Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Logo for

Science 318 (5849): 447-450

Copyright © 2007 by the American Association for the Advancement of Science

Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination

Min Gyu Lee,1 Raffaella Villa,2 Patrick Trojer,3 Jessica Norman,1 Kai-Ping Yan,1 Danny Reinberg,3 Luciano Di Croce,2 Ramin Shiekhattar1,2*

Abstract: Methylation of histone H3 lysine 27 (H3K27) is a posttranslational modification that is highly correlated with genomic silencing. Here we show that human UTX, a member of the Jumonji C family of proteins, is a di- and trimethyl H3K27 demethylase. UTX occupies the promoters of HOX gene clusters and regulates their transcriptional output by modulating the recruitment of polycomb repressive complex 1 and the monoubiquitination of histone H2A. Moreover, UTX associates with mixed-lineage leukemia (MLL) 2/3 complexes, and during retinoic acid signaling events, the recruitment of the UTX complex to HOX genes results in H3K27 demethylation and a concomitant methylation of H3K4. Our results suggest a concerted mechanism for transcriptional activation in which cycles of H3K4 methylation by MLL2/3 are linked with the demethylation of H3K27 through UTX.

1 The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
2 Institució Catalana de Recerca i Estudis Avançats and Centre de Regulació Genòmica, Barcelona, Spain.
3 Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA.

* To whom correspondence should be addressed. E-mail: ramin.shiekhattar{at}crg.es

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanisms of epigenetic deregulation in lymphoid neoplasms.
Y. Jiang, K. Hatzi, and R. Shaknovich (2013)
Blood 121, 4271-4279
   Full Text »    PDF »
Chromatin organization and global regulation of Hox gene clusters.
T. Montavon and D. Duboule (2013)
Phil Trans R Soc B 368, 20120367
   Abstract »    Full Text »    PDF »
RNA polymerase II progression through H3K27me3-enriched gene bodies requires JMJD3 histone demethylase.
C. Estaras, R. Fueyo, N. Akizu, S. Beltran, and M. A. Martinez-Balbas (2013)
Mol. Biol. Cell 24, 351-360
   Abstract »    Full Text »    PDF »
Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4.
S. S. Dhar, S.-H. Lee, P.-Y. Kan, P. Voigt, L. Ma, X. Shi, D. Reinberg, and M. G. Lee (2012)
Genes & Dev. 26, 2749-2762
   Abstract »    Full Text »    PDF »
Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4.
H.-M. Herz, M. Mohan, A. S. Garruss, K. Liang, Y.-h. Takahashi, K. Mickey, O. Voets, C. P. Verrijzer, and A. Shilatifard (2012)
Genes & Dev. 26, 2604-2620
   Abstract »    Full Text »    PDF »
Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A.
C.-P. Chaturvedi, B. Somasundaram, K. Singh, R. L. Carpenedo, W. L. Stanford, F. J. Dilworth, and M. Brand (2012)
PNAS 109, 18845-18850
   Abstract »    Full Text »    PDF »
UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.
C. Wang, J.-E. Lee, Y.-W. Cho, Y. Xiao, Q. Jin, C. Liu, and K. Ge (2012)
PNAS 109, 15324-15329
   Abstract »    Full Text »    PDF »
X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner.
G. G. Welstead, M. P. Creyghton, S. Bilodeau, A. W. Cheng, S. Markoulaki, R. A. Young, and R. Jaenisch (2012)
PNAS 109, 13004-13009
   Abstract »    Full Text »    PDF »
Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program.
C. Estaras, N. Akizu, A. Garcia, S. Beltran, X. de la Cruz, and M. A. Martinez-Balbas (2012)
Development 139, 2681-2691
   Abstract »    Full Text »    PDF »
KDM3B Is the H3K9 Demethylase Involved in Transcriptional Activation of lmo2 in Leukemia.
J.-Y. Kim, K.-B. Kim, G. H. Eom, N. Choe, H. J. Kee, H.-J. Son, S.-T. Oh, D.-W. Kim, J. H. Pak, H. J. Baek, et al. (2012)
Mol. Cell. Biol. 32, 2917-2933
   Abstract »    Full Text »    PDF »
State of the Science: An Update on Renal Cell Carcinoma.
E. Jonasch, P. A. Futreal, I. J. Davis, S. T. Bailey, W. Y. Kim, J. Brugarolas, A. J. Giaccia, G. Kurban, A. Pause, J. Frydman, et al. (2012)
Mol. Cancer Res. 10, 859-880
   Abstract »    Full Text »    PDF »
Histone Demethylase UTX and Chromatin Remodeler BRM Bind Directly to CBP and Modulate Acetylation of Histone H3 Lysine 27.
F. Tie, R. Banerjee, P. A. Conrad, P. C. Scacheri, and P. J. Harte (2012)
Mol. Cell. Biol. 32, 2323-2334
   Abstract »    Full Text »    PDF »
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
S. Chen, J. Ma, F. Wu, L.-j. Xiong, H. Ma, W. Xu, R. Lv, X. Li, J. Villen, S. P. Gygi, et al. (2012)
Genes & Dev. 26, 1364-1375
   Abstract »    Full Text »    PDF »
Emerging Epigenetic Targets and Therapies in Cancer Medicine.
R. Popovic and J. D. Licht (2012)
Cancer Discovery 2, 405-413
   Abstract »    Full Text »    PDF »
Tetrahymena thermophila JMJD3 Homolog Regulates H3K27 Methylation and Nuclear Differentiation.
P.-H. Chung and M.-C. Yao (2012)
Eukaryot. Cell 11, 601-614
   Abstract »    Full Text »    PDF »
FLC: A Hidden Polycomb Response Element Shows Up in Silence.
D. M. Buzas, Y. Tamada, and T. Kurata (2012)
Plant Cell Physiol. 53, 785-793
   Abstract »    Full Text »    PDF »
RYBP Represses Endogenous Retroviruses and Preimplantation- and Germ Line-Specific Genes in Mouse Embryonic Stem Cells.
K. Hisada, C. Sanchez, T. A. Endo, M. Endoh, M. Roman-Trufero, J. Sharif, H. Koseki, and M. Vidal (2012)
Mol. Cell. Biol. 32, 1139-1149
   Abstract »    Full Text »    PDF »
Hydroxylation mediates chromatin demethylation.
Y.-i. Tsukada (2012)
J. Biochem. 151, 229-246
   Abstract »    Full Text »    PDF »
Jumonji domain-containing protein 3 regulates histone 3 lysine 27 methylation during bovine preimplantation development.
S. Canovas, J. B. Cibelli, and P. J. Ross (2012)
PNAS 109, 2400-2405
   Abstract »    Full Text »    PDF »
Lysine methylation: beyond histones.
X. Zhang, H. Wen, and X. Shi (2012)
Acta Biochim Biophys Sin 44, 14-27
   Abstract »    Full Text »    PDF »
KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells.
F. Pereira, A. Barbachano, J. Silva, F. Bonilla, M. J. Campbell, A. Munoz, and M. J. Larriba (2011)
Hum. Mol. Genet. 20, 4655-4665
   Abstract »    Full Text »    PDF »
The COMPASS Family of H3K4 Methylases in Drosophila.
M. Mohan, H.-M. Herz, E. R. Smith, Y. Zhang, J. Jackson, M. P. Washburn, L. Florens, J. C. Eissenberg, and A. Shilatifard (2011)
Mol. Cell. Biol. 31, 4310-4318
   Abstract »    Full Text »    PDF »
Diverse ways to be specific: a novel Zn-binding domain confers substrate specificity to UTX/KDM6A histone H3 Lys 27 demethylase.
E. Kim and J.-J. Song (2011)
Genes & Dev. 25, 2223-2226
   Abstract »    Full Text »    PDF »
Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A.
T. Sengoku and S. Yokoyama (2011)
Genes & Dev. 25, 2266-2277
   Abstract »    Full Text »    PDF »
Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes.
S. Tae, V. Karkhanis, K. Velasco, M. Yaneva, H. Erdjument-Bromage, P. Tempst, and S. Sif (2011)
Nucleic Acids Res. 39, 5424-5438
   Abstract »    Full Text »    PDF »
Remembering one's identity: the epigenetic basis of stem cell fate decisions.
G. L. Sen (2011)
FASEB J 25, 2123-2128
   Abstract »    Full Text »    PDF »
Targeting Histone Demethylases: A New Avenue for the Fight against Cancer.
D. Rotili and A. Mai (2011)
Genes & Cancer 2, 663-679
   Abstract »    Full Text »    PDF »
The super elongation complex (SEC) and MLL in development and disease.
E. Smith, C. Lin, and A. Shilatifard (2011)
Genes & Dev. 25, 661-672
   Abstract »    Full Text »    PDF »
Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells.
T. Angrisano, S. Sacchetti, F. Natale, A. Cerrato, R. Pero, S. Keller, S. Peluso, B. Perillo, V. E. Avvedimento, A. Fusco, et al. (2011)
Nucleic Acids Res. 39, 1993-2006
   Abstract »    Full Text »    PDF »
Epigenomic Reorganization of the Clustered Hox Genes in Embryonic Stem Cells Induced by Retinoic Acid.
V. Kashyap, L. J. Gudas, F. Brenet, P. Funk, A. Viale, and J. M. Scandura (2011)
J. Biol. Chem. 286, 3250-3260
   Abstract »    Full Text »    PDF »
Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming.
M. E. McLaughlin-Drubin, C. P. Crum, and K. Munger (2011)
PNAS 108, 2130-2135
   Abstract »    Full Text »    PDF »
Role of H3K27 Demethylases Jmjd3 and UTX in Transcriptional Regulation.
M. R. Hubner and D. L. Spector (2011)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation.
L. Thorrez, I. Laudadio, K. Van Deun, R. Quintens, N. Hendrickx, M. Granvik, K. Lemaire, A. Schraenen, L. Van Lommel, S. Lehnert, et al. (2011)
Genome Res. 21, 95-105
   Abstract »    Full Text »    PDF »
Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus.
C. C. van Bavel, J. W. Dieker, Y. Kroeze, W. P. Tamboer, R. Voll, S. Muller, J. H. Berden, and J. van der Vlag (2011)
Ann Rheum Dis 70, 201-207
   Abstract »    Full Text »    PDF »
Polycomb proteins in hematologic malignancies.
D. Martin-Perez, M. A. Piris, and M. Sanchez-Beato (2010)
Blood 116, 5465-5475
   Abstract »    Full Text »    PDF »
Chatting histone modifications in mammals.
A. Izzo and R. Schneider (2010)
Briefings in Functional Genomics 9, 429-443
   Abstract »    Full Text »    PDF »
Dynamic Patterns of Histone Lysine Methylation in the Developing Retina.
R. C. Rao, K. T. Tchedre, M. T. A. Malik, N. Coleman, Y. Fang, V. E. Marquez, and D. F. Chen (2010)
Invest. Ophthalmol. Vis. Sci. 51, 6784-6792
   Abstract »    Full Text »    PDF »
Epigenetic control of embryonic stem cell fate.
N. S. Christophersen and K. Helin (2010)
J. Exp. Med. 207, 2287-2295
   Abstract »    Full Text »    PDF »
Regulation of mouse steroidogenesis by WHISTLE and JMJD1C through histone methylation balance.
S.-M. Kim, J.-Y. Kim, N.-W. Choe, I.-H. Cho, J.-R. Kim, D.-W. Kim, J.-E. Seol, S. E. Lee, H. Kook, K.-I. Nam, et al. (2010)
Nucleic Acids Res. 38, 6389-6403
   Abstract »    Full Text »    PDF »
H3K27me3 regulates BMP activity in developing spinal cord.
N. Akizu, C. Estaras, L. Guerrero, E. Marti, and M. A. Martinez-Balbas (2010)
Development 137, 2915-2925
   Abstract »    Full Text »    PDF »
Identification and Characterization of a Novel Human PP1 Phosphatase Complex.
J.-H. Lee, J. You, E. Dobrota, and D. G. Skalnik (2010)
J. Biol. Chem. 285, 24466-24476
   Abstract »    Full Text »    PDF »
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.
I. J. Majewski, M. E. Ritchie, B. Phipson, J. Corbin, M. Pakusch, A. Ebert, M. Busslinger, H. Koseki, Y. Hu, G. K. Smyth, et al. (2010)
Blood 116, 731-739
   Abstract »    Full Text »    PDF »
Phenotypic annotation of the mouse X chromosome.
B. J. Cox, M. Vollmer, O. Tamplin, M. Lu, S. Biechele, M. Gertsenstein, C. van Campenhout, T. Floss, R. Kuhn, W. Wurst, et al. (2010)
Genome Res. 20, 1154-1164
   Abstract »    Full Text »    PDF »
Phosphorylation of Mixed Lineage Leukemia 5 by Cdc2 Affects Its Cellular Distribution and Is Required for Mitotic Entry.
J. Liu, X. N. Wang, F. Cheng, Y.-C. Liou, and L.-W. Deng (2010)
J. Biol. Chem. 285, 20904-20914
   Abstract »    Full Text »    PDF »
PHF8 Targets Histone Methylation and RNA Polymerase II To Activate Transcription.
K. Fortschegger, P. de Graaf, N. S. Outchkourov, F. M. A. van Schaik, H. T. M. Timmers, and R. Shiekhattar (2010)
Mol. Cell. Biol. 30, 3286-3298
   Abstract »    Full Text »    PDF »
The H3K27me3 Demethylase dUTX Is a Suppressor of Notch- and Rb-Dependent Tumors in Drosophila.
H. M. Herz, L. D. Madden, Z. Chen, C. Bolduc, E. Buff, R. Gupta, R. Davuluri, A. Shilatifard, I. K. Hariharan, and A. Bergmann (2010)
Mol. Cell. Biol. 30, 2485-2497
   Abstract »    Full Text »    PDF »
The histone demethylase UTX enables RB-dependent cell fate control.
J. K. Wang, M.-C. Tsai, G. Poulin, A. S. Adler, S. Chen, H. Liu, Y. Shi, and H. Y. Chang (2010)
Genes & Dev. 24, 327-332
   Abstract »    Full Text »    PDF »
A histone demethylase is necessary for regeneration in zebrafish.
S. Stewart, Z.-Y. Tsun, and J. C. I. Belmonte (2009)
PNAS 106, 19889-19894
   Abstract »    Full Text »    PDF »
Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice.
B. Schuettengruber and G. Cavalli (2009)
Development 136, 3531-3542
   Abstract »    Full Text »    PDF »
Epigenetic regulation of the alternatively activated macrophage phenotype.
M. Ishii, H. Wen, C. A. S. Corsa, T. Liu, A. L. Coelho, R. M. Allen, W. F. Carson IV, K. A. Cavassani, X. Li, N. W. Lukacs, et al. (2009)
Blood 114, 3244-3254
   Abstract »    Full Text »    PDF »
ASCOM Controls Farnesoid X Receptor Transactivation through Its Associated Histone H3 Lysine 4 Methyltransferase Activity.
D.-H. Kim, J. Lee, B. Lee, and J. W. Lee (2009)
Mol. Endocrinol. 23, 1556-1562
   Abstract »    Full Text »    PDF »
Nucleosomes are well positioned in exons and carry characteristic histone modifications.
R. Andersson, S. Enroth, A. Rada-Iglesias, C. Wadelius, and J. Komorowski (2009)
Genome Res. 19, 1732-1741
   Abstract »    Full Text »    PDF »
CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.
F. Tie, R. Banerjee, C. A. Stratton, J. Prasad-Sinha, V. Stepanik, A. Zlobin, M. O. Diaz, P. C. Scacheri, and P. J. Harte (2009)
Development 136, 3131-3141
   Abstract »    Full Text »    PDF »
Alterations of histone modifications by cobalt compounds.
Q. Li, Q. Ke, and M. Costa (2009)
Carcinogenesis 30, 1243-1251
   Abstract »    Full Text »    PDF »
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.
J. Lee, D.-H. Kim, S. Lee, Q.-H. Yang, D. K. Lee, S.-K. Lee, R. G. Roeder, and J. W. Lee (2009)
PNAS 106, 8513-8518
   Abstract »    Full Text »    PDF »
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence.
K. Agger, P. A.C. Cloos, L. Rudkjaer, K. Williams, G. Andersen, J. Christensen, and K. Helin (2009)
Genes & Dev. 23, 1171-1176
   Abstract »    Full Text »    PDF »
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS.
M. Barradas, E. Anderton, J. C. Acosta, S. Li, A. Banito, M. Rodriguez-Niedenfuhr, G. Maertens, M. Banck, M.-M. Zhou, M. J. Walsh, et al. (2009)
Genes & Dev. 23, 1177-1182
   Abstract »    Full Text »    PDF »
Crucial Roles for Interactions between MLL3/4 and INI1 in Nuclear Receptor Transactivation.
S. Lee, D.-H. Kim, Y. H. Goo, Y. C. Lee, S.-K. Lee, and J. W. Lee (2009)
Mol. Endocrinol. 23, 610-619
   Abstract »    Full Text »    PDF »
Identification and Characterization of a Novel Nuclear Protein Complex Involved in Nuclear Hormone Receptor-mediated Gene Regulation.
S. Garapaty, C.-F. Xu, P. Trojer, M. A. Mahajan, T. A. Neubert, and H. H. Samuels (2009)
J. Biol. Chem. 284, 7542-7552
   Abstract »    Full Text »    PDF »
Developmental roles of the histone lysine demethylases.
A. Nottke, M. P. Colaiacovo, and Y. Shi (2009)
Development 136, 879-889
   Abstract »    Full Text »    PDF »
Loss of Mll5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.
M. Heuser, D. B. Yap, M. Leung, T. R. de Algara, A. Tafech, S. McKinney, J. Dixon, R. Thresher, B. Colledge, M. Carlton, et al. (2009)
Blood 113, 1432-1443
   Abstract »    Full Text »    PDF »
Molecular Regulation of H3K4 Trimethylation by Wdr82, a Component of Human Set1/COMPASS.
M. Wu, P. F. Wang, J. S. Lee, S. Martin-Brown, L. Florens, M. Washburn, and A. Shilatifard (2008)
Mol. Cell. Biol. 28, 7337-7344
   Abstract »    Full Text »    PDF »
Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.
J. Lee, P. K. Saha, Q.-H. Yang, S. Lee, J. Y. Park, Y. Suh, S.-K. Lee, L. Chan, R. G. Roeder, and J. W. Lee (2008)
PNAS 105, 19229-19234
   Abstract »    Full Text »    PDF »
Regulation of Stem Cell Differentiation by Histone Methyltransferases and Demethylases.
D. Pasini, A.P. Bracken, K. Agger, J. Christensen, K. Hansen, P.A.C. Cloos, and K. Helin (2008)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression.
S. A. Miller, A. C. Huang, M. M. Miazgowicz, M. M. Brassil, and A. S. Weinmann (2008)
Genes & Dev. 22, 2980-2993
   Abstract »    Full Text »    PDF »
dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing.
A. Lagarou, A. Mohd-Sarip, Y. M. Moshkin, G. E. Chalkley, K. Bezstarosti, J. A.A. Demmers, and C. P. Verrijzer (2008)
Genes & Dev. 22, 2799-2810
   Abstract »    Full Text »    PDF »
Arsenite alters global histone H3 methylation.
X. Zhou, H. Sun, T. P. Ellen, H. Chen, and M. Costa (2008)
Carcinogenesis 29, 1831-1836
   Abstract »    Full Text »    PDF »
Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3.
G. L. Sen, D. E. Webster, D. I. Barragan, H. Y. Chang, and P. A. Khavari (2008)
Genes & Dev. 22, 1865-1870
   Abstract »    Full Text »    PDF »
Activating Signal Cointegrator-2 Is an Essential Adaptor to Recruit Histone H3 Lysine 4 Methyltransferases MLL3 and MLL4 to the Liver X Receptors.
S. Lee, J. Lee, S.-K. Lee, and J. W. Lee (2008)
Mol. Endocrinol. 22, 1312-1319
   Abstract »    Full Text »    PDF »
Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing.
X. Wu, Y. Gong, J. Yue, B. Qiang, J. Yuan, and X. Peng (2008)
Nucleic Acids Res. 36, 3590-3599
   Abstract »    Full Text »    PDF »
The LIM Protein AJUBA Recruits Protein Arginine Methyltransferase 5 To Mediate SNAIL-Dependent Transcriptional Repression.
Z. Hou, H. Peng, K. Ayyanathan, K.-P. Yan, E. M. Langer, G. D. Longmore, and F. J. Rauscher III (2008)
Mol. Cell. Biol. 28, 3198-3207
   Abstract »    Full Text »    PDF »
SWI/SNF Mediates Polycomb Eviction and Epigenetic Reprogramming of the INK4b-ARF-INK4a Locus.
S. K. Kia, M. M. Gorski, S. Giannakopoulos, and C. P. Verrijzer (2008)
Mol. Cell. Biol. 28, 3457-3464
   Abstract »    Full Text »    PDF »
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.
D. Pasini, K. H. Hansen, J. Christensen, K. Agger, P. A.C. Cloos, and K. Helin (2008)
Genes & Dev. 22, 1345-1355
   Abstract »    Full Text »    PDF »
Changes in the Distributions and Dynamics of Polycomb Repressive Complexes during Embryonic Stem Cell Differentiation.
X. Ren, C. Vincenz, and T. K. Kerppola (2008)
Mol. Cell. Biol. 28, 2884-2895
   Abstract »    Full Text »    PDF »
Characterization of Drosophila melanogaster JmjC+N histone demethylases.
M. Lloret-Llinares, C. Carre, A. Vaquero, N. de Olano, and F. Azorin (2008)
Nucleic Acids Res. 36, 2852-2863
   Abstract »    Full Text »    PDF »
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.
P. A.C. Cloos, J. Christensen, K. Agger, and K. Helin (2008)
Genes & Dev. 22, 1115-1140
   Abstract »    Full Text »    PDF »
Sex-Specific Differences in Expression of Histone Demethylases Utx and Uty in Mouse Brain and Neurons.
J. Xu, X. Deng, R. Watkins, and C. M. Disteche (2008)
J. Neurosci. 28, 4521-4527
   Abstract »    Full Text »    PDF »
Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells.
D. Phanstiel, J. Brumbaugh, W. T. Berggren, K. Conard, X. Feng, M. E. Levenstein, G. C. McAlister, J. A. Thomson, and J. J. Coon (2008)
PNAS 105, 4093-4098
   Abstract »    Full Text »    PDF »
Drosophila UTX Is a Histone H3 Lys27 Demethylase That Colocalizes with the Elongating Form of RNA Polymerase II.
E. R. Smith, M. G. Lee, B. Winter, N. M. Droz, J. C. Eissenberg, R. Shiekhattar, and A. Shilatifard (2008)
Mol. Cell. Biol. 28, 1041-1046
   Abstract »    Full Text »    PDF »
MOLECULAR BIOLOGY: Unlocking Cell Fate.
A. G. Rivenbark and B. D. Strahl (2007)
Science 318, 403-404
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882