Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 316 (5828): 1160-1166

Copyright © 2007 by the American Association for the Advancement of Science

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Shuhei Matsuoka,1 Bryan A. Ballif,2* Agata Smogorzewska,1,3{dagger} E. Robert McDonald, III,1{dagger} Kristen E. Hurov,1{dagger} Ji Luo,1{dagger} Corey E. Bakalarski,2 Zhenming Zhao,1 Nicole Solimini,1 Yaniv Lerenthal,4 Yosef Shiloh,4 Steven P. Gygi,2{ddagger} Stephen J. Elledge1{ddagger}

Abstract: Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the signal transduction portion of this pathway are known, but little is known about the physiological scope of the DNA damage response (DDR). We performed a large-scale proteomic analysis of proteins phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR and identified more than 900 regulated phosphorylation sites encompassing over 700 proteins. Functional analysis of a subset of this data set indicated that this list is highly enriched for proteins involved in the DDR. This set of proteins is highly interconnected, and we identified a large number of protein modules and networks not previously linked to the DDR. This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals.

1 Department of Genetics and Center for Genetics and Genomics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
2 Department of Cell Biology and Taplin Biological Mass Spectrometry Facility, Harvard Medical School, Boston, MA 02115, USA.
3 Department of Pathology, Massachusetts General Hospital, Boston, MA 02214, USA.
4 Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

* Present address: Department of Biology, University of Vermont, Burlington, VT 05405, USA.

{dagger} These authors contributed equally to this work.

{ddagger} To whom correspondence should be addressed. E-mail: selledge{at}, steven_gygi{at}

NuMA promotes homologous recombination repair by regulating the accumulation of the ISWI ATPase SNF2h at DNA breaks.
P.-A. Vidi, J. Liu, D. Salles, S. Jayaraman, G. Dorfman, M. Gray, P. Abad, P. V. Moghe, J. M. Irudayaraj, L. Wiesmuller, et al. (2014)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.
M. Gatei, A. W. Kijas, D. Biard, T. Dork, and M. F. Lavin (2014)
Hum. Mol. Genet.
   Abstract »    Full Text »    PDF »
Clustering phenotype populations by genome-wide RNAi and multiparametric imaging.
F. Fuchs, G. Pau, D. Kranz, O. Sklyar, C. Budjan, S. Steinbrink, T. Horn, A. Pedal, W. Huber, and M. Boutros (2014)
Mol Syst Biol 6, 370
   Abstract »    Full Text »    PDF »
The phosphoproteome of toll-like receptor-activated macrophages.
G. Weintz, J. V. Olsen, K. Fruhauf, M. Niedzielska, I. Amit, J. Jantsch, J. Mages, C. Frech, L. Dolken, M. Mann, et al. (2014)
Mol Syst Biol 6, 371
   Abstract »    Full Text »    PDF »
The Ddc1-Mec3-Rad17 Sliding Clamp Regulates Histone-Histone Chaperone Interactions and DNA Replication-coupled Nucleosome Assembly in Budding Yeast.
R. J. Burgess, J. Han, and Z. Zhang (2014)
J. Biol. Chem. 289, 10518-10529
   Abstract »    Full Text »    PDF »
HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation.
B. Hu, S. Li, X. Zhang, and X. Zheng (2014)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Evolution and functional cross-talk of protein post-translational modifications.
P. Beltrao, P. Bork, N. J. Krogan, and V. van Noort (2014)
Mol Syst Biol 9, 714
   Abstract »    Full Text »    PDF »
Dynamic Regulation of the COP9 Signalosome in Response to DNA Damage.
M. G. Fuzesi-Levi, G. Ben-Nissan, E. Bianchi, H. Zhou, M. J. Deery, K. S. Lilley, Y. Levin, and M. Sharon (2014)
Mol. Cell. Biol. 34, 1066-1076
   Abstract »    Full Text »    PDF »
ATDC/TRIM29 Phosphorylation by ATM/MAPKAP Kinase 2 Mediates Radioresistance in Pancreatic Cancer Cells.
L. Wang, H. Yang, P. L. Palmbos, G. Ney, T. A. Detzler, D. Coleman, J. Leflein, M. Davis, M. Zhang, W. Tang, et al. (2014)
Cancer Res. 74, 1778-1788
   Abstract »    Full Text »    PDF »
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
D. A. Nathanson, A. L. Armijo, M. Tom, Z. Li, E. Dimitrova, W. R. Austin, J. Nomme, D. O. Campbell, L. Ta, T. M. Le, et al. (2014)
J. Exp. Med. 211, 473-486
   Abstract »    Full Text »    PDF »
Environmental Stress Affects the Activity of Metabolic and Growth Factor Signaling Networks and Induces Autophagy Markers in MCF7 Breast Cancer Cells.
P. Casado, B. Bilanges, V. Rajeeve, B. Vanhaesebroeck, and P. R. Cutillas (2014)
Mol. Cell. Proteomics 13, 836-848
   Abstract »    Full Text »    PDF »
An increase of oxidised nucleotides activates DNA damage checkpoint pathway that regulates post-embryonic development in Caenorhabditis elegans.
Y. Sanada and Q.-M. Zhang-Akiyama (2014)
Mutagenesis 29, 107-114
   Abstract »    Full Text »    PDF »
The Adherens Junction Protein Afadin Is an AKT Substrate that Regulates Breast Cancer Cell Migration.
S. Elloul, D. Kedrin, N. W. Knoblauch, A. H. Beck, and A. Toker (2014)
Mol. Cancer Res. 12, 464-476
   Abstract »    Full Text »    PDF »
Speckle-type POZ protein, SPOP, is involved in the DNA damage response.
D. Zhang, H. Wang, M. Sun, J. Yang, W. Zhang, S. Han, and B. Xu (2014)
   Abstract »    Full Text »    PDF »
A Novel DDB2-ATM Feedback Loop Regulates Human Cytomegalovirus Replication.
X. E, G. Savidis, C. R. Chin, S. Wang, S. Lu, A. L. Brass, and T. F. Kowalik (2014)
J. Virol. 88, 2279-2290
   Abstract »    Full Text »    PDF »
The Novel Zinc Finger Protein dASCIZ Regulates Mitosis in Drosophila via an Essential Role in Dynein Light-Chain Expression.
O. Zaytseva, N. Tenis, N. Mitchell, S.-i. Kanno, A. Yasui, J. Heierhorst, and L. M. Quinn (2014)
Genetics 196, 443-453
   Abstract »    Full Text »    PDF »
The Aspergillus nidulans ATM Kinase Regulates Mitochondrial Function, Glucose Uptake and the Carbon Starvation Response.
N. G. Krohn, N. A. Brown, A. C. Colabardini, T. Reis, M. Savoldi, T. M. Dinamarco, M. H. S. Goldman, and G. H. Goldman (2014)
g3 4, 49-62
   Abstract »    Full Text »    PDF »
Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length.
P. Gao, S.-H. Yoo, K.-J. Lee, C. Rosensweig, J. S. Takahashi, B. P. Chen, and C. B. Green (2013)
J. Biol. Chem. 288, 35277-35286
   Abstract »    Full Text »    PDF »
BaP-induced DNA damage initiated p53-independent necroptosis via the mitochondrial pathway involving Bax and Bcl-2.
Y. Jiang, X. Chen, G. Yang, Q. Wang, J. Wang, W. Xiong, and J. Yuan (2013)
Human and Experimental Toxicology 32, 1245-1257
   Abstract »    Full Text »    PDF »
SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition.
S. Hahn, R. Jackstadt, H. Siemens, S. Hunten, and H. Hermeking (2013)
EMBO J. 32, 3079-3095
   Abstract »    Full Text »    PDF »
Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition.
D. S. Kirkpatrick, D. J. Bustos, T. Dogan, J. Chan, L. Phu, A. Young, L. S. Friedman, M. Belvin, Q. Song, C. E. Bakalarski, et al. (2013)
PNAS 110, 19426-19431
   Abstract »    Full Text »    PDF »
Inactivation of Uaf1 Causes Defective Homologous Recombination and Early Embryonic Lethality in Mice.
E. Park, J. M. Kim, B. Primack, D. M. Weinstock, L. A. Moreau, K. Parmar, and A. D. D'Andrea (2013)
Mol. Cell. Biol. 33, 4360-4370
   Abstract »    Full Text »    PDF »
Identification of Proteins at Active, Stalled, and Collapsed Replication Forks Using Isolation of Proteins on Nascent DNA (iPOND) Coupled with Mass Spectrometry.
B. M. Sirbu, W. H. McDonald, H. Dungrawala, A. Badu-Nkansah, G. M. Kavanaugh, Y. Chen, D. L. Tabb, and D. Cortez (2013)
J. Biol. Chem. 288, 31458-31467
   Abstract »    Full Text »    PDF »
Interrogating cAMP-dependent Kinase Signaling in Jurkat T Cells via a Protein Kinase A Targeted Immune-precipitation Phosphoproteomics Approach.
P. Giansanti, M. P. Stokes, J. C. Silva, A. Scholten, and A. J. R. Heck (2013)
Mol. Cell. Proteomics 12, 3350-3359
   Abstract »    Full Text »    PDF »
A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation.
G. Wan, X. Hu, Y. Liu, C. Han, A. K. Sood, G. A. Calin, X. Zhang, and X. Lu (2013)
EMBO J. 32, 2833-2847
   Abstract »    Full Text »    PDF »
FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.
J. Zou, F. Tian, J. Li, W. Pickner, M. Long, K. Rezvani, H. Wang, and D. Zhang (2013)
Biology Open 2, 1022-1031
   Abstract »    Full Text »    PDF »
A specific N-terminal extension of the 8 kDa domain is required for DNA end-bridging by human Pol{micro} and Pol{lambda}.
M. J. Martin, M. V. Garcia-Ortiz, A. Gomez-Bedoya, V. Esteban, S. Guerra, and L. Blanco (2013)
Nucleic Acids Res. 41, 9105-9116
   Abstract »    Full Text »    PDF »
The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks.
S. M. H. Sy, J. Jiang, W. S. O, Y. Deng, and M. S. Y. Huen (2013)
Nucleic Acids Res. 41, 8572-8580
   Abstract »    Full Text »    PDF »
53BP1 Is Limiting for NHEJ Repair in ATM-deficient Model Systems That Are Subjected to Oncogenic Stress or Radiation.
I. Rybanska-Spaeder, T. L. Reynolds, J. Chou, M. Prakash, T. Jefferson, D. L. Huso, S. Desiderio, and S. Franco (2013)
Mol. Cancer Res. 11, 1223-1234
   Abstract »    Full Text »    PDF »
Brd4 Shields Chromatin from ATM Kinase Signaling Storms.
S. Choi and C. J. Bakkenist (2013)
Science Signaling 6, pe30
   Abstract »    Full Text »    PDF »
DNA Damage Sensing by the ATM and ATR Kinases.
A. Marechal and L. Zou (2013)
Cold Spring Harb Perspect Biol 5, a012716
   Abstract »    Full Text »    PDF »
The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage.
A. S. Mastrocola, S. H. Kim, A. T. Trinh, L. A. Rodenkirch, and R. S. Tibbetts (2013)
J. Biol. Chem. 288, 24731-24741
   Abstract »    Full Text »    PDF »
DNA structure-specific priming of ATR activation by DNA-PKcs.
S. Vidal-Eychenie, C. Decaillet, J. Basbous, and A. Constantinou (2013)
J. Cell Biol. 202, 421-429
   Abstract »    Full Text »    PDF »
Quantitative Measurement of Phosphoproteome Response to Osmotic Stress in Arabidopsis Based on Library-Assisted eXtracted Ion Chromatogram (LAXIC).
L. Xue, P. Wang, L. Wang, E. Renzi, P. Radivojac, H. Tang, R. Arnold, J.-K. Zhu, and W. A. Tao (2013)
Mol. Cell. Proteomics 12, 2354-2369
   Abstract »    Full Text »    PDF »
DNA Damage Response: Three Levels of DNA Repair Regulation.
B. M. Sirbu and D. Cortez (2013)
Cold Spring Harb Perspect Biol 5, a012724
   Abstract »    Full Text »    PDF »
EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.
E. A. Bard-Chapeau, J. Gunaratne, P. Kumar, B. Q. Chua, J. Muller, F. A. Bard, W. Blackstock, N. G. Copeland, and N. A. Jenkins (2013)
PNAS 110, E2885-E2894
   Abstract »    Full Text »    PDF »
Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress.
C. Bassi, J. Ho, T. Srikumar, R. J. O. Dowling, C. Gorrini, S. J. Miller, T. W. Mak, B. G. Neel, B. Raught, and V. Stambolic (2013)
Science 341, 395-399
   Abstract »    Full Text »    PDF »
Nuclear BAG6-UBL4A-GET4 Complex Mediates DNA Damage Signaling and Cell Death.
G. Krenciute, S. Liu, N. Yucer, Y. Shi, P. Ortiz, Q. Liu, B.-J. Kim, A. O. Odejimi, M. Leng, J. Qin, et al. (2013)
J. Biol. Chem. 288, 20547-20557
   Abstract »    Full Text »    PDF »
MEN1 Is a Melanoma Tumor Suppressor That Preserves Genomic Integrity by Stimulating Transcription of Genes That Promote Homologous Recombination-Directed DNA Repair.
M. Fang, F. Xia, M. Mahalingam, C.-M. Virbasius, N. Wajapeyee, and M. R. Green (2013)
Mol. Cell. Biol. 33, 2635-2647
   Abstract »    Full Text »    PDF »
The Nuclear Import of Oncoprotein Hepatitis B X-interacting Protein Depends on Interacting with c-Fos and Phosphorylation of Both Proteins in Breast Cancer Cells.
Y. Zhang, Y. Zhao, H. Li, Y. Li, X. Cai, Y. Shen, H. Shi, L. Li, Q. Liu, X. Zhang, et al. (2013)
J. Biol. Chem. 288, 18961-18974
   Abstract »    Full Text »    PDF »
A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.
R. Stewart, S. Kozlov, N. Matigian, G. Wali, M. Gatei, R. Sutharsan, B. Bellette, A. W. Kijas, J. Cochrane, M. Coulthard, et al. (2013)
Hum. Mol. Genet. 22, 2495-2509
   Abstract »    Full Text »    PDF »
ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status.
C. J. Huntoon, K. S. Flatten, A. E. Wahner Hendrickson, A. M. Huehls, S. L. Sutor, S. H. Kaufmann, and L. M. Karnitz (2013)
Cancer Res. 73, 3683-3691
   Abstract »    Full Text »    PDF »
ATM Kinase Inhibition Preferentially Sensitizes p53-Mutant Glioma to Ionizing Radiation.
L. Biddlestone-Thorpe, M. Sajjad, E. Rosenberg, J. M. Beckta, N. C. K. Valerie, M. Tokarz, B. R. Adams, A. F. Wagner, A. Khalil, D. Gilfor, et al. (2013)
Clin. Cancer Res. 19, 3189-3200
   Abstract »    Full Text »    PDF »
Regulation of FANCD2 by the mTOR Pathway Contributes to the Resistance of Cancer Cells to DNA Double-Strand Breaks.
C. Shen, D. Oswald, D. Phelps, H. Cam, C. E. Pelloski, Q. Pang, and P. J. Houghton (2013)
Cancer Res. 73, 3393-3401
   Abstract »    Full Text »    PDF »
ATM- and ATR-Mediated Phosphorylation of XRCC3 Regulates DNA Double-Strand Break-Induced Checkpoint Activation and Repair.
K. Somyajit, S. Basavaraju, R. Scully, and G. Nagaraju (2013)
Mol. Cell. Biol. 33, 1830-1844
   Abstract »    Full Text »    PDF »
The Innate Immune Response Transcription Factor Relish Is Necessary for Neurodegeneration in a Drosophila Model of Ataxia-Telangiectasia.
A. J. Petersen, R. J. Katzenberger, and D. A. Wassarman (2013)
Genetics 194, 133-142
   Abstract »    Full Text »    PDF »
Comparative Phosphoproteomic Analysis of Checkpoint Recovery Identifies New Regulators of the DNA Damage Response.
V. A. Halim, M. Alvarez-Fernandez, Y. J. Xu, M. Aprelia, H. W. P. van den Toorn, A. J. R. Heck, S. Mohammed, and R. H. Medema (2013)
Science Signaling 6, rs9
   Abstract »    Full Text »    PDF »
Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover.
B. Szakal and D. Branzei (2013)
EMBO J. 32, 1155-1167
   Abstract »    Full Text »    PDF »
ATR localizes to the photoreceptor connecting cilium and deficiency leads to severe photoreceptor degeneration in mice.
L. Valdes-Sanchez, B. De la Cerda, F. J. Diaz-Corrales, S. Massalini, C. F. Chakarova, A. F. Wright, and S. S. Bhattacharya (2013)
Hum. Mol. Genet. 22, 1507-1515
   Abstract »    Full Text »    PDF »
Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally.
M. Yekezare, B. Gomez-Gonzalez, and J. F. X. Diffley (2013)
J. Cell Sci. 126, 1297-1306
   Abstract »    Full Text »    PDF »
The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability.
J. Korczeniewska and B. J. Barnes (2013)
Mol. Cell. Biol. 33, 1124-1138
   Abstract »    Full Text »    PDF »
The Emergence of the Conserved AAA+ ATPases Pontin and Reptin on the Signaling Landscape.
J. Rosenbaum, S. H. Baek, A. Dutta, W. A. Houry, O. Huber, T. R. Hupp, and P. M. Matias (2013)
Science Signaling 6, mr1
   Abstract »    Full Text »    PDF »
Bone marrow transplantation improves the outcome of Atm-deficient mice through the migration of ATM-competent cells.
J. Pietzner, P. C. Baer, R. P. Duecker, M. B. Merscher, C. Satzger-Prodinger, I. Bechmann, A. Wietelmann, D. Del Turco, C. Doering, S. Kuci, et al. (2013)
Hum. Mol. Genet. 22, 493-507
   Abstract »    Full Text »    PDF »
Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress.
S.-Y. Choi, H. Jang, J.-S. Roe, S.-T. Kim, E.-J. Cho, and H.-D. Youn (2013)
Nucleic Acids Res. 41, 2180-2190
   Abstract »    Full Text »    PDF »
ISG15 Deregulates Autophagy in Genotoxin-treated Ataxia Telangiectasia Cells.
S. D. Desai, R. E. Reed, S. Babu, and E. A. Lorio (2013)
J. Biol. Chem. 288, 2388-2402
   Abstract »    Full Text »    PDF »
Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2.
I. Perez de Castro and M. Malumbres (2013)
Genes & Cancer
   Abstract »    Full Text »    PDF »
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
A. Bothmer, P. C. Rommel, A. Gazumyan, F. Polato, C. R. Reczek, M. F. Muellenbeck, S. Schaetzlein, W. Edelmann, P.-L. Chen, R. M. Brosh Jr., et al. (2013)
J. Exp. Med. 210, 115-123
   Abstract »    Full Text »    PDF »
The Cellular Ataxia Telangiectasia-Mutated Kinase Promotes Epstein-Barr Virus Lytic Reactivation in Response to Multiple Different Types of Lytic Reactivation-Inducing Stimuli.
S. R. Hagemeier, E. A. Barlow, Q. Meng, and S. C. Kenney (2012)
J. Virol. 86, 13360-13370
   Abstract »    Full Text »    PDF »
Sumoylation of SAE2 C Terminus Regulates SAE Nuclear Localization.
K. Truong, T. D. Lee, B. Li, and Y. Chen (2012)
J. Biol. Chem. 287, 42611-42619
   Abstract »    Full Text »    PDF »
Targeting Protein for Xenopus Kinesin-like Protein 2 (TPX2) Regulates {gamma}-Histone 2AX ({gamma}-H2AX) Levels upon Ionizing Radiation.
G. Neumayer, A. Helfricht, S. Y. Shim, H. T. Le, C. Lundin, C. Belzil, M. Chansard, Y. Yu, S. P. Lees-Miller, O. J. Gruss, et al. (2012)
J. Biol. Chem. 287, 42206-42222
   Abstract »    Full Text »    PDF »
Variation in Genes Related to Obesity, Weight, and Weight Change and Risk of Contralateral Breast Cancer in the WECARE Study Population.
J. D. Brooks, L. Bernstein, S. N. Teraoka, J. A. Knight, L. Mellemkjaer, E. M. John, K. E. Malone, A. S. Reiner, C. F. Lynch, P. Concannon, et al. (2012)
Cancer Epidemiol. Biomarkers Prev. 21, 2261-2267
   Abstract »    Full Text »    PDF »
Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities.
R. M. Finn, K. Ellard, J. M. Eirin-Lopez, and J. Ausio (2012)
FASEB J 26, 4788-4804
   Abstract »    Full Text »    PDF »
ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.
M. C. Humbert, K. Weihbrecht, C. C. Searby, Y. Li, R. M. Pope, V. C. Sheffield, and S. Seo (2012)
PNAS 109, 19691-19696
   Abstract »    Full Text »    PDF »
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.
W. R. Austin, A. L. Armijo, D. O. Campbell, A. S. Singh, T. Hsieh, D. Nathanson, H. R. Herschman, M. E. Phelps, O. N. Witte, J. Czernin, et al. (2012)
J. Exp. Med. 209, 2215-2228
   Abstract »    Full Text »    PDF »
The Saccharomyces cerevisiae Chromatin Remodeler Fun30 Regulates DNA End Resection and Checkpoint Deactivation.
V. V. Eapen, N. Sugawara, M. Tsabar, W.-H. Wu, and J. E. Haber (2012)
Mol. Cell. Biol. 32, 4727-4740
   Abstract »    Full Text »    PDF »
Toward an Improved Definition of the Tumor Spectrum Associated With BAP1 Germline Mutations.
T. Wiesner, I. Fried, P. Ulz, E. Stacher, H. Popper, R. Murali, H. Kutzner, S. Lax, F. Smolle-Juttner, J. B. Geigl, et al. (2012)
J. Clin. Oncol. 30, e337-e340
   Full Text »    PDF »
The centriolar satellite protein Cep131 is important for genome stability.
C. J. Staples, K. N. Myers, R. D. D. Beveridge, A. A. Patil, A. J. X. Lee, C. Swanton, M. Howell, S. J. Boulton, and S. J. Collis (2012)
J. Cell Sci. 125, 4770-4779
   Abstract »    Full Text »    PDF »
Activation of the ATM-Snail pathway promotes breast cancer metastasis.
M. Sun, X. Guo, X. Qian, H. Wang, C. Yang, K. L. Brinkman, M. Serrano-Gonzalez, R. S. Jope, B. Zhou, D. A. Engler, et al. (2012)
J Mol Cell Biol 4, 304-315
   Abstract »    Full Text »    PDF »
Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage.
C. Yang, M. Lee, J. Hao, X. Cui, X. Guo, C. Smal, F. Bontemps, S. Ma, X. Liu, D. Engler, et al. (2012)
Nucleic Acids Res. 40, 9621-9632
   Abstract »    Full Text »    PDF »
Searching for the Holy Grail; protein-protein interaction analysis and modulation.
X. Morelli and T. Hupp (2012)
EMBO Rep. 13, 877-879
   Abstract »    Full Text »    PDF »
Systematic Analysis of Protein Phosphorylation Networks From Phosphoproteomic Data.
C. Song, M. Ye, Z. Liu, H. Cheng, X. Jiang, G. Han, Z. Songyang, Y. Tan, H. Wang, J. Ren, et al. (2012)
Mol. Cell. Proteomics 11, 1070-1083
   Abstract »    Full Text »    PDF »
Signaling Pathways that Regulate Cell Division.
N. Rhind and P. Russell (2012)
Cold Spring Harb Perspect Biol 4, a005942
   Abstract »    Full Text »    PDF »
Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex.
I. M. Munoz, T. MacArtney, L. Sanchez-Pulido, C. P. Ponting, S. Rocha, and J. Rouse (2012)
J. Biol. Chem. 287, 32346-32353
   Abstract »    Full Text »    PDF »
Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks.
B. A. Joughin, C. Liu, D. A. Lauffenburger, C. W. V. Hogue, and M. B. Yaffe (2012)
Phil Trans R Soc B 367, 2574-2583
   Abstract »    Full Text »    PDF »
Charting the Landscape of Tandem BRCT Domain-Mediated Protein Interactions.
N. T. Woods, R. D. Mesquita, M. Sweet, M. A. Carvalho, X. Li, Y. Liu, H. Nguyen, C. E. Thomas, E. S. Iversen Jr., S. Marsillac, et al. (2012)
Science Signaling 5, rs6
   Abstract »    Full Text »    PDF »
Sp1 Facilitates DNA Double-Strand Break Repair through a Nontranscriptional Mechanism.
K. Beishline, C. M. Kelly, B. A. Olofsson, S. Koduri, J. Emrich, R. A. Greenberg, and J. Azizkhan-Clifford (2012)
Mol. Cell. Biol. 32, 3790-3799
   Abstract »    Full Text »    PDF »
Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase.
S. Kocher, T. Rieckmann, G. Rohaly, W. Y. Mansour, E. Dikomey, I. Dornreiter, and J. Dahm-Daphi (2012)
Nucleic Acids Res. 40, 8336-8347
   Abstract »    Full Text »    PDF »
Human Papillomaviruses Recruit Cellular DNA Repair and Homologous Recombination Factors to Viral Replication Centers.
K. A. Gillespie, K. P. Mehta, L. A. Laimins, and C. A. Moody (2012)
J. Virol. 86, 9520-9526
   Abstract »    Full Text »    PDF »
Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex.
I. Ilves, N. Tamberg, and M. R. Botchan (2012)
PNAS 109, 13163-13170
   Abstract »    Full Text »    PDF »
Loss of ATM kinase activity leads to embryonic lethality in mice.
J. A. Daniel, M. Pellegrini, B.-S. Lee, Z. Guo, D. Filsuf, N. V. Belkina, Z. You, T. T. Paull, B. P. Sleckman, L. Feigenbaum, et al. (2012)
J. Cell Biol. 198, 295-304
   Abstract »    Full Text »    PDF »
The ATM protein: The importance of being active.
Y. Shiloh and Y. Ziv (2012)
J. Cell Biol. 198, 273-275
   Abstract »    Full Text »    PDF »
Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.
G. Balmus, M. Zhu, S. Mukherjee, A. M. Lyndaker, K. R. Hume, J. Lee, M. L. Riccio, A. P. Reeves, N. B. Sutter, D. M. Noden, et al. (2012)
Hum. Mol. Genet. 21, 3408-3420
   Abstract »    Full Text »    PDF »
Omcg1 is critically required for mitosis in rapidly dividing mouse intestinal progenitors and embryonic stem cells.
T. Leguillier, S. Vandormael-Pournin, J. Artus, M. Houlard, C. Picard, F. Bernex, S. Robine, and M. Cohen-Tannoudji (2012)
Biology Open 1, 648-657
   Abstract »    Full Text »    PDF »
Homologous recombination and its regulation.
L. Krejci, V. Altmannova, M. Spirek, and X. Zhao (2012)
Nucleic Acids Res. 40, 5795-5818
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882