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Science 316 (5833): 1901-1904

Copyright © 2007 by the American Association for the Advancement of Science

Dopamine-Mushroom Body Circuit Regulates Saliency-Based Decision-Making in Drosophila

Ke Zhang,1,2 Jian Zeng Guo,1 Yueqing Peng,1,2 Wang Xi,1,2 Aike Guo1,3*

Abstract: Drosophila melanogaster can make appropriate choices among alternative flight options on the basis of the relative salience of competing visual cues. We show that this choice behavior consists of early and late phases; the former requires activation of the dopaminergic system and mushroom bodies, whereas the latter is independent of these activities. Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila.

1 Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), 320 Yueyang Road, Shanghai 200031, China.
2 Graduate School of Chinese Academy of Sciences, Beijing 100049, China.
3 State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, CAS, 15 Datun Road, Chaoyang District, Beijing 100101, China.

* To whom correspondence should be addressed. E-mail: akguo{at}ion.ac.cn

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