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Science 317 (5838): 627-629

Copyright © 2007 by the American Association for the Advancement of Science

Emerging Challenges in Regulatory T Cell Function and Biology

Shimon Sakaguchi1, and Fiona Powrie2

Abstract: Much progress has been made in understanding how the immune system is regulated, with a great deal of recent interest in naturally occurring CD4+ regulatory T cells that actively engage in the maintenance of immunological self-tolerance and immune homeostasis. The challenge ahead for immunologists is the further elucidation of the molecular and cellular processes that govern the development and function of these cells. From this, exciting possibilities are emerging for the manipulation of regulatory T cell pathways in treating immunological diseases and suppressing or augmenting physiological immune responses.

1 Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
2 Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.


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