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Science 316 (5824): 608-611

Copyright © 2007 by the American Association for the Advancement of Science

Requirement of bic/microRNA-155 for Normal Immune Function

Antony Rodriguez,1* Elena Vigorito,2* Simon Clare,1 Madhuri V. Warren,1,3 Philippe Couttet,1 Dalya R. Soond,2 Stijn van Dongen,1 Russell J. Grocock,1 Partha P. Das,4 Eric A. Miska,4 David Vetrie,1 Klaus Okkenhaug,2 Anton J. Enright,1 Gordon Dougan,1 Martin Turner,2{dagger} Allan Bradley1{dagger}

Abstract: MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155–deficient CD4+ T cells identified a wide spectrum of microRNA-155–regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.

1 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
2 Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, CB2 4AT, UK.
3 Department of Pathology, Addenbroke's Hospital, University of Cambridge, Cambridge, CB2 2QQ, UK.
4 Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QN, UK.

* These authors contributed equally to this work

{dagger} To whom correspondence should be addressed: abradley{at}sanger.ac.uk (A.B.); martin.turner{at}bbsrc.ac.uk (M.T.)


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R. Pandey and M. Mukerji (2011)
Briefings in Functional Genomics 10, 294-311
   Abstract »    Full Text »    PDF »
MicroRNA Regulation of Molecular Networks Mapped by Global MicroRNA, mRNA, and Protein Expression in Activated T Lymphocytes.
Y. A. Grigoryev, S. M. Kurian, T. Hart, A. A. Nakorchevsky, C. Chen, D. Campbell, S. R. Head, J. R. Yates III, and D. R. Salomon (2011)
J. Immunol. 187, 2233-2243
   Abstract »    Full Text »    PDF »
Oncogenic IRFs Provide a Survival Advantage for Epstein-Barr Virus- or Human T-Cell Leukemia Virus Type 1-Transformed Cells through Induction of BIC Expression.
L. Wang, N. L. Toomey, L. A. Diaz, G. Walker, J. C. Ramos, G. N. Barber, and S. Ning (2011)
J. Virol. 85, 8328-8337
   Abstract »    Full Text »    PDF »
MicroRNA Expression Profiles of Human Blood Monocyte-derived Dendritic Cells and Macrophages Reveal miR-511 as Putative Positive Regulator of Toll-like Receptor 4.
L. Tserel, T. Runnel, K. Kisand, M. Pihlap, L. Bakhoff, R. Kolde, H. Peterson, J. Vilo, P. Peterson, and A. Rebane (2011)
J. Biol. Chem. 286, 26487-26495
   Abstract »    Full Text »    PDF »
Signature microRNA Expression Profile of Essential Hypertension and Its Novel Link to Human Cytomegalovirus Infection.
S. Li, J. Zhu, W. Zhang, Y. Chen, K. Zhang, L. M. Popescu, X. Ma, W. Bond Lau, R. Rong, X. Yu, et al. (2011)
Circulation 124, 175-184
   Abstract »    Full Text »    PDF »
MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis.
M. Kurowska-Stolarska, S. Alivernini, L. E. Ballantine, D. L. Asquith, N. L. Millar, D. S. Gilchrist, J. Reilly, M. Ierna, A. R. Fraser, B. Stolarski, et al. (2011)
PNAS 108, 11193-11198
   Abstract »    Full Text »    PDF »
MicroRNAs in Development and Disease.
D. Sayed and M. Abdellatif (2011)
Physiol Rev 91, 827-887
   Abstract »    Full Text »    PDF »
A trio of microRNAs that control Toll-like receptor signalling.
S. R. Quinn and L. A. O'Neill (2011)
Int. Immunol. 23, 421-425
   Abstract »    Full Text »    PDF »
MicroRNA-155 is involved in the remodelling of human-trophoblast-derived HTR-8/SVneo cells induced by lipopolysaccharides.
Y. Dai, Z. Diao, H. Sun, R. Li, Z. Qiu, and Y. Hu (2011)
Hum. Reprod. 26, 1882-1891
   Abstract »    Full Text »    PDF »
A detailed investigation of accessibilities around target sites of siRNAs and miRNAs.
H. Kiryu, G. Terai, O. Imamura, H. Yoneyama, K. Suzuki, and K. Asai (2011)
Bioinformatics 27, 1788-1797
   Abstract »    Full Text »    PDF »

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