Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 316 (5824): 612-616

Copyright © 2007 by the American Association for the Advancement of Science

Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation

Sven Burgdorf,* Andreas Kautz, Volker Böhnert, Percy A. Knolle, Christian Kurts*

Abstract: The mechanisms that allow antigen-presenting cells (APCs) to selectively present extracellular antigen to CD8+ effector T cells (cross-presentation) or to CD4+ T helper cells are not fully resolved. We demonstrated that APCs use distinct endocytosis mechanisms to simultaneously introduce soluble antigen into separate intracellular compartments, which were dedicated to presentation to CD8+ or CD4+ T cells. Specifically, the mannose receptor supplied an early endosomal compartment distinct from lysosomes, which was committed to cross-presentation. These findings imply that antigen does not require intracellular diversion to access the cross-presentation pathway, because it can enter the pathway already during endocytosis.

Institute of Molecular Medicine and Experimental Immunology, Friedrich-Wilhelms-Universität, Bonn, Germany.

* To whom correspondence should be addressed. E-mail: ckurts{at}web.de (C.K.); sven.burgdorf{at}ukb.uni-bonn.de (S.B.)


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ovalbumin Modified with Pyrraline, a Maillard Reaction Product, shows Enhanced T-cell Immunogenicity.
M. Heilmann, A. Wellner, G. Gadermaier, A. Ilchmann, P. Briza, M. Krause, R. Nagai, S. Burgdorf, S. Scheurer, S. Vieths, et al. (2014)
J. Biol. Chem. 289, 7919-7928
   Abstract »    Full Text »    PDF »
Controlling immune responses by targeting antigens to dendritic cell subsets and B cells.
C. P. Chappell, N. V. Giltiay, C. Dresch, and E. A. Clark (2014)
Int. Immunol. 26, 3-11
   Abstract »    Full Text »    PDF »
Enhanced Endoplasmic Reticulum Entry of Tumor Antigen Is Crucial for Cross-Presentation Induced by Dendritic Cell-Targeted Vaccination.
H. Wang, X. Yu, C. Guo, D. Zuo, P. B. Fisher, J. R. Subjeck, and X.-Y. Wang (2013)
J. Immunol. 191, 6010-6021
   Abstract »    Full Text »    PDF »
Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.
D. Tseng, J.-P. Volkmer, S. B. Willingham, H. Contreras-Trujillo, J. W. Fathman, N. B. Fernhoff, J. Seita, M. A. Inlay, K. Weiskopf, M. Miyanishi, et al. (2013)
PNAS 110, 11103-11108
   Abstract »    Full Text »    PDF »
Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation.
K. J. Sandgren, A. Smed-Sorensen, M. N. Forsell, M. Soldemo, W. C. Adams, F. Liang, L. Perbeck, R. A. Koup, R. T. Wyatt, G. B. Karlsson Hedestam, et al. (2013)
J. Immunol. 191, 60-69
   Abstract »    Full Text »    PDF »
Podocytes Are Nonhematopoietic Professional Antigen-Presenting Cells.
A. Goldwich, M. Burkard, M. Olke, C. Daniel, K. Amann, C. Hugo, C. Kurts, A. Steinkasserer, and A. Gessner (2013)
J. Am. Soc. Nephrol. 24, 906-916
   Abstract »    Full Text »    PDF »
Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation.
L. Cohn, B. Chatterjee, F. Esselborn, A. Smed-Sorensen, N. Nakamura, C. Chalouni, B.-C. Lee, R. Vandlen, T. Keler, P. Lauer, et al. (2013)
J. Exp. Med. 210, 1049-1063
   Abstract »    Full Text »    PDF »
{beta}2-Adrenoreceptor Agonist Inhibits Antigen Cross-Presentation by Dendritic Cells.
J. Herve, L. Dubreil, V. Tardif, M. Terme, S. Pogu, I. Anegon, B. Rozec, C. Gauthier, J.-M. Bach, and P. Blancou (2013)
J. Immunol. 190, 3163-3171
   Abstract »    Full Text »    PDF »
Staphylococcus aureus Phenol-Soluble Modulin Peptides Modulate Dendritic Cell Functions and Increase In Vitro Priming of Regulatory T Cells.
J. Schreiner, D. Kretschmer, J. Klenk, M. Otto, H.-J. Buhring, S. Stevanovic, J. M. Wang, S. Beer-Hammer, A. Peschel, and S. E. Autenrieth (2013)
J. Immunol. 190, 3417-3426
   Abstract »    Full Text »    PDF »
Robust T-cell stimulation by Epstein-Barr virus-transformed B cells after antigen targeting to DEC-205.
C. S. Leung, M. A. Maurer, S. Meixlsperger, A. Lippmann, C. Cheong, J. Zuo, T. A. Haigh, G. S. Taylor, and C. Munz (2013)
Blood 121, 1584-1594
   Abstract »    Full Text »    PDF »
Immunoglobulins drive terminal maturation of splenic dendritic cells.
N. Zietara, M. Lyszkiewicz, J. Puchalka, G. Pei, M. G. Gutierrez, S. Lienenklaus, E. Hobeika, M. Reth, V. A. P. Martins dos Santos, A. Krueger, et al. (2013)
PNAS 110, 2282-2287
   Abstract »    Full Text »    PDF »
An Anti-Nucleic Acid Antibody Delivers Antigen to the Cross-Presentation Pathway in Dendritic Cells and Potentiates Therapeutic Antitumor Effects.
C. D. Pham, M.-Y. Woo, Y.-S. Kim, S. Park, and M.-H. Kwon (2012)
J. Immunol. 189, 5755-5763
   Abstract »    Full Text »    PDF »
The mannose receptor.
L. Martinez-Pomares (2012)
J. Leukoc. Biol. 92, 1177-1186
   Abstract »    Full Text »    PDF »
Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor.
B. Everts, L. Hussaarts, N. N. Driessen, M. H. J. Meevissen, G. Schramm, A. J. van der Ham, B. van der Hoeven, T. Scholzen, S. Burgdorf, M. Mohrs, et al. (2012)
J. Exp. Med. 209, 1753-1767
   Abstract »    Full Text »    PDF »
Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells.
B. Chatterjee, A. Smed-Sorensen, L. Cohn, C. Chalouni, R. Vandlen, B.-C. Lee, J. Widger, T. Keler, L. Delamarre, and I. Mellman (2012)
Blood 120, 2011-2020
   Abstract »    Full Text »    PDF »
Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets.
K. A. Markey, M. Koyama, R. D. Kuns, K. E. Lineburg, Y. A. Wilson, S. D. Olver, N. C. Raffelt, A. L. J. Don, A. Varelias, R. J. Robb, et al. (2012)
Blood 119, 5918-5930
   Abstract »    Full Text »    PDF »
CD13 Regulates Dendritic Cell Cross-Presentation and T Cell Responses by Inhibiting Receptor-Mediated Antigen Uptake.
M. Ghosh, B. McAuliffe, J. Subramani, S. Basu, and L. H. Shapiro (2012)
J. Immunol. 188, 5489-5499
   Abstract »    Full Text »    PDF »
Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor {gamma}.
S. Hucke, J. Flossdorf, B. Grutzke, I. R. Dunay, K. Frenzel, J. Jungverdorben, B. Linnartz, M. Mack, M. Peitz, O. Brustle, et al. (2012)
Brain 135, 1586-1605
   Abstract »    Full Text »    PDF »
ADAMTS13 meets MR, then what?.
X. L. Zheng (2012)
Blood 119, 3652-3654
   Full Text »    PDF »
The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells.
N. Sorvillo, W. Pos, L. M. van den Berg, R. Fijnheer, L. Martinez-Pomares, T. B. Geijtenbeek, E. Herczenik, and J. Voorberg (2012)
Blood 119, 3828-3835
   Abstract »    Full Text »    PDF »
Conventional Dendritic Cells Require IRAP-Rab14 Endosomes for Efficient Cross-Presentation.
M. Weimershaus, S. Maschalidi, F. Sepulveda, B. Manoury, P. van Endert, and L. Saveanu (2012)
J. Immunol. 188, 1840-1846
   Abstract »    Full Text »    PDF »
IFN-{alpha} enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing.
F. Spadaro, C. Lapenta, S. Donati, L. Abalsamo, V. Barnaba, F. Belardelli, S. M. Santini, and M. Ferrantini (2012)
Blood 119, 1407-1417
   Abstract »    Full Text »    PDF »
The Proteoglycan Biglycan Enhances Antigen-Specific T Cell Activation Potentially via MyD88 and TRIF Pathways and Triggers Autoimmune Perimyocarditis.
Z. V. Popovic, S. Wang, M. Papatriantafyllou, Z. Kaya, S. Porubsky, M. Meisner, M. Bonrouhi, S. Burgdorf, M. F. Young, L. Schaefer, et al. (2011)
J. Immunol. 187, 6217-6226
   Abstract »    Full Text »    PDF »
Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen-presenting potential of plasmacytoid DCs.
M. Kool, C. GeurtsVanKessel, F. Muskens, F. B. Madeira, M. van Nimwegen, H. Kuipers, K. Thielemans, H. C. Hoogsteden, H. Hammad, and B. N. Lambrecht (2011)
J. Leukoc. Biol. 90, 1177-1190
   Abstract »    Full Text »    PDF »
Tumor-Derived Autophagosome Vaccine: Mechanism of Cross-Presentation and Therapeutic Efficacy.
Y. Li, L.-X. Wang, P. Pang, Z. Cui, S. Aung, D. Haley, B. A. Fox, W. J. Urba, and H.-M. Hu (2011)
Clin. Cancer Res. 17, 7047-7057
   Abstract »    Full Text »    PDF »
Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation.
P. J. Tacken, W. Ginter, L. Berod, L. J. Cruz, B. Joosten, T. Sparwasser, C. G. Figdor, and A. Cambi (2011)
Blood 118, 4111-4119
   Abstract »    Full Text »    PDF »
TRAIL/DR5 Plays a Critical Role in NK Cell-Mediated Negative Regulation of Dendritic Cell Cross-Priming of T Cells.
M. Iyori, T. Zhang, H. Pantel, B. A. Gagne, and C. L. Sentman (2011)
J. Immunol. 187, 3087-3095
   Abstract »    Full Text »    PDF »
Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation.
M. Zehner, A. I. Chasan, V. Schuette, M. Embgenbroich, T. Quast, W. Kolanus, and S. Burgdorf (2011)
PNAS 108, 9933-9938
   Abstract »    Full Text »    PDF »
Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells.
C. Russo, I. Cornella-Taracido, L. Galli-Stampino, R. Jain, E. Harrington, Y. Isome, S. Tavarini, C. Sammicheli, S. Nuti, M. L. Mbow, et al. (2011)
Blood 117, 5683-5691
   Abstract »    Full Text »    PDF »
Type I IFNs Control Antigen Retention and Survival of CD8{alpha}+ Dendritic Cells after Uptake of Tumor Apoptotic Cells Leading to Cross-Priming.
S. Lorenzi, F. Mattei, A. Sistigu, L. Bracci, F. Spadaro, M. Sanchez, M. Spada, F. Belardelli, L. Gabriele, and G. Schiavoni (2011)
J. Immunol. 186, 5142-5150
   Abstract »    Full Text »    PDF »
A Marked Reduction in Priming of Cytotoxic CD8+ T Cells Mediated by Stress-Induced Glucocorticoids Involves Multiple Deficiencies in Cross-Presentation by Dendritic Cells.
J. T. Hunzeker, M. D. Elftman, J. C. Mellinger, M. F. Princiotta, R. H. Bonneau, M. E. Truckenmiller, and C. C. Norbury (2011)
J. Immunol. 186, 183-194
   Abstract »    Full Text »    PDF »
GM-CSF Is an Essential Regulator of T Cell Activation Competence in Uterine Dendritic Cells during Early Pregnancy in Mice.
L. M. Moldenhauer, S. N. Keenihan, J. D. Hayball, and S. A. Robertson (2010)
J. Immunol. 185, 7085-7096
   Abstract »    Full Text »    PDF »
Role of the P2Y12 Receptor in the Modulation of Murine Dendritic Cell Function by ADP.
A. Ben Addi, D. Cammarata, P. B. Conley, J.-M. Boeynaems, and B. Robaye (2010)
J. Immunol. 185, 5900-5906
   Abstract »    Full Text »    PDF »
Essential Role of Endogenous Heat Shock Protein 90 of Dendritic Cells in Antigen Cross-Presentation.
T. Ichiyanagi, T. Imai, C. Kajiwara, S. Mizukami, A. Nakai, T. Nakayama, and H. Udono (2010)
J. Immunol. 185, 2693-2700
   Abstract »    Full Text »    PDF »
Dendritic Cells Inhibit the Progression of Listeria monocytogenes Intracellular Infection by Retaining Bacteria in Major Histocompatibility Complex Class II-Rich Phagosomes and by Limiting Cytosolic Growth.
M. M. Westcott, C. J. Henry, J. E. Amis, and E. M. Hiltbold (2010)
Infect. Immun. 78, 2956-2965
   Abstract »    Full Text »    PDF »
Distribution and Function of Macrophage Galactose-type C-type Lectin 2 (MGL2/CD301b): EFFICIENT UPTAKE AND PRESENTATION OF GLYCOSYLATED ANTIGENS BY DENDRITIC CELLS.
K. Denda-Nagai, S. Aida, K. Saba, K. Suzuki, S. Moriyama, S. Oo-puthinan, M. Tsuiji, A. Morikawa, Y. Kumamoto, D. Sugiura, et al. (2010)
J. Biol. Chem. 285, 19193-19204
   Abstract »    Full Text »    PDF »
Fusion Proteins for Versatile Antigen Targeting to Cell Surface Receptors Reveal Differential Capacity to Prime Immune Responses.
R. Kratzer, F.-X. Mauvais, A. Burgevin, E. Barilleau, and P. van Endert (2010)
J. Immunol. 184, 6855-6864
   Abstract »    Full Text »    PDF »
Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action.
A. Lev, M. F. Princiotta, D. Zanker, K. Takeda, J. S. Gibbs, C. Kumagai, E. Waffarn, B. P. Dolan, A. Burgevin, P. Van Endert, et al. (2010)
PNAS 107, 6964-6969
   Abstract »    Full Text »    PDF »
Reply to Burgdorf et al.: The mannose receptor is not involved in antigen cross-presentation by steady-state dendritic cells.
E. Segura, N. Gupta, A. L. Albiston, I. P. Wicks, S. Y. Chai, and J. A. Villadangos (2010)
PNAS 107, E50-E51
   Full Text »    PDF »
Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments.
S. Burgdorf, V. Schuette, V. Semmling, K. Hochheiser, V. Lukacs-Kornek, P. A. Knolle, and C. Kurts (2010)
PNAS 107, E48-E49
   Full Text »    PDF »
Mature dendritic cells use endocytic receptors to capture and present antigens.
C. D. Platt, J. K. Ma, C. Chalouni, M. Ebersold, H. Bou-Reslan, R. A. D. Carano, I. Mellman, and L. Delamarre (2010)
PNAS 107, 4287-4292
   Abstract »    Full Text »    PDF »
LOX-1 as a natural IFN-{alpha}-mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells.
S. Parlato, G. Romagnoli, F. Spadaro, I. Canini, P. Sirabella, P. Borghi, C. Ramoni, I. Filesi, S. Biocca, L. Gabriele, et al. (2010)
Blood 115, 1554-1563
   Abstract »    Full Text »    PDF »
Nucleotide Oligomerization Binding Domain-Like Receptor Signaling Enhances Dendritic Cell-Mediated Cross-Priming In Vivo.
J. Asano, H. Tada, N. Onai, T. Sato, Y. Horie, Y. Fujimoto, K. Fukase, A. Suzuki, T. W. Mak, and T. Ohteki (2010)
J. Immunol. 184, 736-745
   Abstract »    Full Text »    PDF »
Different cross-presentation pathways in steady-state and inflammatory dendritic cells.
E. Segura, A. L. Albiston, I. P. Wicks, S. Y. Chai, and J. A. Villadangos (2009)
PNAS 106, 20377-20381
   Abstract »    Full Text »    PDF »
Targeting to Static Endosome Is Required for Efficient Cross-Presentation of Endoplasmic Reticulum-Resident Oxygen-Regulated Protein 150-Peptide Complexes.
G. Kutomi, Y. Tamura, K. Okuya, T. Yamamoto, Y. Hirohashi, K. Kamiguchi, J. Oura, K. Saito, T. Torigoe, S. Ogawa, et al. (2009)
J. Immunol. 183, 5861-5869
   Abstract »    Full Text »    PDF »
Enhanced Dendritic Cell-Induced Immune Responses Mediated by the Novel C-Type Lectin Receptor mDCAR1.
S. A. Kaden, S. Kurig, K. Vasters, K. Hofmann, K. S. Zaenker, J. Schmitz, and G. Winkels (2009)
J. Immunol. 183, 5069-5078
   Abstract »    Full Text »    PDF »
Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation.
R. Belizaire and E. R. Unanue (2009)
PNAS 106, 17463-17468
   Abstract »    Full Text »    PDF »
The Dendritic Cell-like Functions of IFN-Producing Killer Dendritic Cells Reside in the CD11b+ Subset and Are Licensed by Tumor Cells.
M. Terme, G. Mignot, E. Ullrich, M. Bonmort, V. Minard-Colin, A. Jacquet, J. L. Schultze, G. Kroemer, C. Leclerc, N. Chaput, et al. (2009)
Cancer Res. 69, 6590-6597
   Abstract »    Full Text »    PDF »
Targeted Delivery of Tumor Antigens to Activated Dendritic Cells via CD11c Molecules Induces Potent Antitumor Immunity in Mice.
H. Wei, S. Wang, D. Zhang, S. Hou, W. Qian, B. Li, H. Guo, G. Kou, J. He, H. Wang, et al. (2009)
Clin. Cancer Res. 15, 4612-4621
   Abstract »    Full Text »    PDF »
PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation.
I. Tirapu, B. Giquel, L. Alexopoulou, S. Uematsu, R. Flavell, S. Akira, and S. S. Diebold (2009)
Int. Immunol. 21, 871-879
   Abstract »    Full Text »    PDF »
Increased Antigen Cross-Presentation but Impaired Cross-Priming after Activation of Peroxisome Proliferator-Activated Receptor {gamma} Is Mediated by Up-Regulation of B7H1.
L. Klotz, S. Hucke, D. Thimm, S. Classen, A. Gaarz, J. Schultze, F. Edenhofer, C. Kurts, T. Klockgether, A. Limmer, et al. (2009)
J. Immunol. 183, 129-136
   Abstract »    Full Text »    PDF »
The C-Type Lectin Clec12A Present on Mouse and Human Dendritic Cells Can Serve as a Target for Antigen Delivery and Enhancement of Antibody Responses.
M. H. Lahoud, A. I. Proietto, F. Ahmet, S. Kitsoulis, L. Eidsmo, L. Wu, P. Sathe, S. Pietersz, H.-W. Chang, I. D. Walker, et al. (2009)
J. Immunol. 182, 7587-7594
   Abstract »    Full Text »    PDF »
Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity.
N. van Montfoort, M. G. Camps, S. Khan, D. V. Filippov, J. J. Weterings, J. M. Griffith, H. J. Geuze, T. van Hall, J. S. Verbeek, C. J. Melief, et al. (2009)
PNAS 106, 6730-6735
   Abstract »    Full Text »    PDF »
Clathrin- and Dynamin-Dependent Endocytic Pathway Regulates Muramyl Dipeptide Internalization and NOD2 Activation.
N. Marina-Garcia, L. Franchi, Y.-G. Kim, Y. Hu, D. E. Smith, G.-J. Boons, and G. Nunez (2009)
J. Immunol. 182, 4321-4327
   Abstract »    Full Text »    PDF »
Influenza Virus and Poly(I:C) Inhibit MHC Class I-Restricted Presentation of Cell-Associated Antigens Derived from Infected Dead Cells Captured by Human Dendritic Cells.
D. Frleta, C. I. Yu, E. Klechevsky, A.-L. Flamar, G. Zurawski, J. Banchereau, and A. K. Palucka (2009)
J. Immunol. 182, 2766-2776
   Abstract »    Full Text »    PDF »
ISCOMATRIX Adjuvant Induces Efficient Cross-Presentation of Tumor Antigen by Dendritic Cells via Rapid Cytosolic Antigen Delivery and Processing via Tripeptidyl Peptidase II.
M. Schnurr, M. Orban, N. C. Robson, A. Shin, H. Braley, D. Airey, J. Cebon, E. Maraskovsky, and S. Endres (2009)
J. Immunol. 182, 1253-1259
   Abstract »    Full Text »    PDF »
Targeting Antigen to MHC Class II Molecules Promotes Efficient Cross-Presentation and Enhances Immunotherapy.
N. Dickgreber, P. Stoitzner, Y. Bai, K. M. Price, K. J. Farrand, K. Manning, C. E. Angel, P. R. Dunbar, F. Ronchese, J. D. Fraser, et al. (2009)
J. Immunol. 182, 1260-1269
   Abstract »    Full Text »    PDF »
Recruitment of Rab27a to Phagosomes Controls Microbial Antigen Cross-Presentation by Dendritic Cells.
S. H. Kim, A. Visser, C. Cruijsen, A. W. M. van der Velden, and M. Boes (2008)
Infect. Immun. 76, 5373-5380
   Abstract »    Full Text »    PDF »
CX3CR1+c-kit+ Bone Marrow Cells Give Rise to CD103+ and CD103- Dendritic Cells with Distinct Functional Properties.
M.-L. del Rio, J.-I. Rodriguez-Barbosa, J. Bolter, M. Ballmaier, O. Dittrich-Breiholz, M. Kracht, S. Jung, and R. Forster (2008)
J. Immunol. 181, 6178-6188
   Abstract »    Full Text »    PDF »
Primary CD8+ T-Cell Response to Soluble Ovalbumin Is Improved by Chloroquine Treatment In Vivo.
B. Garulli, M. G. Stillitano, V. Barnaba, and M. R. Castrucci (2008)
Clin. Vaccine Immunol. 15, 1497-1504
   Abstract »    Full Text »    PDF »
The Adjuvanticity of a Mannosylated Antigen Reveals TLR4 Functionality Essential for Subset Specialization and Functional Maturation of Mouse Dendritic Cells.
K.-C. Sheng, M. Kalkanidis, D. S. Pouniotis, M. D. Wright, G. A. Pietersz, and V. Apostolopoulos (2008)
J. Immunol. 181, 2455-2464
   Abstract »    Full Text »    PDF »
In Vivo Visualization of Dendritic Cells, Macrophages, and Microglial Cells Responding to Laser-Induced Damage in the Fundus of the Eye.
N. Eter, D. R. Engel, L. Meyer, H.-M. Helb, F. Roth, J. Maurer, F. G. Holz, and C. Kurts (2008)
Invest. Ophthalmol. Vis. Sci. 49, 3649-3658
   Abstract »    Full Text »    PDF »
In vivo Colocalization of Antigen and CpG within Dendritic Cells Is Associated with the Efficacy of Cancer Immunotherapy.
S. Nierkens, M. H. den Brok, R. P.M. Sutmuller, O. M. Grauer, E. Bennink, M. E. Morgan, C. G. Figdor, T. J.M. Ruers, and G. J. Adema (2008)
Cancer Res. 68, 5390-5396
   Abstract »    Full Text »    PDF »
Immunology of the gut and liver: a love/hate relationship.
D H Adams, B Eksteen, and S M Curbishley (2008)
Gut 57, 838-848
   Full Text »    PDF »
Invariant NKT Cells Promote CD8+ Cytotoxic T Cell Responses by Inducing CD70 Expression on Dendritic Cells.
V. Y. Taraban, S. Martin, K. E. Attfield, M. J. Glennie, T. Elliott, D. Elewaut, S. Van Calenbergh, B. Linclau, and A. Al-Shamkhani (2008)
J. Immunol. 180, 4615-4620
   Abstract »    Full Text »    PDF »
The Kidney-Renal Lymph Node-System Contributes to Cross-Tolerance against Innocuous Circulating Antigen.
V. Lukacs-Kornek, S. Burgdorf, L. Diehl, S. Specht, M. Kornek, and C. Kurts (2008)
J. Immunol. 180, 706-715
   Abstract »    Full Text »    PDF »
Secretory IgA Mediates Bacterial Translocation to Dendritic Cells in Mouse Peyer's Patches with Restriction to Mucosal Compartment.
K. A. Kadaoui and B. Corthesy (2007)
J. Immunol. 179, 7751-7757
   Abstract »    Full Text »    PDF »
Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens.
L. J. Young, N. S. Wilson, P. Schnorrer, A. Mount, R. J. Lundie, N. L. La Gruta, B. S. Crabb, G. T. Belz, W. R. Heath, and J. A. Villadangos (2007)
PNAS 104, 17753-17758
   Abstract »    Full Text »    PDF »
Private Lives: Reflections and Challenges in Understanding the Cell Biology of the Immune System.
I. Mellman (2007)
Science 317, 625-627
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882