and miR-27a-3p in Peripheral Blood Mononuclear Cells to Diagnose Pancreatic Cancer.
W.-S. Wang, L.-X. Liu, G.-P. Li, Y. Chen, C.-Y. Li, D.-Y. Jin, and X.-L. Wang (2013)
Cancer Prevention Research
6, 331-338
|Abstract »|Full Text »|PDF »
1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of TLR Signaling via Targeting MicroRNA-155-SOCS1 in Macrophages.
Y. Chen, W. Liu, T. Sun, Y. Huang, Y. Wang, D. K. Deb, D. Yoon, J. Kong, R. Thadhani, and Y. C. Li (2013)
J. Immunol.
190, 3687-3695
|Abstract »|Full Text »|PDF »
MicroRNAs and respiratory diseases.
H. Rupani, T. Sanchez-Elsner, and P. Howarth (2013)
Eur. Respir. J.
41, 695-705
|Abstract »|Full Text »|PDF »
Enhanced Susceptibility to Citrobacter rodentium Infection in MicroRNA-155-Deficient Mice.
S. Clare, V. John, A. W. Walker, J. L. Hill, C. Abreu-Goodger, C. Hale, D. Goulding, T. D. Lawley, P. Mastroeni, G. Frankel, et al. (2013)
Infect. Immun.
81, 723-732
|Abstract »|Full Text »|PDF »
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.
Y. Bronevetsky, A. V. Villarino, C. J. Eisley, R. Barbeau, A. J. Barczak, G. A. Heinz, E. Kremmer, V. Heissmeyer, M. T. McManus, D. J. Erle, et al. (2013)
J. Exp. Med.
210, 417-432
|Abstract »|Full Text »|PDF »
Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis.
A. Mildner, E. Chapnik, O. Manor, S. Yona, K.-W. Kim, T. Aychek, D. Varol, G. Beck, Z. B. Itzhaki, E. Feldmesser, et al. (2013)
Blood
121, 1016-1027
|Abstract »|Full Text »|PDF »
MicroRNAs in Immune Response and Macrophage Polarization.
Micro-RNA 155 Is Required for Optimal CD8+ T Cell Responses to Acute Viral and Intracellular Bacterial Challenges.
E. F. Lind, A. R. Elford, and P. S. Ohashi (2013)
J. Immunol.
190, 1210-1216
|Abstract »|Full Text »|PDF »
Potential Function of miRNAs in Herpetic Stromal Keratitis.
S. Mulik, S. Bhela, and B. T. Rouse (2013)
Invest. Ophthalmol. Vis. Sci.
54, 563-573
|Abstract »|Full Text »|PDF »
In Vitro Sensitivity of CLL Cells to Fludarabine May Be Modulated by the Stimulation of Toll-like Receptors.
E. Fonte, B. Apollonio, L. Scarfo, P. Ranghetti, C. Fazi, P. Ghia, F. Caligaris-Cappio, and M. Muzio (2013)
Clin. Cancer Res.
19, 367-379
|Abstract »|Full Text »|PDF »
Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing.
L. N. Schulte, A. J. Westermann, and J. Vogel (2013)
Nucleic Acids Res.
41, 542-553
|Abstract »|Full Text »|PDF »
BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.
K. Basso, C. Schneider, Q. Shen, A. B. Holmes, M. Setty, C. Leslie, and R. Dalla-Favera (2012)
J. Exp. Med.
209, 2455-2465
|Abstract »|Full Text »|PDF »
miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the E{micro}-miR-155 transgenic mouse model.
S. K. Sandhu, S. Volinia, S. Costinean, M. Galasso, R. Neinast, R. Santhanam, M. R. Parthun, D. Perrotti, G. Marcucci, R. Garzon, et al. (2012)
PNAS
109, 20047-20052
|Abstract »|Full Text »|PDF »
miR-146a controls the resolution of T cell responses in mice.
L. Yang, M. P. Boldin, Y. Yu, C. S. Liu, C.-K. Ea, P. Ramakrishnan, K. D. Taganov, J. L. Zhao, and D. Baltimore (2012)
J. Exp. Med.
209, 1655-1670
|Abstract »|Full Text »|PDF »
Decreased microRNA-155 Expression in Ocular Behcet's Disease but Not in Vogt Koyanagi Harada Syndrome.
Q. Zhou, X. Xiao, C. Wang, X. Zhang, F. Li, Y. Zhou, A. Kijlstra, and P. Yang (2012)
Invest. Ophthalmol. Vis. Sci.
53, 5665-5674
|Abstract »|Full Text »|PDF »
Knocking Out Viral Myocarditis: Reality or a MiRage?.
X. Sun and M. W. Feinberg (2012)
Circ. Res.
111, 388-391
|Full Text »|PDF »
MicroRNA Profiling Identifies MicroRNA-155 as an Adverse Mediator of Cardiac Injury and Dysfunction During Acute Viral Myocarditis.
M. F. Corsten, A. Papageorgiou, W. Verhesen, P. Carai, M. Lindow, S. Obad, G. Summer, S. L. M. Coort, M. Hazebroek, R. van Leeuwen, et al. (2012)
Circ. Res.
111, 415-425
|Abstract »|Full Text »|PDF »
Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma.
I. A. Babar, C. J. Cheng, C. J. Booth, X. Liang, J. B. Weidhaas, W. M. Saltzman, and F. J. Slack (2012)
PNAS
109, E1695-E1704
|Abstract »|Full Text »|PDF »
MicroRNA-155 Is Required for Mycobacterium bovis BCG-Mediated Apoptosis of Macrophages.
D. S. Ghorpade, R. Leyland, M. Kurowska-Stolarska, S. A. Patil, and K. N. Balaji (2012)
Mol. Cell. Biol.
32, 2239-2253
|Abstract »|Full Text »|PDF »
Regulation of acute graft-versus-host disease by microRNA-155.
P. Ranganathan, C. E. A. Heaphy, S. Costinean, N. Stauffer, C. Na, M. Hamadani, R. Santhanam, C. Mao, P. A. Taylor, S. Sandhu, et al. (2012)
Blood
119, 4786-4797
|Abstract »|Full Text »|PDF »
microRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination.
M. P. Mycko, M. Cichalewska, A. Machlanska, H. Cwiklinska, M. Mariasiewicz, and K. W. Selmaj (2012)
PNAS
109, E1248-E1257
|Abstract »|Full Text »|PDF »
miR-155 regulates IFN-{gamma} production in natural killer cells.
R. Trotta, L. Chen, D. Ciarlariello, S. Josyula, C. Mao, S. Costinean, L. Yu, J. P. Butchar, S. Tridandapani, C. M. Croce, et al. (2012)
Blood
119, 3478-3485
|Abstract »|Full Text »|PDF »
Reprogramming Tumor-Associated Dendritic Cells In Vivo Using miRNA Mimetics Triggers Protective Immunity against Ovarian Cancer.
J. R. Cubillos-Ruiz, J. R. Baird, A. J. Tesone, M. R. Rutkowski, U. K. Scarlett, A. L. Camposeco-Jacobs, J. Anadon-Arnillas, N. M. Harwood, M. Korc, S. N. Fiering, et al. (2012)
Cancer Res.
72, 1683-1693
|Abstract »|Full Text »|PDF »
MicroRNA-127 Inhibits Lung Inflammation by Targeting IgG Fc{gamma} Receptor I.
T. Xie, J. Liang, N. Liu, Q. Wang, Y. Li, P. W. Noble, and D. Jiang (2012)
J. Immunol.
188, 2437-2444
|Abstract »|Full Text »|PDF »
Breakdown in Peripheral Tolerance in Type 1 Diabetes in Mice and Humans.
L. T. Jeker, H. Bour-Jordan, and J. A. Bluestone (2012)
Cold Spring Harb Perspect Med
2, a007807
|Abstract »|Full Text »|PDF »
Developing MicroRNA Therapeutics.
E. van Rooij, A. L. Purcell, and A. A. Levin (2012)
Circ. Res.
110, 496-507
|Abstract »|Full Text »|PDF »
MicroRNAs are shaping the hematopoietic landscape.
miR-155 regulates HGAL expression and increases lymphoma cell motility.
L. N. Dagan, X. Jiang, S. Bhatt, E. Cubedo, K. Rajewsky, and I. S. Lossos (2012)
Blood
119, 513-520
|Abstract »|Full Text »|PDF »
Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells.
A. Gerrits, M. A. Walasek, S. Olthof, E. Weersing, M. Ritsema, E. Zwart, R. van Os, L. V. Bystrykh, and G. de Haan (2012)
Blood
119, 377-387
|Abstract »|Full Text »|PDF »
microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2.
J. Nie, L. Liu, W. Zheng, L. Chen, X. Wu, Y. Xu, X. Du, and W. Han (2012)
Carcinogenesis
33, 220-225
|Abstract »|Full Text »|PDF »
Circulating MicroRNAs in Patients with Active Pulmonary Tuberculosis.
Y. Fu, Z. Yi, X. Wu, J. Li, and F. Xu (2011)
J. Clin. Microbiol.
49, 4246-4251
|Abstract »|Full Text »|PDF »
Integrative Deep Sequencing of the Mouse Lung Transcriptome Reveals Differential Expression of Diverse Classes of Small RNAs in Response to Respiratory Virus Infection.
X. Peng, L. Gralinski, M. T. Ferris, M. B. Frieman, M. J. Thomas, S. Proll, M. J. Korth, J. R. Tisoncik, M. Heise, S. Luo, et al. (2011)
mBio
2, e00198-11
|Abstract »|Full Text »|PDF »
MicroRNAs Regulate Dendritic Cell Differentiation and Function.
M. L. Turner, F. M. Schnorfeil, and T. Brocker (2011)
J. Immunol.
187, 3911-3917
|Abstract »|Full Text »|PDF »
miR-155 Inhibits Expression of the MEF2A Protein to Repress Skeletal Muscle Differentiation.
H. Y. Seok, M. Tatsuguchi, T. E. Callis, A. He, W. T. Pu, and D.-Z. Wang (2011)
J. Biol. Chem.
286, 35339-35346
|Abstract »|Full Text »|PDF »
Differential micro-RNA expression in primary CNS and nodal diffuse large B-cell lymphomas.
L. Fischer, M. Hummel, A. Korfel, D. Lenze, K. Joehrens, and E. Thiel (2011)
Neuro Oncology
13, 1090-1098
|Abstract »|Full Text »|PDF »
MicroRNA-155 Is Essential for the T Cell-Mediated Control of Helicobacter pylori Infection and for the Induction of Chronic Gastritis and Colitis.
M. Oertli, D. B. Engler, E. Kohler, M. Koch, T. F. Meyer, and A. Muller (2011)
J. Immunol.
187, 3578-3586
|Abstract »|Full Text »|PDF »
MicroRNA Regulation of Molecular Networks Mapped by Global MicroRNA, mRNA, and Protein Expression in Activated T Lymphocytes.
Y. A. Grigoryev, S. M. Kurian, T. Hart, A. A. Nakorchevsky, C. Chen, D. Campbell, S. R. Head, J. R. Yates III, and D. R. Salomon (2011)
J. Immunol.
187, 2233-2243
|Abstract »|Full Text »|PDF »
G. Murugaiyan, V. Beynon, A. Mittal, N. Joller, and H. L. Weiner (2011)
J. Immunol.
187, 2213-2221
|Abstract »|Full Text »|PDF »
Oncogenic IRFs Provide a Survival Advantage for Epstein-Barr Virus- or Human T-Cell Leukemia Virus Type 1-Transformed Cells through Induction of BIC Expression.
L. Wang, N. L. Toomey, L. A. Diaz, G. Walker, J. C. Ramos, G. N. Barber, and S. Ning (2011)
J. Virol.
85, 8328-8337
|Abstract »|Full Text »|PDF »
MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis.
M. Kurowska-Stolarska, S. Alivernini, L. E. Ballantine, D. L. Asquith, N. L. Millar, D. S. Gilchrist, J. Reilly, M. Ierna, A. R. Fraser, B. Stolarski, et al. (2011)
PNAS
108, 11193-11198
|Abstract »|Full Text »|PDF »
MicroRNA-155 is involved in the remodelling of human-trophoblast-derived HTR-8/SVneo cells induced by lipopolysaccharides.
Y. Dai, Z. Diao, H. Sun, R. Li, Z. Qiu, and Y. Hu (2011)
Hum. Reprod.
26, 1882-1891
|Abstract »|Full Text »|PDF »
Novel Therapeutic Options in Anaplastic Large Cell Lymphoma: Molecular Targets and Immunological Tools.
O. Merkel, F. Hamacher, E. Sifft, L. Kenner, R. Greil, and for the European Research Initiative on Anaplastic (2011)
Mol. Cancer Ther.
10, 1127-1136
|Abstract »|Full Text »|PDF »
MicroRNAs and their roles in mammalian stem cells.
Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage.
D. C. Spierings, D. McGoldrick, A. M. Hamilton-Easton, G. Neale, E. P. Murchison, G. J. Hannon, D. R. Green, and S. Withoff (2011)
Blood
117, 5340-5349
|Abstract »|Full Text »|PDF »
Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function.
I. Dunand-Sauthier, M.-L. Santiago-Raber, L. Capponi, C. E. Vejnar, O. Schaad, M. Irla, Q. Seguin-Estevez, P. Descombes, E. M. Zdobnov, H. Acha-Orbea, et al. (2011)
Blood
117, 4490-4500
|Abstract »|Full Text »|PDF »
Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.
X. Li, T. Sanda, A. T. Look, C. D. Novina, and H. von Boehmer (2011)
J. Exp. Med.
208, 663-675
|Abstract »|Full Text »|PDF »
MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia.
K. Vargova, N. Curik, P. Burda, P. Basova, V. Kulvait, V. Pospisil, F. Savvulidi, J. Kokavec, E. Necas, A. Berkova, et al. (2011)
Blood
117, 3816-3825
|Abstract »|Full Text »|PDF »
Dynamic BRG1 Recruitment during T Helper Differentiation and Activation Reveals Distal Regulatory Elements.
S. De, A. L. Wurster, P. Precht, W. H. Wood III, K. G. Becker, and M. J. Pazin (2011)
Mol. Cell. Biol.
31, 1512-1527
|Abstract »|Full Text »|PDF »
Regulation of mouse stomach development and Barx1 expression by specific microRNAs.
B.-M. Kim, J. Woo, C. Kanellopoulou, and R. A. Shivdasani (2011)
Development
138, 1081-1086
|Abstract »|Full Text »|PDF »
Targeting inflammation by modulating the Jun/AP-1 pathway.
H. B. Schonthaler, J. Guinea-Viniegra, and E. F. Wagner (2011)
Ann Rheum Dis
70, i109-i112
|Abstract »|Full Text »|PDF »
Slowly Produced MicroRNAs Control Protein Levels.
Z. L. Whichard, A. E. Motter, P. J. Stein, and S. J. Corey (2011)
J. Biol. Chem.
286, 4742-4748
|Abstract »|Full Text »|PDF »
MicroRNA in Osteoarthritis.
C. Yu, W.-P. Chen, and X.-H. Wang (2011)
Journal of International Medical Research
39, 1-9
|Abstract »|PDF »
Dynamic Changes of microRNAs in the Eye during the Development of Experimental Autoimmune Uveoretinitis.
W. Ishida, K. Fukuda, T. Higuchi, M. Kajisako, S. Sakamoto, and A. Fukushima (2011)
Invest. Ophthalmol. Vis. Sci.
52, 611-617
|Abstract »|Full Text »|PDF »
NF-{kappa}B Down-regulates Expression of the B-lymphoma Marker CD10 through a miR-155/PU.1 Pathway.
R. C. Thompson, M. Herscovitch, I. Zhao, T. J. Ford, and T. D. Gilmore (2011)
J. Biol. Chem.
286, 1675-1682
|Abstract »|Full Text »|PDF »
The Interleukin 13 (IL-13) Pathway in Human Macrophages Is Modulated by MicroRNA-155 via Direct Targeting of Interleukin 13 Receptor {alpha}1 (IL13R{alpha}1).
R. T. Martinez-Nunez, F. Louafi, and T. Sanchez-Elsner (2011)
J. Biol. Chem.
286, 1786-1794
|Abstract »|Full Text »|PDF »
Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor {alpha} (TNF{alpha}) Production via Increased mRNA Half-life in Alcoholic Liver Disease.
S. Bala, M. Marcos, K. Kodys, T. Csak, D. Catalano, P. Mandrekar, and G. Szabo (2011)
J. Biol. Chem.
286, 1436-1444
|Abstract »|Full Text »|PDF »
Follicular dendritic cell-dependent drug resistance of non-Hodgkin lymphoma involves cell adhesion-mediated Bim down-regulation through induction of microRNA-181a.
T. Lwin, J. Lin, Y. S. Choi, X. Zhang, L. C. Moscinski, K. L. Wright, E. M. Sotomayor, W. S. Dalton, and J. Tao (2010)
Blood
116, 5228-5236
|Abstract »|Full Text »|PDF »
MicroRNA expression in maturing murine megakaryocytes.
J. B. Opalinska, A. Bersenev, Z. Zhang, A. A. Schmaier, J. Choi, Y. Yao, J. D'Souza, W. Tong, and M. J. Weiss (2010)
Blood
116, e128-e138
|Abstract »|Full Text »|PDF »
Virally Induced Cellular MicroRNA miR-155 Plays a Key Role in B-Cell Immortalization by Epstein-Barr Virus.
S. D. Linnstaedt, E. Gottwein, R. L. Skalsky, M. A. Luftig, and B. R. Cullen (2010)
J. Virol.
84, 11670-11678
|Abstract »|Full Text »|PDF »
Inducible microRNA-155 Feedback Promotes Type I IFN Signaling in Antiviral Innate Immunity by Targeting Suppressor of Cytokine Signaling 1.
P. Wang, J. Hou, L. Lin, C. Wang, X. Liu, D. Li, F. Ma, Z. Wang, and X. Cao (2010)
J. Immunol.
185, 6226-6233
|Abstract »|Full Text »|PDF »
Next-generation sequencing identifies the natural killer cell microRNA transcriptome.
T. A. Fehniger, T. Wylie, E. Germino, J. W. Leong, V. J. Magrini, S. Koul, C. R. Keppel, S. E. Schneider, D. C. Koboldt, R. P. Sullivan, et al. (2010)
Genome Res.
20, 1590-1604
|Abstract »|Full Text »|PDF »
Analysis of microRNA knockouts in mice.
C. Y. Park, Y. S. Choi, and M. T. McManus (2010)
Hum. Mol. Genet.
19, R169-R175
|Abstract »|Full Text »|PDF »
HOXA9 regulates miR-155 in hematopoietic cells.
Y.-L. Hu, S. Fong, C. Largman, and W.-F. Shen (2010)
Nucleic Acids Res.
38, 5472-5478
|Abstract »|Full Text »|PDF »
Fluorescence-Based Codetection with Protein Markers Reveals Distinct Cellular Compartments for Altered MicroRNA Expression in Solid Tumors.
L. F. Sempere, M. Preis, T. Yezefski, H. Ouyang, A. A. Suriawinata, A. Silahtaroglu, J. R. Conejo-Garcia, S. Kauppinen, W. Wells, and M. Korc (2010)
Clin. Cancer Res.
16, 4246-4255
|Abstract »|Full Text »|PDF »
IL-10 Inhibits miR-155 Induction by Toll-like Receptors.
C. E. McCoy, F. J. Sheedy, J. E. Qualls, S. L. Doyle, S. R. Quinn, P. J. Murray, and L. A. J. O'Neill (2010)
J. Biol. Chem.
285, 20492-20498
|Abstract »|Full Text »|PDF »
MicroRNA miR-155 Inhibits Bone Morphogenetic Protein (BMP) Signaling and BMP-Mediated Epstein-Barr Virus Reactivation.
Q. Yin, X. Wang, C. Fewell, J. Cameron, H. Zhu, M. Baddoo, Z. Lin, and E. K. Flemington (2010)
J. Virol.
84, 6318-6327
|Abstract »|Full Text »|PDF »
Efficient inhibition of miR-155 function in vivo by peptide nucleic acids.
M. M. Fabani, C. Abreu-Goodger, D. Williams, P. A. Lyons, A. G. Torres, K. G. C. Smith, A. J. Enright, M. J. Gait, and E. Vigorito (2010)
Nucleic Acids Res.
38, 4466-4475
|Abstract »|Full Text »|PDF »
MicroRNA 125b inhibition of B cell differentiation in germinal centers.
M. Gururajan, C. L. Haga, S. Das, C.-M. Leu, D. Hodson, S. Josson, M. Turner, and M. D. Cooper (2010)
Int. Immunol.
22, 583-592
|Abstract »|Full Text »|PDF »
CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells.
S. Rom, I. Rom, G. Passiatore, M. Pacifici, S. Radhakrishnan, L. Del Valle, S. Pina-Oviedo, K. Khalili, D. Eletto, and F. Peruzzi (2010)
FASEB J
24, 2292-2300
|Abstract »|Full Text »|PDF »
MicroRNA-155 Regulates Cell Survival, Growth, and Chemosensitivity by Targeting FOXO3a in Breast Cancer.
W. Kong, L. He, M. Coppola, J. Guo, N. N. Esposito, D. Coppola, and J. Q. Cheng (2010)
J. Biol. Chem.
285, 17869-17879
|Abstract »|Full Text »|PDF »
Small RNAs Guide Hematopoietic Cell Differentiation and Function.
Reprogramming of miRNA networks in cancer and leukemia.
S. Volinia, M. Galasso, S. Costinean, L. Tagliavini, G. Gamberoni, A. Drusco, J. Marchesini, N. Mascellani, M. E. Sana, R. Abu Jarour, et al. (2010)
Genome Res.
20, 589-599
|Abstract »|Full Text »|PDF »
miR-146a Is Differentially Expressed by Myeloid Dendritic Cell Subsets and Desensitizes Cells to TLR2-Dependent Activation.
J. Jurkin, Y. M. Schichl, R. Koeffel, T. Bauer, S. Richter, S. Konradi, B. Gesslbauer, and H. Strobl (2010)
J. Immunol.
184, 4955-4965
|Abstract »|Full Text »|PDF »
M. F. Segura, I. Belitskaya-Levy, A. E. Rose, J. Zakrzewski, A. Gaziel, D. Hanniford, F. Darvishian, R. S. Berman, R. L. Shapiro, A. C. Pavlick, et al. (2010)
Clin. Cancer Res.
16, 1577-1586
|Abstract »|Full Text »|PDF »
Targeting of SMAD5 links microRNA-155 to the TGF-{beta} pathway and lymphomagenesis.
D. Rai, S.-W. Kim, M. R. McKeller, P. L. M. Dahia, and R. C. T. Aguiar (2010)
PNAS
107, 3111-3116
|Abstract »|Full Text »|PDF »
An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes.
G. Curtale, F. Citarella, C. Carissimi, M. Goldoni, N. Carucci, V. Fulci, D. Franceschini, F. Meloni, V. Barnaba, and G. Macino (2010)
Blood
115, 265-273
|Abstract »|Full Text »|PDF »
