Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Abstract:
The cellular immune response to tissue damage and infectionrequires the recruitment of blood leukocytes. This process ismediated through a classical multistep mechanism, which involvestransient rolling on the endothelium and recognition of inflammationfollowed by extravasation. We have shown, by direct examinationof blood monocyte functions in vivo, that a subset of monocytespatrols healthy tissues through long-range crawling on the restingendothelium. This patrolling behavior depended on the integrinLFA-1 and the chemokine receptor CX3CR1 and was required forrapid tissue invasion at the site of an infection by this "resident"monocyte population, which initiated an early immune responseand differentiated into macrophages.
1 Institut Nationale de la Santé et de la Recherche Médicale (INSERM) U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Fédératif de Recherche Necker-Enfants Malades, Paris, France. 2 University Paris-Descartes, Paris, France. 3 Hôpital Necker-Enfants Malades, AP-HP, Paris, France. 4 INSERM U668, Unité de Développement des Lymphocytes, Institut Pasteur, Paris, France. 5 INSERM E03-44, Institut de Pharmacologie Moleculaire et Cellulaire, Nice, France.
* To whom correspondence should be addressed. E-mail: geissmann{at}necker.fr
The editors suggest the following Related Resources on Science sites:
In Science Magazine
INTRODUCTION TO SPECIAL ISSUE
Stephen J. Simpson and John Travis (3 August 2007) Science317 (5838), 611.
[DOI: 10.1126/science.317.5838.611] |Summary »|PDF »
In Science Signaling
EDITORS' CHOICE
Stephen J. Simpson (7 August 2007) Sci. STKE2007 (398), tw285.
[DOI: 10.1126/stke.3982007tw285] |Abstract »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biomechanical factors and macrophages in plaque stability.
A. Seneviratne, M. Hulsmans, P. Holvoet, and C. Monaco (2013)
Cardiovasc Res
|Abstract »|Full Text »|PDF »
Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress.
K. S. Harker, N. Ueno, T. Wang, C. Bonhomme, W. Liu, and M. B. Lodoen (2013)
J. Leukoc. Biol.
93, 789-800
|Abstract »|Full Text »|PDF »
Endoscopic Time-Lapse Imaging of Immune Cells in Infarcted Mouse Hearts.
K. Jung, P. Kim, F. Leuschner, R. Gorbatov, J. K. Kim, T. Ueno, M. Nahrendorf, and S. H. Yun (2013)
Circ. Res.
112, 891-899
|Abstract »|Full Text »|PDF »
Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction.
S. Frantz, U. Hofmann, D. Fraccarollo, A. Schafer, S. Kranepuhl, I. Hagedorn, B. Nieswandt, M. Nahrendorf, H. Wagner, B. Bayer, et al. (2013)
FASEB J
27, 871-881
|Abstract »|Full Text »|PDF »
Neutrophil-Derived Cathelicidin Promotes Adhesion of Classical Monocytes.
S. Wantha, J.-E. Alard, R. T. A. Megens, A. M. van der Does, Y. Doring, M. Drechsler, C. T. N. Pham, M.-W. Wang, J.-M. Wang, R. L. Gallo, et al. (2013)
Circ. Res.
112, 792-801
|Abstract »|Full Text »|PDF »
Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium.
C. Rius, C. Company, L. Piqueras, J. M. Cerda-Nicolas, C. Gonzalez, E. Servera, A. Ludwig, E. J. Morcillo, and M.-J. Sanz (2013)
Thorax
68, 177-186
|Abstract »|Full Text »|PDF »
Arterial and Venous Endothelia Display Differential Functional Fractalkine (CX3CL1) Expression by Angiotensin-II.
C. Rius, L. Piqueras, H. Gonzalez-Navarro, F. Albertos, C. Company, C. Lopez-Gines, A. Ludwig, J.-I. Blanes, E. J. Morcillo, and M.-J. Sanz (2013)
Arterioscler Thromb Vasc Biol
33, 96-104
|Abstract »|Full Text »|PDF »
Collaboration Between Macrophages and Vaccine-Induced CD4+ T Cells Confers Protection Against Lethal Pseudomonas aeruginosa Pneumonia During Neutropenia.
A. Kamei, W. Wu, D. C. Traficante, A. Y. Koh, N. Van Rooijen, G. B. Pier, and G. P. Priebe (2013)
The Journal of Infectious Disease
207, 39-49
|Abstract »|Full Text »|PDF »
Cell-based interventions for therapeutic angiogenesis: review of potential cell sources.
R. A. Brenes, M. Bear, C. Jadlowiec, M. Goodwin, P. Hashim, C. D. Protack, K. R. Ziegler, X. Li, L. S. Model, W. Lv, et al. (2012)
Vascular
20, 360-368
|Abstract »|Full Text »|PDF »
Monocyte Chemoattractant Protein-1/CCR2 Axis Promotes Vein Graft Neointimal Hyperplasia Through Its Signaling in Graft-Extrinsic Cell Populations.
C. Fu, P. Yu, M. Tao, T. Gupta, L. L. Moldawer, S. A. Berceli, and Z. Jiang (2012)
Arterioscler Thromb Vasc Biol
32, 2418-2426
|Abstract »|Full Text »|PDF »
The TRPM4 Channel Controls Monocyte and Macrophage, but Not Neutrophil, Function for Survival in Sepsis.
N. Serafini, A. Dahdah, G. Barbet, M. Demion, T. Attout, G. Gautier, M. Arcos-Fajardo, H. Souchet, M.-H. Jouvin, F. Vrtovsnik, et al. (2012)
J. Immunol.
189, 3689-3699
|Abstract »|Full Text »|PDF »
Monocytes Control Second-Phase Neutrophil Emigration in Established Lipopolysaccharide-induced Murine Lung Injury.
K. Dhaliwal, E. Scholefield, D. Ferenbach, M. Gibbons, R. Duffin, D. A. Dorward, A. C. Morris, D. Humphries, A. MacKinnon, T. S. Wilkinson, et al. (2012) 186, 514-524
|Abstract »|Full Text »|PDF »
IL-10 Acts As a Developmental Switch Guiding Monocyte Differentiation to Macrophages during a Murine Peritoneal Infection.
H.-H. Nguyen, B.-T. Tran, W. Muller, and R. S. Jack (2012)
J. Immunol.
189, 3112-3120
|Abstract »|Full Text »|PDF »
Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation.
R. Darbousset, G. M. Thomas, S. Mezouar, C. Frere, R. Bonier, N. Mackman, T. Renne, F. Dignat-George, C. Dubois, and L. Panicot-Dubois (2012)
Blood
120, 2133-2143
|Abstract »|Full Text »|PDF »
Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation - Mechanisms and Therapeutic Targets.
G. R. Romeo, J. Lee, and S. E. Shoelson (2012)
Arterioscler Thromb Vasc Biol
32, 1771-1776
|Abstract »|Full Text »|PDF »
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair.
S. Willenborg, T. Lucas, G. van Loo, J. A. Knipper, T. Krieg, I. Haase, B. Brachvogel, M. Hammerschmidt, A. Nagy, N. Ferrara, et al. (2012)
Blood
120, 613-625
|Abstract »|Full Text »|PDF »
Activation of Invariant NKT Cells in Early Phase of Experimental Autoimmune Encephalomyelitis Results in Differentiation of Ly6Chi Inflammatory Monocyte to M2 Macrophages and Improved Outcome.
L. Denney, W. L. Kok, S. L. Cole, S. Sanderson, A. J. McMichael, and L.-P. Ho (2012)
J. Immunol.
189, 551-557
|Abstract »|Full Text »|PDF »
Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.
Y.-M. Hyun, R. Sumagin, P. P. Sarangi, E. Lomakina, M. G. Overstreet, C. M. Baker, D. J. Fowell, R. E. Waugh, I. H. Sarelius, and M. Kim (2012)
J. Exp. Med.
209, 1349-1362
|Abstract »|Full Text »|PDF »
A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System.
R. N. Germain, E. A. Robey, and M. D. Cahalan (2012)
Science
336, 1676-1681
|Abstract »|Full Text »|PDF »
Loss of TNF Signaling Facilitates the Development of a Novel Ly-6Clow Macrophage Population Permissive for Leishmania major Infection.
P. D. Fromm, J. Kling, M. Mack, J. D. Sedgwick, and H. Korner (2012)
J. Immunol.
188, 6258-6266
|Abstract »|Full Text »|PDF »
Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis.
N. Boivin, R. Menasria, D. Gosselin, S. Rivest, and G. Boivin (2012)
J. Gen. Virol.
93, 1294-1304
|Abstract »|Full Text »|PDF »
CD16 Regulates TRIF-Dependent TLR4 Response in Human Monocytes and Their Subsets.
I. N. Shalova, T. Kajiji, J. Y. Lim, V. Gomez-Pina, I. Fernandez-Ruiz, F. Arnalich, P. T. C. Iau, E. Lopez-Collazo, S.-C. Wong, and S. K. Biswas (2012)
J. Immunol.
188, 3584-3593
|Abstract »|Full Text »|PDF »
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells.
C. Schulz, E. G. Perdiguero, L. Chorro, H. Szabo-Rogers, N. Cagnard, K. Kierdorf, M. Prinz, B. Wu, S. E. W. Jacobsen, J. W. Pollard, et al. (2012)
Science
336, 86-90
|Abstract »|Full Text »|PDF »
Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice.
A. M. Gil-Bernabe, S. Ferjancic, M. Tlalka, L. Zhao, P. D. Allen, J. H. Im, K. Watson, S. A. Hill, A. Amirkhosravi, J. L. Francis, et al. (2012)
Blood
119, 3164-3175
|Abstract »|Full Text »|PDF »
Endogenous Regulatory T Cells Adhere in Inflamed Dermal Vessels via ICAM-1: Association with Regulation of Effector Leukocyte Adhesion.
J. A. Deane, L. D. Abeynaike, M. U. Norman, J. L. Wee, A. R. Kitching, P. Kubes, and M. J. Hickey (2012)
J. Immunol.
188, 2179-2188
|Abstract »|Full Text »|PDF »
P2X4 Receptors Influence Inflammasome Activation after Spinal Cord Injury.
J. P. de Rivero Vaccari, D. Bastien, G. Yurcisin, I. Pineau, W. D. Dietrich, Y. De Koninck, R. W. Keane, and S. Lacroix (2012)
J. Neurosci.
32, 3058-3066
|Abstract »|Full Text »|PDF »
Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling.
NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis.
R. N. Hanna, I. Shaked, H. G. Hubbeling, J. A. Punt, R. Wu, E. Herrley, C. Zaugg, H. Pei, F. Geissmann, K. Ley, et al. (2012)
Circ. Res.
110, 416-427
|Abstract »|Full Text »|PDF »
K. E. Berg, I. Ljungcrantz, L. Andersson, C. Bryngelsson, B. Hedblad, G. N. Fredrikson, J. Nilsson, and H. Bjorkbacka (2012)
Circ Cardiovasc Genet
5, 122-131
|Abstract »|Full Text »|PDF »
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.
F. Leuschner, P. J. Rauch, T. Ueno, R. Gorbatov, B. Marinelli, W. W. Lee, P. Dutta, Y. Wei, C. Robbins, Y. Iwamoto, et al. (2012)
J. Exp. Med.
209, 123-137
|Abstract »|Full Text »|PDF »
Protumoral role of monocytes in human B-cell precursor acute lymphoblastic leukemia: involvement of the chemokine CXCL10.
Y. Lee, M. Chittezhath, V. Andre, H. Zhao, M. Poidinger, A. Biondi, G. D'Amico, and S. K. Biswas (2012)
Blood
119, 227-237
|Abstract »|Full Text »|PDF »
The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood.
M. Mizutani, P. A. Pino, N. Saederup, I. F. Charo, R. M. Ransohoff, and A. E. Cardona (2012)
J. Immunol.
188, 29-36
|Abstract »|Full Text »|PDF »
Human CD16+ and CD16- monocyte subsets display unique effector properties in inflammatory conditions in vivo.
S. R. Aguilar-Ruiz, H. Torres-Aguilar, E. Gonzalez-Dominguez, J. Narvaez, G. Gonzalez-Perez, G. Vargas-Ayala, M. A. Meraz-Rios, E. A. Garcia-Zepeda, and C. Sanchez-Torres (2011)
J. Leukoc. Biol.
90, 1119-1131
|Abstract »|Full Text »|PDF »
Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking.
K. Mayol, V. Biajoux, J. Marvel, K. Balabanian, and T. Walzer (2011)
Blood
118, 4863-4871
|Abstract »|Full Text »|PDF »
Lung dendritic cells at the innate-adaptive immune interface.
T. V. Condon, R. T. Sawyer, M. J. Fenton, and D. W. H. Riches (2011)
J. Leukoc. Biol.
90, 883-895
|Abstract »|Full Text »|PDF »
The role of monocytes and inflammation in the pathophysiology of heart failure.
B. J. Wrigley, G. Y. H. Lip, and E. Shantsila (2011)
Eur J Heart Fail
13, 1161-1171
|Abstract »|Full Text »|PDF »
Distinct Roles of CSF-1 Isoforms in Lupus Nephritis.
J. Menke, Y. Iwata, W. A. Rabacal, R. Basu, E. R. Stanley, and V. R. Kelley (2011)
J. Am. Soc. Nephrol.
22, 1821-1833
|Abstract »|Full Text »|PDF »
SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset.
A. M. Zawada, K. S. Rogacev, B. Rotter, P. Winter, R.-R. Marell, D. Fliser, and G. H. Heine (2011)
Blood
118, e50-e61
|Abstract »|Full Text »|PDF »
Increased Toll-like Receptor-2 Expression on Nonclassic CD16+ Monocytes from Patients with Inflammatory Stage of Eales' Disease.
A. Sen, I. H. Chowdhury, D. Mukhopadhyay, S. K. Paine, A. Mukherjee, L. K. Mondal, M. Chatterjee, and B. Bhattacharya (2011)
Invest. Ophthalmol. Vis. Sci.
52, 6940-6948
|Abstract »|Full Text »|PDF »
Regulation of Macrophage Arginase Expression and Tumor Growth by the Ron Receptor Tyrosine Kinase.
D. R. Sharda, S. Yu, M. Ray, M. L. Squadrito, M. De Palma, T. A. Wynn, S. M. Morris Jr., and P. A. Hankey (2011)
J. Immunol.
187, 2181-2192
|Abstract »|Full Text »|PDF »
Plasticity of Ly-6Chi Myeloid Cells in T Cell Regulation.
B. Zhu, J. K. Kennedy, Y. Wang, C. Sandoval-Garcia, L. Cao, S. Xiao, C. Wu, W. Elyaman, and S. J. Khoury (2011)
J. Immunol.
187, 2418-2432
|Abstract »|Full Text »|PDF »
Monocyte and Macrophage Dynamics During Atherogenesis.
K. Ley, Y. I. Miller, and C. C. Hedrick (2011)
Arterioscler Thromb Vasc Biol
31, 1506-1516
|Abstract »|Full Text »|PDF »
The Spatial and Developmental Relationships in the Macrophage Family.
PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions.
S. Y. Thomas, S. T. Scanlon, K. G. Griewank, M. G. Constantinides, A. K. Savage, K. A. Barr, F. Meng, A. D. Luster, and A. Bendelac (2011)
J. Exp. Med.
208, 1179-1188
|Abstract »|Full Text »|PDF »
Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection.
R. Goncalves, X. Zhang, H. Cohen, A. Debrabant, and D. M. Mosser (2011)
J. Exp. Med.
208, 1253-1265
|Abstract »|Full Text »|PDF »
TNF-{alpha}-dependent Regulation of Acute Pancreatitis Severity by Ly-6Chi Monocytes in Mice.
G. Perides, E. R. Weiss, E. S. Michael, J. M. Laukkarinen, J. S. Duffield, and M. L. Steer (2011)
J. Biol. Chem.
286, 13327-13335
|Abstract »|Full Text »|PDF »
Dissemination of Persistent Intestinal Bacteria via the Mesenteric Lymph Nodes Causes Typhoid Relapse.
A. J. Griffin, L.-X. Li, S. Voedisch, O. Pabst, and S. J. McSorley (2011)
Infect. Immun.
79, 1479-1488
|Abstract »|Full Text »|PDF »
Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity.
Primary Monocytes Regulate Endothelial Cell Survival Through Secretion of Angiopoietin-1 and Activation of Endothelial Tie2.
S. Y. Schubert, A. Benarroch, J. Monter-Solans, and E. R. Edelman (2011)
Arterioscler Thromb Vasc Biol
31, 870-875
|Abstract »|Full Text »|PDF »
Leukocytes and the Natural History of Deep Vein Thrombosis: Current Concepts and Future Directions.
P. Saha, J. Humphries, B. Modarai, K. Mattock, M. Waltham, C. E. Evans, A. Ahmad, A. S. Patel, S. Premaratne, O. T. A. Lyons, et al. (2011)
Arterioscler Thromb Vasc Biol
31, 506-512
|Abstract »|Full Text »|PDF »
Monocyte Angiotensin Converting Enzyme Expression May Be Associated with Atherosclerosis Rather than Arteriosclerosis in Hemodialysis Patients.
C. Ulrich, E. Seibert, G. H. Heine, D. Fliser, and M. Girndt (2011)
Clin. J. Am. Soc. Nephrol.
6, 505-511
|Abstract »|Full Text »|PDF »
CX3CR1+ Lung Mononuclear Phagocytes Spatially Confined to the Interstitium Produce TNF-{alpha} and IL-6 and Promote Cigarette Smoke-Induced Emphysema.
Z. Xiong, A. S. Leme, P. Ray, S. D. Shapiro, and J. S. Lee (2011)
J. Immunol.
186, 3206-3214
|Abstract »|Full Text »|PDF »
Accelerated Dendritic Cell Differentiation from Migrating Ly6Clo Bone Marrow Monocytes in Early Dermal West Nile Virus Infection.
CD14++CD16+ monocytes and cardiovascular outcome in patients with chronic kidney disease.
K. S. Rogacev, S. Seiler, A. M. Zawada, B. Reichart, E. Herath, D. Roth, C. Ulrich, D. Fliser, and G. H. Heine (2011)
Eur. Heart J.
32, 84-92
|Abstract »|Full Text »|PDF »
Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury.
H. Lu, D. Huang, N. Saederup, I. F. Charo, R. M. Ransohoff, and L. Zhou (2011)
FASEB J
25, 358-369
|Abstract »|Full Text »|PDF »
Exercise improves the dilatation function of mesenteric arteries in postmyocardial infarction rats via a PI3K/Akt/eNOS pathway-mediated mechanism.
Y. Wang, S. Wang, W. G. Wier, Q. Zhang, H. Jiang, Q. Li, S. Chen, Z. Tian, Y. Li, X. Yu, et al. (2010)
Am J Physiol Heart Circ Physiol
299, H2097-H2106
|Abstract »|Full Text »|PDF »
LFA-1 and Mac-1 Define Characteristically Different Intralumenal Crawling and Emigration Patterns for Monocytes and Neutrophils In Situ.
R. Sumagin, H. Prizant, E. Lomakina, R. E. Waugh, and I. H. Sarelius (2010)
J. Immunol.
185, 7057-7066
|Abstract »|Full Text »|PDF »
Nomenclature of monocytes and dendritic cells in blood.
L. Ziegler-Heitbrock, P. Ancuta, S. Crowe, M. Dalod, V. Grau, D. N. Hart, P. J. M. Leenen, Y.-J. Liu, G. MacPherson, G. J. Randolph, et al. (2010)
Blood
116, e74-e80
|Abstract »|Full Text »|PDF »
Regulation of monocyte subset systemic levels by distinct chemokine receptors controls post-ischaemic neovascularization.
C. Cochain, M. P. Rodero, J. Vilar, A. Recalde, A. L. Richart, C. Loinard, Y. Zouggari, C. Guerin, M. Duriez, B. Combadiere, et al. (2010)
Cardiovasc Res
88, 186-195
|Abstract »|Full Text »|PDF »
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils.
S. Massena, G. Christoffersson, E. Hjertstrom, E. Zcharia, I. Vlodavsky, N. Ausmees, C. Rolny, J.-P. Li, and M. Phillipson (2010)
Blood
116, 1924-1931
|Abstract »|Full Text »|PDF »
CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses.
J. Zhou, P. C. Y. Tang, L. Qin, P. M. Gayed, W. Li, E. A. Skokos, T. R. Kyriakides, J. S. Pober, and G. Tellides (2010)
J. Exp. Med.
207, 1951-1966
|Abstract »|Full Text »|PDF »
Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing.
R. T. Boscacci, F. Pfeiffer, K. Gollmer, A. I. C. Sevilla, A. M. Martin, S. F. Soriano, D. Natale, S. Henrickson, U. H. von Andrian, Y. Fukui, et al. (2010)
Blood
116, 915-925
|Abstract »|Full Text »|PDF »
Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes.
K. Movahedi, D. Laoui, C. Gysemans, M. Baeten, G. Stange, J. Van den Bossche, M. Mack, D. Pipeleers, P. In't Veld, P. De Baetselier, et al. (2010)
Cancer Res.
70, 5728-5739
|Abstract »|Full Text »|PDF »
Circulating monocyte subpopulations with high expression of angiotensin-converting enzyme predict mortality in patients with end-stage renal disease.
C. Ulrich, G. H. Heine, E. Seibert, D. Fliser, and M. Girndt (2010)
Nephrol. Dial. Transplant.
25, 2265-2272
|Abstract »|Full Text »|PDF »
The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B.
M. Rosas, B. Thomas, M. Stacey, S. Gordon, and P. R. Taylor (2010)
J. Leukoc. Biol.
88, 169-180
|Abstract »|Full Text »|PDF »
Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice.
F. I. Kostadinova, T. Baba, Y. Ishida, T. Kondo, B. K. Popivanova, and N. Mukaida (2010)
J. Leukoc. Biol.
88, 133-143
|Abstract »|Full Text »|PDF »
Distribution and Function of Macrophage Galactose-type C-type Lectin 2 (MGL2/CD301b): EFFICIENT UPTAKE AND PRESENTATION OF GLYCOSYLATED ANTIGENS BY DENDRITIC CELLS.
K. Denda-Nagai, S. Aida, K. Saba, K. Suzuki, S. Moriyama, S. Oo-puthinan, M. Tsuiji, A. Morikawa, Y. Kumamoto, D. Sugiura, et al. (2010)
J. Biol. Chem.
285, 19193-19204
|Abstract »|Full Text »|PDF »
Monocytes: Protagonists of Infarct Inflammation and Repair After Myocardial Infarction.
M. Nahrendorf, M. J. Pittet, and F. K. Swirski (2010)
Circulation
121, 2437-2445
|Full Text »|PDF »
Monocyte Trafficking to Hepatic Sites of Bacterial Infection Is Chemokine Independent and Directed by Focal Intercellular Adhesion Molecule-1 Expression.
C. Shi, P. Velazquez, T. M. Hohl, I. Leiner, M. L. Dustin, and E. G. Pamer (2010)
J. Immunol.
184, 6266-6274
|Abstract »|Full Text »|PDF »
Intercellular Adhesion Molecule-1 Enrichment near Tricellular Endothelial Junctions Is Preferentially Associated with Leukocyte Transmigration and Signals for Reorganization of These Junctions To Accommodate Leukocyte Passage.
O. Barreiro, P. Martin, R. Gonzalez-Amaro, and F. Sanchez-Madrid (2010)
Cardiovasc Res
86, 174-182
|Abstract »|Full Text »|PDF »
Inflammatory Monocytes but Not Neutrophils Are Necessary To Control Infection with Toxoplasma gondii in Mice.
I. R. Dunay, A. Fuchs, and L. D. Sibley (2010)
Infect. Immun.
78, 1564-1570
|Abstract »|Full Text »|PDF »
Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage.
W.-K. Kim, Y. Sun, H. Do, P. Autissier, E. F. Halpern, M. Piatak Jr., J. D. Lifson, T. H. Burdo, M. S. McGrath, and K. Williams (2010)
J. Leukoc. Biol.
87, 557-567
|Abstract »|Full Text »|PDF »
The macrophage: the intersection between HIV infection and atherosclerosis.
S. M. Crowe, C. L. V. Westhorpe, N. Mukhamedova, A. Jaworowski, D. Sviridov, and M. Bukrinsky (2010)
J. Leukoc. Biol.
87, 589-598
|Abstract »|Full Text »|PDF »
Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes.
E. J. Park, A. Peixoto, Y. Imai, A. Goodarzi, G. Cheng, C. V. Carman, U. H. von Andrian, and M. Shimaoka (2010)
Blood
115, 1572-1581
|Abstract »|Full Text »|PDF »
Mycobacterium bovis Bacillus Calmette-Guerin Vaccination Mobilizes Innate Myeloid-Derived Suppressor Cells Restraining In Vivo T Cell Priming via IL-1R-Dependent Nitric Oxide Production.
A. Martino, E. Badell, V. Abadie, V. Balloy, M. Chignard, M.-Y. Mistou, B. Combadiere, C. Combadiere, and N. Winter (2010)
J. Immunol.
184, 2038-2047
|Abstract »|Full Text »|PDF »
Two physically, functionally, and developmentally distinct peritoneal macrophage subsets.
E. E. B. Ghosn, A. A. Cassado, G. R. Govoni, T. Fukuhara, Y. Yang, D. M. Monack, K. R. Bortoluci, S. R. Almeida, L. A. Herzenberg, and L. A. Herzenberg (2010)
PNAS
107, 2568-2573
|Abstract »|Full Text »|PDF »
Development of Monocytes, Macrophages, and Dendritic Cells.
F. Geissmann, M. G. Manz, S. Jung, M. H. Sieweke, M. Merad, and K. Ley (2010)
Science
327, 656-661
|Abstract »|Full Text »|PDF »
Monocyte heterogeneity in obesity and subclinical atherosclerosis.
K. S. Rogacev, C. Ulrich, L. Blomer, F. Hornof, K. Oster, M. Ziegelin, B. Cremers, Y. Grenner, J. Geisel, A. Schlitt, et al. (2010)
Eur. Heart J.
31, 369-376
|Abstract »|Full Text »|PDF »