Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 317 (5834): 121-124

Copyright © 2007 by the American Association for the Advancement of Science

Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production

Willscott E. Naugler,1,2 Toshiharu Sakurai,1 Sunhwa Kim,1 Shin Maeda,3 KyoungHyun Kim,1 Ahmed M. Elsharkawy,1,4 Michael Karin1*

Abstract: Hepatocellular carcinoma (HCC), the most common liver cancer, occurs mainly in men. Similar gender disparity is seen in mice given a chemical carcinogen, diethylnitrosamine (DEN). DEN administration caused greater increases in serum interleukin-6 (IL-6) concentration in males than it did in females. Furthermore, ablation of IL-6 abolished the gender differences in hepatocarcinogenesis in mice. DEN exposure promoted production of IL-6 in Kupffer cells (KCs) in a manner dependent on the Toll-like receptor adaptor protein MyD88, ablation of which also protected male mice from DEN-induced hepatocarcinogenesis. Estrogen inhibited secretion of IL-6 from KCs exposed to necrotic hepatocytes and reduced circulating concentrations of IL-6 in DEN-treated male mice. We propose that estrogen-mediated inhibition of IL-6 production by KCs reduces liver cancer risk in females, and these findings may be used to prevent HCC in males.

1 Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, University of California, San Diego, CA 93093, USA.
2 Department of Medicine, Division of Gastroenterology, University of California, San Diego, CA 93093, USA.
3 Division of Gastroenterology, The Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo 100-0005, Japan.
4 Liver Research Group, University of Newcastle, Newcastle Upon Tyne NE2 4HH, UK.

* To whom correspondence should be addressed: 9500 Gilman Road, Mail Code 0723 University of California, San Diego, San Diego, CA 92093–0636, USA. E-mail: karinoffice{at}ucsd.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hepatocellular carcinoma: clinical frontiers and perspectives.
J. Bruix, G. J. Gores, and V. Mazzaferro (2014)
Gut 63, 844-855
   Abstract »    Full Text »    PDF »
Microphysiological modeling of the reproductive tract: A fertile endeavor.
S. L. Eddie, J. J. Kim, T. K. Woodruff, and J. E. Burdette (2014)
Experimental Biology and Medicine
   Abstract »    Full Text »    PDF »
Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion.
R. Luisier, E. B. Unterberger, J. I. Goodman, M. Schwarz, J. Moggs, R. Terranova, and E. van Nimwegen (2014)
Nucleic Acids Res. 42, 4180-4195
   Abstract »    Full Text »    PDF »
Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer.
J. Heijmans, M. C. B. Wielenga, S. L. Rosekrans, J. F. van Lidth de Jeude, J. Roelofs, P. Groothuis, A. Ederveen, E. S. M. de Jonge-Muller, I. Biemond, J. C. H. Hardwick, et al. (2014)
Gut 63, 310-316
   Abstract »    Full Text »    PDF »
MicroRNAs and liver disease: viral hepatitis, liver fibrosis and hepatocellular carcinoma.
G. Li, G. Cai, D. Li, and W. Yin (2014)
Postgrad. Med. J. 90, 106-112
   Abstract »    Full Text »    PDF »
Deficiency of the Myeloid Differentiation Primary Response Molecule MyD88 Leads to an Early and Rapid Development of Helicobacter-Induced Gastric Malignancy.
A. Banerjee, S. Thamphiwatana, E. M. Carmona, B. Rickman, K. S. Doran, and M. Obonyo (2014)
Infect. Immun. 82, 356-363
   Abstract »    Full Text »    PDF »
Evaluation of Metabolite Biomarkers for Hepatocellular Carcinoma through Stratified Analysis by Gender, Race, and Alcoholic Cirrhosis.
J. Xiao, Y. Zhao, R. S. Varghese, B. Zhou, C. Di Poto, L. Zhang, M. G. Tadesse, D. H. Ziada, K. Shetty, and H. W. Ressom (2014)
Cancer Epidemiol. Biomarkers Prev. 23, 64-72
   Abstract »    Full Text »    PDF »
Male-Specific W4P/R Mutation in the Pre-S1 Region of Hepatitis B Virus, Increasing the Risk of Progression of Liver Diseases in Chronic Patients.
S.-A. Lee, K.-J. Kim, D.-W. Kim, and B.-J. Kim (2013)
J. Clin. Microbiol. 51, 3928-3936
   PDF »
Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation.
Q. Zhong, G. Shi, Q. Zhang, Y. Zhang, D. Levy, and S. Zhong (2013)
Carcinogenesis 34, 2460-2469
   Abstract »    Full Text »    PDF »
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.
B. Xu, S.-H. Li, R. Zheng, S.-B. Gao, L.-H. Ding, Z.-Y. Yin, X. Lin, Z.-J. Feng, S. Zhang, X.-M. Wang, et al. (2013)
PNAS 110, 17480-17485
   Abstract »    Full Text »    PDF »
LIM-Only Protein FHL2 Activates NF-{kappa}B Signaling in the Control of Liver Regeneration and Hepatocarcinogenesis.
J. Dahan, Y. Nouet, G. Jouvion, F. Levillayer, M. Adib-Conquy, A.-M. Cassard-Doulcier, A. Tebbi, F. Blanc, L. Remy, J. Chen, et al. (2013)
Mol. Cell. Biol. 33, 3299-3308
   Abstract »    Full Text »    PDF »
Evidence for a Gender-Specific Protective Role of Innate Immune Receptors in a Model of Perinatal Brain Injury.
P. M. Pimentel-Coelho, J.-P. Michaud, and S. Rivest (2013)
J. Neurosci. 33, 11556-11572
   Abstract »    Full Text »    PDF »
TLR agonists: our best frenemy in cancer immunotherapy.
S. Kaczanowska, A. M. Joseph, and E. Davila (2013)
J. Leukoc. Biol. 93, 847-863
   Abstract »    Full Text »    PDF »
Myeloid Differentiation Factor 88 Promotes Growth and Metastasis of Human Hepatocellular Carcinoma.
B. Liang, R. Chen, T. Wang, L. Cao, Y. Liu, F. Yin, M. Zhu, X. Fan, Y. Liang, L. Zhang, et al. (2013)
Clin. Cancer Res. 19, 2905-2916
   Abstract »    Full Text »    PDF »
Alteration of the Serum N-glycome of Mice Locally Exposed to High Doses of Ionizing Radiation.
T. Chaze, M.-C. Slomianny, F. Milliat, G. Tarlet, T. Lefebvre-Darroman, P. Gourmelon, E. Bey, M. Benderitter, J.-C. Michalski, and O. Guipaud (2013)
Mol. Cell. Proteomics 12, 283-301
   Abstract »    Full Text »    PDF »
Proinflammatory Homeobox Gene, ISX, Regulates Tumor Growth and Survival in Hepatocellular Carcinoma.
S.-H. Hsu, L.-T. Wang, K.-T. Lee, Y.-L. Chen, K.-Y. Liu, J.-L. Suen, C.-Y. Chai, and S.-N. Wang (2013)
Cancer Res. 73, 508-518
   Abstract »    Full Text »    PDF »
MyD88: A Critical Adaptor Protein in Innate Immunity Signal Transduction.
N. Warner and G. Nunez (2013)
J. Immunol. 190, 3-4
   Full Text »    PDF »
p38{alpha} Inhibits Liver Fibrogenesis and Consequent Hepatocarcinogenesis by Curtailing Accumulation of Reactive Oxygen Species.
T. Sakurai, M. Kudo, A. Umemura, G. He, A. M. Elsharkawy, E. Seki, and M. Karin (2013)
Cancer Res. 73, 215-224
   Abstract »    Full Text »    PDF »
Gender Differences in Chemical Carcinogenesis in National Toxicology Program 2-Year Bioassays.
S. Kadekar, S. Peddada, I. Silins, J. E. French, J. Hogberg, and U. Stenius (2012)
Toxicol Pathol 40, 1160-1168
   Abstract »    Full Text »    PDF »
Estrogen Represses Hepatocellular Carcinoma (HCC) Growth via Inhibiting Alternative Activation of Tumor-associated Macrophages (TAMs).
W. Yang, Y. Lu, Y. Xu, L. Xu, W. Zheng, Y. Wu, L. Li, and P. Shen (2012)
J. Biol. Chem. 287, 40140-40149
   Abstract »    Full Text »    PDF »
Resveratrol inhibits LPS-induced epithelial-mesenchymal transition in mouse melanoma model.
M.-C. Chen, W.-W. Chang, Y.-D. Kuan, S.-T. Lin, H.-C. Hsu, and C.-H. Lee (2012)
Innate Immunity 18, 685-693
   Abstract »    Full Text »    PDF »
Does Childhood Misfortune Increase Cancer Risk in Adulthood?.
P. M. Morton, M. H. Schafer, and K. F. Ferraro (2012)
J Aging Health 24, 948-984
   Abstract »    PDF »
The Great Escape: Microbiotal LPS Takes a Toll on the Liver.
D. S. Weiss (2012)
Cancer Prevention Research 5, 1078-1080
   Abstract »    Full Text »    PDF »
The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma.
J. Wu, J. Li, R. Salcedo, N. F. Mivechi, G. Trinchieri, and A. Horuzsko (2012)
Cancer Res. 72, 3977-3986
   Abstract »    Full Text »    PDF »
Context-specific roles for paracrine IL-6 in lymphomagenesis.
L. A. Gilbert and M. T. Hemann (2012)
Genes & Dev. 26, 1758-1768
   Abstract »    Full Text »    PDF »
A Single Neonatal Exposure to Aflatoxin B1 Induces Prolonged Genetic Damage in Two Loci of Mouse Liver.
R. Wattanawaraporn, L. L. Woo, C. Belanger, S.-c. Chang, J. E. Adams, L. J. Trudel, J. T. Bouhenguel, P. A. Egner, J. D. Groopman, R. G. Croy, et al. (2012)
Toxicol. Sci. 128, 326-333
   Abstract »    Full Text »    PDF »
Induction of hepatocellular carcinoma by in vivo gene targeting.
P.-R. Wang, M. Xu, S. Toffanin, Y. Li, J. M. Llovet, and D. W. Russell (2012)
PNAS 109, 11264-11269
   Abstract »    Full Text »    PDF »
Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-{alpha}.
K. Kanda, H. Komekado, T. Sawabu, S. Ishizu, Y. Nakanishi, M. Nakatsuji, R. Akitake-Kawano, M. Ohno, Y. Hiraoka, M. Kawada, et al. (2012)
EMBO Mol Med. 4, 396-411
   Abstract »    Full Text »    PDF »
Inorganic mercury exposure in prairie voles (Microtus ochrogaster) alters the expression of toll-like receptor 4 and activates inflammatory pathways in the liver in a sex-specific manner.
S. Assefa, J. Curtis, S. Sethi, R. Davis, Y. Chen, and R. Kaul (2012)
Human and Experimental Toxicology 31, 376-386
   Abstract »    Full Text »    PDF »
Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma.
V. Chew, J. Chen, D. Lee, E. Loh, J. Lee, K. H. Lim, A. Weber, K. Slankamenac, R. T. P. Poon, H. Yang, et al. (2012)
Gut 61, 427-438
   Abstract »    Full Text »    PDF »
Metastatic Cells Can Escape the Proapoptotic Effects of TNF-{alpha} through Increased Autocrine IL-6/STAT3 Signaling.
S. Li, N. Wang, and P. Brodt (2012)
Cancer Res. 72, 865-875
   Abstract »    Full Text »    PDF »
Diethylnitrosamine-induced hepatocarcinogenesis is suppressed in lecithin:retinol acyltransferase-deficient mice primarily through retinoid actions immediately after carcinogen administration.
Y. Shirakami, M. E. Gottesman, and W. S. Blaner (2012)
Carcinogenesis 33, 268-274
   Abstract »    Full Text »    PDF »
2-Amino-3-Methylimidazo[4,5-f]Quinoline (IQ) Promotes Mouse Hepatocarcinogenesis by Activating Transforming Growth Factor-{beta} and Wnt/{beta}-Catenin Signaling Pathways.
X.-L. Xie, M. Wei, A. Kakehashi, S. Yamano, M. Tajiri, and H. Wanibuchi (2012)
Toxicol. Sci. 125, 392-400
   Abstract »    Full Text »    PDF »
Interleukin-11 Links Oxidative Stress and Compensatory Proliferation.
T. Nishina, S. Komazawa-Sakon, S. Yanaka, X. Piao, D.-M. Zheng, J.-H. Piao, Y. Kojima, S. Yamashina, E. Sano, T. Putoczki, et al. (2012)
Science Signaling 5, ra5
   Abstract »    Full Text »    PDF »
JNK-Induced Apoptosis, Compensatory Growth, and Cancer Stem Cells.
F. Chen (2012)
Cancer Res. 72, 379-386
   Abstract »    Full Text »    PDF »
CUEDC2 (CUE Domain-containing 2) and SOCS3 (Suppressors of Cytokine Signaling 3) Cooperate to Negatively Regulate Janus Kinase 1/Signal Transducers and Activators of Transcription 3 Signaling.
W.-N. Zhang, L. Wang, Q. Wang, X. Luo, D.-F. Fang, Y. Chen, X. Pan, J.-H. Man, Q. Xia, B.-F. Jin, et al. (2012)
J. Biol. Chem. 287, 382-392
   Abstract »    Full Text »    PDF »
A Critical Role for Macrophages in Promotion of Urethane-Induced Lung Carcinogenesis.
R. Zaynagetdinov, T. P. Sherrill, V. V. Polosukhin, W. Han, J. A. Ausborn, A. G. McLoed, F. B. McMahon, L. A. Gleaves, A. L. Degryse, G. T. Stathopoulos, et al. (2011)
J. Immunol. 187, 5703-5711
   Abstract »    Full Text »    PDF »
CDC23 regulates cancer cell phenotype and is overexpressed in papillary thyroid cancer.
L. Zhang, R. Rahbari, M. He, and E. Kebebew (2011)
Endocr. Relat. Cancer 18, 731-742
   Abstract »    Full Text »    PDF »
Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice.
R. S. Scotland, M. J. Stables, S. Madalli, P. Watson, and D. W. Gilroy (2011)
Blood 118, 5918-5927
   Abstract »    Full Text »    PDF »
Evolution of the TIR Domain-Containing Adaptors in Humans: Swinging between Constraint and Adaptation.
S. Fornarino, G. Laval, L. B. Barreiro, J. Manry, E. Vasseur, and L. Quintana-Murci (2011)
Mol. Biol. Evol. 28, 3087-3097
   Abstract »    Full Text »    PDF »
Interleukin-6 as a Therapeutic Target in Human Ovarian Cancer.
J. Coward, H. Kulbe, P. Chakravarty, D. Leader, V. Vassileva, D. A. Leinster, R. Thompson, T. Schioppa, J. Nemeth, J. Vermeulen, et al. (2011)
Clin. Cancer Res. 17, 6083-6096
   Abstract »    Full Text »    PDF »
Human serum N-glycan profiles are age and sex dependent.
N. Ding, H. Nie, X. Sun, W. Sun, Y. Qu, X. Liu, Y. Yao, X. Liang, C. C. Chen, and Y. Li (2011)
Age Ageing 40, 568-575
   Abstract »    Full Text »    PDF »
Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis.
J. Kluwe, N. Wongsiriroj, J. S. Troeger, G.-Y. Gwak, D. H. Dapito, J.-P. Pradere, H. Jiang, M. Siddiqi, R. Piantedosi, S. M. O'Byrne, et al. (2011)
Gut 60, 1260-1268
   Abstract »    Full Text »    PDF »
CXCR3 Enhances a T-Cell-Dependent Epidermal Proliferative Response and Promotes Skin Tumorigenesis.
A. E. Winkler, J. J. Brotman, M. E. Pittman, N. P. Judd, J. S. Lewis Jr, R. D. Schreiber, and R. Uppaluri (2011)
Cancer Res. 71, 5707-5716
   Abstract »    Full Text »    PDF »
Exercise-induced muscle-derived cytokines inhibit mammary cancer cell growth.
P. Hojman, C. Dethlefsen, C. Brandt, J. Hansen, L. Pedersen, and B. K. Pedersen (2011)
Am J Physiol Endocrinol Metab 301, E504-E510
   Abstract »    Full Text »    PDF »
17{beta}-Estradiol and Tamoxifen Prevent Gastric Cancer by Modulating Leukocyte Recruitment and Oncogenic Pathways in Helicobacter Pylori-Infected INS-GAS Male Mice.
A. Sheh, Z. Ge, N. M. A. Parry, S. Muthupalani, J. E. Rager, A. R. Raczynski, M. W. Mobley, A. F. McCabe, R. C. Fry, T. C. Wang, et al. (2011)
Cancer Prevention Research 4, 1426-1435
   Abstract »    Full Text »    PDF »
miR-22 Promotes HBV-Related Hepatocellular Carcinoma Development in Males.
R. Jiang, L. Deng, L. Zhao, X. Li, F. Zhang, Y. Xia, Y. Gao, X. Wang, and B. Sun (2011)
Clin. Cancer Res. 17, 5593-5603
   Abstract »    Full Text »    PDF »
The role for estrogen receptor-alpha and prolactin receptor in sex-dependent DEN-induced liver tumorigenesis.
R. M. Bigsby and A. Caperell-Grant (2011)
Carcinogenesis 32, 1162-1166
   Abstract »    Full Text »    PDF »
Chemotherapeutic Resistance: Surviving Stressful Situations.
L. A. Gilbert and M. T. Hemann (2011)
Cancer Res. 71, 5062-5066
   Abstract »    Full Text »    PDF »
Celecoxib Inhibits Interleukin-6/Interleukin-6 Receptor-Induced JAK2/STAT3 Phosphorylation in Human Hepatocellular Carcinoma Cells.
Y. Liu, A. Liu, H. Li, C. Li, and J. Lin (2011)
Cancer Prevention Research 4, 1296-1305
   Abstract »    Full Text »    PDF »
Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells.
M. Jinushi, S. Chiba, H. Yoshiyama, K. Masutomi, I. Kinoshita, H. Dosaka-Akita, H. Yagita, A. Takaoka, and H. Tahara (2011)
PNAS 108, 12425-12430
   Abstract »    Full Text »    PDF »
Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data.
Y. Tao, J. Ruan, S.-H. Yeh, X. Lu, Y. Wang, W. Zhai, J. Cai, S. Ling, Q. Gong, Z. Chong, et al. (2011)
PNAS 108, 12042-12047
   Abstract »    Full Text »    PDF »
Aflatoxin B1-DNA Adduct Formation and Mutagenicity in Livers of Neonatal Male and Female B6C3F1 Mice.
L. L. Woo, P. A. Egner, C. L. Belanger, R. Wattanawaraporn, L. J. Trudel, R. G. Croy, J. D. Groopman, J. M. Essigmann, and G. N. Wogan (2011)
Toxicol. Sci. 122, 38-44
   Abstract »    Full Text »    PDF »
HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis.
Z. C. Hartman, X.-Y. Yang, O. Glass, G. Lei, T. Osada, S. S. Dave, M. A. Morse, T. M. Clay, and H. K. Lyerly (2011)
Cancer Res. 71, 4380-4391
   Abstract »    Full Text »    PDF »
Intratumoral Administration of TLR4 Agonist Absorbed into a Cellular Vector Improves Antitumor Responses.
M. B. Davis, D. Vasquez-Dunddel, J. Fu, E. Albesiano, D. Pardoll, and Y. J. Kim (2011)
Clin. Cancer Res. 17, 3984-3992
   Abstract »    Full Text »    PDF »
Chronic Inflammatory IFN-{gamma} Signaling Suppresses Hepatocarcinogenesis in Mice by Sensitizing Hepatocytes for Apoptosis.
S. Luth, J. Schrader, S. Zander, A. Carambia, J. Buchkremer, S. Huber, K. Reifenberg, K.-I. Yamamura, P. Schirmacher, A. W. Lohse, et al. (2011)
Cancer Res. 71, 3763-3771
   Abstract »    Full Text »    PDF »
Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion.
R. D. Schreiber, L. J. Old, and M. J. Smyth (2011)
Science 331, 1565-1570
   Abstract »    Full Text »    PDF »
The role of JNK in the development of hepatocellular carcinoma.
M. Das, D. S. Garlick, D. L. Greiner, and R. J. Davis (2011)
Genes & Dev. 25, 634-645
   Abstract »    Full Text »    PDF »
Preventive Effects of (-)-Epigallocatechin Gallate on Diethylnitrosamine-Induced Liver Tumorigenesis in Obese and Diabetic C57BL/KsJ-db/db Mice.
M. Shimizu, H. Sakai, Y. Shirakami, Y. Yasuda, M. Kubota, D. Terakura, A. Baba, T. Ohno, Y. Hara, T. Tanaka, et al. (2011)
Cancer Prevention Research 4, 396-403
   Abstract »    Full Text »    PDF »
Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage.
S. I. Grivennikov and M. Karin (2011)
Ann Rheum Dis 70, i104-i108
   Abstract »    Full Text »    PDF »
Interleukin 6, but Not T Helper 2 Cytokines, Promotes Lung Carcinogenesis.
C. E. Ochoa, S. G. Mirabolfathinejad, V. A. Ruiz, S. E. Evans, M. Gagea, C. M. Evans, B. F. Dickey, and S. J. Moghaddam (2011)
Cancer Prevention Research 4, 51-64
   Abstract »    Full Text »    PDF »
Acyclic Retinoid Inhibits Diethylnitrosamine-Induced Liver Tumorigenesis in Obese and Diabetic C57BLKS/J- +Leprdb/+Leprdb Mice.
M. Shimizu, H. Sakai, Y. Shirakami, J. Iwasa, Y. Yasuda, M. Kubota, K. Takai, H. Tsurumi, T. Tanaka, and H. Moriwaki (2011)
Cancer Prevention Research 4, 128-136
   Abstract »    Full Text »    PDF »
Isoflurane activates intestinal sphingosine kinase to protect against bilateral nephrectomy-induced liver and intestine dysfunction.
M. Kim, S. W. Park, M. Kim, V. D. D'Agati, and H. T. Lee (2011)
Am J Physiol Renal Physiol 300, F167-F176
   Abstract »    Full Text »    PDF »
gp130 at the nexus of inflammation, autoimmunity, and cancer.
J. S. Silver and C. A. Hunter (2010)
J. Leukoc. Biol. 88, 1145-1156
   Abstract »    Full Text »    PDF »
Interleukin 6/Interleukin 6 Receptor Interaction and its Role as a Therapeutic Target for Treatment of Cachexia and Cancer.
U. H. WEIDLE, S. KLOSTERMANN, D. EGGLE, and A. KRUGER (2010)
Cancer Genomics Proteomics 7, 287-302
   Abstract »    Full Text »    PDF »
Sexually Dimorphic Actions of Glucocorticoids Provide a Link to Inflammatory Diseases with Gender Differences in Prevalence.
D. Duma, J. B. Collins, J. W. Chou, and J. A. Cidlowski (2010)
Science Signaling 3, ra74
   Abstract »    Full Text »    PDF »
B7-H1-Dependent Sex-Related Differences in Tumor Immunity and Immunotherapy Responses.
P.-Y. Lin, L. Sun, S. R. Thibodeaux, S. M. Ludwig, R. K. Vadlamudi, V. J. Hurez, R. Bahar, M. J. Kious, C. B. Livi, S. R. Wall, et al. (2010)
J. Immunol. 185, 2747-2753
   Abstract »    Full Text »    PDF »
Inhibition of STAT3 Signaling Blocks the Anti-apoptotic Activity of IL-6 in Human Liver Cancer Cells.
Y. Liu, P.-K. Li, C. Li, and J. Lin (2010)
J. Biol. Chem. 285, 27429-27439
   Abstract »    Full Text »    PDF »
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18.
R. Salcedo, A. Worschech, M. Cardone, Y. Jones, Z. Gyulai, R.-M. Dai, E. Wang, W. Ma, D. Haines, C. O'hUigin, et al. (2010)
J. Exp. Med. 207, 1625-1636
   Abstract »    Full Text »    PDF »
Estrogen Receptors and Endothelium.
J.-F. Arnal, C. Fontaine, A. Billon-Gales, J. Favre, H. Laurell, F. Lenfant, and P. Gourdy (2010)
Arterioscler Thromb Vasc Biol 30, 1506-1512
   Abstract »    Full Text »    PDF »
Apoptosis-promoted tumorigenesis: {gamma}-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death.
E. M. Michalak, C. J. Vandenberg, A. R. D. Delbridge, L. Wu, C. L. Scott, J. M. Adams, and A. Strasser (2010)
Genes & Dev. 24, 1608-1613
   Abstract »    Full Text »    PDF »
TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells.
D. Mittal, F. Saccheri, E. Venereau, T. Pusterla, M. E. Bianchi, and M. Rescigno (2010)
EMBO J. 29, 2242-2252
   Abstract »    Full Text »    PDF »
Ontogenetic Complexity of Sexual Dimorphism and Sex-Specific Selection.
J. E. Mank, K. Nam, B. Brunstrom, and H. Ellegren (2010)
Mol. Biol. Evol. 27, 1570-1578
   Abstract »    Full Text »    PDF »
Toll-Like Receptor 6 Ser249Pro Polymorphism Is Associated With Lower Left Ventricular Wall Thickness and Inflammatory Response in Hypertensive Women.
M. L. Sales, R. Schreiber, M. C. S. Ferreira-Sae, M. N. Fernandes, C. S. C. Piveta, J. A. A. Cipolli, C. C. Cardoso, J. R. Matos-Souza, B. Geloneze, K. G. Franchini, et al. (2010)
Am J Hypertens 23, 649-654
   Abstract »    Full Text »    PDF »
Resveratrol Suppresses Oxidative Stress and Inflammatory Response in Diethylnitrosamine-Initiated Rat Hepatocarcinogenesis.
A. Bishayee, K. F. Barnes, D. Bhatia, A. S. Darvesh, and R. T. Carroll (2010)
Cancer Prevention Research 3, 753-763
   Abstract »    Full Text »    PDF »
Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor.
M. K. Connolly, J. Mallen-St. Clair, A. S. Bedrosian, A. Malhotra, V. Vera, J. Ibrahim, J. Henning, H. L. Pachter, D. Bar-Sagi, A. B. Frey, et al. (2010)
J. Leukoc. Biol. 87, 713-725
   Abstract »    Full Text »    PDF »
Toll-like Receptor 3-Mediated Suppression of TRAMP Prostate Cancer Shows the Critical Role of Type I Interferons in Tumor Immune Surveillance.
A. I. Chin, A. K. Miyahira, A. Covarrubias, J. Teague, B. Guo, P. W. Dempsey, and G. Cheng (2010)
Cancer Res. 70, 2595-2603
   Abstract »    Full Text »    PDF »
Interleukin-6: a therapeutic Jekyll and Hyde in gastrointestinal and hepatic diseases.
S. Danese and B. Gao (2010)
Gut 59, 149-151
   Full Text »    PDF »
CADPE Suppresses Cyclin D1 Expression in Hepatocellular Carcinoma by Blocking IL-6-induced STAT3 Activation.
C. WON, C. S. LEE, J.-K. LEE, T.-J. KIM, K.-H. LEE, Y. M. YANG, Y.-N. KIM, S.-K. YE, and M.-H. CHUNG (2010)
Anticancer Res 30, 481-488
   Abstract »    Full Text »    PDF »
Nuclear Factor-{kappa}B and Tumor-Associated Macrophages.
A. Mancino and T. Lawrence (2010)
Clin. Cancer Res. 16, 784-789
   Abstract »    Full Text »    PDF »
Roles for Inflammation and Regulatory T Cells in Colon Cancer.
S. E. Erdman and T. Poutahidis (2010)
Toxicol Pathol 38, 76-87
   Abstract »    Full Text »    PDF »
Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens.
J G Fox, Y Feng, E J Theve, A R Raczynski, J L A Fiala, A L Doernte, M Williams, J L McFaline, J M Essigmann, D B Schauer, et al. (2010)
Gut 59, 88-97
   Abstract »    Full Text »    PDF »
The Aryl Hydrocarbon Receptor Functions as a Tumor Suppressor of Liver Carcinogenesis.
Y. Fan, G. P. Boivin, E. S. Knudsen, D. W. Nebert, Y. Xia, and A. Puga (2010)
Cancer Res. 70, 212-220
   Abstract »    Full Text »    PDF »
Hepatocellular carcinoma for the non-specialist.
T Kumagi, Y Hiasa, and G M Hirschfield (2009)
BMJ 339, b5039
   Full Text »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882