Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 317 (5839): 807-810

Copyright © 2007 by the American Association for the Advancement of Science

Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis

Andrew S. Brack,1 Michael J. Conboy,1 Sudeep Roy,1 Mark Lee,2 Calvin J. Kuo,2 Charles Keller,3 Thomas A. Rando1,4*

Abstract: The regenerative potential of skeletal muscle declines with age, and this impairment is associated with an increase in tissue fibrosis. We show that muscle stem cells (satellite cells) from aged mice tend to convert from a myogenic to a fibrogenic lineage as they begin to proliferate and that this conversion is mediated by factors in the systemic environment of the old animals. We also show that this lineage conversion is associated with an activation of the canonical Wnt signaling pathway in aged myogenic progenitors and can be suppressed by Wnt inhibitors. Furthermore, components of serum from aged mice that bind to the Frizzled family of proteins, which are Wnt receptors, may account for the elevated Wnt signaling in aged cells. These results indicate that the Wnt signaling pathway may play a critical role in tissue-specific stem cell aging and an increase in tissue fibrosis with age.

1 Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
2 Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
3 Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
4 Geriatric Research, Education, and Clinical Center (GRECC) and Neurology Service, Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA 94304, USA.

* To whom correspondence should be addressed. E-mail: rando{at}

RAGE signaling deficiency in rhabdomyosarcoma cells causes upregulation of PAX7 and uncontrolled proliferation.
F. Riuzzi, G. Sorci, R. Sagheddu, A. Sidoni, R. Alaggio, V. Ninfo, and R. Donato (2014)
J. Cell Sci. 127, 1699-1711
   Abstract »    Full Text »    PDF »
Wnt Protein-mediated Satellite Cell Conversion in Adult and Aged Mice Following Voluntary Wheel Running.
S. Fujimaki, R. Hidaka, M. Asashima, T. Takemasa, and T. Kuwabara (2014)
J. Biol. Chem. 289, 7399-7412
   Abstract »    Full Text »    PDF »
Aging increases CCN1 expression leading to muscle senescence.
J. Du, J. D. Klein, F. Hassounah, J. Zhang, C. Zhang, and X. H. Wang (2014)
Am J Physiol Cell Physiol 306, C28-C36
   Abstract »    Full Text »    PDF »
Nfatc1 orchestrates aging in hair follicle stem cells.
B. E. Keyes, J. P. Segal, E. Heller, W.-H. Lien, C.-Y. Chang, X. Guo, D. S. Oristian, D. Zheng, and E. Fuchs (2013)
PNAS 110, E4950-E4959
   Abstract »    Full Text »    PDF »
Human skeletal muscle fibroblasts, but not myogenic cells, readily undergo adipogenic differentiation.
C. C. Agley, A. M. Rowlerson, C. P. Velloso, N. R. Lazarus, and S. D. R. Harridge (2013)
J. Cell Sci. 126, 5610-5625
   Abstract »    Full Text »    PDF »
Cellular dynamics in the muscle satellite cell niche.
C. F. Bentzinger, Y. X. Wang, N. A. Dumont, and M. A. Rudnicki (2013)
EMBO Rep. 14, 1062-1072
   Abstract »    Full Text »    PDF »
Hedgehog-Dependent Regulation of Angiogenesis and Myogenesis Is Impaired in Aged Mice.
M.-A. Renault, F. Robbesyn, C. Chapouly, Q. Yao, S. Vandierdonck, A. Reynaud, I. Belloc, E. Traiffort, M. Ruat, C. Desgranges, et al. (2013)
Arterioscler Thromb Vasc Biol 33, 2858-2866
   Abstract »    Full Text »    PDF »
Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle.
A. Birbrair, T. Zhang, Z.-M. Wang, M. L. Messi, A. Mintz, and O. Delbono (2013)
Am J Physiol Cell Physiol 305, C1098-C1113
   Abstract »    Full Text »    PDF »
Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models.
F. Demontis, R. Piccirillo, A. L. Goldberg, and N. Perrimon (2013)
Dis. Model. Mech. 6, 1339-1352
   Abstract »    Full Text »    PDF »
Age-associated epigenetic drift: implications, and a case of epigenetic thrift?.
A. E. Teschendorff, J. West, and S. Beck (2013)
Hum. Mol. Genet. 22, R7-R15
   Abstract »    Full Text »    PDF »
Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans.
E. K. Merritt, M. J. Stec, A. Thalacker-Mercer, S. T. Windham, J. M. Cross, D. P. Shelley, S. Craig Tuggle, D. J. Kosek, J.-s. Kim, and M. M. Bamman (2013)
J Appl Physiol 115, 937-948
   Abstract »    Full Text »    PDF »
Requirement for active glycogen synthase kinase-3{beta} in TGF-{beta}1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts.
M. Bahammam, S. A. Black Jr., S. S. Sume, M. A. Assaggaf, M. Faibish, and P. C. Trackman (2013)
Am J Physiol Cell Physiol 305, C581-C590
   Abstract »    Full Text »    PDF »
Wnt4/{beta}-Catenin Signaling in Medullary Kidney Myofibroblasts.
D. P. DiRocco, A. Kobayashi, M. M. Taketo, A. P. McMahon, and B. D. Humphreys (2013)
J. Am. Soc. Nephrol. 24, 1399-1412
   Abstract »    Full Text »    PDF »
Ageing of the heart reversed by youthful systemic factors!.
A. S. Brack (2013)
EMBO J. 32, 2189-2190
   Full Text »    PDF »
Cellular Mechanisms of Tissue Fibrosis. 4. Structural and functional consequences of skeletal muscle fibrosis.
R. L. Lieber and S. R. Ward (2013)
Am J Physiol Cell Physiol 305, C241-C252
   Abstract »    Full Text »    PDF »
Interactions between p-Akt and Smad3 in injured muscles initiate myogenesis or fibrogenesis.
Y. Dong, R. Lakhia, S. S. Thomas, Y. Dong, X. H. Wang, K. A. S. Silva, and L. Zhang (2013)
Am J Physiol Endocrinol Metab 305, E367-E375
   Abstract »    Full Text »    PDF »
Androgens Up-regulate Transcription of the Notch Inhibitor Numb in C2C12 Myoblasts via Wnt/{beta}-Catenin Signaling to T Cell Factor Elements in the Numb Promoter.
X.-H. Liu, Y. Wu, S. Yao, A. C. Levine, A. Kirschenbaum, L. Collier, W. A. Bauman, and C. P. Cardozo (2013)
J. Biol. Chem. 288, 17990-17998
   Abstract »    Full Text »    PDF »
Telomere stability--Wnt it or lose it.
K. Bauer, S. Tao, and K. L. Rudolph (2013)
EMBO Rep. 14, 297-298
   Full Text »    PDF »
Intradermal adipocytes mediate fibroblast recruitment during skin wound healing.
B. A. Schmidt and V. Horsley (2013)
Development 140, 1517-1527
   Abstract »    Full Text »    PDF »
Pathological changes associated with white striping in broiler breast muscles.
V. A. Kuttappan, H. L. Shivaprasad, D. P. Shaw, B. A. Valentine, B. M. Hargis, F. D. Clark, S. R. McKee, and C. M. Owens (2013)
Poultry Science 92, 331-338
   Abstract »    Full Text »    PDF »
Satellite Cells and the Muscle Stem Cell Niche.
H. Yin, F. Price, and M. A. Rudnicki (2013)
Physiol Rev 93, 23-67
   Abstract »    Full Text »    PDF »
Celebrating 30 Years of Wnt Signaling.
F. Verkaar, K. M. Cadigan, and R. van Amerongen (2012)
Science Signaling 5, mr2
   Abstract »    Full Text »    PDF »
The Obestatin/GPR39 System Is Up-regulated by Muscle Injury and Functions as an Autocrine Regenerative System.
U. Gurriaran-Rodriguez, I. Santos-Zas, O. Al-Massadi, C. S. Mosteiro, D. Beiroa, R. Nogueiras, A. B. Crujeiras, L. M. Seoane, J. Senaris, T. Garcia-Caballero, et al. (2012)
J. Biol. Chem. 287, 38379-38389
   Abstract »    Full Text »    PDF »
Concise Review: Stem Cell Therapy for Muscular Dystrophies.
K. J. Wilschut, V. B. Ling, and H. S. Bernstein (2012)
Stem Cells Trans Med 1, 833-842
   Abstract »    Full Text »    PDF »
Secondary muscle pathology and metabolic dysregulation in adults with cerebral palsy.
M. D. Peterson, P. M. Gordon, E. A. Hurvitz, and C. F. Burant (2012)
Am J Physiol Endocrinol Metab 303, E1085-E1093
   Abstract »    Full Text »    PDF »
Age-associated inflammation inhibits epidermal stem cell function.
J. Doles, M. Storer, L. Cozzuto, G. Roma, and W. M. Keyes (2012)
Genes & Dev. 26, 2144-2153
   Abstract »    Full Text »    PDF »
Myostatin is associated with age-related human muscle stem cell dysfunction.
B. R. McKay, D. I. Ogborn, L. M. Bellamy, M. A. Tarnopolsky, and G. Parise (2012)
FASEB J 26, 2509-2521
   Abstract »    Full Text »    PDF »
HMGB1-RAGE regulates muscle satellite cell homeostasis through p38-MAPK- and myogenin-dependent repression of Pax7 transcription.
F. Riuzzi, G. Sorci, R. Sagheddu, and R. Donato (2012)
J. Cell Sci. 125, 1440-1454
   Abstract »    Full Text »    PDF »
Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing.
A. V. Ergen, N. C. Boles, and M. A. Goodell (2012)
Blood 119, 2500-2509
   Abstract »    Full Text »    PDF »
Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle.
A. Uezumi, T. Ito, D. Morikawa, N. Shimizu, T. Yoneda, M. Segawa, M. Yamaguchi, R. Ogawa, M. M. Matev, Y. Miyagoe-Suzuki, et al. (2011)
J. Cell Sci. 124, 3654-3664
   Abstract »    Full Text »    PDF »
Wnt5a Skews Dendritic Cell Differentiation to an Unconventional Phenotype with Tolerogenic Features.
J. Valencia, C. Hernandez-Lopez, V. G. Martinez, L. Hidalgo, A. G. Zapata, A. Vicente, A. Varas, and R. Sacedon (2011)
J. Immunol. 187, 4129-4139
   Abstract »    Full Text »    PDF »
Stem cells for skeletal muscle repair.
J. L. Shadrach and A. J. Wagers (2011)
Phil Trans R Soc B 366, 2297-2306
   Abstract »    Full Text »    PDF »
Wnt5a is a cell-extrinsic factor that supports self-renewal of mouse spermatogonial stem cells.
J. R. Yeh, X. Zhang, and M. C. Nagano (2011)
J. Cell Sci. 124, 2357-2366
   Abstract »    Full Text »    PDF »
S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner.
F. Riuzzi, G. Sorci, and R. Donato (2011)
J. Cell Sci. 124, 2389-2400
   Abstract »    Full Text »    PDF »
Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition.
O. Aisagbonhi, M. Rai, S. Ryzhov, N. Atria, I. Feoktistov, and A. K. Hatzopoulos (2011)
Dis. Model. Mech. 4, 469-483
   Abstract »    Full Text »    PDF »
Maternal Obesity-Impaired Insulin Signaling in Sheep and Induced Lipid Accumulation and Fibrosis in Skeletal Muscle of Offspring.
X. Yan, Y. Huang, J.-X. Zhao, N. M. Long, A. B. Uthlaut, M.-J. Zhu, S. P. Ford, P. W. Nathanielsz, and M. Du (2011)
Biol Reprod 85, 172-178
   Abstract »    Full Text »    PDF »
Rb1 Gene Inactivation Expands Satellite Cell and Postnatal Myoblast Pools.
T. Hosoyama, K. Nishijo, S. I. Prajapati, G. Li, and C. Keller (2011)
J. Biol. Chem. 286, 19556-19564
   Abstract »    Full Text »    PDF »
The Dual Role of Sirtuins in Cancer.
L. Bosch-Presegue and A. Vaquero (2011)
Genes & Cancer 2, 648-662
   Abstract »    Full Text »    PDF »
Age-related impairment of T cell-induced skeletal muscle precursor cell function.
B. R. Dumke and S. J. Lees (2011)
Am J Physiol Cell Physiol 300, C1226-C1233
   Abstract »    Full Text »    PDF »
T-cells and muscle just don't talk like they used to: Focus on "Age-related impairment of T cell-induced skeletal muscle precursor cell function".
T. J. Hawke (2011)
Am J Physiol Cell Physiol 300, C1223-C1225
   Full Text »    PDF »
Wnt4 activates the canonical {beta}-catenin pathway and regulates negatively myostatin: functional implication in myogenesis.
H. Bernardi, S. Gay, Y. Fedon, B. Vernus, A. Bonnieu, and F. Bacou (2011)
Am J Physiol Cell Physiol 300, C1122-C1138
   Abstract »    Full Text »    PDF »
Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating {beta}-catenin-TCF activity.
H. Benchabane, N. Xin, A. Tian, B. P. Hafler, K. Nguyen, A. Ahmed, and Y. Ahmed (2011)
EMBO J. 30, 1444-1458
   Abstract »    Full Text »    PDF »
Manifestations and mechanisms of stem cell aging.
L. Liu and T. A. Rando (2011)
J. Cell Biol. 193, 257-266
   Abstract »    Full Text »    PDF »
A WNT/{beta}-Catenin Signaling Activator, R-spondin, Plays Positive Regulatory Roles during Skeletal Myogenesis.
X. H. Han, Y.-R. Jin, M. Seto, and J. K. Yoon (2011)
J. Biol. Chem. 286, 10649-10659
   Abstract »    Full Text »    PDF »
Wnt Signaling Regulates Hepatic Metabolism.
H. Liu, M. M. Fergusson, J. J. Wu, I. I. Rovira, J. Liu, O. Gavrilova, T. Lu, J. Bao, D. Han, M. N. Sack, et al. (2011)
Science Signaling 4, ra6
   Abstract »    Full Text »    PDF »
Connective tissue fibroblasts and Tcf4 regulate myogenesis.
S. J. Mathew, J. M. Hansen, A. J. Merrell, M. M. Murphy, J. A. Lawson, D. A. Hutcheson, M. S. Hansen, M. Angus-Hill, and G. Kardon (2011)
Development 138, 371-384
   Abstract »    Full Text »    PDF »
Stem cell ageing and non-random chromosome segregation.
G. W. Charville and T. A. Rando (2011)
Phil Trans R Soc B 366, 85-93
   Abstract »    Full Text »    PDF »
Skeletal Muscle Satellite Cells Are Committed to Myogenesis and Do Not Spontaneously Adopt Nonmyogenic Fates.
J. D. Starkey, M. Yamamoto, S. Yamamoto, and D. J. Goldhamer (2011)
Journal of Histochemistry & Cytochemistry 59, 33-46
   Abstract »    Full Text »    PDF »
Skeletal Muscle Stem Cells: Effects of Aging and Metabolism on Muscle Regenerative Function.
Y. C. Jang, M. Sinha, M. Cerletti, C. Dall'Osso, and A. J. Wagers (2011)
Cold Spring Harb Symp Quant Biol 76, 101-111
   Abstract »    Full Text »    PDF »
Aging and Bone.
A. L. Boskey and R. Coleman (2010)
Journal of Dental Research 89, 1333-1348
   Abstract »    Full Text »    PDF »
The Emerging Relationship Between Regenerative Medicine and Physical Therapeutics.
F. Ambrosio, S. L. Wolf, A. Delitto, G. K. Fitzgerald, S. F. Badylak, M. L. Boninger, and A. J. Russell (2010)
Physical Therapy 90, 1807-1814
   Abstract »    Full Text »    PDF »
Wnt Signaling and Aging-Related Heart Disorders.
A. T. Naito, I. Shiojima, and I. Komuro (2010)
Circ. Res. 107, 1295-1303
   Abstract »    Full Text »    PDF »
Prevention of Muscle Aging by Myofiber-Associated Satellite Cell Transplantation.
J. K. Hall, G. B. Banks, J. S. Chamberlain, and B. B. Olwin (2010)
Science Translational Medicine 2, 57ra83
   Abstract »    Full Text »    PDF »
Are Human and Mouse Satellite Cells Really the Same?.
L. Boldrin, F. Muntoni, and J. E. Morgan (2010)
Journal of Histochemistry & Cytochemistry 58, 941-955
   Abstract »    Full Text »    PDF »
A muscle resident cell population promotes fibrosis in hindlimb skeletal muscles of mdx mice through the Wnt canonical pathway.
F. Trensz, S. Haroun, A. Cloutier, M. V. Richter, and G. Grenier (2010)
Am J Physiol Cell Physiol 299, C939-C947
   Abstract »    Full Text »    PDF »
Glomerular Epithelial Stem Cells: The Good, The Bad, and The Ugly.
L. Lasagni and P. Romagnani (2010)
J. Am. Soc. Nephrol. 21, 1612-1619
   Abstract »    Full Text »    PDF »
Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?.
F. Takahashi-Yanaga and M. Kahn (2010)
Clin. Cancer Res. 16, 3153-3162
   Abstract »    Full Text »    PDF »
Interstitial lung disease in elderly subjects.
M. Selman, P. Spagnolo, and L. Richeldi (2010)
Respiratory Diseases in the Elderly 150-162
   Abstract »    Full Text »    PDF »
Enhanced transforming growth factor-{beta} signaling and fibrogenesis in ovine fetal skeletal muscle of obese dams at late gestation.
Y. Huang, X. Yan, M. J. Zhu, R. J. McCormick, S. P. Ford, P. W. Nathanielsz, and M. Du (2010)
Am J Physiol Endocrinol Metab 298, E1254-E1260
   Abstract »    Full Text »    PDF »
Aging and its effects on inflammation in skeletal muscle at rest and following exercise-induced muscle injury.
J. Peake, P. D. Gatta, and D. Cameron-Smith (2010)
Am J Physiol Regulatory Integrative Comp Physiol 298, R1485-R1495
   Abstract »    Full Text »    PDF »
Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration.
Y. C. Jang, M. S. Lustgarten, Y. Liu, F. L. Muller, A. Bhattacharya, H. Liang, A. B. Salmon, S. V. Brooks, L. Larkin, C. R. Hayworth, et al. (2010)
FASEB J 24, 1376-1390
   Abstract »    Full Text »    PDF »
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion.
I. Beerman, D. Bhattacharya, S. Zandi, M. Sigvardsson, I. L. Weissman, D. Bryder, and D. J. Rossi (2010)
PNAS 107, 5465-5470
   Abstract »    Full Text »    PDF »
Focal Adhesion Kinase Signaling Regulates the Expression of Caveolin 3 and {beta}1 Integrin, Genes Essential for Normal Myoblast Fusion.
N. L. Quach, S. Biressi, L. F. Reichardt, C. Keller, and T. A. Rando (2009)
Mol. Biol. Cell 20, 3422-3435
   Abstract »    Full Text »    PDF »
Expression profiling of skeletal muscle in young bulls treated with steroidal growth promoters.
L. Carraro, S. Ferraresso, B. Cardazzo, C. Romualdi, C. Montesissa, F. Gottardo, T. Patarnello, M. Castagnaro, and L. Bargelloni (2009)
Physiol Genomics 38, 138-148
   Abstract »    Full Text »    PDF »
Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease.
K. D. Boudoulas and A. K. Hatzopoulos (2009)
Dis. Model. Mech. 2, 344-358
   Abstract »    Full Text »    PDF »
Enhanced Endothelial Cell Senescence by Lithium-induced Matrix Metalloproteinase-1 Expression.
I. T. Struewing, S. N. Durham, C. D. Barnett, and C. D. Mao (2009)
J. Biol. Chem. 284, 17595-17606
   Abstract »    Full Text »    PDF »
Attenuated muscle regeneration is a key factor in dysferlin-deficient muscular dystrophy.
Y.-H. Chiu, M. A. Hornsey, L. Klinge, L. H. Jorgensen, S. H. Laval, R. Charlton, R. Barresi, V. Straub, H. Lochmuller, and K. Bushby (2009)
Hum. Mol. Genet. 18, 1976-1989
   Abstract »    Full Text »    PDF »
Axin expression in thymic stromal cells contributes to an age-related increase in thymic adiposity and is associated with reduced thymopoiesis independently of ghrelin signaling.
H. Yang, Y.-H. Youm, Y. Sun, J.-S. Rim, C. J. Galban, B. Vandanmagsar, and V. D. Dixit (2009)
J. Leukoc. Biol. 85, 928-938
   Abstract »    Full Text »    PDF »
Regulation and Function of Skeletal Muscle Stem Cells.
M. Cerletti, J.L. Shadrach, S. Jurga, R. Sherwood, and A.J. Wagers (2009)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Stem Cells Use Distinct Self-renewal Programs at Different Ages.
B.P. Levi and S.J. Morrison (2009)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Wnt1 Expression Induces Short-Range and Long-Range Cell Recruitments That Modify Mammary Tumor Development and Are Not Induced by a Cell-Autonomous {beta}-Catenin Effector.
Y. C. Kim, R. J. Clark, E. A. Ranheim, and C. M. Alexander (2008)
Cancer Res. 68, 10145-10153
   Abstract »    Full Text »    PDF »
The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair.
M. P. Alfaro, M. Pagni, A. Vincent, J. Atkinson, M. F. Hill, J. Cates, J. M. Davidson, J. Rottman, E. Lee, and P. P. Young (2008)
PNAS 105, 18366-18371
   Abstract »    Full Text »    PDF »
Canonical Wnt signalling induces satellite-cell proliferation during adult skeletal muscle regeneration.
A. Otto, C. Schmidt, G. Luke, S. Allen, P. Valasek, F. Muntoni, D. Lawrence-Watt, and K. Patel (2008)
J. Cell Sci. 121, 2939-2950
   Abstract »    Full Text »    PDF »
Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish.
L. K. Mathew, S. S. Sengupta, J. LaDu, E. A. Andreasen, and R. L. Tanguay (2008)
FASEB J 22, 3087-3096
   Abstract »    Full Text »    PDF »
A genome-wide RNAi screen for Wnt/{beta}-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer.
W. Tang, M. Dodge, D. Gundapaneni, C. Michnoff, M. Roth, and L. Lum (2008)
PNAS 105, 9697-9702
   Abstract »    Full Text »    PDF »
Sca-1-Expressing Nonmyogenic Cells Contribute to Fibrosis in Aged Skeletal Muscle.
M. Hidestrand, S. Richards-Malcolm, C. M. Gurley, G. Nolen, B. Grimes, A. Waterstrat, G. V. Zant, and C. A. Peterson (2008)
J Gerontol A Biol Sci Med Sci 63, 566-579
   Abstract »    Full Text »    PDF »
The impact of aging on kidney repair.
R. Schmitt and L. G. Cantley (2008)
Am J Physiol Renal Physiol 294, F1265-F1272
   Abstract »    Full Text »    PDF »
Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging.
E. Meshorer and Y. Gruenbaum (2008)
J. Cell Biol. 181, 9-13
   Abstract »    Full Text »    PDF »
Satellite and stem cells in muscle growth and repair.
F. Le Grand and M. Rudnicki (2007)
Development 134, 3953-3957
   Abstract »    Full Text »    PDF »
Wnt makes stem cells act their age.
M. Leslie (2007)
J. Cell Biol. 178, 892
   Full Text »    PDF »
Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging.
H. Liu, M. M Fergusson, R. M. Castilho, J. Liu, L. Cao, J. Chen, D. Malide, I. I. Rovira, D. Schimel, C. J. Kuo, et al. (2007)
Science 317, 803-806
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882