Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 317 (5838): 666-670

Copyright © 2007 by the American Association for the Advancement of Science

Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior

Cedric Auffray,1 Darin Fogg,1 Meriem Garfa,1 Gaelle Elain,1 Olivier Join-Lambert,2,3 Samer Kayal,1,2,3 Sabine Sarnacki,2,3 Ana Cumano,4 Gregoire Lauvau,5 Frederic Geissmann1,2,3*

Abstract: The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended on the integrin LFA-1 and the chemokine receptor CX3CR1 and was required for rapid tissue invasion at the site of an infection by this "resident" monocyte population, which initiated an early immune response and differentiated into macrophages.

1 Institut Nationale de la Santé et de la Recherche Médicale (INSERM) U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Fédératif de Recherche Necker-Enfants Malades, Paris, France.
2 University Paris-Descartes, Paris, France.
3 Hôpital Necker-Enfants Malades, AP-HP, Paris, France.
4 INSERM U668, Unité de Développement des Lymphocytes, Institut Pasteur, Paris, France.
5 INSERM E03-44, Institut de Pharmacologie Moleculaire et Cellulaire, Nice, France.

* To whom correspondence should be addressed. E-mail: geissmann{at}necker.fr


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diverse macrophage populations mediate acute lung inflammation and resolution.
N. R. Aggarwal, L. S. King, and F. R. D'Alessio (2014)
Am J Physiol Lung Cell Mol Physiol 306, L709-L725
   Abstract »    Full Text »    PDF »
Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis.
J. Rolin and A. A. Maghazachi (2014)
J. Leukoc. Biol. 95, 575-585
   Abstract »    Full Text »    PDF »
Vascular Associations and Dynamic Process Motility in Perivascular Myeloid Cells of the Mouse Choroid: Implications for Function and Senescent Change.
A. Kumar, L. Zhao, R. N. Fariss, P. G. McMenamin, and W. T. Wong (2014)
Invest. Ophthalmol. Vis. Sci. 55, 1787-1796
   Abstract »    Full Text »    PDF »
Ribosomal Protein L13a Deficiency in Macrophages Promotes Atherosclerosis by Limiting Translation Control-Dependent Retardation of Inflammation.
A. Basu, D. Poddar, P. Robinet, J. D. Smith, M. Febbraio, W. M. Baldwin III, and B. Mazumder (2014)
Arterioscler Thromb Vasc Biol 34, 533-542
   Abstract »    Full Text »    PDF »
Fluorescent Leukocytes Enter Plaque on the Microscope Stage.
M. Nahrendorf and F. K. Swirski (2014)
Circ. Res. 114, 740-741
   Full Text »    PDF »
High-Resolution Imaging of Intravascular Atherogenic Inflammation in Live Mice.
R. Chevre, J. M. Gonzalez-Granado, R. T. A. Megens, V. Sreeramkumar, C. Silvestre-Roig, P. Molina-Sanchez, C. Weber, O. Soehnlein, A. Hidalgo, and V. Andres (2014)
Circ. Res. 114, 770-779
   Abstract »    Full Text »    PDF »
Multiple-Site Activation of the Cysteinyl Leukotriene Receptor 2 Is Required for Exacerbation of Ischemia/Reperfusion Injury.
N. C. Ni, L. L. Ballantyne, J. D. Mewburn, and C. D. Funk (2014)
Arterioscler Thromb Vasc Biol 34, 321-330
   Abstract »    Full Text »    PDF »
Cellular dynamics in the muscle satellite cell niche.
C. F. Bentzinger, Y. X. Wang, N. A. Dumont, and M. A. Rudnicki (2013)
EMBO Rep. 14, 1062-1072
   Abstract »    Full Text »    PDF »
Tissue LyC6- Macrophages Are Generated in the Absence of Circulating LyC6- Monocytes and Nur77 in a Model of Muscle Regeneration.
T. Varga, R. Mounier, P. Gogolak, S. Poliska, B. Chazaud, and L. Nagy (2013)
J. Immunol. 191, 5695-5701
   Abstract »    Full Text »    PDF »
Beyond Stem Cells: Self-Renewal of Differentiated Macrophages.
M. H. Sieweke and J. E. Allen (2013)
Science 342, 1242974
   Abstract »    Full Text »    PDF »
Conjugated Linoleic Acid Targets {beta}2 Integrin Expression To Suppress Monocyte Adhesion.
M. de Gaetano, E. Dempsey, S. Marcone, W. G. James, and O. Belton (2013)
J. Immunol. 191, 4326-4336
   Abstract »    Full Text »    PDF »
The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis.
S. J. Cohen, I. Gurevich, S. W. Feigelson, E. Petrovich, M. Moser, G. Shakhar, R. Fassler, and R. Alon (2013)
Blood 122, 2609-2617
   Abstract »    Full Text »    PDF »
Pharmacological Inhibition of the Chemokine Receptor, CX3CR1, Reduces Atherosclerosis in Mice.
L. Poupel, A. Boissonnas, P. Hermand, K. Dorgham, E. Guyon, C. Auvynet, F. S. Charles, P. Lesnik, P. Deterre, and C. Combadiere (2013)
Arterioscler Thromb Vasc Biol 33, 2297-2305
   Abstract »    Full Text »    PDF »
Tyrosine Phosphorylation of CD13 Regulates Inflammatory Cell-Cell Adhesion and Monocyte Trafficking.
J. Subramani, M. Ghosh, M. M. Rahman, L. A. Caromile, C. Gerber, K. Rezaul, D. K. Han, and L. H. Shapiro (2013)
J. Immunol. 191, 3905-3912
   Abstract »    Full Text »    PDF »
CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice.
F. E. Pereira, C. Cronin, M. Ghosh, S.-Y. Zhou, M. Agosto, J. Subramani, R. Wang, J.-B. Shen, W. Schacke, B. Liang, et al. (2013)
Cardiovasc Res 100, 74-83
   Abstract »    Full Text »    PDF »
Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6Chi Inflammatory Monocytes.
K. D. Nguyen, S. J. Fentress, Y. Qiu, K. Yun, J. S. Cox, and A. Chawla (2013)
Science 341, 1483-1488
   Abstract »    Full Text »    PDF »
Noninvasive MRI Monitoring of the Effect of Interventions on Endothelial Permeability in Murine Atherosclerosis Using an Albumin-Binding Contrast Agent.
A. Phinikaridou, M. E. Andia, G. Passacquale, A. Ferro, and R. M. Botnar (2013)
JAHA 2, e000402
   Abstract »    Full Text »    PDF »
Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior.
E. S. Wohleb, N. D. Powell, J. P. Godbout, and J. F. Sheridan (2013)
J. Neurosci. 33, 13820-13833
   Abstract »    Full Text »    PDF »
Innate Immune Cells in Inflammation and Cancer.
R. Nowarski, N. Gagliani, S. Huber, and R. A. Flavell (2013)
Cancer Immunology 1, 77-84
   Abstract »    Full Text »    PDF »
Regulation of Adaptive Immunity by the Fractalkine Receptor during Autoimmune Inflammation.
J. A. Garcia, P. A. Pino, M. Mizutani, S. M. Cardona, I. F. Charo, R. M. Ransohoff, T. G. Forsthuber, and A. E. Cardona (2013)
J. Immunol. 191, 1063-1072
   Abstract »    Full Text »    PDF »
CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice.
S. Jacquelin, F. Licata, K. Dorgham, P. Hermand, L. Poupel, E. Guyon, P. Deterre, D. A. Hume, C. Combadiere, and A. Boissonnas (2013)
Blood 122, 674-683
   Abstract »    Full Text »    PDF »
Biomechanical factors and macrophages in plaque stability.
A. Seneviratne, M. Hulsmans, P. Holvoet, and C. Monaco (2013)
Cardiovasc Res 99, 284-293
   Abstract »    Full Text »    PDF »
Comparative Analysis of Monocyte Subsets in the Pig.
L. Fairbairn, R. Kapetanovic, D. Beraldi, D. P. Sester, C. K. Tuggle, A. L. Archibald, and D. A. Hume (2013)
J. Immunol. 190, 6389-6396
   Abstract »    Full Text »    PDF »
Monocyte and Macrophage Heterogeneity in the Heart.
M. Nahrendorf and F. K. Swirski (2013)
Circ. Res. 112, 1624-1633
   Abstract »    Full Text »    PDF »
Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress.
K. S. Harker, N. Ueno, T. Wang, C. Bonhomme, W. Liu, and M. B. Lodoen (2013)
J. Leukoc. Biol. 93, 789-800
   Abstract »    Full Text »    PDF »
Integrin Regulation during Leukocyte Recruitment.
J. Herter and A. Zarbock (2013)
J. Immunol. 190, 4451-4457
   Abstract »    Full Text »    PDF »
Seminal Plasma Affects Prostaglandin Synthesis and Angiogenesis in the Porcine Uterus.
M. M. Kaczmarek, K. Krawczynski, and J. Filant (2013)
Biol Reprod 88, 72
   Abstract »    Full Text »    PDF »
Endoscopic Time-Lapse Imaging of Immune Cells in Infarcted Mouse Hearts.
K. Jung, P. Kim, F. Leuschner, R. Gorbatov, J. K. Kim, T. Ueno, M. Nahrendorf, and S. H. Yun (2013)
Circ. Res. 112, 891-899
   Abstract »    Full Text »    PDF »
Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction.
S. Frantz, U. Hofmann, D. Fraccarollo, A. Schafer, S. Kranepuhl, I. Hagedorn, B. Nieswandt, M. Nahrendorf, H. Wagner, B. Bayer, et al. (2013)
FASEB J 27, 871-881
   Abstract »    Full Text »    PDF »
Neutrophil-Derived Cathelicidin Promotes Adhesion of Classical Monocytes.
S. Wantha, J.-E. Alard, R. T. A. Megens, A. M. van der Does, Y. Doring, M. Drechsler, C. T. N. Pham, M.-W. Wang, J.-M. Wang, R. L. Gallo, et al. (2013)
Circ. Res. 112, 792-801
   Abstract »    Full Text »    PDF »
Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium.
C. Rius, C. Company, L. Piqueras, J. M. Cerda-Nicolas, C. Gonzalez, E. Servera, A. Ludwig, E. J. Morcillo, and M.-J. Sanz (2013)
Thorax 68, 177-186
   Abstract »    Full Text »    PDF »
Arterial and Venous Endothelia Display Differential Functional Fractalkine (CX3CL1) Expression by Angiotensin-II.
C. Rius, L. Piqueras, H. Gonzalez-Navarro, F. Albertos, C. Company, C. Lopez-Gines, A. Ludwig, J.-I. Blanes, E. J. Morcillo, and M.-J. Sanz (2013)
Arterioscler Thromb Vasc Biol 33, 96-104
   Abstract »    Full Text »    PDF »
Collaboration Between Macrophages and Vaccine-Induced CD4+ T Cells Confers Protection Against Lethal Pseudomonas aeruginosa Pneumonia During Neutropenia.
A. Kamei, W. Wu, D. C. Traficante, A. Y. Koh, N. Van Rooijen, G. B. Pier, and G. P. Priebe (2013)
The Journal of Infectious Disease 207, 39-49
   Abstract »    Full Text »    PDF »
Cell-based interventions for therapeutic angiogenesis: review of potential cell sources.
R. A. Brenes, M. Bear, C. Jadlowiec, M. Goodwin, P. Hashim, C. D. Protack, K. R. Ziegler, X. Li, L. S. Model, W. Lv, et al. (2012)
Vascular 20, 360-368
   Abstract »    Full Text »    PDF »
Monocyte Chemoattractant Protein-1/CCR2 Axis Promotes Vein Graft Neointimal Hyperplasia Through Its Signaling in Graft-Extrinsic Cell Populations.
C. Fu, P. Yu, M. Tao, T. Gupta, L. L. Moldawer, S. A. Berceli, and Z. Jiang (2012)
Arterioscler Thromb Vasc Biol 32, 2418-2426
   Abstract »    Full Text »    PDF »
The TRPM4 Channel Controls Monocyte and Macrophage, but Not Neutrophil, Function for Survival in Sepsis.
N. Serafini, A. Dahdah, G. Barbet, M. Demion, T. Attout, G. Gautier, M. Arcos-Fajardo, H. Souchet, M.-H. Jouvin, F. Vrtovsnik, et al. (2012)
J. Immunol. 189, 3689-3699
   Abstract »    Full Text »    PDF »
IL-10 Acts As a Developmental Switch Guiding Monocyte Differentiation to Macrophages during a Murine Peritoneal Infection.
H.-H. Nguyen, B.-T. Tran, W. Muller, and R. S. Jack (2012)
J. Immunol. 189, 3112-3120
   Abstract »    Full Text »    PDF »
Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation.
R. Darbousset, G. M. Thomas, S. Mezouar, C. Frere, R. Bonier, N. Mackman, T. Renne, F. Dignat-George, C. Dubois, and L. Panicot-Dubois (2012)
Blood 120, 2133-2143
   Abstract »    Full Text »    PDF »
Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation - Mechanisms and Therapeutic Targets.
G. R. Romeo, J. Lee, and S. E. Shoelson (2012)
Arterioscler Thromb Vasc Biol 32, 1771-1776
   Abstract »    Full Text »    PDF »
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair.
S. Willenborg, T. Lucas, G. van Loo, J. A. Knipper, T. Krieg, I. Haase, B. Brachvogel, M. Hammerschmidt, A. Nagy, N. Ferrara, et al. (2012)
Blood 120, 613-625
   Abstract »    Full Text »    PDF »
Activation of Invariant NKT Cells in Early Phase of Experimental Autoimmune Encephalomyelitis Results in Differentiation of Ly6Chi Inflammatory Monocyte to M2 Macrophages and Improved Outcome.
L. Denney, W. L. Kok, S. L. Cole, S. Sanderson, A. J. McMichael, and L.-P. Ho (2012)
J. Immunol. 189, 551-557
   Abstract »    Full Text »    PDF »
Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.
Y.-M. Hyun, R. Sumagin, P. P. Sarangi, E. Lomakina, M. G. Overstreet, C. M. Baker, D. J. Fowell, R. E. Waugh, I. H. Sarelius, and M. Kim (2012)
J. Exp. Med. 209, 1349-1362
   Abstract »    Full Text »    PDF »
A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System.
R. N. Germain, E. A. Robey, and M. D. Cahalan (2012)
Science 336, 1676-1681
   Abstract »    Full Text »    PDF »
Loss of TNF Signaling Facilitates the Development of a Novel Ly-6Clow Macrophage Population Permissive for Leishmania major Infection.
P. D. Fromm, J. Kling, M. Mack, J. D. Sedgwick, and H. Korner (2012)
J. Immunol. 188, 6258-6266
   Abstract »    Full Text »    PDF »
Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis.
N. Boivin, R. Menasria, D. Gosselin, S. Rivest, and G. Boivin (2012)
J. Gen. Virol. 93, 1294-1304
   Abstract »    Full Text »    PDF »
CD16 Regulates TRIF-Dependent TLR4 Response in Human Monocytes and Their Subsets.
I. N. Shalova, T. Kajiji, J. Y. Lim, V. Gomez-Pina, I. Fernandez-Ruiz, F. Arnalich, P. T. C. Iau, E. Lopez-Collazo, S.-C. Wong, and S. K. Biswas (2012)
J. Immunol. 188, 3584-3593
   Abstract »    Full Text »    PDF »
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells.
C. Schulz, E. G. Perdiguero, L. Chorro, H. Szabo-Rogers, N. Cagnard, K. Kierdorf, M. Prinz, B. Wu, S. E. W. Jacobsen, J. W. Pollard, et al. (2012)
Science 336, 86-90
   Abstract »    Full Text »    PDF »
Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice.
A. M. Gil-Bernabe, S. Ferjancic, M. Tlalka, L. Zhao, P. D. Allen, J. H. Im, K. Watson, S. A. Hill, A. Amirkhosravi, J. L. Francis, et al. (2012)
Blood 119, 3164-3175
   Abstract »    Full Text »    PDF »
Endogenous Regulatory T Cells Adhere in Inflamed Dermal Vessels via ICAM-1: Association with Regulation of Effector Leukocyte Adhesion.
J. A. Deane, L. D. Abeynaike, M. U. Norman, J. L. Wee, A. R. Kitching, P. Kubes, and M. J. Hickey (2012)
J. Immunol. 188, 2179-2188
   Abstract »    Full Text »    PDF »
P2X4 Receptors Influence Inflammasome Activation after Spinal Cord Injury.
J. P. de Rivero Vaccari, D. Bastien, G. Yurcisin, I. Pineau, W. D. Dietrich, Y. De Koninck, R. W. Keane, and S. Lacroix (2012)
J. Neurosci. 32, 3058-3066
   Abstract »    Full Text »    PDF »
Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling.
D. A. Hume and K. P. A. MacDonald (2012)
Blood 119, 1810-1820
   Abstract »    Full Text »    PDF »
NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis.
R. N. Hanna, I. Shaked, H. G. Hubbeling, J. A. Punt, R. Wu, E. Herrley, C. Zaugg, H. Pei, F. Geissmann, K. Ley, et al. (2012)
Circ. Res. 110, 416-427
   Abstract »    Full Text »    PDF »
Elevated CD14++CD16- Monocytes Predict Cardiovascular Events.
K. E. Berg, I. Ljungcrantz, L. Andersson, C. Bryngelsson, B. Hedblad, G. N. Fredrikson, J. Nilsson, and H. Bjorkbacka (2012)
Circ Cardiovasc Genet 5, 122-131
   Abstract »    Full Text »    PDF »
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.
F. Leuschner, P. J. Rauch, T. Ueno, R. Gorbatov, B. Marinelli, W. W. Lee, P. Dutta, Y. Wei, C. Robbins, Y. Iwamoto, et al. (2012)
J. Exp. Med. 209, 123-137
   Abstract »    Full Text »    PDF »
Protumoral role of monocytes in human B-cell precursor acute lymphoblastic leukemia: involvement of the chemokine CXCL10.
Y. Lee, M. Chittezhath, V. Andre, H. Zhao, M. Poidinger, A. Biondi, G. D'Amico, and S. K. Biswas (2012)
Blood 119, 227-237
   Abstract »    Full Text »    PDF »
The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood.
M. Mizutani, P. A. Pino, N. Saederup, I. F. Charo, R. M. Ransohoff, and A. E. Cardona (2012)
J. Immunol. 188, 29-36
   Abstract »    Full Text »    PDF »
Human CD16+ and CD16- monocyte subsets display unique effector properties in inflammatory conditions in vivo.
S. R. Aguilar-Ruiz, H. Torres-Aguilar, E. Gonzalez-Dominguez, J. Narvaez, G. Gonzalez-Perez, G. Vargas-Ayala, M. A. Meraz-Rios, E. A. Garcia-Zepeda, and C. Sanchez-Torres (2011)
J. Leukoc. Biol. 90, 1119-1131
   Abstract »    Full Text »    PDF »
Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking.
K. Mayol, V. Biajoux, J. Marvel, K. Balabanian, and T. Walzer (2011)
Blood 118, 4863-4871
   Abstract »    Full Text »    PDF »
Lung dendritic cells at the innate-adaptive immune interface.
T. V. Condon, R. T. Sawyer, M. J. Fenton, and D. W. H. Riches (2011)
J. Leukoc. Biol. 90, 883-895
   Abstract »    Full Text »    PDF »
The role of monocytes and inflammation in the pathophysiology of heart failure.
B. J. Wrigley, G. Y. H. Lip, and E. Shantsila (2011)
Eur J Heart Fail 13, 1161-1171
   Abstract »    Full Text »    PDF »
Distinct Roles of CSF-1 Isoforms in Lupus Nephritis.
J. Menke, Y. Iwata, W. A. Rabacal, R. Basu, E. R. Stanley, and V. R. Kelley (2011)
J. Am. Soc. Nephrol. 22, 1821-1833
   Abstract »    Full Text »    PDF »
SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset.
A. M. Zawada, K. S. Rogacev, B. Rotter, P. Winter, R.-R. Marell, D. Fliser, and G. H. Heine (2011)
Blood 118, e50-e61
   Abstract »    Full Text »    PDF »
Increased Toll-like Receptor-2 Expression on Nonclassic CD16+ Monocytes from Patients with Inflammatory Stage of Eales' Disease.
A. Sen, I. H. Chowdhury, D. Mukhopadhyay, S. K. Paine, A. Mukherjee, L. K. Mondal, M. Chatterjee, and B. Bhattacharya (2011)
Invest. Ophthalmol. Vis. Sci. 52, 6940-6948
   Abstract »    Full Text »    PDF »
Regulation of Macrophage Arginase Expression and Tumor Growth by the Ron Receptor Tyrosine Kinase.
D. R. Sharda, S. Yu, M. Ray, M. L. Squadrito, M. De Palma, T. A. Wynn, S. M. Morris Jr., and P. A. Hankey (2011)
J. Immunol. 187, 2181-2192
   Abstract »    Full Text »    PDF »
Plasticity of Ly-6Chi Myeloid Cells in T Cell Regulation.
B. Zhu, J. K. Kennedy, Y. Wang, C. Sandoval-Garcia, L. Cao, S. Xiao, C. Wu, W. Elyaman, and S. J. Khoury (2011)
J. Immunol. 187, 2418-2432
   Abstract »    Full Text »    PDF »
Monocyte and Macrophage Dynamics During Atherogenesis.
K. Ley, Y. I. Miller, and C. C. Hedrick (2011)
Arterioscler Thromb Vasc Biol 31, 1506-1516
   Abstract »    Full Text »    PDF »
The Spatial and Developmental Relationships in the Macrophage Family.
F. K. Swirski (2011)
Arterioscler Thromb Vasc Biol 31, 1517-1522
   Abstract »    Full Text »    PDF »
No Need to Coax Monocytes.
G. J. Randolph (2011)
Science 332, 1268-1269
   Abstract »    Full Text »    PDF »
PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions.
S. Y. Thomas, S. T. Scanlon, K. G. Griewank, M. G. Constantinides, A. K. Savage, K. A. Barr, F. Meng, A. D. Luster, and A. Bendelac (2011)
J. Exp. Med. 208, 1179-1188
   Abstract »    Full Text »    PDF »
Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection.
R. Goncalves, X. Zhang, H. Cohen, A. Debrabant, and D. M. Mosser (2011)
J. Exp. Med. 208, 1253-1265
   Abstract »    Full Text »    PDF »
TNF-{alpha}-dependent Regulation of Acute Pancreatitis Severity by Ly-6Chi Monocytes in Mice.
G. Perides, E. R. Weiss, E. S. Michael, J. M. Laukkarinen, J. S. Duffield, and M. L. Steer (2011)
J. Biol. Chem. 286, 13327-13335
   Abstract »    Full Text »    PDF »
Dissemination of Persistent Intestinal Bacteria via the Mesenteric Lymph Nodes Causes Typhoid Relapse.
A. J. Griffin, L.-X. Li, S. Voedisch, O. Pabst, and S. J. McSorley (2011)
Infect. Immun. 79, 1479-1488
   Abstract »    Full Text »    PDF »
Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity.
D. A. Hume (2011)
J. Leukoc. Biol. 89, 525-538
   Abstract »    Full Text »    PDF »
Primary Monocytes Regulate Endothelial Cell Survival Through Secretion of Angiopoietin-1 and Activation of Endothelial Tie2.
S. Y. Schubert, A. Benarroch, J. Monter-Solans, and E. R. Edelman (2011)
Arterioscler Thromb Vasc Biol 31, 870-875
   Abstract »    Full Text »    PDF »
Leukocytes and the Natural History of Deep Vein Thrombosis: Current Concepts and Future Directions.
P. Saha, J. Humphries, B. Modarai, K. Mattock, M. Waltham, C. E. Evans, A. Ahmad, A. S. Patel, S. Premaratne, O. T. A. Lyons, et al. (2011)
Arterioscler Thromb Vasc Biol 31, 506-512
   Abstract »    Full Text »    PDF »
Monocyte Angiotensin Converting Enzyme Expression May Be Associated with Atherosclerosis Rather than Arteriosclerosis in Hemodialysis Patients.
C. Ulrich, E. Seibert, G. H. Heine, D. Fliser, and M. Girndt (2011)
Clin. J. Am. Soc. Nephrol. 6, 505-511
   Abstract »    Full Text »    PDF »
CX3CR1+ Lung Mononuclear Phagocytes Spatially Confined to the Interstitium Produce TNF-{alpha} and IL-6 and Promote Cigarette Smoke-Induced Emphysema.
Z. Xiong, A. S. Leme, P. Ray, S. D. Shapiro, and J. S. Lee (2011)
J. Immunol. 186, 3206-3214
   Abstract »    Full Text »    PDF »
Accelerated Dendritic Cell Differentiation from Migrating Ly6Clo Bone Marrow Monocytes in Early Dermal West Nile Virus Infection.
A. M. Davison and N. J. C. King (2011)
J. Immunol. 186, 2382-2396
   Abstract »    Full Text »    PDF »
CD14++CD16+ monocytes and cardiovascular outcome in patients with chronic kidney disease.
K. S. Rogacev, S. Seiler, A. M. Zawada, B. Reichart, E. Herath, D. Roth, C. Ulrich, D. Fliser, and G. H. Heine (2011)
Eur. Heart J. 32, 84-92
   Abstract »    Full Text »    PDF »
Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury.
H. Lu, D. Huang, N. Saederup, I. F. Charo, R. M. Ransohoff, and L. Zhou (2011)
FASEB J 25, 358-369
   Abstract »    Full Text »    PDF »
Exercise improves the dilatation function of mesenteric arteries in postmyocardial infarction rats via a PI3K/Akt/eNOS pathway-mediated mechanism.
Y. Wang, S. Wang, W. G. Wier, Q. Zhang, H. Jiang, Q. Li, S. Chen, Z. Tian, Y. Li, X. Yu, et al. (2010)
Am J Physiol Heart Circ Physiol 299, H2097-H2106
   Abstract »    Full Text »    PDF »
LFA-1 and Mac-1 Define Characteristically Different Intralumenal Crawling and Emigration Patterns for Monocytes and Neutrophils In Situ.
R. Sumagin, H. Prizant, E. Lomakina, R. E. Waugh, and I. H. Sarelius (2010)
J. Immunol. 185, 7057-7066
   Abstract »    Full Text »    PDF »
Nomenclature of monocytes and dendritic cells in blood.
L. Ziegler-Heitbrock, P. Ancuta, S. Crowe, M. Dalod, V. Grau, D. N. Hart, P. J. M. Leenen, Y.-J. Liu, G. MacPherson, G. J. Randolph, et al. (2010)
Blood 116, e74-e80
   Abstract »    Full Text »    PDF »
Regulation of monocyte subset systemic levels by distinct chemokine receptors controls post-ischaemic neovascularization.
C. Cochain, M. P. Rodero, J. Vilar, A. Recalde, A. L. Richart, C. Loinard, Y. Zouggari, C. Guerin, M. Duriez, B. Combadiere, et al. (2010)
Cardiovasc Res 88, 186-195
   Abstract »    Full Text »    PDF »
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils.
S. Massena, G. Christoffersson, E. Hjertstrom, E. Zcharia, I. Vlodavsky, N. Ausmees, C. Rolny, J.-P. Li, and M. Phillipson (2010)
Blood 116, 1924-1931
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882