Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 318 (5847): 68-69

Copyright © 2007 by the American Association for the Advancement of Science

Advances in Cytokinin Signaling

Bruno Müller, and Jen Sheen*

Abstract: Cytokinins are essential plant hormones that control various processes in plants' development and response to external stimuli. The Arabidopsis cytokinin signal transduction pathway involves hybrid histidine protein kinase sensors, phosphotransfer proteins, and regulators as transcription activators and repressors in a phosphorelay system. Each step is executed by components encoded by multigene families. Recent findings have revealed new functions, new feedback loops, and connections to other signaling pathways.

Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.

* To whom correspondence should be addressed. E-mail: sheen{at}

Adenine Phosphoribosyl Transferase 1 is a Key Enzyme Catalyzing Cytokinin Conversion from Nucleobases to Nucleotides in Arabidopsis.
X. Zhang, Y. Chen, X. Lin, X. Hong, Y. Zhu, W. Li, W. He, F. An, and H. Guo (2013)
Mol Plant 6, 1661-1672
   Abstract »    Full Text »    PDF »
Sensing the environment: key roles of membrane-localized kinases in plant perception and response to abiotic stress.
Y. Osakabe, K. Yamaguchi-Shinozaki, K. Shinozaki, and L.-S. P. Tran (2013)
J. Exp. Bot. 64, 445-458
   Abstract »    Full Text »    PDF »
The Arabidopsis O-Linked N-Acetylglucosamine Transferase SPINDLY Interacts with Class I TCPs to Facilitate Cytokinin Responses in Leaves and Flowers.
E. Steiner, I. Efroni, M. Gopalraj, K. Saathoff, T.-S. Tseng, M. Kieffer, Y. Eshed, N. Olszewski, and D. Weiss (2012)
PLANT CELL 24, 96-108
   Abstract »    Full Text »    PDF »
A Phylogenetic Strategy Based on a Legume-Specific Whole Genome Duplication Yields Symbiotic Cytokinin Type-A Response Regulators.
R. H. M. Op den Camp, S. De Mita, A. Lillo, Q. Cao, E. Limpens, T. Bisseling, and R. Geurts (2011)
Plant Physiology 157, 2013-2022
   Abstract »    Full Text »    PDF »
Ligand-binding properties and subcellular localization of maize cytokinin receptors.
S. N. Lomin, K. Yonekura-Sakakibara, G. A. Romanov, and H. Sakakibara (2011)
J. Exp. Bot. 62, 5149-5159
   Abstract »    Full Text »    PDF »
Cytokinin Interplay with Ethylene, Auxin, and Glucose Signaling Controls Arabidopsis Seedling Root Directional Growth.
S. Kushwah, A. M. Jones, and A. Laxmi (2011)
Plant Physiology 156, 1851-1866
   Abstract »    Full Text »    PDF »
The Perception of Cytokinin: A Story 50 Years in the Making.
J. J. Kieber and G. E. Schaller (2010)
Plant Physiology 154, 487-492
   Full Text »    PDF »
Cytokinin-binding protein (70 kDa) from etioplasts and amyloplasts of etiolated maize seedlings and chloroplasts of green plants and its putative function.
F. A. Brovko, V. S. Vasil'eva, A. L. Lushnikova, S. Y. Selivankina, N. N. Karavaiko, K. M. Boziev, A. O. Shepelyakovskaya, D. A. Moshkov, L. L. Pavlik, V. V. Kusnetsov, et al. (2010)
J. Exp. Bot. 61, 3461-3474
   Abstract »    Full Text »    PDF »
Arabidopsis Histidine Kinase CKI1 Acts Upstream of HISTIDINE PHOSPHOTRANSFER PROTEINS to Regulate Female Gametophyte Development and Vegetative Growth.
Y. Deng, H. Dong, J. Mu, B. Ren, B. Zheng, Z. Ji, W.-C. Yang, Y. Liang, and J. Zuo (2010)
PLANT CELL 22, 1232-1248
   Abstract »    Full Text »    PDF »
Cytokinin and WUSCHEL tie the knot around plant stem cells.
R. Sablowski (2009)
PNAS 106, 16016-16017
   Full Text »    PDF »
Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem.
S. P. Gordon, V. S. Chickarmane, C. Ohno, and E. M. Meyerowitz (2009)
PNAS 106, 16529-16534
   Abstract »    Full Text »    PDF »
Genetic and Epigenetic Regulation of Stem Cell Homeostasis in Plants.
M. Lodha, C.F. Marco, and M.C.P. Timmermans (2009)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Characterization of Cytokinin and Adenine Transport in Arabidopsis Cell Cultures.
A. Cedzich, H. Stransky, B. Schulz, and W. B. Frommer (2008)
Plant Physiology 148, 1857-1867
   Abstract »    Full Text »    PDF »
A Genetic Framework for the Control of Cell Division and Differentiation in the Root Meristem.
R. D. Ioio, K. Nakamura, L. Moubayidin, S. Perilli, M. Taniguchi, M. T. Morita, T. Aoyama, P. Costantino, and S. Sabatini (2008)
Science 322, 1380-1384
   Abstract »    Full Text »    PDF »
Functional Specialization of the TRANSPARENT TESTA GLABRA1 Network Allows Differential Hormonal Control of Laminal and Marginal Trichome Initiation in Arabidopsis Rosette Leaves.
L. Maes, D. Inze, and A. Goossens (2008)
Plant Physiology 148, 1453-1464
   Abstract »    Full Text »    PDF »
Comprehensive Transcriptome Analysis of Phytohormone Biosynthesis and Signaling Genes in Microspore/Pollen and Tapetum of Rice.
K. Hirano, K. Aya, T. Hobo, H. Sakakibara, M. Kojima, R. A. Shim, Y. Hasegawa, M. Ueguchi-Tanaka, and M. Matsuoka (2008)
Plant Cell Physiol. 49, 1429-1450
   Abstract »    Full Text »    PDF »
Hormone- and light-regulated nucleocytoplasmic transport in plants: current status.
Y. Lee, H.-S. Lee, J.-S. Lee, S.-K. Kim, and S.-H. Kim (2008)
J. Exp. Bot. 59, 3229-3245
   Abstract »    Full Text »    PDF »
The Transcriptional Repressor ARR1-SRDX Suppresses Pleiotropic Cytokinin Activities in Arabidopsis.
A. Heyl, E. Ramireddy, W. G. Brenner, M. Riefler, J. Allemeersch, and T. Schmulling (2008)
Plant Physiology 147, 1380-1395
   Abstract »    Full Text »    PDF »
GeBP and GeBP-Like Proteins Are Noncanonical Leucine-Zipper Transcription Factors That Regulate Cytokinin Response in Arabidopsis.
F. Chevalier, D. Perazza, F. Laporte, G. Le Henanff, P. Hornitschek, J.-M. Bonneville, M. Herzog, and G. Vachon (2008)
Plant Physiology 146, 1142-1154
   Abstract »    Full Text »    PDF »
Cytokinin Regulates Type-A Arabidopsis Response Regulator Activity and Protein Stability via Two-Component Phosphorelay.
J. P.C. To, J. Deruere, B. B. Maxwell, V. F. Morris, C. E. Hutchison, F. J. Ferreira, G. E. Schaller, and J. J. Kieber (2007)
PLANT CELL 19, 3901-3914
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882