Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Logo for

Science 317 (5838): 666-670

Copyright © 2007 by the American Association for the Advancement of Science

Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior

Cedric Auffray,1 Darin Fogg,1 Meriem Garfa,1 Gaelle Elain,1 Olivier Join-Lambert,2,3 Samer Kayal,1,2,3 Sabine Sarnacki,2,3 Ana Cumano,4 Gregoire Lauvau,5 Frederic Geissmann1,2,3*

Abstract: The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended on the integrin LFA-1 and the chemokine receptor CX3CR1 and was required for rapid tissue invasion at the site of an infection by this "resident" monocyte population, which initiated an early immune response and differentiated into macrophages.

1 Institut Nationale de la Santé et de la Recherche Médicale (INSERM) U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Fédératif de Recherche Necker-Enfants Malades, Paris, France.
2 University Paris-Descartes, Paris, France.
3 Hôpital Necker-Enfants Malades, AP-HP, Paris, France.
4 INSERM U668, Unité de Développement des Lymphocytes, Institut Pasteur, Paris, France.
5 INSERM E03-44, Institut de Pharmacologie Moleculaire et Cellulaire, Nice, France.

* To whom correspondence should be addressed. E-mail: geissmann{at}necker.fr

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biomechanical factors and macrophages in plaque stability.
A. Seneviratne, M. Hulsmans, P. Holvoet, and C. Monaco (2013)
Cardiovasc Res
   Abstract »    Full Text »    PDF »
Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress.
K. S. Harker, N. Ueno, T. Wang, C. Bonhomme, W. Liu, and M. B. Lodoen (2013)
J. Leukoc. Biol. 93, 789-800
   Abstract »    Full Text »    PDF »
Integrin Regulation during Leukocyte Recruitment.
J. Herter and A. Zarbock (2013)
J. Immunol. 190, 4451-4457
   Abstract »    Full Text »    PDF »
Seminal Plasma Affects Prostaglandin Synthesis and Angiogenesis in the Porcine Uterus.
M. M. Kaczmarek, K. Krawczynski, and J. Filant (2013)
Biol Reprod 88, 72
   Abstract »    Full Text »    PDF »
Endoscopic Time-Lapse Imaging of Immune Cells in Infarcted Mouse Hearts.
K. Jung, P. Kim, F. Leuschner, R. Gorbatov, J. K. Kim, T. Ueno, M. Nahrendorf, and S. H. Yun (2013)
Circ. Res. 112, 891-899
   Abstract »    Full Text »    PDF »
Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction.
S. Frantz, U. Hofmann, D. Fraccarollo, A. Schafer, S. Kranepuhl, I. Hagedorn, B. Nieswandt, M. Nahrendorf, H. Wagner, B. Bayer, et al. (2013)
FASEB J 27, 871-881
   Abstract »    Full Text »    PDF »
Neutrophil-Derived Cathelicidin Promotes Adhesion of Classical Monocytes.
S. Wantha, J.-E. Alard, R. T. A. Megens, A. M. van der Does, Y. Doring, M. Drechsler, C. T. N. Pham, M.-W. Wang, J.-M. Wang, R. L. Gallo, et al. (2013)
Circ. Res. 112, 792-801
   Abstract »    Full Text »    PDF »
Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium.
C. Rius, C. Company, L. Piqueras, J. M. Cerda-Nicolas, C. Gonzalez, E. Servera, A. Ludwig, E. J. Morcillo, and M.-J. Sanz (2013)
Thorax 68, 177-186
   Abstract »    Full Text »    PDF »
Arterial and Venous Endothelia Display Differential Functional Fractalkine (CX3CL1) Expression by Angiotensin-II.
C. Rius, L. Piqueras, H. Gonzalez-Navarro, F. Albertos, C. Company, C. Lopez-Gines, A. Ludwig, J.-I. Blanes, E. J. Morcillo, and M.-J. Sanz (2013)
Arterioscler Thromb Vasc Biol 33, 96-104
   Abstract »    Full Text »    PDF »
Collaboration Between Macrophages and Vaccine-Induced CD4+ T Cells Confers Protection Against Lethal Pseudomonas aeruginosa Pneumonia During Neutropenia.
A. Kamei, W. Wu, D. C. Traficante, A. Y. Koh, N. Van Rooijen, G. B. Pier, and G. P. Priebe (2013)
The Journal of Infectious Disease 207, 39-49
   Abstract »    Full Text »    PDF »
Cell-based interventions for therapeutic angiogenesis: review of potential cell sources.
R. A. Brenes, M. Bear, C. Jadlowiec, M. Goodwin, P. Hashim, C. D. Protack, K. R. Ziegler, X. Li, L. S. Model, W. Lv, et al. (2012)
Vascular 20, 360-368
   Abstract »    Full Text »    PDF »
Monocyte Chemoattractant Protein-1/CCR2 Axis Promotes Vein Graft Neointimal Hyperplasia Through Its Signaling in Graft-Extrinsic Cell Populations.
C. Fu, P. Yu, M. Tao, T. Gupta, L. L. Moldawer, S. A. Berceli, and Z. Jiang (2012)
Arterioscler Thromb Vasc Biol 32, 2418-2426
   Abstract »    Full Text »    PDF »
The TRPM4 Channel Controls Monocyte and Macrophage, but Not Neutrophil, Function for Survival in Sepsis.
N. Serafini, A. Dahdah, G. Barbet, M. Demion, T. Attout, G. Gautier, M. Arcos-Fajardo, H. Souchet, M.-H. Jouvin, F. Vrtovsnik, et al. (2012)
J. Immunol. 189, 3689-3699
   Abstract »    Full Text »    PDF »
Monocytes Control Second-Phase Neutrophil Emigration in Established Lipopolysaccharide-induced Murine Lung Injury.
K. Dhaliwal, E. Scholefield, D. Ferenbach, M. Gibbons, R. Duffin, D. A. Dorward, A. C. Morris, D. Humphries, A. MacKinnon, T. S. Wilkinson, et al. (2012)
186, 514-524
   Abstract »    Full Text »    PDF »
IL-10 Acts As a Developmental Switch Guiding Monocyte Differentiation to Macrophages during a Murine Peritoneal Infection.
H.-H. Nguyen, B.-T. Tran, W. Muller, and R. S. Jack (2012)
J. Immunol. 189, 3112-3120
   Abstract »    Full Text »    PDF »
Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation.
R. Darbousset, G. M. Thomas, S. Mezouar, C. Frere, R. Bonier, N. Mackman, T. Renne, F. Dignat-George, C. Dubois, and L. Panicot-Dubois (2012)
Blood 120, 2133-2143
   Abstract »    Full Text »    PDF »
Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation - Mechanisms and Therapeutic Targets.
G. R. Romeo, J. Lee, and S. E. Shoelson (2012)
Arterioscler Thromb Vasc Biol 32, 1771-1776
   Abstract »    Full Text »    PDF »
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair.
S. Willenborg, T. Lucas, G. van Loo, J. A. Knipper, T. Krieg, I. Haase, B. Brachvogel, M. Hammerschmidt, A. Nagy, N. Ferrara, et al. (2012)
Blood 120, 613-625
   Abstract »    Full Text »    PDF »
Activation of Invariant NKT Cells in Early Phase of Experimental Autoimmune Encephalomyelitis Results in Differentiation of Ly6Chi Inflammatory Monocyte to M2 Macrophages and Improved Outcome.
L. Denney, W. L. Kok, S. L. Cole, S. Sanderson, A. J. McMichael, and L.-P. Ho (2012)
J. Immunol. 189, 551-557
   Abstract »    Full Text »    PDF »
Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.
Y.-M. Hyun, R. Sumagin, P. P. Sarangi, E. Lomakina, M. G. Overstreet, C. M. Baker, D. J. Fowell, R. E. Waugh, I. H. Sarelius, and M. Kim (2012)
J. Exp. Med. 209, 1349-1362
   Abstract »    Full Text »    PDF »
A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System.
R. N. Germain, E. A. Robey, and M. D. Cahalan (2012)
Science 336, 1676-1681
   Abstract »    Full Text »    PDF »
Loss of TNF Signaling Facilitates the Development of a Novel Ly-6Clow Macrophage Population Permissive for Leishmania major Infection.
P. D. Fromm, J. Kling, M. Mack, J. D. Sedgwick, and H. Korner (2012)
J. Immunol. 188, 6258-6266
   Abstract »    Full Text »    PDF »
Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis.
N. Boivin, R. Menasria, D. Gosselin, S. Rivest, and G. Boivin (2012)
J. Gen. Virol. 93, 1294-1304
   Abstract »    Full Text »    PDF »
CD16 Regulates TRIF-Dependent TLR4 Response in Human Monocytes and Their Subsets.
I. N. Shalova, T. Kajiji, J. Y. Lim, V. Gomez-Pina, I. Fernandez-Ruiz, F. Arnalich, P. T. C. Iau, E. Lopez-Collazo, S.-C. Wong, and S. K. Biswas (2012)
J. Immunol. 188, 3584-3593
   Abstract »    Full Text »    PDF »
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells.
C. Schulz, E. G. Perdiguero, L. Chorro, H. Szabo-Rogers, N. Cagnard, K. Kierdorf, M. Prinz, B. Wu, S. E. W. Jacobsen, J. W. Pollard, et al. (2012)
Science 336, 86-90
   Abstract »    Full Text »    PDF »
Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice.
A. M. Gil-Bernabe, S. Ferjancic, M. Tlalka, L. Zhao, P. D. Allen, J. H. Im, K. Watson, S. A. Hill, A. Amirkhosravi, J. L. Francis, et al. (2012)
Blood 119, 3164-3175
   Abstract »    Full Text »    PDF »
Endogenous Regulatory T Cells Adhere in Inflamed Dermal Vessels via ICAM-1: Association with Regulation of Effector Leukocyte Adhesion.
J. A. Deane, L. D. Abeynaike, M. U. Norman, J. L. Wee, A. R. Kitching, P. Kubes, and M. J. Hickey (2012)
J. Immunol. 188, 2179-2188
   Abstract »    Full Text »    PDF »
P2X4 Receptors Influence Inflammasome Activation after Spinal Cord Injury.
J. P. de Rivero Vaccari, D. Bastien, G. Yurcisin, I. Pineau, W. D. Dietrich, Y. De Koninck, R. W. Keane, and S. Lacroix (2012)
J. Neurosci. 32, 3058-3066
   Abstract »    Full Text »    PDF »
Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling.
D. A. Hume and K. P. A. MacDonald (2012)
Blood 119, 1810-1820
   Abstract »    Full Text »    PDF »
NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis.
R. N. Hanna, I. Shaked, H. G. Hubbeling, J. A. Punt, R. Wu, E. Herrley, C. Zaugg, H. Pei, F. Geissmann, K. Ley, et al. (2012)
Circ. Res. 110, 416-427
   Abstract »    Full Text »    PDF »
Elevated CD14++CD16- Monocytes Predict Cardiovascular Events.
K. E. Berg, I. Ljungcrantz, L. Andersson, C. Bryngelsson, B. Hedblad, G. N. Fredrikson, J. Nilsson, and H. Bjorkbacka (2012)
Circ Cardiovasc Genet 5, 122-131
   Abstract »    Full Text »    PDF »
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.
F. Leuschner, P. J. Rauch, T. Ueno, R. Gorbatov, B. Marinelli, W. W. Lee, P. Dutta, Y. Wei, C. Robbins, Y. Iwamoto, et al. (2012)
J. Exp. Med. 209, 123-137
   Abstract »    Full Text »    PDF »
Protumoral role of monocytes in human B-cell precursor acute lymphoblastic leukemia: involvement of the chemokine CXCL10.
Y. Lee, M. Chittezhath, V. Andre, H. Zhao, M. Poidinger, A. Biondi, G. D'Amico, and S. K. Biswas (2012)
Blood 119, 227-237
   Abstract »    Full Text »    PDF »
The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood.
M. Mizutani, P. A. Pino, N. Saederup, I. F. Charo, R. M. Ransohoff, and A. E. Cardona (2012)
J. Immunol. 188, 29-36
   Abstract »    Full Text »    PDF »
Human CD16+ and CD16- monocyte subsets display unique effector properties in inflammatory conditions in vivo.
S. R. Aguilar-Ruiz, H. Torres-Aguilar, E. Gonzalez-Dominguez, J. Narvaez, G. Gonzalez-Perez, G. Vargas-Ayala, M. A. Meraz-Rios, E. A. Garcia-Zepeda, and C. Sanchez-Torres (2011)
J. Leukoc. Biol. 90, 1119-1131
   Abstract »    Full Text »    PDF »
Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking.
K. Mayol, V. Biajoux, J. Marvel, K. Balabanian, and T. Walzer (2011)
Blood 118, 4863-4871
   Abstract »    Full Text »    PDF »
Lung dendritic cells at the innate-adaptive immune interface.
T. V. Condon, R. T. Sawyer, M. J. Fenton, and D. W. H. Riches (2011)
J. Leukoc. Biol. 90, 883-895
   Abstract »    Full Text »    PDF »
The role of monocytes and inflammation in the pathophysiology of heart failure.
B. J. Wrigley, G. Y. H. Lip, and E. Shantsila (2011)
Eur J Heart Fail 13, 1161-1171
   Abstract »    Full Text »    PDF »
Distinct Roles of CSF-1 Isoforms in Lupus Nephritis.
J. Menke, Y. Iwata, W. A. Rabacal, R. Basu, E. R. Stanley, and V. R. Kelley (2011)
J. Am. Soc. Nephrol. 22, 1821-1833
   Abstract »    Full Text »    PDF »
SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset.
A. M. Zawada, K. S. Rogacev, B. Rotter, P. Winter, R.-R. Marell, D. Fliser, and G. H. Heine (2011)
Blood 118, e50-e61
   Abstract »    Full Text »    PDF »
Increased Toll-like Receptor-2 Expression on Nonclassic CD16+ Monocytes from Patients with Inflammatory Stage of Eales' Disease.
A. Sen, I. H. Chowdhury, D. Mukhopadhyay, S. K. Paine, A. Mukherjee, L. K. Mondal, M. Chatterjee, and B. Bhattacharya (2011)
Invest. Ophthalmol. Vis. Sci. 52, 6940-6948
   Abstract »    Full Text »    PDF »
Regulation of Macrophage Arginase Expression and Tumor Growth by the Ron Receptor Tyrosine Kinase.
D. R. Sharda, S. Yu, M. Ray, M. L. Squadrito, M. De Palma, T. A. Wynn, S. M. Morris Jr., and P. A. Hankey (2011)
J. Immunol. 187, 2181-2192
   Abstract »    Full Text »    PDF »
Plasticity of Ly-6Chi Myeloid Cells in T Cell Regulation.
B. Zhu, J. K. Kennedy, Y. Wang, C. Sandoval-Garcia, L. Cao, S. Xiao, C. Wu, W. Elyaman, and S. J. Khoury (2011)
J. Immunol. 187, 2418-2432
   Abstract »    Full Text »    PDF »
Monocyte and Macrophage Dynamics During Atherogenesis.
K. Ley, Y. I. Miller, and C. C. Hedrick (2011)
Arterioscler Thromb Vasc Biol 31, 1506-1516
   Abstract »    Full Text »    PDF »
The Spatial and Developmental Relationships in the Macrophage Family.
F. K. Swirski (2011)
Arterioscler Thromb Vasc Biol 31, 1517-1522
   Abstract »    Full Text »    PDF »
No Need to Coax Monocytes.
G. J. Randolph (2011)
Science 332, 1268-1269
   Abstract »    Full Text »    PDF »
PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions.
S. Y. Thomas, S. T. Scanlon, K. G. Griewank, M. G. Constantinides, A. K. Savage, K. A. Barr, F. Meng, A. D. Luster, and A. Bendelac (2011)
J. Exp. Med. 208, 1179-1188
   Abstract »    Full Text »    PDF »
Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection.
R. Goncalves, X. Zhang, H. Cohen, A. Debrabant, and D. M. Mosser (2011)
J. Exp. Med. 208, 1253-1265
   Abstract »    Full Text »    PDF »
TNF-{alpha}-dependent Regulation of Acute Pancreatitis Severity by Ly-6Chi Monocytes in Mice.
G. Perides, E. R. Weiss, E. S. Michael, J. M. Laukkarinen, J. S. Duffield, and M. L. Steer (2011)
J. Biol. Chem. 286, 13327-13335
   Abstract »    Full Text »    PDF »
Dissemination of Persistent Intestinal Bacteria via the Mesenteric Lymph Nodes Causes Typhoid Relapse.
A. J. Griffin, L.-X. Li, S. Voedisch, O. Pabst, and S. J. McSorley (2011)
Infect. Immun. 79, 1479-1488
   Abstract »    Full Text »    PDF »
Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity.
D. A. Hume (2011)
J. Leukoc. Biol. 89, 525-538
   Abstract »    Full Text »    PDF »
Primary Monocytes Regulate Endothelial Cell Survival Through Secretion of Angiopoietin-1 and Activation of Endothelial Tie2.
S. Y. Schubert, A. Benarroch, J. Monter-Solans, and E. R. Edelman (2011)
Arterioscler Thromb Vasc Biol 31, 870-875
   Abstract »    Full Text »    PDF »
Leukocytes and the Natural History of Deep Vein Thrombosis: Current Concepts and Future Directions.
P. Saha, J. Humphries, B. Modarai, K. Mattock, M. Waltham, C. E. Evans, A. Ahmad, A. S. Patel, S. Premaratne, O. T. A. Lyons, et al. (2011)
Arterioscler Thromb Vasc Biol 31, 506-512
   Abstract »    Full Text »    PDF »
Monocyte Angiotensin Converting Enzyme Expression May Be Associated with Atherosclerosis Rather than Arteriosclerosis in Hemodialysis Patients.
C. Ulrich, E. Seibert, G. H. Heine, D. Fliser, and M. Girndt (2011)
Clin. J. Am. Soc. Nephrol. 6, 505-511
   Abstract »    Full Text »    PDF »
CX3CR1+ Lung Mononuclear Phagocytes Spatially Confined to the Interstitium Produce TNF-{alpha} and IL-6 and Promote Cigarette Smoke-Induced Emphysema.
Z. Xiong, A. S. Leme, P. Ray, S. D. Shapiro, and J. S. Lee (2011)
J. Immunol. 186, 3206-3214
   Abstract »    Full Text »    PDF »
Accelerated Dendritic Cell Differentiation from Migrating Ly6Clo Bone Marrow Monocytes in Early Dermal West Nile Virus Infection.
A. M. Davison and N. J. C. King (2011)
J. Immunol. 186, 2382-2396
   Abstract »    Full Text »    PDF »
CD14++CD16+ monocytes and cardiovascular outcome in patients with chronic kidney disease.
K. S. Rogacev, S. Seiler, A. M. Zawada, B. Reichart, E. Herath, D. Roth, C. Ulrich, D. Fliser, and G. H. Heine (2011)
Eur. Heart J. 32, 84-92
   Abstract »    Full Text »    PDF »
Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury.
H. Lu, D. Huang, N. Saederup, I. F. Charo, R. M. Ransohoff, and L. Zhou (2011)
FASEB J 25, 358-369
   Abstract »    Full Text »    PDF »
Exercise improves the dilatation function of mesenteric arteries in postmyocardial infarction rats via a PI3K/Akt/eNOS pathway-mediated mechanism.
Y. Wang, S. Wang, W. G. Wier, Q. Zhang, H. Jiang, Q. Li, S. Chen, Z. Tian, Y. Li, X. Yu, et al. (2010)
Am J Physiol Heart Circ Physiol 299, H2097-H2106
   Abstract »    Full Text »    PDF »
LFA-1 and Mac-1 Define Characteristically Different Intralumenal Crawling and Emigration Patterns for Monocytes and Neutrophils In Situ.
R. Sumagin, H. Prizant, E. Lomakina, R. E. Waugh, and I. H. Sarelius (2010)
J. Immunol. 185, 7057-7066
   Abstract »    Full Text »    PDF »
Nomenclature of monocytes and dendritic cells in blood.
L. Ziegler-Heitbrock, P. Ancuta, S. Crowe, M. Dalod, V. Grau, D. N. Hart, P. J. M. Leenen, Y.-J. Liu, G. MacPherson, G. J. Randolph, et al. (2010)
Blood 116, e74-e80
   Abstract »    Full Text »    PDF »
Regulation of monocyte subset systemic levels by distinct chemokine receptors controls post-ischaemic neovascularization.
C. Cochain, M. P. Rodero, J. Vilar, A. Recalde, A. L. Richart, C. Loinard, Y. Zouggari, C. Guerin, M. Duriez, B. Combadiere, et al. (2010)
Cardiovasc Res 88, 186-195
   Abstract »    Full Text »    PDF »
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils.
S. Massena, G. Christoffersson, E. Hjertstrom, E. Zcharia, I. Vlodavsky, N. Ausmees, C. Rolny, J.-P. Li, and M. Phillipson (2010)
Blood 116, 1924-1931
   Abstract »    Full Text »    PDF »
CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses.
J. Zhou, P. C. Y. Tang, L. Qin, P. M. Gayed, W. Li, E. A. Skokos, T. R. Kyriakides, J. S. Pober, and G. Tellides (2010)
J. Exp. Med. 207, 1951-1966
   Abstract »    Full Text »    PDF »
Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing.
R. T. Boscacci, F. Pfeiffer, K. Gollmer, A. I. C. Sevilla, A. M. Martin, S. F. Soriano, D. Natale, S. Henrickson, U. H. von Andrian, Y. Fukui, et al. (2010)
Blood 116, 915-925
   Abstract »    Full Text »    PDF »
Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes.
K. Movahedi, D. Laoui, C. Gysemans, M. Baeten, G. Stange, J. Van den Bossche, M. Mack, D. Pipeleers, P. In't Veld, P. De Baetselier, et al. (2010)
Cancer Res. 70, 5728-5739
   Abstract »    Full Text »    PDF »
Circulating monocyte subpopulations with high expression of angiotensin-converting enzyme predict mortality in patients with end-stage renal disease.
C. Ulrich, G. H. Heine, E. Seibert, D. Fliser, and M. Girndt (2010)
Nephrol. Dial. Transplant. 25, 2265-2272
   Abstract »    Full Text »    PDF »
The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B.
M. Rosas, B. Thomas, M. Stacey, S. Gordon, and P. R. Taylor (2010)
J. Leukoc. Biol. 88, 169-180
   Abstract »    Full Text »    PDF »
Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice.
F. I. Kostadinova, T. Baba, Y. Ishida, T. Kondo, B. K. Popivanova, and N. Mukaida (2010)
J. Leukoc. Biol. 88, 133-143
   Abstract »    Full Text »    PDF »
Distribution and Function of Macrophage Galactose-type C-type Lectin 2 (MGL2/CD301b): EFFICIENT UPTAKE AND PRESENTATION OF GLYCOSYLATED ANTIGENS BY DENDRITIC CELLS.
K. Denda-Nagai, S. Aida, K. Saba, K. Suzuki, S. Moriyama, S. Oo-puthinan, M. Tsuiji, A. Morikawa, Y. Kumamoto, D. Sugiura, et al. (2010)
J. Biol. Chem. 285, 19193-19204
   Abstract »    Full Text »    PDF »
Monocytes: Protagonists of Infarct Inflammation and Repair After Myocardial Infarction.
M. Nahrendorf, M. J. Pittet, and F. K. Swirski (2010)
Circulation 121, 2437-2445
   Full Text »    PDF »
Monocyte Trafficking to Hepatic Sites of Bacterial Infection Is Chemokine Independent and Directed by Focal Intercellular Adhesion Molecule-1 Expression.
C. Shi, P. Velazquez, T. M. Hohl, I. Leiner, M. L. Dustin, and E. G. Pamer (2010)
J. Immunol. 184, 6266-6274
   Abstract »    Full Text »    PDF »
Intercellular Adhesion Molecule-1 Enrichment near Tricellular Endothelial Junctions Is Preferentially Associated with Leukocyte Transmigration and Signals for Reorganization of These Junctions To Accommodate Leukocyte Passage.
R. Sumagin and I. H. Sarelius (2010)
J. Immunol. 184, 5242-5252
   Abstract »    Full Text »    PDF »
Molecular regulators of leucocyte chemotaxis during inflammation.
C. H. Y. Wong, B. Heit, and P. Kubes (2010)
Cardiovasc Res 86, 183-191
   Abstract »    Full Text »    PDF »
Molecular cues guiding inflammatory responses.
O. Barreiro, P. Martin, R. Gonzalez-Amaro, and F. Sanchez-Madrid (2010)
Cardiovasc Res 86, 174-182
   Abstract »    Full Text »    PDF »
Inflammatory Monocytes but Not Neutrophils Are Necessary To Control Infection with Toxoplasma gondii in Mice.
I. R. Dunay, A. Fuchs, and L. D. Sibley (2010)
Infect. Immun. 78, 1564-1570
   Abstract »    Full Text »    PDF »
Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage.
W.-K. Kim, Y. Sun, H. Do, P. Autissier, E. F. Halpern, M. Piatak Jr., J. D. Lifson, T. H. Burdo, M. S. McGrath, and K. Williams (2010)
J. Leukoc. Biol. 87, 557-567
   Abstract »    Full Text »    PDF »
The macrophage: the intersection between HIV infection and atherosclerosis.
S. M. Crowe, C. L. V. Westhorpe, N. Mukhamedova, A. Jaworowski, D. Sviridov, and M. Bukrinsky (2010)
J. Leukoc. Biol. 87, 589-598
   Abstract »    Full Text »    PDF »
Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes.
E. J. Park, A. Peixoto, Y. Imai, A. Goodarzi, G. Cheng, C. V. Carman, U. H. von Andrian, and M. Shimaoka (2010)
Blood 115, 1572-1581
   Abstract »    Full Text »    PDF »
Mycobacterium bovis Bacillus Calmette-Guerin Vaccination Mobilizes Innate Myeloid-Derived Suppressor Cells Restraining In Vivo T Cell Priming via IL-1R-Dependent Nitric Oxide Production.
A. Martino, E. Badell, V. Abadie, V. Balloy, M. Chignard, M.-Y. Mistou, B. Combadiere, C. Combadiere, and N. Winter (2010)
J. Immunol. 184, 2038-2047
   Abstract »    Full Text »    PDF »
Two physically, functionally, and developmentally distinct peritoneal macrophage subsets.
E. E. B. Ghosn, A. A. Cassado, G. R. Govoni, T. Fukuhara, Y. Yang, D. M. Monack, K. R. Bortoluci, S. R. Almeida, L. A. Herzenberg, and L. A. Herzenberg (2010)
PNAS 107, 2568-2573
   Abstract »    Full Text »    PDF »
Development of Monocytes, Macrophages, and Dendritic Cells.
F. Geissmann, M. G. Manz, S. Jung, M. H. Sieweke, M. Merad, and K. Ley (2010)
Science 327, 656-661
   Abstract »    Full Text »    PDF »
Monocyte heterogeneity in obesity and subclinical atherosclerosis.
K. S. Rogacev, C. Ulrich, L. Blomer, F. Hornof, K. Oster, M. Ziegelin, B. Cremers, Y. Grenner, J. Geisel, A. Schlitt, et al. (2010)
Eur. Heart J. 31, 369-376
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882