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Quantitative Morphological Signatures Define Local Signaling Networks Regulating Cell Morphology
Although classical genetic and biochemical approaches have identifiedhundreds of proteins that function in the dynamic remodelingof cell shape in response to upstream signals, there is currentlylittle systems-level understanding of the organization and compositionof signaling networks that regulate cell morphology. We havedeveloped quantitative morphological profiling methods to systematicallyinvestigate the role of individual genes in the regulation ofcell morphology in a fast, robust, and cost-efficient manner.We analyzed a compendium of quantitative morphological signaturesand described the existence of local signaling networks thatact to regulate cell protrusion, adhesion, and tension.
1 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. 2 Howard Hughes Medical Institute, Boston, MA 02215, USA. 3 MIT Computer Science and Technology Laboratory, Cambridge, MA 02139, USA.
* These authors contributed equally to this work.
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