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Science 316 (5825): 758-761

Copyright © 2007 by the American Association for the Advancement of Science

Specialized Inhibitory Synaptic Actions Between Nearby Neocortical Pyramidal Neurons

Ming Ren, Yumiko Yoshimura, Naoki Takada, Shoko Horibe, Yukio Komatsu*

Abstract: We found that, in the mouse visual cortex, action potentials generated in a single layer-2/3 pyramidal (excitatory) neuron can reliably evoke large, constant-latency inhibitory postsynaptic currents in other nearby pyramidal cells. This effect is mediated by axo-axonic ionotropic glutamate receptor–mediated excitation of the nerve terminals of inhibitory interneurons, which connect to the target pyramidal cells. Therefore, individual cortical excitatory neurons can generate inhibition independently from the somatic firing of inhibitory interneurons.

Department of Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.

* To whom correspondence should be addressed. E-mail: komatsu{at}riem.nagoya-u.ac.jp

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