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Science 316 (5824): 608-611

Copyright © 2007 by the American Association for the Advancement of Science

Requirement of bic/microRNA-155 for Normal Immune Function

Antony Rodriguez,1* Elena Vigorito,2* Simon Clare,1 Madhuri V. Warren,1,3 Philippe Couttet,1 Dalya R. Soond,2 Stijn van Dongen,1 Russell J. Grocock,1 Partha P. Das,4 Eric A. Miska,4 David Vetrie,1 Klaus Okkenhaug,2 Anton J. Enright,1 Gordon Dougan,1 Martin Turner,2{dagger} Allan Bradley1{dagger}

Abstract: MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155–deficient CD4+ T cells identified a wide spectrum of microRNA-155–regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.

1 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
2 Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, CB2 4AT, UK.
3 Department of Pathology, Addenbroke's Hospital, University of Cambridge, Cambridge, CB2 2QQ, UK.
4 Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QN, UK.

* These authors contributed equally to this work

{dagger} To whom correspondence should be addressed: abradley{at}sanger.ac.uk (A.B.); martin.turner{at}bbsrc.ac.uk (M.T.)

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   Abstract »    Full Text »    PDF »
Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD.
E. Tili, J.-J. Michaille, B. Adair, H. Alder, E. Limagne, C. Taccioli, M. Ferracin, D. Delmas, N. Latruffe, and C. M. Croce (2010)
Carcinogenesis 31, 1561-1566
   Abstract »    Full Text »    PDF »
Fluorescence-Based Codetection with Protein Markers Reveals Distinct Cellular Compartments for Altered MicroRNA Expression in Solid Tumors.
L. F. Sempere, M. Preis, T. Yezefski, H. Ouyang, A. A. Suriawinata, A. Silahtaroglu, J. R. Conejo-Garcia, S. Kauppinen, W. Wells, and M. Korc (2010)
Clin. Cancer Res. 16, 4246-4255
   Abstract »    Full Text »    PDF »
Transcriptome and targetome analysis in MIR155 expressing cells using RNA-seq.
G. Xu, C. Fewell, C. Taylor, N. Deng, D. Hedges, X. Wang, K. Zhang, M. Lacey, H. Zhang, Q. Yin, et al. (2010)
RNA 16, 1610-1622
   Abstract »    Full Text »    PDF »
IL-10 Inhibits miR-155 Induction by Toll-like Receptors.
C. E. McCoy, F. J. Sheedy, J. E. Qualls, S. L. Doyle, S. R. Quinn, P. J. Murray, and L. A. J. O'Neill (2010)
J. Biol. Chem. 285, 20492-20498
   Abstract »    Full Text »    PDF »
MicroRNA miR-155 Inhibits Bone Morphogenetic Protein (BMP) Signaling and BMP-Mediated Epstein-Barr Virus Reactivation.
Q. Yin, X. Wang, C. Fewell, J. Cameron, H. Zhu, M. Baddoo, Z. Lin, and E. K. Flemington (2010)
J. Virol. 84, 6318-6327
   Abstract »    Full Text »    PDF »
Efficient inhibition of miR-155 function in vivo by peptide nucleic acids.
M. M. Fabani, C. Abreu-Goodger, D. Williams, P. A. Lyons, A. G. Torres, K. G. C. Smith, A. J. Enright, M. J. Gait, and E. Vigorito (2010)
Nucleic Acids Res. 38, 4466-4475
   Abstract »    Full Text »    PDF »
MicroRNA 125b inhibition of B cell differentiation in germinal centers.
M. Gururajan, C. L. Haga, S. Das, C.-M. Leu, D. Hodson, S. Josson, M. Turner, and M. D. Cooper (2010)
Int. Immunol. 22, 583-592
   Abstract »    Full Text »    PDF »
CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells.
S. Rom, I. Rom, G. Passiatore, M. Pacifici, S. Radhakrishnan, L. Del Valle, S. Pina-Oviedo, K. Khalili, D. Eletto, and F. Peruzzi (2010)
FASEB J 24, 2292-2300
   Abstract »    Full Text »    PDF »

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